PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation by Elena Dozio, Massimiliano Ruscica, Elena Vianello, Chiara Macchi, Clementina Sitzia, Gerd Schmitz, Lorenza Tacchini, Massimiliano M. Corsi Romanelli

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Esters of quinoxaline-7-carboxylate-1,4-di-N-oxide as Trichomonas vaginalis triosephosphate isomerase inhibitors by Palos Isidro, Moo-Puc Rosa, Vique-Sánchez José Luis, Benítez-Cardoza Claudia G., Monge Antonio, Villalobos-Rocha Juan Carlos, Paz-Gonzalez Alma D., Rivera Gildardo

“…Therefore, it is essential to propose new pharmacological agents against this disease. In this work, esters of quinoxaline-7-carboxylate-1,4-di-N-oxide (EQX-NO) were evaluated in in vitro assays as novel trichomonicidal agents. …”
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Is Exploration of Alternate Immune Pathways Needed in Hidradenitis Suppurativa? A Case of Atopic Dermatitis and Concurrent Hidradenitis Suppurativa Responding to Dupilumab by Sean McCormack, Noor Tazudeen, Benjamin C. Garden

“…This case highlights how the inflammatory process of HS is not fully understood and how biologic pharmacologic interventions need to be further studied to determine their efficacy in treating HS.…”
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Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases by Shuai Chen, Caifei Shen, Xiaorui Zeng, Luqiang Sun, Fangli Luo, Renhong Wan, Yupeng Zhang, Xinyun Chen, Yujun Hou, Wen Wang, Qianhua Zheng, Ying Li

“…Research indicates that dietary interventions, such as a low FODMAP diet, can enhance the colonization of probiotics and improve the fermentation metabolism of SCFAs. Pharmacological strategies to elevate SCFA levels can activate the AMPK pathway and rectify abnormalities in energy metabolism. …”
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Bone Health in Patients with Multiple Sclerosis by Vit Zikan

“…The physical as well as pharmacological interventions which can counteract the bone remodeling imbalance, particularly osteocyte apoptosis, will be promising for prevention and treatment of osteoporosis in patients with MS.…”
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Decreased Clostridium Abundance after Electroconvulsive Therapy in the Gut Microbiota of a Patient with Schizophrenia by Misako Kanayama, Maiko Hayashida, Sadayuki Hashioka, Tsuyoshi Miyaoka, Masatoshi Inagaki

“…Previous studies have shown that Clostridium spp. are increased in patients with schizophrenia compared with those in healthy individuals and that Clostridium is reduced after pharmacological treatment. Our report is the first report on the gut microbiota of a patient with schizophrenia receiving ECT. …”
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Perbedaan Pengaruh Terapi Bermain Mewarnai Gambar dengan Bermain Puzzle Terhadap Kecemasan Anak Usia Prasekolah di IRNA Anak RSUP Dr.M.Djamil Padang by Elza Sri Pratiwi, Deswita

“… Illness and hospitalization are stressors that cause anxiety in children. The non-pharmacological management such as coloring pictures and play puzzle can be an alternative to reduce the anxiety. …”
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The first experience with sodium‐glucose cotransporter 2 inhibitor for the treatment of systemic right ventricular failure by Anastasia D. Egorova, Marieke Nederend, Laurens F. Tops, Hubert W. Vliegen, Monique R.M. Jongbloed, Philippine Kiès

“…This chronic exposure to pressure overload ultimately leads to systemic right ventricular (sRV) dysfunction and heart failure. Pharmacological options for the treatment of sRV failure are poorly defined and no solid recommendations are made in the most recent guidelines. …”
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The Effect of Hand Reflexology Massage on Pain and Fatigue in Patients after Coronary Angiography: A Randomized Controlled Clinical Trial by Nahid Rejeh, Seyed Davood Tadrisi, Shahrooz Yazdani, Kiarash Saatchi, Mojtaba Vaismoradi

“…Hand reflexology as a nonpharmacological and safe technique can be used by nurses along with other pharmacologic interventions in order to reduce patients’ suffering related to invasive procedures. …”
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Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels by Jenifer d’El-Rei, Ana Rosa Cunha, Michelle Trindade, Mario Fritsch Neves

“…Thus, nutritional interventions are recognized as important strategies for primary prevention of hypertension and as adjuvants to pharmacological therapies to reduce cardiovascular risk. …”
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Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration by Pradeep V. Mahajan, Swetha Subramanian, Siddhesh C. Parab, Sanskruti Mahajan

“…Sudden twisting movements during weight bearing or trauma can cause injury to the menisci, which leads to symptoms such as pain, swelling, and difficulty in performing movements, among others. Conventional pharmacological and surgical treatments are effective in treating the condition; however, do not result in regeneration of healthy tissues. …”
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Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins by Sharon Inberg, Yael Iosilevskii, Alba Calatayud-Sanchez, Hagar Setty, Meital Oren-Suissa, Michael Krieg, Benjamin Podbilewicz

“…Our genetic results, supported by optogenetic, behavioral, and pharmacological evidence, suggest an activity-dependent homeostatic mechanism for dendritic structural plasticity, that in parallel controls escape response to noxious mechanosensory stimuli.…”
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Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells by Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-Oliveira, Miguel A. Prieto, Ka-Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao

“…Dietary flavonoids are abundant in natural plants and possess multiple pharmacological and nutritional activities. In this study, apigenin, luteolin, and baicalein were chosen to evaluate their anti-diabetic effect in high-glucose and dexamethasone induced insulin-resistant (IR) HepG2 cells. …”
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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

“…These findings suggest two complementary mechanisms by which aspirin regulates the degradation of soluble and insoluble proteins, providing insights into its diverse pharmacological effects that can aid in future drug development efforts.…”
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Importance and Relevance of Phytochemicals Present in Galenia africana by Dario Heredia, Ivan Green, Jeremy Klaasen, Farzana Rahiman

“…This is a report on the phytochemical composition of G. africana and a review on the pharmacological importance and relevance of these phytochemicals. …”
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Physical activity and depression by Monika Wojtasik, Katarzyna Żak, Adam Załóg, Maria Nowak, Edyta Pietryszak, Wojciech Kulej, Paulina Szołtek, Rafał Pardela, Marcel Paruzel, Martyna Łęcka

“…In a therapeutic context, the article examines how physical activity can be an effective complement to traditional methods of treating depression, both pharmacological and psychotherapeutic. The importance of adapting training programs to individual needs and preferences of patients is also emphasized. …”
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Decreased impulsiveness and MEG normalization after AI-digital therapy in ADHD children: a RCT by Danylyna Shpakivska Bilan, Irene Alice Chicchi Giglioli, Pablo Cuesta, Elena Cañadas, Ignacio de Ramón, Fernando Maestú, Jose Alda, Josep Antoni Ramos-Quiroga, Jorge A. Herrera, Alfonso Amado, Javier Quintero

“…Abstract Attention-deficit/hyperactivity disorder (ADHD) presents with symptoms like impulsiveness, inattention, and hyperactivity, often affecting children’s academic and social functioning. Non-pharmacological interventions, such as digital cognitive therapy, are emerging as complementary treatments for ADHD. …”
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Maternal phthalates exposure promotes neural stem cell differentiation into phagocytic astrocytes and synapse engulfment via IRE1α/XBP1s pathway by Fengzhen Cui, Shiyu Deng, Yan Fu, Tongtong Xu, Shuangshuang Bao, Siyi Wang, Yahang Lin, Xianghui Wang, Faming Zhao, Tingting Zhang, Shunqing Xu, Zhijun Zhang, Wanlu Li, Guo-Yuan Yang, Huanwen Tang, Jixian Wang, Xia Sheng, Yaohui Tang

“…Conditional knockout or pharmacological inhibition of IRE1α markedly inhibits NSC differentiation into astrocytes and astrocyte reactivity, attenuates synapse phagocytosis, and improves cognitive function. …”
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Telomere-to-telomere Phragmites australis reference genome assembly with a B chromosome provides insights into its evolution and polysaccharide biosynthesis by Jipeng Cui, Rui Wang, Ruoqing Gu, Minghui Chen, Ziyao Wang, Li Li, Jianming Hong, Suxia Cui

“…Based on multi-tissue transcriptomic data, we identified structural genes in the biosynthetic pathway of pharmacologically active Phragmitis rhizoma polysaccharides with essential roles in rhizome development. …”
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Pancreatic lipase inhibitory activity of selected pharmaceutical agents by Hamdan Imad I., Kasabri Violet N., Al-Hiari Yusuf M., El-Sabawi Dina, Zalloum Hiba

“…In conclusion, synergistic lipase inhibitory activity between OsT and some other pharmaceutical compounds was demonstrated for the first time, which might help improve the pharmacological effect of OsT.…”
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