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5021
Selective mPGES-1 Inhibitor Ameliorated Adjuvant-Induced Arthritis in the Rat Model
Published 2024-01-01“…Therefore, MPO-0144 represents a valuable pharmacological tool for the study of regulation of inducible mPGES-1 in an inflammatory arthritis rat model.…”
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5022
Research protocol for a systematic review and meta-analysis of the effects of music on anxiety and physiological outcomes in patients undergoing bronchoscopy.
Published 2025-01-01“…<h4>Conclusion</h4>The systematic review produced from this protocol will provide evidence on the effectiveness of music for patients undergoing bronchoscopy and will contribute to strengthening the existing body of knowledge on non-pharmacological interventions for anxiety management during medical procedures.…”
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5023
Effects of Anti-Obesity Strategies on Bone Mineral Density: A Comprehensive Meta-Analysis of Randomized Controlled Trials
Published 2025-01-01“…At follow-up examination, the BMD of the lumbar spine decreased significantly after metabolic surgery (mean difference [MD]=-0.40 g/cm2; 95% confidence interval [CI], -0.73 to -0.07; I2=0%); lifestyle and pharmacological interventions did not result in a significant decrease in BMD at any location. …”
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5024
Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells
Published 2020-01-01“…Although various pharmacological studies of C. orbiculatus extract has been reported, an anti-inflammatory mechanism study of their phytochemical constituents has not been fully elucidated. …”
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5025
Protective Effect of Shenfu Injection against Sepsis-induced Acute Lung Injury by Suppressing Inflammation and Apoptosis Through the Regulation of the Janus Kinase 2/Signal Transdu...
Published 2024-12-01“…Shenfu injection (SFI) is a Chinese herbal medicine extracted from red ginseng and Aconite, Radix Aconiti, with various pharmacological activities. This study aimed to investigate the potential mechanism of action of SFI in preventing sepsis-induced ALI. …”
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5026
Relationship between secondary metabolites and ecological suitability zones for Eucommia ulmoides.
Published 2025-01-01“…The contents of six pharmacologically active secondary metabolites, including chlorogenic acid, aucubin, geniposidic acid, geniposide, pinoresinol monoglucoside, and pinoresinol diglucoside were measured in the EU bark. …”
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5027
Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of a Novel Class of Bradykinin B2 Receptor Antagonist P...
Published 2014-01-01“…Using a preconstricted preparation of rat tail arterial smooth muscle, a single dose of 10−6 M of the peptide effectively inhibited the dose-dependent relaxation effect of bradykinin between 10−11 M and 10−5 M and subsequently, this effect was pharmacologically-characterized using specific bradykinin B1- (desArg-HOE140) and B2-receptor (HOE140) antagonists; the data from which demonstrated that the antagonism of the novel peptide was mediated through B2-receptors. …”
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5028
Diabetic microangiopathies: mechanisms of development, approaches to the therapy
Published 2018-07-01“…<br> Calcium dobesilate refers to the pharmacological group of angioprotectors and microcirculatory correctors.…”
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5029
Phylogenetic Analysis and Extracellular Enzyme Profiles of Yeast Strains Isolated from Raspberry Fruits
Published 2021-03-01“…Raspberry fruit contains phenolic compounds, flavones, flavonoids, vitamins, and antioxidant substances that are important properties for health and pharmacological sciences. Edible berries provide also a suitable habitat for the growth of various microorganisms. …”
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5030
The Effects of Six Weeks of Patella Taping on Function, Proprioception, and Balance in Women with Knee Osteoarthritis
Published 2024-11-01“…Patella taping may be an effective non-pharmacological tool for enhancing these outcomes and is recommended for use by sports trainers and physiotherapists.…”
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5031
Alcohol Misuse and Alcohol Use Disorder in Adolescents
Published 2024-12-01“…Family therapy, particularly multidimensional family therapy, has proven to be highly effective. While pharmacological options exist, such as disulfiram and naltrexone, their use is limited and requires careful monitoring due to potential risks. …”
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5032
Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice
Published 2021-01-01“…Our results reveal pharmacological effect of RIPC in promoting microglia/macrophage transferring from M1 to M2 phenotype after MCAO/R in mice, which provides theoretical support for the therapeutic effect of RIPC in ischemic stroke.…”
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5033
Antihyperglycemic Potential of Dried Powder Combination of Hygrophila auriculata and Cordia macleodii: In Vivo Study in Sprague Dawley Rats
Published 2024-12-01“…A key role in modulating the pharmacological action is played by the components derived from plants, including alkaloids and flavonoids. …”
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5034
Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects
Published 2025-01-01“…Furthermore, we explore the challenges associated with LDRT’s integration into combination therapies, addressing crucial factors such as optimal dosage, fractionation, treatment frequency, and synergy with other pharmacological agents. Considering its low toxicity profile, LDRT presents a compelling case for application across multiple lesions, augmenting the antitumor immune response in poly-metastatic disease scenarios. …”
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5035
Exercise training and chronic kidney disease: characterization and bibliometrics of citation classics of clinical intervention trials
Published 2024-12-01“…Reported dropout rates ranged from 0.0% to 47.4%.Conclusion A bibliometric analysis of citation classics on exercise training and CKD highlights the potential benefits of exercise as a non-pharmacological therapy for patients with CKD, as well as developments and hotspots in the field.…”
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5036
Post-chemoradiotherapy adjuvant chemotherapy of rectal cancer
Published 2018-08-01“…To present the analysis of available data on approach to pharmacological antineoplastic therapy at rectal cancer (RC) after chemoradiotherapy followed by surgical treatment, as well as within the «watch & wait» concept. …”
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5037
Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent
Published 2013-01-01“…Genetic or pharmacological ablation of toll-like receptor 2 (TLR2) protects against myocardial ischemia/reperfusion injury (MI/R). …”
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5038
Current treatment modalities for dry eye disease
Published 2021-03-01“…These data are required for the understanding of the pharmacological effects of various drug classes prescribed for DED and early treatment initiation.…”
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5039
Phenobarbital as an adjunctive agent for sedation in pediatric intensive care unit patients: A single-center, retrospective study from Colorado
Published 2024-09-01“…Background: Pediatric patients require pharmacological management of pain and agitation associated with mechanical ventilation. …”
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5040
“Lung-on-a-chip” as an instrument for studying the pathophysiology of human respiration
Published 2024-12-01“…“Lung-on-a-chip” (LoC) is a microfluidic device, imitating the gas-fluid interface of the pulmonary alveole in the human lung and intended for pathophysiological, pharmacological and molecular-biological studies of the air-blood barrier in vitro. …”
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