Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3 by Peipei Li, Zhini Zhu, Yong Wang, Xuyuan Zhang, Chuanhui Yang, Yalan Zhu, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang, Pu Gao, Qianhui Qu

“…Despite their physiological and pharmacological significance, the molecular underpinnings of substrate and drug recognition remain unknown. …”
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Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential by Alexander Fuerlinger, Alina Stockner, Simon Sedej, Mahmoud Abdellatif

“…Furthermore, we discuss the potential for pharmacologically mimicking the beneficial effects of caloric restriction in HFpEF using clinically approved and emerging caloric restriction mimetics. …”
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Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice by Fabiola Silva Angulo, Claudine Vanessa Joseph, Lou Delval, Lucie Deruyter, Séverine Heumel, Marie Bicharel, Patricia Brito Rodrigues, Valentin Sencio, Tom Bourguignon, Marina Gomes Machado, Marie Fourcot, Stéphane Delhaye, Sophie Salomé-Desnoulez, Philippe Valet, Serge Adnot, Isabelle Wolowczuk, Jean-Claude Sirard, Muriel Pichavant, Bart Staels, Joel T. Haas, Ruxandra Gref, Jimmy Vandel, Arnaud Machelart, Hélène Duez, Benoit Pourcet, François Trottein

“…In young-adult mice, we discovered an interaction between Rev-erb-α and the apelinergic axis that controls host defenses against S. pneumoniae via alveolar macrophages. Pharmacological repression of Rev-erb-α in elderly mice resulted in greater resistance to pneumococcal infection. …”
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IDENTIFICATION OF DEPRESSION IN THE ELDERLY by Rindayati Rindayati, Abd Nasir, Makhfudli Makhfudli, Ali Sairozi, Andini Wulan Sari

“…Conclusions: Depression as one of the effects of the aging process is significant to be recognized early by using the Geriatric Depression Scale. Non-pharmacological prevention of depression with regular physical exercise is highly recommended.…”
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Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential by Lyca R. da Fonseca, Rafaele de A. Rodrigues, Aline de S. Ramos, Jefferson D. da Cruz, José Luiz P. Ferreira, Jefferson Rocha de A. Silva, Ana Claudia F. Amaral

“…Thus, this article was based on a search into the uses of the main species of the genus Passiflora with anxiolytic activity and its main secondary metabolites and some pharmacological studies, patents, and registered products containing Passiflora. …”
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Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease by Helen C. Steel, Riana Cockeran, Ronald Anderson, Charles Feldman

“…The final section of the review is devoted to a consideration of pharmacological, anti-inflammatory strategies with adjunctive potential in the antimicrobial chemotherapy of CAP. …”
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Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease by Hugh J Freeman

“…Classification of Crohn's disease behaviour using the Vienna classification schema revealed that virtually all patients in this study suffered from intestinal stricture formation or penetrating disease complications. Moreover, pharmacological therapies with corticosteroids and immunosuppressant drugs were rarely successful, with virtually all patients requiring at least one, and usually multiple, intestinal resections. …”
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Health Implications of Anabolic-Androgenic Steroids: Usage, Risks, and Treatment Approaches - The Literature Review by Krzysztof Jodłowski, Ewa Dubniewicz, Paula Majewska, Alicja Staszek, Wiktoria Łoskot, Jan Szwech, Mateusz Matczak, Karol Jasiński, Aleksandra Broda, Kacper Hoksa

“…The review explores the health implications of AAS use, highlighting the importance of an interdisciplinary approach to managing AAS-related health issues, emphasizing harm reduction, pharmacological interventions, and fertility preservation techniques. …”
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Allergen degradation of bee pollen by lactic acid bacteria fermentation and its alleviatory effects on allergic reactions in BALB/c mice by Shuting Yin, Qiangqiang Li, Yuxiao Tao, Enning Zhou, Kun Wang, Wanwen Chen, Xiangxin Li, Liming Wu

“…Bee pollen (BP) is a typical food with allergenic potentials, although it performs various nutritional/pharmacological functions to humans. In this study, lactic acid bacteria (LAB) were used to ferment Brassica napus BP for alleviating its allergenicity. …”
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Post-retrieval noradrenergic activation impairs subsequent memory depending on cortico-hippocampal reactivation by Hendrik Heinbockel, Gregor Leicht, Anthony D Wagner, Lars Schwabe

“…In a three-day study, we measured brain activity using fMRI during initial encoding, 24 hr-delayed memory cueing followed by pharmacological elevations of glucocorticoid or noradrenergic activity, and final recall. …”
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<i>Akkermansia muciniphila</i>: A Potential Target for the Prevention of Diabetes by Kairu He, Feiyu An, Henan Zhang, Danli Yan, Tong Li, Junrui Wu, Rina Wu

“…Diabetes treatments that rely on altering changes in <i>A. muciniphila</i> abundance are also reviewed, including the identification of <i>A. muciniphila</i> active ingredients, and dietary and pharmacological interventions for <i>A. mucinihila</i> abundance. …”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…In addition, we briefly discussed potential pharmacological interventions for glucose metabolism to alleviate MDD, including glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, and pioglitazone, to encourage the development of new therapeutics.…”
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MEDICINAL CHEMISTRY IN POPULAR CULTURE: AN ANALYSIS OF THE REPRESENTATION OF BIOACTIVE SUBSTANCES IN CARTOONS AND GAMES by Aldo S. de Oliveira, Angelica Justino, Thiago H. Doring, Vanessa Nascimento

“…The inclusion of these novel data and analyses not only enriches our understanding of representations of psychoactive substances in popular culture but also provides valuable insights for research in Medicinal Chemistry and the development of future pharmacological therapies. By highlighting the importance of public science communication and media literacy, this study contributes to promoting critical thinking and a broader appreciation of the intersection between science, popular culture, and entertainment.…”
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Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies by Piotr Robert Bakuła, Kamila Jałocha, Joanna Zygadło

“…This review examines emerging pharmacological and regenerative approaches, including disease-modifying osteoarthritis drugs (DMOADs), biologics, and cell-based therapies. …”
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The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin. by Anhua Hu, Maximilian E Pickup, Maryam A Lawal, Hetal J Patel, Mohammed I Ahmed

“…These data will provide a platform for pharmacological manipulation of Elf5 in skin, leading to advancements in many areas of research, including stem cell, regenerative medicine, and ageing.…”
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Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase by Nhung Nguyen Thi Ai, Hai Nguyen Thi Thanh, Quang Thanh Bui, Vinh Phu Nguyen, Tu Quy Phan

“…In this work, they were subjected for further computational efforts to complete their bio-chemo-pharmacological profile, and broaden their anti-fungal potentiality against Colletotrichum gloeosporioides cutinase presentative (PDB-3DEA). …”
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Advances in intrahepatic and extrahepatic vascular dysregulations in cirrhotic portal hypertension by Yanqiu Li, Bingbing Zhu, Ke Shi, Yu Lu, Xuanwei Zeng, Yongqi Li, Qun Zhang, Ying Feng, Xianbo Wang

“…Additionally, therapeutic strategies targeting these vascular mechanisms are diverse, including improvement of sinusoidal microcirculation, therapies targeting hepatic stellate cells activation, and pharmacological modulation of systemic vascular tone. …”
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Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39 by Zhongxiao Fu, Mallikarjunarao Ganesana, Philip Hwang, Xiao Tan, Melissa Marie Kinkaid, Yu-Yo Sun, Emily Bian, Aden Weybright, Hong-Ru Chen, Katia Sol-Church, Ukpong B. Eyo, Clare Pridans, Francisco J. Quintana, Simon C. Robson, Pankaj Kumar, B. Jill Venton, Anne Schaefer, Chia-Yi Kuan

“…The microglial-dependent regulation of cerebral blood flow requires the adenosine triphosphate-sensing P2RY12 receptor and ectonucleotidase CD39 that initiates the dephosphorylation of extracellular adenosine triphosphate into adenosine in both male and female mice. Pharmacological inhibition or CX3CR1-CreER-mediated deletion of CD39 mimics the cerebral blood flow anomalies in microglia-deficient mice and reduces the upsurges of extracellular adenosine following whisker stimulation. …”
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A phytotherapeutic approach to hinder the resistance against clindamycin by MRSA: in vitro and in silico studies by Amal Mayyas, Ali Al-Samydai, Nehaya Al-Karablieh, Waleed A Zalloum, Deniz Al-Tawalbeh, Farah Al-Mamoori, Rula A. Amr, Hamdi Al Nsairat, Simone Carradori, Lidia Kamal Al-Halaseh, Talal Aburjai

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Diabetes and Insulin Therapy, but Not Metformin, Are Related to Hepatocellular Cancer Risk by Luca Miele, Cristina Bosetti, Federica Turati, Gianlodovico Rapaccini, Antonio Gasbarrini, Carlo La Vecchia, Stefania Boccia, Antonio Grieco

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