CXCR2 in Acute Lung Injury by F. M. Konrad, J. Reutershan

“…Since multiple ELR+ CXC chemokines act on both receptors—CXCR1 and CXCR2—a pharmacologic agent blocking both receptors seems to be advantageous. …”
Get full text

Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis by Marcelo Ananias Teocchi, Lília D’Souza-Li

“…Our study points out to TNF and TNF receptor superfamily pathways as important targets for pharmacological studies regarding the benefits of an anti-inflammatory therapy in these patients.…”
Get full text

Evaluation of polyphenol and antioxidant properties of Blumea balsamifera extract as potential therapeutic for breast cancer by Kamila Fairuz Sarah, Annisa Yuslinda, Rosyadah Nuraini, Hermanto Feri Eko, Widyananda Muhammad Hermawan, Dwijayanti Dinia Rizqi, Widodo Nashi

“…Furthermore, computational methods are used to predict the pharmacological properties of compounds in the extract, particularly against breast cancer. …”
Get full text

High Prevalence of Cardiovascular Disease in End-Stage Kidney Disease Patients Ongoing Hemodialysis in Peru: Why Should We Care About It? by Katia Bravo-Jaimes, Alvaro Whittembury, Vilma Santivañez

“…To determine clinical, biochemical, and pharmacological characteristics as well as cardiovascular disease prevalence and its associated factors among end-stage kidney disease patients receiving hemodialysis in the main hemodialysis center in Lima, Peru. …”
Get full text

Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity by Dalia Ali, Elna P. Chalisserry, Muthurangan Manikandan, Rimi Hamam, Musaad Alfayez, Moustapha Kassem, Abdullah Aldahmash, Nehad M. Alajez

“…Global gene expression and signaling pathway analyses of differentially expressed genes revealed a strong enrichment of genes involved in adipogenesis and osteogenesis in romidepsin-treated BMSCs during induction into adipocytes or osteoblasts, respectively. Pharmacological inhibition of FAK signaling during adipogenesis or inhibition of FAK or TGFβ signaling during osteogenesis diminished the biological effects of romidepsin on BMSCs. …”
Get full text

Long-Term Follow-Up in Children with Anisocoria: Cocaine Test Results and Patient Outcome by Fabienne C. Fierz, Christina Gerth-Kahlert

“…Evaluation of anisocoria including pharmacological testing for Horner’s syndrome in the pediatric population is challenging in view of potential serious underlying disease. …”
Get full text

The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysi... by Clàudia Arumí-Trujillo, Francisco José Verdejo-Amengual, Oriol Martínez-Navarro, Jord J.T. Vink, Fran Valenzuela-Pascual

“…Non-invasive brain stimulation (NIBS11 Non-invasive brain stimulation.) techniques have emerged as a promising non-pharmacological adjunct to neurorehabilitation. Children with Cerebral Palsy (CP22 Cerebral Palsy.) exhibit altered cortical excitability, and while CP remains incurable, physiotherapy combined with other interventions is essential for managing motor dysfunction. …”
Get full text

Aduhelm, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer’s Disease: A comprehensive review by Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Salomon Poliwoda, Rachel J. Kaye, Kevin S. Murnane, Adam M Kaye, Alan D. Kaye

“…Cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists have historically been the most widely used pharmacologic therapies for patients with AD; however, these drugs are not curative. …”
Get full text

fragSMILES as a chemical string notation for advanced fragment and chirality representation by Fabrizio Mastrolorito, Fulvio Ciriaco, Maria Vittoria Togo, Nicola Gambacorta, Daniela Trisciuzzi, Cosimo Damiano Altomare, Nicola Amoroso, Francesca Grisoni, Orazio Nicolotti

“…Abstract Generative models have revolutionized de novo drug design, allowing to produce molecules on-demand with desired physicochemical and pharmacological properties. String based molecular representations, such as SMILES (Simplified Molecular Input Line Entry System) and SELFIES (Self-Referencing Embedded Strings), have played a pivotal role in the success of generative approaches, thanks to their capacity to encode atom- and bond- information and ease-of-generation. …”
Get full text

Inhibition of DNA Methylation Impairs Synaptic Plasticity during an Early Time Window in Rats by Pablo Muñoz, Carolina Estay, Paula Díaz, Claudio Elgueta, Álvaro O. Ardiles, Pablo A. Lizana

“…Here, we combined electrophysiological, pharmacological, molecular, and immunohistochemical approaches to examine the contribution of DNA methylation and the phosphorylation of Methyl-CpG-binding protein 2 (MeCP2) to synaptic plasticity. …”
Get full text

Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis by Zhe Hou, Li Deng, Fei Fang, Ting Zhao, Yaojia Zhang, Gang Li, Michael Z. Miao, Yongcang Zhang, Hongchi Yu, Xiaoheng Liu

“…Mechanistically, the MAPK pathway transduces mechanical cues from disturbed flow in ECs, leading to increased secretion of EVs. Pharmacological inhibition of the MAPK pathway reduced the secretion of EVs even under disturbed flow conditions. …”
Get full text

Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats by Balan Rajan, Rajendran Ravikumar, Thandavamoorthy Premkumar, Thiruvengadam Devaki

“…Carvacrol is a main constituent in the essential oils of countless aromatic plants including Origanum Vulgare and Thymus vulgari, which has been assessed for substantial pharmacological properties. In recent years, notable research has been embarked on to establish the biological actions of Carvacrol for its promising use in clinical applications. …”
Get full text

My Bad, You Got This: witnessing, therapist attitude and the synergy between psychedelics and inner healing intelligence in the treatment of trauma by Lawrence Fischman

“…The MAPS (Multidisciplinary Association for Psychedelic Studies) sponsored MDMA-assisted therapy protocol has had greater success in treating trauma in preliminary clinical trials than any prior psychotherapeutic, pharmacologic, or combined approach. It is predicated on a synergy between drug action and the participant’s inner healing intelligence. …”
Get full text

The Role of Dendritic Cell Subsets in Recurrent Spontaneous Abortion and the Regulatory Effect of Baicalin on It by Nannan Lai, Xiaoxiao Fu, Guozhen Hei, Weiwei Song, Ran Wei, Xiaoxiao Zhu, Qiang Guo, Zhen Zhang, Chu Chu, Ke Xu, Xia Li

“…Baicalin from Radix Scutellariae possesses a wide range of pharmacological and biological activities. However, the effect of baicalin on DC function in RSA has not been investigated. …”
Get full text

Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials by Farouc A. Jaffer, Matthias Nahrendorf, David Sosnovik, Kimberly A. Kelly, Elena Aikawa, Ralph Weissleder

“…This study thus provides a foundation for using MFNPs to image genetic and/or pharmacological perturbations of cellular inflammation in experimental atherosclerosis and for the future development of novel targeted nanomaterials for atherosclerosis.…”
Get full text

NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition by María Verónica Baez, Magalí Cecilia Cercato, Diana Alicia Jerusalinsky

“…NMDARs are composed of two GluN1 essential subunits and two regulatory subunits which define their pharmacological and physiological profile. In CNS structures involved in cognitive functions as the hippocampus and prefrontal cortex, GluN2A and GluN2B are major regulatory subunits; their expression is dynamic and tightly regulated, but little is known about specific changes after plasticity induction or memory acquisition. …”
Get full text

Modulation of Second Messenger Signaling in the Brain Through PDE4 and PDE5 Inhibition: Therapeutic Implications for Neurological Disorders by Min Kyu Park, Hyun Wook Yang, Seo Young Woo, Dong Yeon Kim, Dae-Soon Son, Bo Young Choi, Sang Won Suh

“…PDE4 and PDE5 are promising therapeutic targets for neurological disorders. Pharmacological modulation of these enzymes offers potential to enhance cognitive function and mitigate pathological mechanisms underlying brain injuries, neurodegenerative diseases, and psychiatric disorders. …”
Get full text

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae) by Maria Christina dos Santos Verdam, Fernanda Guilhon-Simplicio, Kleyton Cardoso de Andrade, Karina Lorena Meira Fernandes, Tallita Marques Machado, Felipe Moura Araújo da Silva, Mayane Pereira de Souza, Hector Henrique Ferreira Koolen, Cristiane da Silva Paula, Beatriz Cristina Konopatzki Hirota, Vinícius Bednarczuk de Oliveira, Cristina Mayumi Sasaki Miyazaki, Milena Kalegari, Marilis Dallarmi Miguel, Patricia Maria Stuelp-Campelo, Obdulio Gomes Miguel

“…Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless, Byrsonima duckeana W. …”
Get full text

GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models by Yu Huang, Jinyong Wang, Xiling Wei, Hui Zhang, Wei Shang, Xiangling Zhang, Lanjiao Zhai, Xi Chen, Huiming Li, Suofu Qin

“…However, there is currently no effective pharmacological intervention that can reverse body weight loss and improve physical performance in patients with cachexia. …”
Get full text

Antrodia cinnamomea ameliorates neointimal formation by inhibiting inflammatory cell infiltration through downregulation of adhesion molecule expression in vitro and in vivo by Yan Zhang, Aijin Ma, Hao Xi, Ning Chen, Rong Wang, Chenhui Yang, Jinbang Chen, Pin Lv, Fuping Zheng, Wenyi Kang

“…Thus, A. cinnamomea may offer a pharmacological therapy to slow down disease progression in patients with vascular injury.…”
Get full text