Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury by JiaQi Hu, WenYong Fan, Yue Xu, XiaoFei Li, HaoYang Zhang, Shun Li, Lei Xue

“…These AEA-induced transitions were facilitated by increased TRPV1 transcription. Pharmacological and Ca2+ imaging experiments revealed that AEA induced hyperexcitability in nociceptors after SCI via the AEA-TRPV1-Ca2+ pathway, whereas activation of CB1Rs reduced SCI-induced hyperexcitability and maintained cytosolic Ca2+ concentration ([Ca2+]cyto) at low levels in the early stages of SCI. …”
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Management of Hypertension in the Elderly Patient at Abidjan Cardiology Institute (Ivory Coast) by K. E. Kramoh, E. Aké-Traboulsi, C. Konin, Y. N'goran, I. Coulibaly, A. Adoubi, J. Koffi, J. B. Anzouan-Kacou, M. Guikahue

“…According to the European Guidelines stratification of the cardiovascular risk-excess attributable to high blood pressure, 82.1% of the sample had a very high added risk. The pharmacological therapy was prescribed in 93.5%. More than 66% of patients were receiving ≥2 antihypertensive drugs including fixed-dose combination drugs. …”
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Interleukin-17 prevents oxidative stress from damaging osteoblast formation by inhibiting autophagic degradation of metallothionein-2 by Xueyan Ling, Cuixia Wang, Qin Feng, Tao Zhang

“…Ultimately, by using autophagic pharmacological agonist (rapamycin) and lentiviral transduction technology, the relationship between autophagy, IL-17A-regulated MT-2 protein expression and IL-17A-regulated ROS production was further elucidated. …”
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Physical activity and ageing: The role of physiotherapy in promoting healthy ageing by Shane Naidoo, Nirmala Naidoo

“…Clinical implications: The current research base in the field of ageing in SSA is limited, indicating the need for non-pharmacological interventions to manage the prevalence of NCDs, including in mental/cognitive health, where PA has a direct influence.…”
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A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure contr... by Philip Düsing, Stephan H. Schirmer, Sebastian Schäfer, Alexander Krogmann, Jan-Malte Sinning, Nikos Werner, Florian Bönner, Alexander Sedaghat, Cornelius Müller, Irina Eckardt, Georg Nickenig, Andreas Zietzer

“…Therefore, optimal secondary prevention includes managing BP through lifestyle changes and pharmacological therapy. The CHANGE study aimed to provide evidence for optimizing secondary prevention in CCS patients using a smartphone application.MethodsThe CHANGE-Study is a prospective, randomized, controlled trial performed in 9 centers in Germany. …”
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ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis by Ruoxue Chen, Xuan Huang, Jiayun Hou, Junjie Ni, Wenrui Zhao, Quanlin Li, Heng Jiao, Xin Cao

“…Following iterative optimisation and pharmacological validation, ZSH‐2208 was identified as the most promising candidate for effectively targeting ESCC tumour‐repopulating cells (TRCs). …”
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A New Hope for the Patients of Non‐Alcoholic Steatohepatitis: FDA Gives Green Signal for Resmetirom Use by Abdul Haseeb Hasan, Muhammad Ali Abid, Muhammad Hafi Abid, Laiba Suhail, Abubakar Nazir

“…Despite its rising prevalence and significant disease burden, effective pharmacological treatments have been limited to lifestyle modifications and surgical interventions. …”
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Effectiveness of Bay Leaf Extract (Syzygium polyanthum) on Uric Acid and Cholesterol Levels in Caffeine-Induced Male Mice (Mus musculus) by Fahrul Andika Pratama, Salma Aisyafalah, Rochmah Kurnijasanti

“…Bay leaf (Syzygium polyanthum) is one of the plants from Indonesia that has the potential to be used as a raw material for herbal medicine. Pharmacologically, bay leaves containing flavonoids have been shown to have antioxidant activity, which can reduce hyperuricemia and blood cholesterol levels. …”
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Delirium management and current practice among Intensive Care Units Doctors, Khartoum [version 3; peer review: 1 approved, 2 approved with reservations] by Mudawi Mohammed Ahmed Abdallah, Sheema Hamid Seidna Hamid, Hana Eltayeb Salih Elamin, Ghada Omer Hamad Abd El-Raheem

“…Delirium was not regularly assessed in 13.9% of the patients. Non-pharmacological management was applied by 76.4% of doctors, and communication with patients was the most frequent (75%). …”
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Interventions to reduce sedentary behaviour in adults with type 2 diabetes: A systematic review and meta-analysis. by Siobhan Smith, Babac Salmani, Jordan LeSarge, Kirsten Dillon-Rossiter, Anisa Morava, Harry Prapavessis

“…Treatment and management of Type 2 Diabetes (T2D) includes physical activity, nutrition, and pharmacological management. Recently, the importance of reducing and breaking up sedentary behaviour has become recognized. …”
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Medical treatment of patients before surgical myocardial revascularization by I.V. Shklianka, O.J. Zharinov, O.A. Yepanchintseva, B.M. Todurov

“…The review summarizes the existing data on patients’ medical treatment before coronary artery bypass grafting. The strategy for pharmacologic therapy before coronary artery bypass grafting should be aimed at ensuring compliance with guidelines for basic treatment of stable coronary heart disease, as well as adequate correction of concomitant diseases and conditions for the prevention of peri- and postoperative complications. …”
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The effect of acute slow resistance exercise on post-exercise blood pressure in active normotensive male recreational athlete by Ali Ramezanı, Naser Heıdarı

“…Physical activity is a non-pharmacological way to prevent or treat disorders like type 2-diabete, obesity and hypertension. …”
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What all physicians should know about women’s health: a Delphi study by Susanna Price, Eva Gerdts, Julien Mazières, Alexandra Kautzky-Willer, Fedde Scheele, Chiara Benedetto, Kerry Wilbur, Gertraud Stadler, Marieke Wermer, Jeanine Roeters van Lennep, Merel H de Heer-Koster, Vesna Bjegović-Mikanović, Indre Banaitytė-Baleišienė, Mary Perdiou, Alyson McGregor, Connie Newman, Simona Stankevičiūtė, Iris E Sommer, Florence Thibaut, Karine van 't Land

“…In the final round, 35 responses on the 22 selected statements resulted in consensus on 18 statements of the highest importance, within the following domains: the societal position of women in health, patient perception of disease and treatment, differences in symptomatology, pharmacological considerations and the impact of the female life cycle on health and disease.Conclusion Consensus was reached on the top priority clinical conditions and public health issues in women’s health, resulting in a list of 18 statements on women’s health that every physician caring for women should know, regardless of specialty. …”
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Abrupt onset or exacerbation of anorexia nervosa following recent infections: a mini-review and a case report with an atypical manifestation of PANS by Lavalle Raffaele, Tournour Cristina, Rubano Serena, Delsedime Nadia, Panero Matteo, Abbate-Daga Giovanni

“…After significant weight loss and amenorrhea, she was hospitalized for 29 days, receiving psychiatric care, nutritional rehabilitation, and pharmacological treatment. Over 2 months of residential care and ongoing outpatient therapy, she improved notably, though mild body dysmorphophobia persisted. …”
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Role of Renal Nerves in the Treatment of Renovascular Hypertensive Rats with L-Arginine by Sonia Alves Gouvea, Renata V. Tiradentes, Cintia H. Santuzzi, Vinícius Mengal, Henrique de A. Futuro Neto, Nyam F. Silva, Gláucia R. Abreu

“…The 2K1C (two-kidney one-clip model) hypertensive rats were submitted to bilateral surgical-pharmacological renal denervation. The animals were subdivided into six experimental groups: normotensive control rats (SHAM), 2K1C rats, 2K1C rats treated with L-arginine (2K1C + L-arg), denervated normotensive (DN) rats, denervated 2K1C (2K1C + DN) rats, and denervated 2K1C + L-arg (2K1C + DN + L-arg) rats. …”
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A new method of distracting attention: Is it effective for pain and fear during phlebotomy in children? by Mine Aydemir Sahin, Yeliz Cigerci, Hamide Nur Cevik Ozdemir

“…The musical blood collection tube can be used by health professionals as a non-pharmacological method to reduce the pain and fear of children during blood collection. …”
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Elritercept, a modified activin receptor IIA ligand trap, increased erythropoiesis and thrombopoiesis in a phase 1 trial by Jennifer Lachey, Christopher Rovaldi, Suresh Bobba, Jared Tur, Harveen Natarajan, Ben Snyder, Jasbir Seehra

“…The time course and duration of changes in these cell populations supported a differentiated pharmacologic profile that is consistent with the stimulation of both early- and late-stage hematologic pathways. …”
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Effect of acupuncture on patients with major psychiatric disorder and related symptoms caused by earthquake exposure: Protocol for a scoping review of clinical studies. by Hui-Ju Kwon, Jungtae Leem, Da-Woon Kim, Chan-Young Kwon, Sang-Ho Kim

“…Conventional treatments such as pharmacological treatments have several limitations. Acupuncture therapy as a complementary integrative medicine may be an effective alternative treatment for these limitations. …”
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Antimalarial Activity of Tinospora baenzigeri against Plasmodium berghei-Infected Mice by Sakaewan Ounjaijean, Manas Kotepui, Voravuth Somsak

“…Plant species of the genus Tinospora (Menispermaceae) possess several pharmacological properties, and T. crispa has been reported to have antimalarial activity. …”
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Systemic reviews and meta-analysis of the use of midodrine in hepatorenal syndrome by Prem Balaji Reddy Lankapothu, Shrinidhi B., Satish Kumar M., Magesh Kumar S.

“…However, significant, well-designed clinical trials are needed to determine optimal dosage, duration, and pharmacological side effects. The meta-analysis highlights opportunities for further research on midodrine in combination treatments and cost-effectiveness evaluations. …”
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