Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

“…Prior studies have implicated Hedgehog (Hh) signaling in ADPKD, with increased levels of Hh components in experimental ADPKD and reduced cystogenesis following pharmacological Hh inhibition. In contrast, the role of the Hh pathway in ARPKD is poorly understood. …”
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An overview of methods for the treatment and diagnosis of dementia with Lewy bodies. Clinical case analysis by M. Š. Markevičiūtė, M. Karnickas, A. Bagdonaitė

“…Patients may be exceptionally sensitive to antipsychotics for the control of delirium and hallucinations, therefore pharmacological treatment should be individualized. …”
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An Effective Phytoconstituent Aconitine: A Realistic Approach for the Treatment of Trigeminal Neuralgia by Dilek Çankal, Esra Küpeli Akkol, Yeliz Kılınç, Mert İlhan, Raffaele Capasso

“…Aconitine may be an alternative pharmacological agent for the control of trigeminal neuralgia pain.…”
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Cognitive dysfunction in diabetes – the ‘forgotten’ diabetes complication: a narrative review by Åke Sjöholm, Louise Bennet, Peter M. Nilsson

“…Recent years have seen research that has clarified cerebral insulin resistance and defective insulin signaling as examples of pathogenic factors behind this cognitive impairment in diabetes.Method We provide a narrative review of select and contemporary publications with relevance for the interface between diabetes/prediabetes and cognitive function.Results Recently published studies show that physical activity can reverse insulin resistance in the brain as well as cognitive impairment and pathological appetite regulation. Pharmacological interventions with, for example, nasal insulin, GLP-1 receptor agonists, SGLT-2 inhibitors, or PPAR-γ agonists have also shown promising results.Conclusion Optimization of lifestyle factors (e.g. physical activity), as well as several pharmaceutical agents already in clinical use against diabetes, have shown promising results in improving cognitive function in diabetic patients. …”
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Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Methods We previously reported the rendomab B49 antibody (RB49) exhibiting a preferential affinity for the activated conformation of human endothelin B receptor (ETB), not displaced by high endothelin levels, and without any pharmacological properties that could inhibit the division of melanoma cells. …”
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Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 by Dandan Liu, Hewei Qin, Guanghua Liu, Yang Gao, Yu Guo

“…In addition, astragaloside IV has lipid-modulating and antioxidant pharmacological potential. The vasoprotective and anti-ferroptosis effects of astragaloside IV were determined by establishing a high-fat-fed ApoE−/− mouse model of AS and an ox-LDL-induced model of lipid damage in VECs. …”
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Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster by Zana R. Majeed, Esraa Abdeljaber, Robin Soveland, Kristin Cornwell, Aubrey Bankemper, Felicitas Koch, Robin L. Cooper

“…To determine which 5-HT receptor subtype modulates the evoked sensory-motor activity, pharmacological agents were used. In addition, the activity of 5-HT neurons was enhanced by expressing and activating TrpA1 channels or channelrhodopsin-2 while recording the evoked excitatory postsynaptic potentials (EPSPs) in muscle fibers. 5-HT2 receptor activation mediates a modulatory role in a sensory-motor circuit, and the activation of 5-HT neurons can suppress the neural circuit activity, while fluoxetine can significantly decrease the sensory-motor activity.…”
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Therapeutic potential of bisphosphonates - review of medical indications, mechanism of action, interactions and adverse effects by Agnieszka Mikosińska, Mateusz Litwin, Jakub Parys, Patrycja Kałuziak, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek, Marta Jajczak, Maciej Mossakowski

“… Introduction: Bisphosphonates are pharmacological agents that inhibit bone resorption by targeting osteoclasts, thereby increasing bone density and reducing fracture risk. …”
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Genetic approaches to the investigation of serotonergic neuron functions in animals by U. S. Drozd, E. V. Shaburova, N. N. Dygalo

“…Nevertheless, the advantages and limitations of the discussed genetic approaches should be taken into consideration in the course of creating models of pathological conditions and developing pharmacological treatments for their correction.…”
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<i>Musa paradisiaca</i> L. Inflorescence Abrogates Neutrophil Activation by Downregulating TLR4/NF-KB Signaling Pathway in LPS-Induced Acute Lung Injury Model by Francisco Allysson Assis Ferreira Gadelha, Raquel Fragoso Pereira Cavalcanti, Cosmo Isaias Duvirgens Vieira, Joao Batista De Oliveira, Louíse Mangueira De Lima, Adriano Francisco Alves, Matheus Marley Bezerra Pessoa, Leônia Maria Batista, Naiara Naiana Dejani, Marcia Regina Piuvezam

“…<b>Background/Objectives</b>: Acute lung injury (ALI) is an inflammatory disorder affecting patients in intensive care with high mortality. No specific pharmacological treatment is available. <i>Musa paradisiaca</i> L. …”
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Knowledge and Confidence of a Convenience Sample of Australasian Emergency Doctors in Managing Dental Emergencies: Results of a Survey by Hossein Samaei, Tracey Joy Weiland, Stuart Dilley, George Alexander Jelinek

“…Eighty-three percent (360/433) were confident in the pharmacological management of toothache but only 26% (112/434) confident in recognizing periodontal disease. …”
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Barriers and Strategies to Lifestyle and Dietary Pattern Interventions for Prevention and Management of TYPE-2 Diabetes in Africa, Systematic Review by Hirut Bekele, Adisu Asefa, Bekalu Getachew, Abebe Muche Belete

“…Diabetes mellitus is a major chronic illness in Africa that requires lifelong lifestyle interventions and pharmacological therapy. Lifestyle change is the most important aspect of diabetes care and includes diabetes self-management education and support, medical nutrition therapy, physical activity, smoking cessation counseling, and psychosocial care. …”
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The combination treatment of RC48 and STAT3 inhibitor acts as a promising therapeutic strategy for basal bladder cancer by Jingxian Li, Kun Shan, Wei Huang, Qiang Su, Yuanjiong Qi, Zhihong Zhang, Jianqiang Zhu, E. Du

“…In basal or RC48-exposed luminal cells, the JAK/STAT3 pathway was highly enriched, suggesting that downregulation or pharmacological inhibition of ERBB2 leads to compensatory activation of this pathway. …”
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Aspects of improving metrological characteristics of a sensor based on palladium nanoparticles for methionine determination by Eduard V. Gorchakov, Darya O. Perevezentseva, Elena A. Vaitulevich, Oksana V. Dubinina

“…Methionine is a widely used pharmacological drug that has a lipotropic effect and a positive impact on liver function. …”
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Cardiovascular Profile and Cardiovascular Imaging After Bariatric Surgery: A Narrative Review by Mihaela Toader, Liliana Gheorghe, Costin Chirica, Ionuț-Alexandru Ghicu, Sabina-Ioana Chirica, Andreea Isabela Mazga, Danisia Haba, Mădălina Maxim, Ancuța Andreea Miler, Daniela Crișu, Mihai Ștefan Cristian Haba, Daniel Vasile Timofte

“…<i>Background and Objectives</i>: Up until now, behavioral interventions and pharmacological therapies were the main approach available for the management of obesity. …”
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Ultrasound-Guided Genicular Nerve Thermal Radiofrequency Ablation for Chronic Knee Pain by Joshua Wong, Nicholas Bremer, Paul D. Weyker, Christopher A. J. Webb

“…For elderly patients with multiple medical comorbidities who do not wish to undergo total knee arthroplasty (TKA), lifestyle modification, pharmacologic management, and injections are the mainstay of therapy. …”
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Music therapy influence in the reduction of moderately high blood pressure figures by Frank Miguel Hernández Velázquez, Belén de la Caridad Santiesteban Rodríguez, Raúl Javier Pizarro Hechevarría

“…Among the alternatives for its treatment, music therapy is effective together with pharmacological treatment.<br /><strong>Objective</strong>: to describe the music therapy influence in the reduction of moderately high blood pressure figures.…”
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Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank by Jaegyun Jung, Sangyeon Lee, Jeong Ho Lee, Doheon Lee

“…Background Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. …”
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The effect of regular exercise and vitamin C on hs-cTnT TNF-α levels in obese boys students by Mohammadbagher Forghani Ozrudı, Javad Alızade, Aliakbar Raıespour

“…Therefore the use of non-pharmacological methods, exercise, vitamin C and combination of the above interventions may lead to a reduction of inflammation in obese boy’s students.…”
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Advancements in Nanomedicine for the Diagnosis and Treatment of Kidney Stones by Wang Y, Yang J, Amier Y, Yuan D, Xun Y, Yu X

“…In clinical diagnosis and management, traditional surgical interventions and pharmacological treatments are primarily utilized; however, these methods possess inherent limitations. …”
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