Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase by Liset Westera, Alisha M. Jennings, Jad Maamary, Martin Schwemmle, Adolfo García-Sastre, Eric Bortz

“…In IAV infection, PARP1 was required for efficient synthesis of viral nucleoprotein (NP) in human lung A549 cells. Intriguingly, pharmacological inhibition of PARP1 enzymatic activity (PARylation) by 4-amino-1,8-naphthalimide led to a 4-fold increase in RdRP activity, and a 2.3-fold increase in virus titer. …”
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Necrotising Myositis, the Deadly Impersonator by A. Rahman, A. K. Abou-Foul, A. Yusaf, J. Holton, L. Cogswell

“…These two cases highlight the importance of early diagnosis and prompt surgical and pharmacological intervention in managing this life-threatening disease. …”
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UPLC-DAD-QTOF/MS Analysis of Flavonoids from 12 Varieties of Korean Mulberry Fruit by O-Chul Kwon, Wan-Taek Ju, Hyun-Bok Kim, Gyoo-Byung Sung, Yong-Soon Kim

“…Mulberry (Morus alba L.) has been used in East Asia (Korea, China, and Japan) as a medicine because of its various pharmacological effects including the excellent antioxidant properties of its fruit. …”
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Preoperative uterine artery embolisation before hysterectomy in women with giant uterine fibroid and HIV-associated nephropathy by Filip Szkodziak, Sławomir Woźniak, Łukasz Światłowski, Emilia Maleszyk, Piotr Szkodziak, Krzysztof Pyra, Viktor Berczi, Tomasz Paszkowski, Tomasz Jargiełło

“…Current treatment options include surgical procedures, pharmacological therapies, and minimally invasive procedures. …”
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Efficacy and Safety of Direct-Acting Oral Anticoagulants (DOACs) in the Overweight and Obese by Kimberley Doucette, Hira Latif, Anusha Vakiti, Eshetu Tefera, Bhavisha Patel, Kelly Fitzpatrick

“…Obesity plays an essential role in the safety of pharmacologic drugs. There is paucity of data for direct oral anticoagulants (DOACs) in the obese, despite these agents becoming more widely used. …”
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Frotteuristic disorder - a specific paraphilia by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Weronika Chachaj, Aleksandra Winsyk, Ewa Gardocka

“…Cognitive-behavioral therapy has shown significant therapeutic success, while pharmacological treatments typically involve antiandrogenic medications and drugs that lower sexual drive. …”
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Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles by Jacob R. Shaw, Nicholas Caprio, Nhu Truong, Mehari Weldemariam, Anh Tran, Nageswara Pilli, Swarnima Pandey, Jace W. Jones, Maureen A. Kane, Ryan M. Pearson

“…Integrated multi-omics analysis of proteomics, lipidomics, metabolomics, and cytokine datasets highlight a set of differentially enriched TLR4 ligands that correlate with dynamic NP corona-mediated immune activation. Pharmacological inhibition and genetic knockout studies validate that NP coronas mediate this response through TLR4/MyD88/NF-κB signaling. …”
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Western diet promotes the progression of metabolic dysfunction‐associated steatotic liver disease in association with ferroptosis in male mice by Nicole Maddie, Nefia Chacko, David Matatov, Maria Alicia Carrillo‐Sepulveda

“…To date, there are no pharmacological treatments for MASLD. While obesity is a major cause of the development and progression of MASLD, the underlying mechanisms remain unclear. …”
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Fluorofenidone alleviates cigarette smoke exposure-induced chronic lung injury by targeting ferroptosis by Yuan Wu, Binbin Li, Yixuan Xuan, Yu Jiang, Jinping Chen, Hong Liao, Jihua Feng, Jianfeng Zhang

“…Fluorofenidone (AKF) has a wide range of pharmacological effects, including anti-fibrotic, antioxidant, and anti-inflammatory effects. …”
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The Role of Interventional Endoscopic Ultrasound in Liver Diseases: What Have We Learnt? by Cosmas Rinaldi A. Lesmana, Maria Satya Paramitha, Rino A. Gani

“…EUS may be useful in vascular changes of the digestive wall evaluation, performing dynamic assessment of hemodynamic changes, predicting variceal bleeding and rebleeding risk, and assessing the pharmacological effects. In PH management, EUS-guided vascular therapy—which revolves around glue injection, endovascular coil placement/embolization, and combination of both—has shown promising results. …”
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Postcholecystectomy syndrome: the modern approach: resolution of Advisory council by V. T. Ivashkin, A. V. Okhlobystin, D. S. Bordin, E. Ya. Seleznyova, Yu. A. Kucheryavy, Ye. V. Bystrovskaya, O. C. Vasnev, M. F. Osipenko, G. H. Musayev, Yu. O. Shulpekova

“…Biliary sludge and microlithiasis including cases undiagnosed at routine investigation can be one of important factors for development of the PCS. Pharmacological treatment of sphincter of Oddi dysfunction that develop at GSD/PCS include following of dietary recommendations, intake of selective spasmolytics, digestive enzymes and ursodeoxycholic acid. …”
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Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway by Jiawei He, Anhui Yang, Xuyu Zhao, Yang Liu, Shuyan Liu, Di Wang

“…Gloeostereum incarnatum (GI), a fungus with homology of medicine and food, has multiple pharmacological activities. It was investigated in this study that the anti-colon cancer effect of polysaccharides purified from GI (GIPS) in ApcMinC/Gpt mice (an in situ colon cancer mouse model). …”
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Physical and cognitive-based training in healthy older adults: Evidence from a systematic review and meta-analysis by Fatemeh Adelirad, Zeinab Javadivala, Iman Dianat, Aysan Amrahi Tabieh, Vijay Kumar Chattu

“…Conclusion: Our controversial results indicated that the non-pharmacological physical-mental training improves executive function which that can affect the ability of elders, while did not support the improvement of attention, processing speed, and verbal memory.…”
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CD4+CD25highCD127low/-FoxP3+ Regulatory T-Cell Population in Acute Leukemias: A Review of the Literature by M. Niedźwiecki, O. Budziło, E. Adamkiewicz-Drożyńska, D. Pawlik-Gwozdecka, M. Zieliński, L. Maciejka-Kembłowska, T. Szczepański, P. Trzonkowski

“…The possibility of pharmacological intervention in the self-control of the immunological system is now under extensive investigation in many human cancers. …”
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Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice by Hongxing Zhang, Chi Shang, Zhao Tian, Hatem K. Amin, Rami B. Kassab, Ahmed E. Abdel Moneim, Yingang Zhang

“…Diallyl disulfide (DADS) is the major organosulfur constituent in garlic, with a variety of pharmacological activities including antioxidant and anti-inflammatory. …”
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Intestinal Mucosal Barrier Is Injured by BMP2/4 via Activation of NF-κB Signals after Ischemic Reperfusion by Kang Chen, Wei Xie, Binyu Luo, Weidong Xiao, Daniel H. Teitelbaum, Hua Yang, Kebin Zhang, Chaojun Zhang

“…Our results provide background for the development pharmacologic interventions in the management of I/R injury.…”
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Exhibitionism - a review of research by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Weronika Chachaj, Paulina Słomka, Ewa Gardocka

“…Treatment of exhibitionistic disorder primarily involves cognitive behavioral therapy (CBT). Pharmacological approaches are also employed to manage symptoms by modulating serotonergic transmission. …”
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The Science of Memory Loss: Insights into Alzheimer’s Disease by Agnieszka Starzyk, Piotr Charzewski

“…This review synthesizes findings from recent studies sourced from PubMed and Embase, focusing on advances in cerebrospinal fluid and blood-based biomarkers, imaging techniques such as PET and MRI, and therapeutic interventions. Current pharmacological treatments, including cholinesterase inhibitors and NMDA receptor antagonists, provide only symptomatic relief and fail to alter disease progression. …”
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The Influence of Physical Activity on Inflammatory Markers, Intestinal Microbiota Composition and Disease Activity in Inflammatory Bowel Disease by Paulina Jakubczyk, Piotr Widera, Justyna Helis, Maciej Michalik, Aleksandra Buczek, Hubert Bigajski, Aleksandra Banaś, Olga Bilczewska, Wiktoria Janik, Marta Handschuh

“…Future research should focus on longitudinal studies, advanced omics technologies, and combined approaches with dietary and pharmacological therapies. …”
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Ginkgetin Alleviates Inflammation and Senescence by Targeting STING by Yadan Liu, Jialin Ye, Zisheng Fan, Xiaolong Wu, Yinghui Zhang, Ruirui Yang, Bing Jiang, Yajie Wang, Min Wu, Jingyi Zhou, Jingyi Meng, Zhiming Ge, Guizhen Zhou, Yuan Zhu, Yichuan Xiao, Mingyue Zheng, Sulin Zhang

“…In summary, this study, utilizing an artificial intelligence algorithm combined with pharmacological methods, confirms STING serves as a critical target for Ginkgetin in alleviating inflammation and senescence. …”
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