Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells by Geng Yin, Ying Wang, Xiao-min Cen, Min Yang, Yan Liang, Qi-bing Xie

“…Our results indicated that products of lipid peroxidations, 4-HNE, may induce synovial intrinsic inflammations by activating NF-κB pathways and it may lead to cell apoptosis. Pharmacological inhibition of NF-κB activation may reduce the 4-HNE mediated inflammation responses and subsequent cell apoptosis. …”
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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…Systematic reviews and meta-analyses indicate that only a minority of patients with neuropathic pain have an adequate response to pharmacological treatment and that most drugs have dose-limiting side effects. …”
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Aerobic Exercise Improves Signs of Restless Leg Syndrome in End Stage Renal Disease Patients Suffering Chronic Hemodialysis by Mojgan Mortazavi, Babak Vahdatpour, Aida Ghasempour, Diana Taheri, Shahrzad Shahidi, Firouzeh Moeinzadeh, Bahareh Dolatkhah, Shahaboddin Dolatkhah

“…Although there are some known pharmacological managements for this syndrome, the adverse effect of drugs causes a limitation for using them. …”
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Psychedelics for Brain Injury: A Mini-Review by Mia Khan, Gregory T. Carter, Sunil K. Aggarwal, Julie Holland

“…Despite decades of investigation, pharmacologic treatment of brain injury is still a field in its infancy. …”
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Pengaruh Terapi Murotal Terhadap Tingkat Kecemasan Menghadapi Persalinan Pada Ibu Hamil di Wilayah Kerja Puskesmas Andalas by Riza Wahyuni, Deswita

“…Anxiety can have an impact on physically and psychologically in both the mother, the fetus and the labour procces. Non pharmacological management such as murotal therapy. The purpose of this research was to determine the effect of the murotal therapy on anxiety level to face the labour. …”
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Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue by Ye Seul Park, Md Jamal Uddin, Lingjuan Piao, Inah Hwang, Jung Hwa Lee, Hunjoo Ha

“…Interestingly, catalase deficiency also enhanced classical macrophage activation (M1) and inflammation but suppressed alternative activation (M2) regardless of diet. Similarly, pharmacological inhibition of catalase activity using 3-aminotriazole induced the same phenotypic switch and inflammatory response in RAW264.7 macrophages. …”
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Thirty years from FDA approval of pegylated liposomal doxorubicin (Doxil/Caelyx): an updated analysis and future perspective by Alberto A Gabizon, Shira Gabizon-Peretz, Shadan Modaresahmadi, Ninh M La-Beck

“…PLD predated the field of nanomedicine and became a model nanomedicine setting key pharmacological principles (prolonged circulation, slow drug release and the enhanced permeability and retention (EPR) effect) for clinical application of other nano-drugs in cancer therapy. …”
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The effect of rehabilitation on remission following detoxification treatment in alcohol and substance use disorders: A pilot study by Mustafa Danisman, Gamze Zengin Ispir, Kubra Sezer Katar, Zehra Ucar Hasanli, Ziya Bilgin

“…In the treatment of ASUD, in addition to pharmacological treatment and the treatment of comorbid psychiatric disorders, the inclusion of rehabilitation in the treatment processes is also essential because of the high relapse rates after detoxification treatment. …”
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Real and Pseudoaccommodation in Accommodative Lenses by Ioannis G. Pallikaris, Georgios A. Kontadakis, Dimitra M. Portaliou

“…Objective measurement of the accommodative capability offered by the accommodative IOLs is extremely difficult to obtain, and different methods such as autorefractometers, retinoscopy, and ultrasound imaging during accommodative effort, ray tracing, or pharmacological stimulation have been developed but the results are sometimes inconsistent. …”
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The role of diet and physical activity in PCOS - A Quick Review by Natalia Pawelec, Weronika Mazur, Artur Hawajski, Natalia Jankowska, Adrianna Świerzyńska, Alicja Kapciak, Julia Górny, Katarzyna Naja

“…These recommendations are often overlooked or undervalued, with patients frequently expecting immediate pharmacological treatment and not believing in the potential effects of lifestyle changes. …”
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The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response by Hui Chen, Yue Xu, Dingshan Chen, Di Xiao, Bing Yang, Wenqi Wang, Han Han

“…This resistance is mitigated by Hippo pathway-mediated phosphorylation of MTF1. Moreover, pharmacological activation of the Hippo pathway sensitizes cancer cells to platinum-based compounds. …”
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The Angiotensin II Type 2 Receptor in Brain Functions: An Update by Marie-Odile Guimond, Nicole Gallo-Payet

“…If confirmed, these new pharmacological tools should help to improve impaired cognitive performance, not only through its action on brain microcirculation and inflammation, but also through more specific effects on neurons. …”
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Efektivitas Pemberian Jahe Merah (Zingiber Officinale Var Rubrum Rhizoma) Dan Teh Rosella (Hibiscus Sabdariffa) Terhadap Kegawatan Dismenore by Puji Setya Rini Puji Setya Rini, Diah Agustina, Tiwi Pramesti

“…The use of red ginger and rosella tea is one form of non-pharmacological treatment to reduce dysmenorrhea pain. …”
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Effects of Heliox in Stable COPD Patients at Rest and during Exercise by Matteo Pecchiari

“…For these reasons, heliox has been evaluated as a non pharmacological tool to power rehabilitation programs. …”
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Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer by Perumal Elumalai, Jagadeesan Arunakaran

“…Nimbolide exhibits several pharmacological effects among which its anticancer activity is the most promising. …”
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Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment by Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke

“…Recent studies highlight therapeutic strategies that target HIF-1α, such as the use of pharmacological inhibitors, gene editing techniques, and hypoxia-modulating treatments, which show promise in enhancing responses to immunotherapy. …”
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Poststroke Cell Therapy of the Aged Brain by Aurel Popa-Wagner, Madalina Filfan, Adriana Uzoni, Pouya Pourgolafshan, Ana-Maria Buga

“…Stem cell based therapy is a promising approach to promote neuroregeneration after brain injury and can be potentiated when combined with supportive pharmacological drug treatment, especially in the aged. …”
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Impact of the Ketogenic Diet on Neurological Diseases: A Review by Carmen Rubio, Alejandro López-Landa, Hector Romo-Parra, Moisés Rubio-Osornio

“…Background: The ketogenic diet (KD), high in fat and low in carbohydrates, was introduced in the 1920s as a non-pharmacological treatment for refractory epilepsy. Although its mechanism of action is not fully understood, beneficial effects have been observed in neurological diseases such as epilepsy, Alzheimer’s disease, and Parkinson’s disease. …”
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Cycloastragenol promotes dorsal column axon regeneration in mice by Tao Zihan, Tao Zihan, Teng Wenwen, Teng Wenwen, Ma Yanxia, Saijilafu

“…IntroductionCycloastragenol (CAG) has a wide range of pharmacological effects, including anti-inflammatory, antiaging, antioxidative, and antitumorigenic properties. …”
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Antileishmanial Activity of Warifteine: A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos sympodialis Eichl. (Menispermaceae) by Eliete Cavalcanti da Silva, Cynthia Dias Rayol, Paloma Lys Medeiros, Regina Célia Bressan Queiroz Figueiredo, Márcia Regina Piuvezan, José Maria Brabosa-Filho, Alexsandro Fernandes Marinho, Teresinha Gonçalves Silva, Gardenia Carmen Gadelha Militão, Ana Paula Pimentel Cassilhas, Paulo Paes de Andrade

“…In conclusion, warifteine represents an attractive candidate for future pharmacological studies aiming new leishmanicidal drugs.…”
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