Synergistic Antibiofilm Efficacy of Thymol and Piperine in Combination with Three Aminoglycoside Antibiotics against Klebsiella pneumoniae Biofilms by Borel Bisso Ndezo, Christian Ramsès Tokam Kuaté, Jean Paul Dzoyem

“…Thymol and piperine are two naturally occurring bioactive compounds with several pharmacological activities. In this study, their antibiofilm potential either alone or in combination with three aminoglycoside antibiotics was evaluated against a biofilm of Klebsiella pneumoniae. …”
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Quadriceps Activation After Anterior Cruciate Ligament Reconstruction: The Early Bird Gets the Worm! by Ayrton MOIROUX--SAHRAOUI, Florian FORELLI, Jean MAZEAS, Alexandre JM RAMBAUD, Andreas BJERREGAARD, Jérôme RIERA

“…Early management focusing on pain modulation through modalities like ice, compression, and pharmacological agents help mitigate the inflammatory response and alleviate pain, thereby reducing the reflexive inhibition of quadriceps. …”
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Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform by Tommaso Tabaglio, Taniya Agarwal, Wei Yuan Cher, Jin Rong Ow, Ah Keng Chew, Priscila Yun Qian Sun, Raja Sekhar Reddy Gurrampati, Hongfang Lu, Praveena Naidu, Hong Kai Ng, Xavier Le Guezennec, Shi Yan Ng, Manikandan Lakshmanan, Ernesto Guccione, Keng Boon Wee

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Comparison of GLP-1RAs vs Other Pharmacotherapy for Obesity by Andrew Overholser, Eric Czech, Linda Speer, Joel Wilson, Alex Overholser

“…Objectives: This review will summarize evidence comparing the safety and efficacy of GLP-1RAs or GLP-1RAs/GIP agonists with other pharmacologic treatments to achieve and maintain weight loss, improve quality of life, and reduce morbidity in obese adults. …”
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Development of a new composite surface tensiometry parameter for quality evaluation of the maturation process of peloids by contact angle method by Davide Rossi, Nicola Realdon

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The Recognition and Management of Adverse Effects in Electroconvulsive Therapy: Findings From a Finnish Survey Study by Saara H. Huoponen, Katrin Sisa, Tom Saari, Markku Taittonen, Ulla Ahlmén‐Laiho

“…Five units (29%) reported frequent or occasional headache or myalgia and four units (24%) reported occasional nausea experienced by their patients, but these AEs were addressed pharmacologically in those units neither by prophylaxis nor by treatment. …”
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Immediate management of a cirrhosis-induced severe pericardial effusion: a case report and review of the literature by Maryam Taheri, Arash Hassanpour Dargah, Pedram Ramezani, Mohsen Anafje, Amir Nasrollahizadeh, Pouya Ebrahimi, Mohammad Hossein Mandegar

“…Post-procedural management included continuous monitoring, repeat echocardiography, and a comprehensive pharmacological regimen addressing fluid overload, autoimmune hepatitis, and cardiac function. …”
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The effects of high-intensity interval training on cognitive performance: a systematic review and meta-analysis by Kaihang Liu, Wei Zhao, Congcong Li, Ying Tian, Lijuan Wang, Jingyi Zhong, Xu Yan, Yezheng Wang, Liyan Wang, Hongbiao Wang

“…Chronic HIIT represents a potential non-pharmacological intervention for cognitive health. Further high-quality research is required to validate and extend these findings.…”
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Diosgenin and solasodine-based saponins and sapogenines—Effects of structural modifications on Panagrellus redivivus, Spodoptera littoralis and Trichoderma reesei by Christina Rodler, Johann Schinnerl, Miriam Schalamun, Wolfgang Hinterdobler, Lothar Brecker

“…Saponins are a large class of plant natural products that exhibit a great variety of biological and pharmacological properties. Starting from diosgenin and solasodine nine derivatives were synthesized. …”
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Case report: Chest radiotherapy-induced vertebral fractures in lung cancer patients: a case series and literature review by Oscar Arrieta, Francisco Lozano-Ruiz, Alberto Guijosa, Pamela Soberanis-Pina, Monika Blake-Cerda, Ana Pamela Gómez-García, Federico Maldonado-Magos, Emilio Conde-Flores, Andrés F. Cardona, Sandra Ileana Pérez Álvarez, Luis Antonio Cabrera-Miranda

“…Management involved interventional strategies such as vertebroplasty, kyphoplasty, and rhizotomy, along with general and pharmacological measures to prevent subsequent fractures.ConclusionsDespite their low incidence, radiotherapy-induced vertebral fractures in LC patients are clinically significant and may resemble bone metastases on PET-CT imaging. …”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…Treatment of achalasia can be pharmacological, endoscopic (pneumatic balloon dilation, peroral endoscopic myotomy, botulinum toxin injection), aimed at regulating the tone and motility of the esophagus and cardia while preserving all anatomical structures, and surgical (laparoscopic esophagocardiomyotomy, esophagectomy), in which the muscle fibers of the esophagus and esophagogastric junction are intersected or the altered esophagus is completely removed with simultaneous formation of an artificial esophagus from the stomach or colon (esophagoplasty).Conclusion. …”
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A randomized controlled study of auricular point acupressure to manage chemotherapy-induced neuropathy: Study protocol. by Nada Lukkahatai, Michael V Nguyen, Jingyu Zhang, Yu-Min Cho, Chitchanok Benjasirisan, Heijingzi Monica Jia, Claudia M Campbell, Jennifer Kawi, Hulin Wu, Hongyu Wang, Rupsikha Bora, Johannes Thrul, Constance M Johnson, Thomas J Smith

“…Auricular point acupressure (APA), a non-invasive and non-pharmacological alternative, has shown potential for alleviating the pain, numbness, and tingling associated with CIN. …”
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Assessment of Patients Adherence to Oral Regimen of Drug-Resistant   Tuberculosis among Iraqi Patients by Noor Alaa Jasim, Manal Khalid Abdulridha, Ahmed Asmar Mankhy, Ahmed Hadi Tarish

“…It is crucial to determine the prevalence of pharmacological non-adherence among these patients and to know the reasons for this non-adherence. …”
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Metformin in COVID-19: a magical role beyond the hyperglycemia by Gaurav Kumar Chaubey, Rahul Dilawari, Radheshyam Modanwal, Sharmila Talukdar, Asmita Dhiman, Manoj Raje

“…In this review, we attempt to elucidate the role of classical anti-diabetic medicine metformin in the treatment of COVID-19 infections by highlighting the pharmacological role of this drug during elevated glucose levels and insulin resistance. …”
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Effect of life skills training by a midwife on pregnancy anxiety: A randomized controlled trial by Fatemeh Hassanpour, Mozhgan Javadnoori, Elham Maraghi, Fariba Zargar Shirazi

“…Therefore, it can be used by midwives as an effective non-pharmacologic approach in pregnancy .…”
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Description of network meta-analysis geometry: A metrics design study. by Fernanda S Tonin, Helena H Borba, Antonio M Mendes, Astrid Wiens, Fernando Fernandez-Llimos, Roberto Pontarolo

“…<h4>Methods</h4>A previous systematic review of NMAs of pharmacological interventions was performed. Data on the graph's presentation were collected. …”
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In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial. by Baback Roshanravan, Sophia Z Liu, Amir S Ali, Eric G Shankland, Chessa Goss, John K Amory, H Thomas Robertson, David J Marcinek, Kevin E Conley

“…This response represents the first demonstration of a pharmacological intervention that can reverse mitochondrial dysfunction in vivo immediately after treatment in aging human muscle.…”
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Intervention Programmes for First-Episode Psychosis: A Scoping Review by Marta Gouveia, Tânia Morgado, Tiago Costa, Francisco Sampaio, Amorim Rosa, Carlos Sequeira

“…The results showed that there is a great deal of variety in the characteristics of the programmes, with interventions ranging from single-component strategies, such as cognitive–behavioural therapy (CBT) and cognitive remediation therapy (CRT), to multicomponent programmes that integrate a number of different approaches, including psychosocial, pharmacological, and family-focused strategies. The objectives included attempts to improve cognitive functioning; enhance coping skills; reduce caregiver burden; and address symptoms such as anxiety, depression, and hallucinations. …”
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Single postoperative infusion of zoledronic acid to improve patient-reported outcome after hip or knee replacement: study protocol for a randomised, controlled, double-blinded clin... by Jonas Ranstam, Jörg Schilcher, Ewa Roos, Jonathan Brandt, Håkan Ledin, Per Aspenberg

“…The study will be reported in accordance with the Consolidated Standards of Reporting Trials statement for pharmacological trials. The results will be submitted for publication in peer-reviewed academic journals and disseminated to patient organisations and the media.Trial registration number EudraCT: No 2015-001200-55; Pre-results.…”
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Resource constraints, patient emotions, and therapy: experiences of healthcare providers in the screening and management of gestational diabetes mellitus in northern Ghana by Mohammed Bukari, Abdulai Abubakari, Hawa Malechi, Thomas Hinneh, Humphrey Garti, Faith Agbozo

“…The second theme was care-centred experiences, which explored patient emotions during GDM care, and the care they receive post-GDM diagnosis, with subthemes namely: raw emotions, non-pharmacological therapy, and pharmacotherapy. Conclusion Findings suggest the need for health system strengthening through the training and recruitment of dedicated skilled personnel, as well as government intervention through policy revision to cover the cost of GDM diagnostic tests. …”
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