Anticancer effects of PEP06 (TB01) in combination with Trifluridine/Tipiracil (TAS-102) in a xenograft model of human colorectal cancer by Ruohong Lin, Jiaxing Cheng, Jinlong Zhao, Liang Zhou, Jian Li, Xinchun Yang

“…And quantitative assessment of the interaction between TB01 and TAS-102 in the treatment based on pharmacological effects. Methods This study utilized the human CRC HCT-116 xenograft nude mouse model to evaluate the antitumor effects of TAS-102 and TB01, both as mono-therapies and in combination therapies. …”
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Neurostimulation device for ameliorating salivary dysfunction: A novel neuromodulatory perspective by Rajkumar Krishnan, Nagarathinam Anbu Elangovan, Ramya Ramadoss

“…Traditional management approaches have focused on pharmacological interventions and symptom relief; however, innovative therapies are needed to address the underlying causes of salivary gland dysfunction. …”
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Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase. by Moustafa Elkalaf, Petr Tůma, Martin Weiszenstein, Jan Polák, Jan Trnka

“…We found a mixed inhibition of the Krebs cycle enzyme 2-oxoglutarate dehydrogenase complex (OGDHC) with an estimated IC50 3.93 [3.70-4.17] mM, which is pharmacologically plausible since it corresponds to micromolar extracellular concentrations. …”
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Construction of an Integrated Positive Youth Development Conceptual Framework for the Prevention of the Use of Psychotropic Drugs among Adolescents by Tak Yan Lee

“…Theories of drug use and abuse, including neurological, pharmacological, genetic predisposition, psychological, and sociological theories, were reviewed. …”
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Gastric schwannoma with post-surgical gastroparesis: a case report and literature review by Ganggang Miao, Ganggang Miao, De Zhang, Jiajing Li, Yanxiang Deng, Xingwei Gu, Tingting Feng

“…A series of treatments were performed, including correcting fluid-electrolyte disorders and vitamin deficiencies, and nutritional support and pharmacological treatments. The patient ultimately recovered well, and the relevant literatures were reviewed to identify and handle similar cases hereafter.…”
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Advancing statistical treatment of photolocomotor behavioral response study data. by Natalie Mastin, Luke Durell, Bryan W Brooks, Amanda S Hering

“…Fish photolocomotor behavioral response (PBR) studies have become increasingly prevalent in pharmacological and toxicological research to assess the environmental impact of various chemicals. …”
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Neurocirculatory asthenia and mitral valve prolapse syndrome from a psychopathological perspective by Łukasz Grabowski

“…The most common psychological problems in NA and MVPS are anxiety disorders, and they should be corrected pharmacologically and by adequate psychotherapy. However, observation of the somatic state of patients ought to be regular.…”
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Airway clearance technique therapy for atelectasis induced by scoliosis surgery: a case report by Rui Zhai, Hairong Su, Yaxu Wu, Rong Tan, Xiaoli Zhang, Ye Tian, Mei Hu

“…Subsequent chest CT scans demonstrated extensive atelectasis, and pharmacological interventions proved to be ineffective. …”
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Guanidine‐Derived Polymeric Nanoinhibitors Target the Lysosomal V‐ATPase and Activate AMPK Pathway to Ameliorate Liver Lipid Accumulation by Yunfei Zhao, Ke Hu, Fangliang Wang, Lulu Zhao, Yu Su, Jun Chen, Gang Zou, Liming Yang, Li Wei, Mengjiao Deng, Yunyu He, Ping Wang, Xiong Z Ruan, Yaxi Chen, Chao Yu

“…However, the development of the reliable medications and their pharmacological mechanisms remain insufficient. Herein, a polyguanide nanoinhibitors (PGNI) depot is constructed by copolymerizing biguanide derivatives in different proportions onto prepolymers. …”
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Therapeutic Applicability of Anti-Inflammatory and Proresolving Polyunsaturated Fatty Acid-Derived Lipid Mediators by Gerard L. Bannenberg

“…It is held that counter-regulatory lipid mediators and the specific molecular pathways activated by such endogenous agonists may be suitable for pharmacological use in the treatment of inflammatory disease. …”
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AXL inhibitors selected by molecular docking: Option for reducing SARS-CoV-2 entry into cells by Galindo-Hernández Octavio, Vique-Sánchez José Luis

“…It is, therefore, necessary to propose specific pharmacological treatments against COVID-19. A new therapeutic target on the human cellular membrane is AXL (anexelekto), proposed as an independent pathway by which interaction with the S protein of SARS-CoV-2 allows the virus to enter the cell, without the participation of ACE2. …”
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Finding potential inhibitors from phytochemicals against nucleoprotein of crimean congo fever virus using in silico approach by Muhammad Ramzan, Sajid Mahmood, Adnan Amjad, Mohsin Javed, Ammar Zidan, Ali Bahadur, Shahid Iqbal, Muhammad Saad, Namrah Zaka, Shazia Khurshid, Nasser S. Awwad, Hala A. Ibrahium, Toheed Akhter

“…Phytochemicals having pharmacological properties and approved by the Food and Drug Administration are docked over the nucleoprotein of CCHFV. …”
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The Acetone Extract of Sclerocarya birrea (Anacardiaceae) Possesses Antiproliferative and Apoptotic Potential against Human Breast Cancer Cell Lines (MCF-7) by Nicoline Fri Tanih, Roland Ndip Ndip

“…The current study was aimed to further study some pharmacological and toxicological properties of the plant to scientifically justify its use. …”
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3,4-Dihydropyrano [C] chromene Synthesis Using Fe3O4@SiO2-SO3H Magnetic Nanocatalyst by Masoumeh Zakarieie, Masoumeh Taherimehr

“…Synthesis of 4H-chromene and its derivatives has attracted great interest due to their biological and pharmacological activities. Here, a simple and practical method was employed for synthesizing 3,4-Dihydropyrano[c]chromene derivatives, which have found medicinal applications. …”
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Conditioned medium derived from mesenchymal stem cells and spinal cord injury: A review of the current therapeutic capacities by Gholam Reza Kaka, Farrokh Modarresi

“…Nowadays, mesenchymal stem cell (MSC) therapy has received much consideration in scientific communities in light of its pharmacological and therapeutic properties, for instance, anti-inflammatory, regenerative, analgesic, and immunomodulatory influences. …”
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Vascular Remodeling in Experimental Hypertension by Norma R. Risler, Montserrat C. Cruzado, Roberto M. Miatello

“…The understanding of the mechanisms producing the vascular alterations will allow the development of novel pharmacological tools for vascular protection in hypertensive disease.…”
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Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement by Ibrahim Khalil, MBBS, Ahmed Fahim Faiyaz, MBBS, Md. Imran Hossain, MBBS, Mahmuda Akter, MBBS

“…This case emphasizes the necessity of a multidisciplinary approach, including strict blood pressure control, regular imaging, and pharmacological intervention, to address ADPKD's complexities and optimize patient outcomes. …”
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Ethnomedicinal understandings and pharmacognosy of Dischidia (Apocynaceae: Asclepiadoideae): A potential epiphytic genus by Gitartha Saikia, Nilakshee Devi

“…Purpose: The present study focused on the traditional medicinal uses of the genus Dischidia in different corners of the world by diverse indigenous peoples to reflect a lucid image regarding the traditional and ethno pharmacological significance of the genus and their continuous considerable services for the wellbeing of the people from the primordial period to the present era. …”
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Innate Immune Response in Kidney Ischemia/Reperfusion Injury: Potential Target for Therapy by Aleksandra Kezić, Natasa Stajic, Friedrich Thaiss

“…Among numerous so far conducted experiments, observed immunomodulatory role of adenosine and adenosine receptor agonists in complex interactions of dendritic cells, natural killer T cells, and T regulatory cells is emphasized as promising in the treatment of kidney ischemia/reperfusion injury. Potential pharmacological approaches which decrease NF-κB activity and antagonize mechanisms downstream of activated Toll-like receptors are discussed.…”
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Exploring voyeurism: a review of research by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Edyta Gwóźdź, Adrian Muzyka, Julia Rydzek, Ewa Gardocka

“…Treatment primarily involves cognitive behavioral therapy (CBT), with pharmacological support using SSRIs like fluoxetine and paroxetine, showing effectiveness. …”
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