Effect of Phenylephrine on the Accommodative System by José J. Esteve-Taboada, Antonio J. Del Águila-Carrasco, Paula Bernal-Molina, Teresa Ferrer-Blasco, Norberto López-Gil, Robert Montés-Micó

“…Researchers have traditionally faced the challenge of measuring the accommodative properties of the eye through a small pupil and thus have relied on pharmacological agents to dilate the pupil. Achieving pupil dilation (mydriasis) without affecting the accommodative ability of the eye (cycloplegia) could be useful in many clinical and research contexts. …”
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The Efficacy and Safety of Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis for Treatment of Pain in Patients with Pancreatic Cancer by Anna Wiechowska-Kozłowska, Klaudiusz Boer, Maciej Wójcicki, Piotr Milkiewicz

“…Twenty nine subjects with unresectable pancreatic cancer and severe pain despite pharmacological treatment underwent EUS-guided celiac plexus neurolysis with 98% ethanol. …”
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Injectable hydrogel regulates immune infiltration through physical and chemical synergy in the treatment of steroid-induced osteonecrosis of the femoral head by Zherui Fu, Yiwen Xu, Fangqi Xu, Haoyu Zhou, Na Lin, Ning Zhang, Feng Lin

“…This treatment was designed to prevent the infiltration of Th17 cells by regulating the physiological function of stem cells and blocking the negative effect of Th17 cells on stem cells pharmacologically. Thus, the dual synergistic regulation of immune infiltration at the lesion site of SONFH enhanced the physiological activity and function of the stem cells, thereby improving the therapeutic effect of SONFH. …”
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Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish by Ilse Bollaerts, Jessie Van houcke, An Beckers, Kim Lemmens, Sophie Vanhunsel, Lies De Groef, Lieve Moons

“…In contrast to mammals, zebrafish retain high regenerative capacities into adulthood and thus form a powerful model to study the contribution of neuroinflammation to successful regeneration. Here, we used pharmacological immunosuppression methods to study the role of microglia/macrophages during optic nerve regeneration in adult zebrafish. …”
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Using Protein Painting Mass Spectrometry to Define Ligand Receptor Interaction Sites for Acetylcholine Binding Protein by Alexandru Graur, Natalie Erickson, Nadine Kabbani

“…Nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels expressed in nervous and non-nervous system tissue important for memory, movement, and sensory processes. The pharmacological targeting of nAChRs, using small molecules or peptides, is a promising approach for the development of compounds for the treatment of various human diseases including inflammatory and neurogenerative disorders such as Alzheimer’s disease. …”
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A Review of Complicated Cataract in Retinitis Pigmentosa: Pathogenesis and Cataract Surgery by Yingying Hong, Hongzhe Li, Yang Sun, Yinghong Ji

“…Despite the absence of curative pharmacologic treatment, phacoemulsification with intraocular lens implantation to deal with opacification in the lens is preferred due to the considerable visual outcomes. …”
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DFCP1 is a regulator of starvation-driven ATGL-mediated lipid droplet lipolysis by Victoria A. Ismail, Meg Schuetz, Zak N. Baker, Jean A. Castillo-Badillo, Teri V. Naismith, David J. Pagliarini, David J. Kast

“…Here we show that DFCP1 regulates lipid metabolism by directly modulating the activity of Adipose Triglyceride Lipase (ATGL/PNPLA2), the rate-limiting lipase driving the catabolism of LDs. We show through pharmacological inhibition of key enzymes associated with LD metabolism that DFCP1 specifically regulates lipolysis and, to a lesser extent, lipophagy. …”
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Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug by Deysiane Oliveira Brandão, Geovani Pereira Guimarães, Ravely Lucena Santos, Fernando José de Lima Ramos Júnior, Karla Monik Alves da Silva, Fabio Santos de Souza, Rui Oliveira Macêdo

“…Momordica charantia is a species cultivated throughout the world and widely used in folk medicine, and its medicinal benefits are well documented, especially its pharmacological properties, including antimicrobial activities. …”
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Pain Management of Pediatric Musculoskeletal Injury in the Emergency Department: A Systematic Review by Sylvie Le May, Samina Ali, Christelle Khadra, Amy L. Drendel, Evelyne D. Trottier, Serge Gouin, Naveen Poonai

“…Electronic databases were searched systematically for randomized controlled trials of pharmacological and nonpharmacological interventions for children aged 0–18 years, with musculoskeletal injury, in the emergency department. …”
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Lithium Improves Survival of PC12 Pheochromocytoma Cells in High-Density Cultures and after Exposure to Toxic Compounds by Cinzia Fabrizi, Stefania De Vito, Francesca Somma, Elena Pompili, Angela Catizone, Stefano Leone, Paola Lenzi, Francesco Fornai, Lorenzo Fumagalli

“…Taken together these data indicate that pharmacological activation of autophagy allows for the survival of Pheochromocytoma cells in stressful conditions such as high-density cultures and exposure to toxins.…”
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Ganoderma lucidum spore oil (GLSO), a novel antioxidant, extends the average life span in Drosophila melanogaster by Yi Zhang, Hongfei Cai, Zhu Tao, Cheng Yuan, Zhaojian Jiang, Juyan Liu, Hiroshi Kurihara, Wendong Xu

“…In ancient China, Ganoderma lucidum was believed to be a medical fungus that could increase lifespan. Recently, pharmacologic studies have found that polysaccharide peptides and triterpenoids extracted from Ganoderma lucidum have various physiological effects as active compounds. …”
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Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila by Bryon Silva, Claudia Molina-Fernández, María Beatriz Ugalde, Eduardo I. Tognarelli, Cristian Angel, Jorge M. Campusano

“…Our results show that pharmacological and genetic blockade of mAChRs in MB disrupts olfactory aversive memory in larvae. …”
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Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma by Ana Almazán-Moga, Patricia Zarzosa, Isaac Vidal, Carla Molist, Irina Giralt, Natalia Navarro, Aroa Soriano, Miguel F. Segura, Arantza Alfranca, Javier Garcia-Castro, José Sánchez de Toledo, Josep Roma, Soledad Gallego

“…Furthermore, cells contained in spheres and holoclones showed significant Hedgehog pathway induction, the inhibition of which (pharmacologic or genetic) impairs the formation of both holoclones and spheres. …”
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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, Chang-An Geng, Xiaoli Zhao, Huaiyu Wang, Chi-Wai Wong, Kelvin W. K. Yeung, Haobo Pan, William Weijia Lu, Min Guan

“…ESRRA abrogation results in enhanced SPP1 and decreased leptin secretion from both visceral adipocytes and BMAds, concertedly dictating bone marrow stromal stem cell fate commitment and restoring type H vessel formation, constituting a feed-forward loop for bone formation. Pharmacological inhibition of ESRRA protects obese mice against bone loss and high marrow adiposity. …”
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Recent approaches in the drug research and development of novel antimalarial drugs with new targets by Chinnappanna Naveen Kumar Reddy, Yennam Gopi, Chaitanya Chaitanya Budagam Haima Naga Venkata, Pottathil Shinu, Borah Pobitra, Venugopala Katharigatta N., Deb Pran Kishore, Mailavaram Raghu Prasad

“…A number of promising pharmacological interference targets have been uncovered in modern times. …”
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Elucidating Clinical Queries for Tailored Therapy in Patients with Prolactinoma by Min-Ho Lee, Jae Won Hong, Kyungwon Kim, Cheol Ryong Ku, Eun Jig Lee

“…Unlike other pituitary tumors, the first-line management has traditionally been pharmacological rather than surgical. This preference is due to the effectiveness of dopamine agonists (DAs), which typically reduce tumor size and normalize prolactin levels in most patients. …”
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Acute toxicity test and lethal dose (LD50) from a combination of sambiloto extracts (Andrographis paniculate) and catfish oil (Pangasius micronema Blkr.) in mice by Rinanda Al Rissa Rizki Hera, Meitasari Annisa Diyan, Sasongko Heru

“…Sambiloto extracts and catfish oil will be combined to determine the pharmacological effects caused by an acute toxicity test to determine the toxicity and LD50 value of the combination of extracts. …”
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Enhancing Bioactive Cordycepin Production via Precision Fermentation with an Engineered <i>Aspergillus oryzae</i> by Jutamas Anantayanon, Warinthon Chamkhuy, Nakul Rattanaphan, Sarocha Panchanawaporn, Kobkul Laoteng, Sukanya Jeennor

“…A xanthine oxidase inhibitory activity assay demonstrated that the cordycepin product had a pharmacological function. It exhibited strong stability under high thermal and acidic conditions, with over 95% product recovery. …”
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Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers by Li Lai, Yohannes T. Ghebremariam

“…In addition to diet, age, socioeconomic, and environmental factors, genetic factors that impair insulin signaling are centrally involved in the development and exacerbation of IRS. Genetic and pharmacological studies have demonstrated that the nitric oxide (NO) synthase (NOS) genes are critically involved in the regulation of insulin-mediated glucose disposal. …”
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Secondary Trigeminal Neuralgia after a Brainstem Hemorrhagic Stroke with Adverse Reaction to Carbamazepine: A Case Report by I Gusti Agung Ayu Andra Yusari, Ida Ayu Sri Wijayanti, Ketut Widyastuti, I Made Oka Adnyana

“…She experienced severe adverse reactions with the first-line pharmacological therapy, carbamazepine and gabapentin. …”
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