Prediction of the Binding to the Nuclear Factor NF-Kappa-B by Constituents from <i>Teucrium polium</i> L. Essential Oil by Renilson Castro de Barros, Renato Araújo da Costa, Nesrine Guenane, Boulanouar Bakchiche, Farouk Benaceur, Omer Elkiran, Suelem Daniella Pinho Farias, Vanessa Regina Silva Mota, Maria Fani Dolabela

“…Chemical studies have already isolated different types of terpenes from the species, and studies have established its pharmacological potential. The present study evaluates the components of <i>T. polium</i> essential oil cultivated in the Algerian Saharan Atlas. …”
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Designing hydrogel for application in spinal surgery by Rongpeng Dong, Shuang Zheng, Xueliang Cheng

“…Hydrogels can be designed for the localized and controlled delivery of pharmacological agents to enhance therapeutic effects and reduce adverse reactions. …”
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Gaps in the Management of Type 2 Diabetic Patients in a Metropolitan Area of Havana by Armando Rodríguez Salvá, Linet Céspedes Hernández, Addys Díaz Piñera, René García Roche, Susana Balcindes Acosta

“…The main gap was follow-up, with only 69.7 % of the patients consulted in the last year. 68.3 % have indicated pharmacological treatment, and of these 77.5 % is adhered to according to the Morinsky test 83.4 % had their blood glucose levels checked. …”
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Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases by Reem Y. Mahran, Ehab A Fouad, Sozan S Tous, Nermin E. Eleraky

“…Abstract Metformin hydrochloride (MTF) has pharmacological properties for managing inflammatory skin conditions. …”
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Acute toxicity test combination of binahong leaves extract (Anredera cordifolia) and catfish oil (Pangasius micronema Blkr.) in mice by Rahma Shabrina Auliya, Meitasari Annisa Diyan, Sasongko Heru

“…Binahong (Anredera cordifolia) and catfish (Pangasius micronema Blkr.) plants have been proven to have pharmacological effects through various studies. However, there has been no research on the toxicity level of the combination of two ingredients. …”
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Efficacy of a complex plant-based preparation for poultry mycotoxicosis by E. V. Kuzminova, E. P. Dolgov, M. P. Semenenko, P. V. Miroshnichenko

“…Use of fibralin in the feed (3 kg per one ton) for 10 days reduced clinical signs of intoxication, increased flock survival by 13.5% and stimulated body weight gain by 15.8%. Pharmacological effect of fibralin was demonstrated by improvement of blood morphobiochemical parameters in poultry, i.e. reduction of leukocytes by 19.3% and cholesterol by 13.6%; and an increase in the number of erythrocytes by 19.4%, hemoglobin by 8.1% and calcium by 9.5%. …”
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Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury by Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun

“…In this study, through a combined multi‐omics, pharmacological, and pharmacokinetic approaches, it is found that BBR‐induced obesity‐specific DILI is primarily through the potentiation of peroxisome proliferator‐activated receptor gamma (PPARγ) signaling pathways. …”
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Physical Exercise as a Diagnostic, Rehabilitation, and Preventive Tool: Influence on Neuroplasticity and Motor Recovery after Stroke by Caroline Pin-Barre, Jérôme Laurin

“…For the last few years, physical training has been combined with pharmacological treatments to accentuate and/or accelerate beneficial neural and motor effects. …”
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Multi-target combination treatment with rTMS and tDCS for Tourette syndrome: a case report by Shuang Zhao, Shuang Zhao, Qizu Jin, Qi Yang, Jing Liu, Yun Lu, Yun Lu, Haibo Ai

“…Due to the limited efficacy and potential side effects of pharmacological treatments for TS, there is a critical need to develop novel, tailored therapeutic strategies. …”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Maraviroc-mediated pharmacological blockade of the CCL5/CCR5 axis effectively mitigates muscle dystrophy and improves muscle performance. …”
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L-theanine modulates tissue cortisol levels in zebrafish after single stress by Vinícius Luís da Silva, Mariana Spanamberg Mayer, Andriele dos Reis Severo, Andressa Leal Zambra, Joanna Moraes De Almeida, Laura Moura Sestari, Mariana Migliorini Parisi, Ana Cristina Vendrametto Varrone Giacomini, Murilo Sander De Abreu, Josiane Woutheres Bortolotto, Gabriela Bonfanti-Azzolin

“…Stress is a situation characterized by the stimulus to cortisol secretion and without specific pharmacological therapies. Thus, this study investigates the effect of L-theanine on the response to acute stress, evaluated by tissue cortisol level, oxidative status markers, and behavioral parameters, in zebrafish. …”
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A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model by Liqun Chi, Wenyuan Gao, Xiangrong Shu, Xin Lu

“…Icariin, a natural flavonoid glucoside isolated from plants in the Epimedium family, has been proven to have various pharmacological activities. A recent study showed that icariin suppressed cartilage and bone degradation in mice of collagen-induced arthritis. …”
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Automatic ovarian follicle detection using object detection models by Maya Haj Hassan, Eric Reiter, Misbah Razzaq

“…In the prospect of better understanding the mechanisms of folliculogenesis and of developing novel pharmacological approaches to control it, it is important to accurately and quantitatively assess the later stages of ovarian folliculogenesis (i.e. the formation of antral follicles and corpus lutea). …”
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Utilization of Rituximab for Refractory Rowell Syndrome by Sukhraj Singh, Sandra Sheffield, Nisha Chowdhury, Swetha Nuthulaganti, Zareen Vaghaiwalla, Karishma Ramsubeik

“…The clinical picture of atypical erythema multiforme-like lesions, presence of chilblains, speckled ANA pattern, anti-Ro/SSA, or anti-La/SSB antibodies, and absence of infectious or pharmacologic triggers in a patient with systemic lupus erythematosus are some of the classic clinical and serologic features. …”
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Insights into the formulation properties, biocompatibility, and permeability of poorly water-soluble methoxyflavones with PEG400 and propylene glycol by Eze Fredrick Nwude, Jansakul Chaweewan, Srichana Teerapol

“…Furthermore, PEG400 and propylene glycol solutions of the methoxyflavones were shown to be compatible with Caco-2 cells at pharmacologically effective concentrations. In vitro transport studies across the Caco-2 cell monolayer revealed high Papp values of 24.07 × 10–6 to 19.63 × 10–6 cm s–1 for PEG400 solutions of the methoxyflavones. …”
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A Spiritual Care Program for Patients With Cancer and Psychosomatic Disorders in Iran: A Protocol Study by Rahmatollah Marzband, Seyed Hamzeh Hosseini, Zeinab Hamzehgardeshi, Mahmood Moosazadeh, Mohammad Eslamijouybari, Tahereh Yaghoubi, Marzieh Azizi, Fereshteh Araghian Mojarad, Ehsan Abedini

“…Conclusion: The developed cost-effective, non-pharmacological program for spiritual care can be used for patients with psychosomatic disorders and cancers in Iran.…”
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Polyphenolic Compounds in Fabaceous Plants with Antidiabetic Potential by Lucia Guerrero-Becerra, Sumiko Morimoto, Estefania Arrellano-Ordoñez, Angélica Morales-Miranda, Ramón G. Guevara-Gonzalez, Ana Angélica Feregrino-Pérez, Consuelo Lomas-Soria

“…Natural products with antidiabetic and pharmacological treatment potential improve diabetes management by offering more effective and complementary alternatives. …”
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Salvia-Nelumbinis Naturalis Formula Improved Inflammation in LPS Stressed Macrophages via Upregulating MicroRNA-152 by Zansong Ma, Xiangbing Shu, Jie Huang, Haiyan Zhang, Zhen Xiao, Li Zhang

“…We further verified the pharmacological effects in Raw264.7 cells; while transfection with miRNA-152 mimics could reduce TNF-α and IL-6, transfection with miRNA-152 inhibitor blocked the anti-inflammatory effect of SNN-containing serum. …”
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Development and validation of an in vitro release test and use of Strat-M synthetic membrane as a predictor for the in vitro permeation test of topical gel formulations by Marija Grozdanoska Kostadinovska, Sacha Manuel, Nena Velevska, Packa Antovska, Jelena Lazova, Jasmina Tonic Ribarska, Rumenka Petkovska, Suzana Trajkovic Jolevska

“…In order to occur a topical drug product's pharmacological activity, the active pharmaceutical ingredient (API) must first be released from the vehicle and be available to penetrate the skin layers and reach the site of action. …”
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Phytochemical evaluation and antioxidant potential of Echinodorus macrophyllus extracts by Antônio Lisboa Ribeiro, Marcus Vinícius Gonçalves Antunes, Christiane Fátima Oliveira, Rafaela Camargos Rodrigues Machado, Rafael Rodrigues Silva, Brayan Jonas Mano-Sousa, Lucas Santos Azevedo, Joaquim Mauricio Duarte-Almeida, Luciana Alves Rodrigues dos Santos Lima

“…Both extracts were nontoxic to Artemia salina, suggesting the potential health benefits of this plant, which is rich in phenolic compounds and diverse pharmacological properties.…”
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