Significantly improving the solubility and anti-inflammatory activity of fenofibric acid with native and methyl-substituted beta-cyclodextrins via complexation by Rajaram Rajamohan, Perumal Muthuraja, Kuppusamy Murugavel, Murali Krishnan Mani, D. S. Prabakaran, Jeong Hyun Seo, Tabarak Malik, Yong Rok Lee

“…Additionally, our findings reveal that incorporating FFA into the CD cavity as a drug release system enhances the pharmacological profile of this substance, FFA.…”
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Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-κB Pathway by Ling-yun Wu, Zhen-nan Ye, Zong Zhuang, Yongyue Gao, Chao Tang, Chen-hui Zhou, Chun-xi Wang, Xiang-sheng Zhang, Guang-bin Xie, Jing-peng Liu, Meng-liang Zhou, Chun-hua Hang, Ji-xin Shi

“…Biochanin A (BCA), a natural bioactive isoflavonoid, has been confirmed to emerge the anti-inflammatory pharmacological function. This original study was aimed at evaluating and identifying the neuroprotective role of BCA and the underlying molecular mechanism in an experimental Sprague-Dawley rat SAH model. …”
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The Promise of Artificial Intelligence in Neuroanesthesia: An Update by Zhenrui Liao, Niharika Mathur, Vidur Joshi, Shailendra Joshi

“…It will advance the diagnosis and treatment of neurological diseases due to improved risk identification, data integration, early diagnosis, image analysis, and pharmacological and surgical robotic assistance. Beyond direct medical care, AI could also automate many routine administrative tasks in health care, assist with teaching and training, and profoundly impact neuroscience research. …”
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Advanced application of metal nanoparticles in the diagnosis and treatment of rheumatoid arthritis by Wenjing Zhang, Tingting Xu, Yu Chen, Guiyang Zhang, Yongbo Song

“…Although current pharmacological treatments for RA have proven effective, considerable challenges remain, such as the need for high dosages, frequent administration, and a high incidence of severe side effects. …”
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Neural Compensations After Lesion of the Cerebral Cortex by Bryan Kolb, Russell Brown, Alane Witt-Lajeunesse, Robbin Gibb

“…Thus, combining behavioral therapies with pharmacological administration of compounds to increase the availability of trophic factors enhances functional outcome. …”
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Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications by Hao Peng, Zheng Chao, Zefeng Wang, Xiaodong Hao, Zirui Xi, Sheng Ma, Xiangdong Guo, Junbiao Zhang, Qiang Zhou, Guanyu Qu, Yuan Gao, Jing Luo, Zhihua Wang, Jing Wang, Le Li

“…Furthermore, the pharmacological or genetic manipulation of mechanical checkpoints, such as PIEZO1, DDR1, YAP/TAZ, and TRPV4, has shown remarkable potential in immune activation and eradication of tumors. …”
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Nonpharmacologic Interventions for the Self-Management of Anxiety in Parkinson’s Disease: A Comprehensive Review by Susan K. Chandler, Jo Lynne Robins, Patricia A. Kinser

“…Current treatment is largely pharmacologic, which can result in a myriad of undesirable and unsafe side effects. …”
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Animal Models of Diabetic Retinopathy: Summary and Comparison by Angela Ka Wai Lai, Amy C. Y. Lo

“…In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed. They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). …”
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Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity by Suzhen Chen, Yanping Wang, Qian Zhou, Qiqi Qian, Quanxin Jiang, Chuchu Liu, Yan Liu, Peihui Zhou, Jie Xiong, Yao Zhang, Ning Wang, Yang Emma Li, Limin Yin, Hongyuan Yang, Junli Liu

“…Moreover, individuals with obesity exhibit reduced Eepd1 expression. Pharmacological restoration of Eepd1 with Retigabine dihydrochloride effectively mitigates obesity. …”
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Case Report of Presumed (In)voluntary Capsaicin Intoxication Mimicking an Acute Abdomen by Simona Koprdova, Christine Schürmann, Dirk Peetz, Thomas Dürbye, Frank Kolligs, Herbert Koop

“…The clinical picture in the view of pharmacological investigations on intestinal capsaicin infusions suggests that excessive doses of capsaicin can induce severe abdominal pain; the prolonged symptoms were probably due to the failure to vomit. …”
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Diuretic Activity of the Aqueous Extract Leaves of Ficus glumosa Del. (Moraceae) in Rats by Fidèle Ntchapda, Djedouboum Abakar, Blaise Kom, Paulin Nana, Christian Bonabe, Maguirgue Kakesse, Emmanuel Talla, Théophile Dimo

“…The experiments were performed under the same conditions with two synthetic pharmacological diuretics considered as check (Furosemide and Amiloride hydrochlorothiazide). …”
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Inflammation in Diabetic Nephropathy by Andy K. H. Lim, Gregory H. Tesch

“…Lastly, we present the latest data on the pathogenic role of the stress-activated protein kinases in diabetic nephropathy, from studies on the p38 mitogen activated protein kinase and the c-Jun amino terminal kinase cell signalling pathways. The genetic and pharmacological approaches which reduce inflammation in diabetic nephropathy have not only enhanced our understanding of the pathophysiology of the disease but shown promise as potential therapeutic strategies.…”
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Functioning of Women with Migraine Headaches by Dorota Talarska, Małgorzata Zgorzalewicz-Stachowiak, Michał Michalak, Agrypina Czajkowska, Karolina Hudaś

“…This approach would greatly aid the individual in choosing the appropriate treatment, either pharmacological or others.…”
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Spectrum-Effect Relationships of Flavonoids in Glycyrrhiza uralensis Fisch. by Tingting Li, Shiyao Hua, Jiahua Ma, Lin Dong, Fang Xu, Xueyan Fu

“…The spectrum-effect relationships between the HPLC fingerprints and pharmacological activities of flavonoids in G. uralensis Fisch., including the heat clearing, detoxifying effects, cough relief, and phlegm elimination effects, were assessed by gray relational analysis and partial least squares regression. …”
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Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG by Alfredo Durand-Rivera, Efren Alatorre-Miguel, Elizabeth Zambrano-Sánchez, Celia Reyes-Legorreta

“…Attention deficit hyperactivity disorder (ADHD) affects 5-6% of school aged children worldwide. Pharmacological therapy is considered the first-line treatment and methylphenidate (MPH) is considered the first-choice medication. …”
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Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease by Allison Carles, Aline Freyssin, Sarra Guehairia, Thomas Reguero, Michel Vignes, Hélène Hirbec, Gilles Rubinstenn, Tangui Maurice

“…Abstract Background Fluoroethylnormemantine (FENM), a new Memantine (MEM) derivative, prevented amyloid-β[25–35] peptide (Aβ25–35)-induced neurotoxicity in mice, a pharmacological model of Alzheimer's disease (AD) with high predictive value for drug discovery. …”
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Research progress of auricular point therapy to relieve preoperative period anxiety before elective surgery in adults (耳穴压豆缓解成年人择期手术术前焦虑的研究进展)... by GAO Yuan (高原), XU Lingzhi (徐凌志), LI Suxia (李素霞)

“…To alleviate this issue, non-pharmacological interventions such as prayer, massage, music, imagery, and acupuncture have been widely employed. …”
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Exploring phytochemical, antioxidant, and antimicrobial properties of Plumeria pudica Jacq. leaves by Kavan Shukla, Kunal N. Odedra, B. A. Jadeja

“…Consequently, there is an increasing focus on pharmacological research aimed at identifying optimal solutions to this challenge. …”
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Shaping Treatment Expectation to Optimize Efficacy of Interleukin 17A Antagonist Secukinumab in Psoriasis Patients by Hölsken S, Krefting F, Mühlhaus S, Bese D, Schedlowski M, Sondermann W

“…IL-17A levels significantly increased throughout the treatment, with no significant differences between groups despite the 75% dose reduction.Conclusion: This study demonstrates an attempt to modify patients’ treatment expectations to enhance the effectiveness of pharmacological therapy with secukinumab in psoriasis patients. …”
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The Croton genera (Euphorbiaceae) and its richness in chemical constituents with potential range of applications by Carlos Andrés Coy-Barrera, Laura Galvis, Maria Juliana Rueda, Sergio Alejandro Torres-Cortés

“…It aims to summarize information gathered worldwide from studies of Croton species concerning ethnobotanical, pharmacological, and other uses over the past ten years and the respective discussion. …”
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