A scoping review of conventional and laser acupuncture as a modality of treatment for migraine by Chizoba ANYIMUKWU, Vinayak K. NAHAR, Sunita KAPUR, Manoj SHARMA

“…Despite the wide variety of pharmacological medications, patients still experience frequent attacks or are unable to get complete relief from the prescribed medications. …”

Unravelling the outcome of L-glutaminase produced by Streptomyces sp. strain 5 M as an anti-neoplasm activity by Mervat G. Hassan, Gharieb S. El-Sayyad, Mohamed O. Abdel-Monem, Mohamed N. Malash, Mona A. Kishk, Mohamed E. El Awady, Mohamed I. El-khonezy

“…Conclusion Our findings include the discovery of Streptomyces sp. strain 5 M, which yields a free L-glutaminase and maybe a possible applicant for extra pharmacological investigation as an antineoplastic drug.…”
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Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria by A.B. Ojekale, O. Lawal, M.O. Lasisi, C.A. Bamgbose, F.A. Dosu

“…Only 11 (about 35%) of the 31 compounds  identified have established and documented pharmacological use. Some of the bioactive components in each of the bitters support the advertised usage of the formulations. …”
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Insomnia: definition, pathophysiological models, diagnosis, and treatment by E. Sakalauskaitė-Juodeikienė, R. Masaitienė

“…Cognitive behavioural therapy is recommended as the first-line treatment for chronic insomnia in adults of any age. A pharmacological intervention can be offered if cognitive behavioural therapy is not effective or not available. …”
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Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens by Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa

“…Eight key genes associated with signal transduction (MAPK14, MAP3K8, PIK3CD, STAT1, STAT3, MAPK11, LRRK2, and GATA3) were validated via real-time PCR in chicken peripheral blood mononuclear cells (PBMCs) from six biological replicates. Pharmacological inhibitors or chloroquine were employed to elucidate the signalling pathways. …”
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Patient Management in Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus by A. E. Bagriy, A. D. Zubov, M. V. Khomenko, E. S. Mikhailichenko, E. A. Pylaeva, N. A. Khaustova, E. V. Bryukhovetskaya

“…A current overview of non-pharmacological and drug-based approaches to non-alcoholic fatty liver disease (NAFLD) combined with type 2 diabetes mellitus (T2D).Key points. …”
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Bioactive compounds of Calotropis gigantea for cancer treatment by Jayalekshmi C, Nishanth Mohan Das, Rajiv Periakaruppan

“…Calotropis gigantea (C. gigantea), a member of the Apocynaceae family, is a widely distributed plant species known for its diverse pharmacological properties. In recent years, significant attention has been directed towards exploring the therapeutic potential of bioactive compounds derived from C. gigantea in cancer treatment. …”
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Effects of high-intensity interval training on physical performance, systolic blood pressure, oxidative stress and inflammatory markers in skeletal muscle of spontaneously hyperten... by Thaynara Zanoni D'Almeida, Mariana Janini Gomes, Leticia Estevam Engel, Ines Cristina Giometti, Natalia Zamberlan Ferreira, Rafael Stuani, Camila Renata Corrêa, Robson Chacon Castoldi, Sarah Gomes Nunes, Andreo Fernando Aguiar, Anthony César Castilho, Marina Politi Okoshi, Francis Lopes Pacagnelli

“…<h4>Significance</h4>Our results indicate that HIIT is an effective non-pharmacologic strategy to improve physical performance, reduce SBP, and modulate the skeletal muscle oxidative damage and inflammation in hypertensive rats.…”
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Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria by A.B. Ojekale, O. Lawal, M.O. Lasisi, C.A. Bamgbose, F.A. Dosu

“…Only 11 (about 35%) of the 31 compounds  identified have established and documented pharmacological use. Some of the bioactive components in each of the bitters support the advertised usage of the formulations. …”
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Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3β pathway coupled with CREB activation. by Vishal Jain, Iswar Baitharu, Dipti Prasad, Govindasamy Ilavazhagan

“…Hence it may be used as a non invasive and non pharmacological intervention against various neurological disorders.…”
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Infusion therapy for chronic liver diseases by I. A. Kurkina, M. V. Mayevskaya, I. N. Tikhonov, V. N. Zozulya, V. I. Leschenko

“…Comprehensive treatment of liver diseases includes application of modern infusion agents (anti-hypoxia/anti-oxidation) containing pharmacologically active metabolic substances that include succinate-containing drugs developed on the basis of succinic acid and its salts. …”
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Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“…Both phytocannabinoids contribute to physiological and pharmacological effects. Multiple preclinical studies conducted on animal models of AD have shown that THC specifically targets and modifies the pathological markers of AD while simultaneously enhancing cognitive function. …”
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Real-World Experience with AGA Guidelines in the Management of Crohn’s Disease following Ileocolonic Resection: A Retrospective Cohort Study by Shasha Tang, Wei Liu, Weilin Qi, Tunan Yu, Qian Cao, Xiaolong Ge, Wei Zhou

“…Clinical data and risk factors for endoscopic recurrence were analyzed focusing on postoperative pharmacological prophylaxis. Results. All patients were at a high risk of postoperative recurrence according to the AGA guidelines. …”
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Bullatine A suppresses glioma cell growth by targeting SIRT6 by Zhi Wang, Yushuai Zhu, Can Luo, Fan Zhang, Jiannong Zhao, Chuanyi Fu

“…Bullatine A (BLA) is a diterpenoid alkaloid of the genus Aconitum which antirheumatic and anti-inflammatory pharmacological properties. The effects of BLA on gliomas have not yet been elucidated. …”
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Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics. by Md Nayab Sulaimani, Shazia Ahmed, Farah Anjum, Taj Mohammad, Anas Shamsi, Ravins Dohare, Md Imtaiyaz Hassan

“…Subsequently, the selected hits underwent rigorous screening that included the identification of potential pan-assay interference compounds (PAINS), ADMET evaluation, and prediction of pharmacological activities using PASS analysis. Afterwards, we performed a comprehensive interaction analysis to explore the binding prototypes of the screened molecules with the key residues within the MAPK1 kinase domain. …”
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Characterization of tumor prognosis and sensitive chemotherapy drugs based on cuproptosis-related gene signature in ovarian cancer by Wei Tan, Fangfang Dai, Qinyu Ci, Zhimin Deng, Hua Liu, Yanxiang Cheng

“…Conclusions The study highlights the prognostic significance of cuproptosis-related genes and provides new insights into developing pharmacological therapeutic strategies targeting cuproptosis for the prevention and treatment of ovarian cancer.…”
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Effects of an intervention combining physical activity and components of Amygdala and Insula Retraining (AIR) on sleep and working memory among older male adults by Monireh Asadi Ghaleni, Forouzan Fattahi Masrour, Narjes Saryar, Alexandra J. Bratty, Ebrahim Norouzi, Matheus Santos de Sousa Fernandes, Georgian Badicu

“…Pharmaceutical therapy for these conditions is commonplace but has not been particularly effective, and relatively little research exists for their treatment using non-pharmacological approaches. The effectiveness of Physical Activity plus selected components of Amygdala and Insula Retraining (PAAIR) was tested to improve sleep quality, depression, working memory, and emotion regulation among older males.MethodsThis was a parallel, randomized control trial. …”
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Investigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia by Luigi Giuliani, Francesco Sanmarchi, Armida Mucci, Paola Rucci, Edoardo Caporusso, Paola Bucci, Giulia M. Giordano, Mario Amore, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Silvana Galderisi, Mario Maj

“…The role of working memory impairment in the pathways to functional outcomes in schizophrenia highlights the importance of implementing integrated pharmacological and cognitive remediation interventions targeting neurocognition. …”
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Features of albendazole determination and dynamics of its decomposition in biological material by V.K. Shormanov, D.P. Shcherbakov, S.Yu. Garmonov

“…Along with pronounced pharmacological action, this compound is toxic to humans. …”
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Biological activity research of male papaya flowers Carica papaya L. on some common cancer cell lines by Ngô Thị Phương Dung, Nguyễn Hoàng Dũng

“…., is widely cultivated in Vietnam, and its flowers possess various pharmacological properties. This study focuses on the biological activities, including antioxidant and anticancer effects, of different fractions extracted from male papaya flowers. …”
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