Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine by Xiao-Wu Chen, Yuan Ming Di, Jian Zhang, Zhi-Wei Zhou, Chun Guang Li, Shu-Feng Zhou

“…Berberine is one of the main alkaloids found in the Chinese herb Huang lian (Rhizoma Coptidis), which has been reported to have multiple pharmacological activities. This study aimed to analyze the molecular targets of berberine based on literature data followed by a pathway analysis using the PANTHER program. …”
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Cissus quadrangularis: A comprehensive review as an emerging biomaterial for periodontal regeneration by H Nilofer Farjana, G. Mohan Valiathan

“…Cissus quadrangularis (CQ) is known for its use as a folk medicine for pharmacological properties such as antimicrobial, antiulcer, anti-inflammatory, antitumor, antihemorrhagic, antiallergic, antidiabetic, and antioxidant properties. …”
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Tea and depression by Klaus W. Lange, Yukiko Nakamura, Katharina M. Lange, Hui Zhao

“…However, the mechanisms of tea phytochemicals possibly capable of decreasing the risk of depressive symptoms are complex, multifaceted and not well understood. Potent pharmacological effects on circumscribed neurobiological systems may be produced not by individual tea components but rather by the synergistic action of various compounds on multiple pathophysiological mechanisms involved in depression. …”
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Empathic love therapy for adolescents living with HIV in Surabaya, Indonesia by Erika Martining Wardani, Riezky Faisal Nugroho, Siti Nurjanah, Syiddatul Budury, Iis Noventi

“…One of the emotional problems impacting adolescents is depression, as taking life-long medications makes teens depressed. One of non-pharmacological therapies that can be applied is empathic love the­rapy (ELT). …”
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A comprehensive review on nutritional composition, health benefits, and industrial applications of Jackfruit Seeds by Simran Dhani, Hamid, Nomali Ziphorah Ngobese, Sunny Sharma, Amit K. Jaiswal

“…These bioactive compounds hold high antioxidant capacity and various pharmacological properties which lower the risk of various diseases by reducing free radical generation. …”
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Prospective de novo drug design with deep interactome learning by Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F. Nippa, Michael Iff, Jann Ledergerber, Carl C. G. Schiebroek, Valentina Romeo, Jan A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider

“…Abstract De novo drug design aims to generate molecules from scratch that possess specific chemical and pharmacological properties. We present a computational approach utilizing interactome-based deep learning for ligand- and structure-based generation of drug-like molecules. …”
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Pengaruh Teknik Relaksasi Nafas Dalam dan Masase Terhadap Penurunan Skala Nyeri Pasien Pasca Apendiktomi di Ruang Bedah RSUD Dr. M. Zein Painan by Yusrizal, Zarni Zamzahar, Eliza Anas

“…It is advisable to apply deep breathing relaxation techniques and massage as one of the non-pharmacological techniques to reduce pain in post-appendectomy clients. …”
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In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity by Gianandrea Guidetti, Alessandro Di Cerbo, Angela Giovazzino, Valentina Rubino, Anna Teresa Palatucci, Sara Centenaro, Elena Fraccaroli, Laura Cortese, Maria Grazia Bonomo, Giuseppina Ruggiero, Sergio Canello, Giuseppe Terrazzano

“…In conclusion, the use of these botanicals was shown to be able to contrast OTC-toxicity and could represent a new approach for the development of functional foods useful to enhance the standard pharmacological treatment in infections as well as in preventing or reducing the emergence of inflammatory diseases.…”
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Analysis of depression in Brazil and the feasibility of incorporating pharmacogenomics as an auxiliary tool in antidepressant treatment by Rafaela Slaviero Pinheiro Cerdeira, Mario Hiroyuki Hirata

“…This conduct leads many patients to give up following pharmacological treatment. In this scenario, pharmacogenomics emerges as a possible supporting tool of the medical treatment. …”
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Cultured Human Airway Epithelial Cells (Calu-3): A Model of Human Respiratory Function, Structure, and Inflammatory Responses by Yan Zhu, Aaron Chidekel, Thomas H. Shaffer

“…In experiments with pharmacological agents, Lucinactant is protective of Calu-3 cells compared with Beractant and control, and perfluorocarbons also protect against hyperoxia-induced airway epithelial cell injury. …”
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Potential of germanium-based compounds in coronavirus infection by NAROKHA VIOLETTA, NIZHENKOVSKA IRYNA, KUZNETSOVA OLENA

“…The purpose of this review is to summarize the pharmacological potential of various germanium-based compounds studied nowadays, taking into account their mechanisms of action, and to analyze their prospects in the development of integrated approaches in the prevention and treatment of SARS-CoV-2 infection.…”
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Personality structure assessment of people with opiate addiction and people with internet addiction disorder by Milinović Milica, Tepšič-Ostojić Vesna

“…Neurobiological and pharmacological data suggest similarities between the pathophysiology of opiate addiction and pathological gambling. …”
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Antimicrobial Effects of Egyptian Local Chicory, Cichorium endivia subsp. pumilum by Ahmed M. Amer

“…These results offer insights into the antimicrobial potency of this Egyptian local plant and provide a basis for further phytochemical and pharmacological research.…”
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Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy by Pavithra Bharathy, Elizabeth Rani E, Punniyakoti V. Thanikachalam

“…Nanoparticles (NPs) made from organic and inorganic materials have shown promise in delivering therapeutic substances to cancer cells, enhancing their pharmacological efficacy, and reducing their systemic toxicity. …”
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Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure by Georgios Aidonidis, Ioannis Kanonidis, Vasileios Koutsimanis, Till Neumann, Raimund Erbel, Georgios Sakadamis

“…Levosimendan is an inotropic drug with unique pharmacological advantages in patients with acute heart failure. …”
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Effects of <i>Echinacea purpurea</i> and Alkylamides on Respiratory Virus Replication and IL-8 Expression In Vitro by Keely Puchalski, Johanne A. Gerstel, Abiola Jimoh, Yalda Shokoohinia, Jeffrey Langland

“…Different classes of secondary metabolites of the plant, such as alkylamides, caffeic acid derivatives, polysaccharides, flavonoids, and glycoproteins, are believed to be biologically and pharmacologically active. Although previous research suggests that the alkylamides present in <i>Echinacea</i> may be responsible for reducing the symptoms associated with the common cold or flu through their immunomodulatory activity, the roles of specific alkylamides and their targets (i.e., immune and/or antiviral) have not been well-elucidated or established. …”
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Biodistribution of intravenously delivered PEGylated carbon nanotubes to the rat brain cortex by Gisele Eva Bruch, Gisele Eva Bruch, Lidiane Dal Bosco, Lidiane Dal Bosco, Arthur P. Cordeiro, Marcos F. Cordeiro, Sangram K. Sahoo, Carolina Peixoto, Marta C. Klosterhoff, Luis Alberto Romano, Cristiano Fantini, Adelina P. Santos, Daniela M. Barros

“…Due to their reduced size and high stability in physiological media, SWCNT-PEG are candidates for crossing the blood–brain barrier (BBB), with potential use in treating central nervous system diseases that are currently unresponsive to pharmacological interventions because of the tightly regulated permeability of the BBB. …”
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Clumsiness and Disturbed Cerebellar Development: Insights From Animal Experiments by Albert Gramsbergen

“…This late development makes the cerebellar development particularly vulnerable to situations like an insufficient supply of nutrients, which may follow placental dysfunction, or to side effects of pharmacological treatments like the administration of corticosteroids in the postnatal period. …”
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Development and validation of the pain management competency scale for nurses and a nationwide survey of Chinese nurses by Yixue Wu, Xiang Pan, Lihui Gu, Yingge Tong, Siyi Chen, Ke Ni, Hangyan Du, Meng Yang, Jianyi Wang, Yi Chen, Yeling Wei, Lingling Luo, Wenqian Cheng

“…Results The PMCSN comprised six primary dimensions—Pain Assessment and Monitoring, Pharmacological Pain Management, Non-Pharmacological Pain Management, Management of Analgesic Adverse Effects, Patient/Family Education, and Professional Development—and includes 52 tertiary items. …”
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Early bactericidal activity of sitafloxacin against pulmonary tuberculosis by Lihui Nie, Jing Tong, Guihui Wu, Juan Du, Yuanyuan Shang, Yufeng Wang, Zhangjun Wu, Yuanhong Xu, Yi Ren, Youyi Rao, Yu Pang, Mengqiu Gao

“…ABSTRACT Sitafloxacin is a quinolone broad-spectrum antimicrobial agent, and its pharmacologic properties and in vitro data demonstrate that sitafloxacin has a potent killing effect against Mycobacterium tuberculosis, including drug-resistant strains, which is superior to that of other available quinolones. …”
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