Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy by Rossella Borghi, Stefania Petrini, Valentina Apollonio, Marina Trivisano, Nicola Specchio, Sandra Moreno, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci

“…In addition to altering the mitotic spindle formation, the present data unveil that PCDH19 dysfunction leads to altered cytoskeletal rearrangement, providing therapeutic targets and pharmacological options to treat this disorder.…”
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MAP4 kinase-regulated reduced CLSTN1 expression in medulloblastoma is associated with increased invasiveness by Ece Sönmez, Shen Yan, Meng-Syuan Lin, Martin Baumgartner

“…The reduction of CLSTN1 expression significantly increased growth factor-driven invasiveness. Pharmacological inhibition of pro-migratory MAP4 kinases caused increased CLSTN1 expression and CLSTN1 accumulation in cell-cell contacts. …”
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Causal Link between Ventricular Ectopy and Concussion by J. Patrick Neary, Jyotpal Singh, Jonathan P. Christiansen, Taylor A. Teckchandani, Kirsty L. Potter

“…Our study has important implications for both cardiac patients and the patients that sustain a concussion, and if medically managed with appropriate pharmacological intervention, it can reverse ventricular ectopy and concussion symptomology. …”
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Partnering with Palliative Care: A Case Report of Severe Pain in Critical Limb Ischemia Treated Successfully with a Continuous Popliteal Nerve Catheter by Ryan S. D’Souza, Stephanie Shen, Frederick Ojukwu, Halena M. Gazelka, Bridget P. Pulos

“…CLI pain is challenging to control despite multimodal pharmacologic analgesia and surgical intervention. We described the successful use of a continuous local anesthetic infusion via a popliteal nerve catheter to control severe refractory ischemic lower limb pain in a patient who failed surgical intervention and performed a brief narrative literature review on regional anesthesia for ischemic pain. …”
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Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID by David M. Smadja, David M. Smadja, M. Marc Abreu, M. Marc Abreu

“…WBH, particularly in fever-range, enhances mitochondrial function, induces heat shock proteins (HSPs), and modulates neuroinflammation—benefits that pharmacological treatments often struggle to replicate. …”
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Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells by Dominic Gonschorek, Matías A Goldin, Jonathan Oesterle, Tom Schwerd-Kleine, Ryan Arlinghaus, Zhijian Zhao, Timm Schubert, Olivier Marre, Thomas Euler

“…Taken together, our research highlights the selective neuromodulatory effects of NO on RGCs and emphasizes the need of considering non-pharmacological activity changes, like adaptation, in such study designs.…”
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The Effect of Six Weeks of Patella Taping on Pain in Women with Knee Osteoarthritis by Maryam Alikhani, Hamid Tabatabai

“…Therefore, sports trainers and physiotherapists are encouraged to consider patella taping as a non-pharmacological intervention to alleviate pain in women with knee osteoarthritis.…”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Heart diseases remain the major cause of death worldwide. Advances in pharmacological and biomedical management have resulted in an increasing proportion of patients surviving acute heart failure (HF). …”
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Calcium levels modulate embryo yield in Brassica napus microspore embryogenesis by Antonio Calabuig-Serna, Ricardo Mir, Daniel Sancho-Oviedo, Paloma Arjona-Mudarra, Jose M. Seguí-Simarro

“…We also performed a pharmacological study to modulate Ca2+ homeostasis during different stages of the process, using a series of Ca2+-altering chemicals (BAPTA-AM, bepridil, chlorpromazine, cyclopiazonic acid, EGTA, inositol 1,4,5-trisphosphate, ionophore A23187, W-7). …”
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Mental Health Services for Serious Mental Illness: Scoping Review of Randomised Controlled Trials by Pablo Roson Rodriguez, Xiao Chen, Marcelo Arancibia, Eva Madrid, Farhad Shokraneh, Clive E. Adams, Juan Víctor Ariel Franco

“…Methods We retrieved and screened RCTs of service‐level interventions considering non‐pharmacological approaches for mental healthcare of the CSzG register. …”
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Molecular Circuits of Resolution in the Eye by Elvira L. Liclican, Karsten Gronert

“…Protective endogenous roles of LXA4 and NPD1 have been established utilizing lipidomic analysis, knockout mice, and pharmacological, genetic, and dietary manipulation, providing compelling evidence that these intrinsic lipid autacoid circuits play essential roles in restraining inflammation, promoting wound healing, inhibiting pathological angiogenesis, and providing neuroprotection in the delicate visual axis.…”
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Metabolic and motor activity effects of microalgae (Chlorella vulgaris) in laboratory mice by E. L. Zavjalov, D. V. Petrovskii, G. V. Kontsevaya, V. V. Mak, I. P. Uvarov, Y. L. Zav’yalova, O. A.  Rozhkov

“…In recent years, the microalgae (Chlorella vulgaris) have increasingly attracted great interest as a potential source of pharmacologically active compounds. Showing anticoagulation, antioxidant and antitumor activities of Chlorella revealed its hypotensive properties. …”
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Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells by Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie, Aatif Qureshi, Fernando Botelho

“…IL-33 induction was associated with activation of STAT3, and pharmacological inhibition of STAT3 ameliorated IL-33 levels. …”
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Phytoreduced gold nanoparticles from vitalmelon promote white adipocyte browning in murine cells by targeting phospholipase D2 by Sun Young Park, He mi Kang, Kangmin Park, Lu Guo, Jin-Woo Oh, Geuntae Park, Nam Jun Kang, Young-Whan Choi

“…Further investigation using pharmacological inhibition and knockdown experiments revealed that phospholipase D2 inhibition synergistically promoted the browning effects of VW-GNPs. …”
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A review of the effects of pharmaceutical pollutants on humans and aquatic ecosystem by Jaya Vinny Eapen, Sweety Thomas, Shelmi Antony, Paul George, Jayesh Antony

“…Effluents discharged from pharmaceutical industries constitute significant contributors to aquatic ecosystems’ contamination with antibiotics. These pharmacological agents permeate diverse environmental niches, spanning groundwater, surface water, soils, and wastewater treatment facilities, exhibiting concentrations ranging from nanograms to grams per liter. …”
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Aldehyde Dehydrogenases: Not Just Markers, but Functional Regulators of Stem Cells by Giuseppe Vassalli

“…ALDH exerts its functional actions partly through RA biosynthesis, as all-trans RA reverses the functional effects of pharmacological inhibition or genetic suppression of ALDH activity in many cell types in vitro. …”
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Patterns among factors associated with myocardial infarction: chi-squared automatic interaction detection tree and binary logit model by Esra Bayrakçeken, Süheyla Yarali, Uğur Ercan, Ömer Alkan

“…Abstract Background Although mortality from myocardial infarction (MI) has declined worldwide due to advancements in emergency medical care and evidence-based pharmacological treatments, MI remains a significant contributor to global cardiovascular morbidity. …”
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Is there a risk of esketamine misuse in clinical practice? by Carlos Roncero, Milton Merizalde-Torres, Néstor Szerman, Marta Torrens, Pablo Vega, Pilar Andres-Olivera, Francisco Javier Álvarez

“…Real-world studies reinforced these observations, reporting no adverse events (AEs) related to pharmacological interactions of esketamine with any other substance, and no new-onset drug or alcohol misuse, craving, misuse or diversion of use. …”
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Phytochemicals from Pyrrosia longifolia (Burm. f.) C.V. Morton with antibacterial activity by Hilwan Yuda Teruna, Rohimatul Khodijah, Neni Frimayanti, Rudi Hendra

“…However, it has received little attention regarding pharmacological properties and phytochemicals. This study aimed to isolate bioactive compounds and evaluate their antibacterial activities. …”
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Effects of photobiomodulation therapy in patients with chronic non-specific low back pain: protocol for a randomised placebo-controlled trial by Lucíola da Cunha Menezes Costa, Shaiane Silva Tomazoni, Leonardo Oliveira Pena Costa, Layana de Souza Guimarães, Amanda Costa Araujo, Dafne Port Nascimento, Flávia Cordeiro de Medeiros, Marina Athayde Avanzi

“…Photobiomodulation therapy (PBMT) is a frequently used non-pharmacological therapy for the treatment of musculoskeletal disorders. …”
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