PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…By incorporating such radionuclides into molecules of interest, we can directly assess their pharmacokinetic and pharmacodynamic (PK/PD) characteristics in vivo without changing their physicochemical characteristics or eliciting a pharmacological response. As such, PET imaging has long been used as a tool to aid drug discovery programs from preclinical biomarker validation all the way through to clinical trials. …”
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Effects of NSAIDs on the Release of Calcitonin Gene-Related Peptide and Prostaglandin E2 from Rat Trigeminal Ganglia by Vittorio Vellani, Giorgia Moschetti, Silvia Franchi, Chiara Giacomoni, Paola Sacerdote, Giada Amodeo

“…The release of CGRP and prostaglandin E2 (PGE2) from freshly isolated rat trigeminal ganglia was evaluated after oral administration of nimesulide, etoricoxib, and ketoprofen, NSAIDs with different pharmacological features. Thirty minutes after oral administration, nimesulide, 10 mg/Kg, decreased the GCRP release induced by an inflammatory soup, while the other NSAIDs were ineffective at this point in time. …”
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Molecular modelling of four penicillins: bencylpenicillin, phenoxymethylpenicillin, ampicillin and amoxicillin by Elso Manuel Cruz Cruz, Eslhey María Sánchez Domínguez

“…At the same time, they have differences in their pharmacological action that can be associated to modifications included in the betalactamic ring and/or effects localized in the same chains. …”
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Early intervention in eating disorders: introducing the chronopathogram by Antonio Preti, Francesco Bevione, Maria Carla Lacidogna, Andrea Raballo, Michele Poletti, Giovanni Abbate-Daga

“…Despite advancements in psychosocial and pharmacological treatments, improvements remain limited. …”
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Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits by Shoucui Gao, Xiaojing Wang, Daxing Cheng, Jiayan Li, Lu Li, Linwu Ran, Sihai Zhao, Jianglin Fan, Enqi Liu

“…High levels of plasma high-density lipoprotein-cholesterol (HDL-C) are inversely associated with the risk of atherosclerosis and other cardiovascular diseases; thus, pharmacological inhibition of cholesteryl ester transfer protein (CETP) is considered to be a therapeutic method of raising HDL-C levels. …”
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Extraction, Purification, Structural Characteristics, Biological Activities, and Applications of Polysaccharides from <i>Gastrodia elata</i>: A Review by Yan Yang, Yonglin Hai, Yongcheng Yang, Rouyuan Wen, Le Wang, Yan Qian, Jiaxian Zhang, Yongguo Li, Zhilong Shi, Haizhu Zhang

“…Additionally, it delves into structure-activity relationships and pharmacological mechanisms of these polysaccharides, giving support for future research to enhance their application in medicine, food, health products, and cosmetics.…”
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Advances in 3D printing combined with tissue engineering for nerve regeneration and repair by Weifang Liao, Yuying Shi, Zuguang Li, Xiaoping Yin

“…While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative efficacy remains limited. …”
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The Elevation of LC-ESI-Q-TOF-MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives by Wirginia Kukula-Koch

“…Twenty-five methanol extracts obtained from various representatives of Papaveraceae and Berberidaceae botanical families (genera: Papaver, Argemone, Eschscholzia, Chelidonium, Glaucium, and Berberis) were screened for their alkaloid content in an optimized method suitable for the LC-ESI-Q-TOF-MS analysis. Twelve pharmacologically important isoquinoline alkaloids from four groups, aporphines, benzylisoquinolines, protoberberines, and benzophenanthridines, present in these traditionally used plant species were quantitatively determined in each studied sample, providing their alkaloid profile. …”
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Gambaran Drug Related Problems (DRPs) Terapi Farmakologi Pasien ISPA Pediatrik di Rumah Sakit PKU Muhammadiyah Gamping Yogyakarta by Nadia Husna, Siwi Padmasari

“…Keywords:  acute respiratory infection, hospital, pediatrics, pharmacologic therapy…”
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Kleptomania Induced by Venlafaxine by Kumi Sakurada, Masashi Nibuya, Kazuo Yamada, Seishu Nakagawa, Eiji Suzuki

“…It is often observed as a comorbidity in patients undergoing pharmacological treatment for Parkinson’s disease. Recurrent shopliftings are also observed in the clinical course of frontotemporal dementia. …”
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Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome by Alicia A. Thorp, Markus P. Schlaich

“…This review will discuss the regulatory role of the sympathetic nervous system in metabolic control and the proposed pathophysiology linking sympathetic overactivity to metabolic abnormalities. Pharmacological and device-based approaches that target central sympathetic drive will also be discussed as possible therapeutic options to improve metabolic control in at-risk patient cohorts.…”
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Black Pepper’s Anti-Aging and Chemoprevention Properties: A Review by Endah

“…Piperine, chavicine, caryophyllene, and sabinene are a few examples of black pepper components that exhibit pharmacological characteristics. This article reviews black pepper's main ingredients and discusses how effective it is at preventing aging and cancer. …”
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Hemoglobin Variants as Targets for Stabilizing Drugs by Miroslava Žoldáková, Michal Novotný, Krishna P. Khakurel, Gabriel Žoldák

“…Here, we review the progress in research, including the use of allosteric modulators, pharmacological chaperones, and antioxidant treatments, which has begun to improve hemoglobin stability and oxygen affinity. …”
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Isolation of Intact Mitochondria From Drosophila melanogaster and Assessment of Mitochondrial Respiratory Capacity Using Seahorse Analyzer by Christopher Groen, Anthony Windebank

“…The rapid biochemical assessment of mitochondria, in combination with the utility of Drosophila as an in vivo genetic model system, offers great potential for researchers to probe the impact of genetics and pharmacologic interventions on mitochondrial respiratory capacity.…”
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Penile Rehabilitation after Pelvic Cancer Surgery by Fouad Aoun, Alexandre Peltier, Roland van Velthoven

“…The concept of early penile rehabilitation was developed in late nineties with a subsequent number of clinical studies supporting early pharmacologic penile rehabilitation. These studies included all available phosphodiesterase type 5 inhibitors, intracavernosal injection and intraurethral use of prostaglandin E1 and to lesser extent vacuum erectile devices. …”
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miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma by Enrico Pozzo, Laura Yedigaryan, Nefele Giarratana, Chao-chi Wang, Gabriel Miró Garrido, Ewoud Degreef, Vittoria Marini, Gianmarco Rinaldi, Bernard K. van der Veer, Gabriele Sassi, Guy Eelen, Mélanie Planque, Alessandro Fanzani, Kian Peng Koh, Peter Carmeliet, Jason T. Yustein, Sarah-Maria Fendt, Anne Uyttebroeck, Maurilio Sampaolesi

“…Through miR-eCLIP technology, we demonstrate that miR-449a and miR-340 directly target transcripts involved in glycolysis and mitochondrial pyruvate transport, inhibiting the mitochondrial pyruvate carrier (MPC) complex. Pharmacological MPC inhibition induces a similar metabolic shift, reducing metastatic potential and leading to cell cycle exit. …”
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Intracranial artery dolichoectasia: What should the neurologist know? by Lorena Dellagnesi Depieri, Renan Rodrigues Neves Ribeiro do Nascimento, Lorena Souza Viana

“…Finally, we highlight the unmet clinical needs related to IADE management, which may involve pharmacological and surgical therapies tailored to individual cases, with careful consideration of safety and efficacy.…”
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Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats by Olivia A. Ortelli, Jeffrey L. Weiner

“…Furthermore, we assessed the sensitivity of the response requirement choice paradigm by administering the pharmacological stressor yohimbine and by altering the taste of the ethanol solution. …”
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Effect of Ethanol-Derived Clove Leaf Extract on the Oxidative Stress Response in Yeast Schizosaccharomyces pombe by Anninda Faiz Fauzya, Rika Indri Astuti, Nisa Rachmania Mubarik

“…Compared to the widely explored antioxidant activity from the clove bud extract, less data are available regarding the potential pharmacological use of clove leaves. Our study aimed to explore the antioxidant activity of clove leaves extract in the cellular level. …”
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Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration by Jialiu Zeng, Jialiu Zeng, Lenny Yi Tong Cheong, Chih Hung Lo, Chih Hung Lo

“…In this review, we summarize and provide insights into different therapeutic strategies, including methods to alter gut dysbiosis, lifestyle changes, dietary supplementation, as well as pharmacological agents derived from natural sources, that target obesity-induced neuroinflammation and neurodegeneration.…”
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