HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats by Dahu Liang, Zijing Wu, Yanhao Liu, Chao Li, Xianghong Li, Bin Yang, Haitang Xie, Hua Sun

“…Our data represent a valuable foundation for future studies of the pharmacologic and biological characteristics of Schisandrol B.…”
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Functional and Structural Investigation of Myenteric Neurons in the Human Colon by Kristin Elfers, Alina Sophia Sehnert, Alexander Wagner, Ulrich Zwirner, Helena Linge, Ulf Kulik, Daniel Poehnert, Markus Winny, Benjamin Gundert, Heiko Aselmann, Gemma Mazzuoli-Weber

“…Conclusion: Neuroimaging with 1-(3-sulfanatopropyl)-4-[beta[2-(di-n-octylamino)-6-naphthyl]vinyl]pyridinium betaine was successfully adapted to record reproducible responses from human colonic myenteric neurons upon pharmacological stimulation. Evidence exists for an impact of age and inflammation on the serotonergic neuronal signaling and for differences in neuronal numbers in the distinct colonic regions as well as a neuronal decrease with age.…”
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Effects of biophilic virtual reality on cognitive function of patients undergoing laparoscopic surgery: study protocol for a sham randomised controlled trial by Bin Gao, Yanling Zhou, Jianhua Wang, Binbin Zhu, Qiuyan Weng, Wenjun Luo, Xiuchao He, Lufei Jin, Qinwen Wang, Ahmad Khaled Ahmad Harb

“…Due to the lack of an effective postoperative follow-up system, the incidence of POCD in China is not clear, and although many drugs have been proposed to improve POCD in the animal study, their clinical applications are limited, while VR provides an innovative method to provide non-pharmacological management.Methods and design This is a single-centre, randomised, double-blind, sham-controlled clinical trial. …”
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Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review by Maya G. Pillai, Helen Antony

“…Clinical applications of NP-based immunotherapies, such as curcumin and resveratrol in cancer treatment, highlight their diverse pharmacological properties. However, despite these advancements, challenges persist in the clinical implementation of NPs. …”
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New Oral Anaticoagulant Prescribing Decisions amongst General Practitioners: Handle with Care by Ann Kirby, Aileen Murphy, Colin Bradley

“…The introduction of new oral anticoagulants (NOACs) offers a wider choice but they are more costly and their use also brings additional pharmacological considerations. **Objective:** This paper investigates if the identified risk factors (renal impairment, hepatic impairment, other co-morbidities & drug interactions) influence GPs’ NOAC prescribing decisions, using a multivariate probit model, while controlling for other GP characteristics. …”
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Interindividual Variability Response to Resistance and High-Intensity Interval Training on Blood Pressure Reduction in Hypertensive Older Adults by Johnattan Cano-Montoya, Nicolas Hurtado, Carolina Núñez Vergara, Sebastián Báez Vargas, Marcela Rojas-Vargas, Sergio Martínez-Huenchullán, Cristian Alvarez, Mikel Izquierdo

“…Background: This study evaluated the effects of resistance training (RT) and high-intensity interval training (HIIT) on systolic (SBP) and diastolic blood pressure (DBP) in hypertensive older adults undergoing pharmacological therapy over four and eight weeks. We compared the efficacy of RT and HIIT in reducing non-responders (NRs) between weeks 4 and 8 and analyzed time-course adaptations in NRs and responders (Rs). …”
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Effect of Lycium barbarum Polysaccharide on Decreasing Serum Amyloid A3 Expression through Inhibiting NF-κB Activation in a Mouse Model of Diabetic Nephropathy by Fengqi Wan, Fulin Ma, Jiaxin Wu, Xinyu Qiao, Minxue Chen, Wenjian Li, Liang Ma

“…Lycium barbarum polysaccharide (LBP) as one of the main bioactive constituents of the fruit of Lycium barbarum L. (LBL.) has many pharmacological activities, but its antihyperglycemic activity is not fully understood yet. …”
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Identification of Molecular Subtypes and Prognostic Features of Breast Cancer Based on TGF-β Signaling-related Genes by Jia Qu, Mei-Huan Wang, Yue-Hua Gao, Hua-Wei Zhang

“…Immune checkpoint inhibitors (ICIs) and pharmacological agents that target TGF-β offer significant potential as therapeutic options for cancer. …”
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A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombina... by Xingxing Li, Yue Wu, Min Zhang, Fengliang Wang, Hong Yin, Yanrong Zhang, Shuli Zhao, Jiehua Ma, Mingming Lv, Cheng Lu

“…Nevertheless, to date, no pharmacological agents capable of directly targeting and inducing the degradation of C1QBP have been identified. …”
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Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity by Parichehr Amiri, Seyed Ahmad Hosseini, Maryam Saghafi-Asl, Amin Akbari-Naserkiadeh, Seyedeh Asal Jenani Zavieh, Sara Arefhosseini, Samira Asghari, Neda Roshanravan

“…Microbiome-derived short-chain fatty acids, particularly sodium butyrate (NaBu) has been presented a plethora of pharmacological features in the treatment of metabolic conditions. …”
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Computer analysis of regulation of hepatocarcinoma marker genes hypermethylated by HCV proteins by E. A. Antropova, T. M. Khlebodarova, P. S. Demenkov, A. S. Venzel, N. V. Ivanisenko, A.  D.  Gavrilenko, T.  V. Ivanisenko, A. V. Adamovskaya, P. M. Revva, I. N. Lavrik, V. A. Ivanisenko

“…The results obtained can be used in the search for pharmacological targets to develop new drugs against HCV-induced HCC.…”
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Anticancer Activity of Rhizophora mucronata Leaves Extract on Sprague–Dawley Rats: In Vivo Model by Asbin Mary X, Syed Ali Mohamed Yacoob, Anuradha Venkatraman, Ruban Packiasamy, Meivelu Moovendhan, Murugesan Gnanadesigan, Yogananth Nagarajan

“…Based on these findings, it has been concluded that methanolic extract of Rhizophora mucronata leaves (MERML) was safe at both higher and lower dosages and could be assessed for pharmacological study.…”
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Psychological impact and coping mechanisms among sudanese medical students: a study on anxiety, depression, behavioral, and cognitive changes post COVID-19 lockdown and ongoing con... by Ali Awadallah Saeed, Ahmad Mohammad Al Zamel, Abrar Abdu Abass, Aisha Ahmed Mohammed, Fidaaldeen Adil Abdallh, Hiba Elhadi Ali, Nooralain Mohammed Hassan, Raad Mohammed Osman, Toga Abdelmutaal Mohammed, Azza Osman Yousif, Lamya Bashir Eisa

“…The study revealed that most individuals utilized pharmacological coping strategies following significant life changes due to uncontrollable situations. …”
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A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms by David Trombley McSwiggen, Helen Liu, Ruensern Tan, Sebastia Agramunt Puig, Lakshmi B Akella, Russell Berman, Mason Bretan, Hanzhe Chen, Xavier Darzacq, Kelsey Ford, Ruth Godbey, Eric Gonzalez, Adi Hanuka, Alec Heckert, Jaclyn J Ho, Stephanie L Johnson, Reed Kelso, Aaron Klammer, Ruchira Krishnamurthy, Jifu Li, Kevin Lin, Brian Margolin, Patrick McNamara, Laurence Meyer, Sarah E Pierce, Akshay Sule, Connor Stashko, Yangzhong Tang, Daniel J Anderson, Hilary P Beck

“…We addressed these limitations by developing a high-throughput single-molecule tracking (htSMT) platform for pharmacologic dissection of protein dynamics in living cells at an unprecedented scale (capable of imaging >106 cells/day and screening >104 compounds). …”
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The Efficacy of Pulsed Electromagnetic Fields on Pain, Stiffness, and Physical Function in Osteoarthritis: A Systematic Review and Meta-Analysis by Jie Tong, Zhengyu Chen, Guanghua Sun, Jun Zhou, Ye Zeng, Peirui Zhong, Chengyuan Deng, Xiaocui Chen, Liu Liu, Shiyong Wang, Jiaqian Chen, Ying Liao

“…Although there are many pharmacological interventions for adults with osteoarthritis (OA) who do not meet the indications for surgery, side effects and adverse effects cannot be ignored. …”
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Exploring the Antioxidant and Neuroprotective Potential of Muscari armeniacum: Phenolic Profiling and Enzyme Inhibition by Fevzi Topal, Firat Yılmaz, Meryem Topal, Ahmed Menevşeoğlu

“…Its potential applications in the treatment of oxidative stress-related diseases and neurodegenerative disorders make it a promising candidate for further pharmacological studies. This research underscores the importance of exploring native plants for their medicinal and therapeutic potential, contributing to the development of alternative treatments for challenging health conditions.…”
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Effect of nanoemulsion carbonated hydroxyapatite-statin administration on Acp 5 and Runx-2 expression during orthodontic relapse in rats by Ananto Ali Alhasyimi, Niswati Fathmah Rosyida, Ika Dewi Ana

“…In the past two decades, numerous biological treatments have been developed to alleviate orthodontic relapse. Pharmacologic bone modulation is a viable approach to mitigate relapse. …”
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Relationship between physical activity and depressive symptoms in stroke survivors: a cross-sectional study of 1,140 individuals by Yihao Wang, Jiali Chen, Yanwei Zou, Mengshu Yang, Xiaoyun Kong, Ling Wang, Jingyuan Xue, Ci Dong

“…Conclusion: Regular physical activity, particularly of moderate or higher intensity, is associated with milder depressive symptoms in stroke survivors, suggesting the potential for non-pharmacological intervention. …”
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Green synthesis of silver and gold nanoparticles using quercetin extracted from Arctium lappa by HPLC, Characterization and Estimation of antioxidant activity by Mahmood Zaki Lafta, Rafah Razooq Hameed Al-Samarrai, Mohamed Bouaziz

“…Quercetin, a major flavonoid, is recognized for its pharmacological properties. The purpose of this study was to extract quercetin from A. lappa and use it for the green synthesis of gold (AuNPs) and silver nanoparticles (AgNPs) to evaluate their antioxidant properties. …”
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Higher Trace Elements and Lower Fatty Acids Levels in Erythrocytes as Predictors of Preeclampsia by Ruth Widhiati Raharjo Putri, Damar Prasmusinto, Noroyono Wibowo, Rima Irwinda, Yuditiya Purwosunu, Yudianto Budi Saroyo

“…Many studies only focus on the diagnosis and pharmacological treatment of preeclampsia. However, predictors of preeclampsia need to be observed to add more focus on the etiology and prevention of preeclampsia. …”
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