Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity by Khanh Tien Nguyen Pham, Takahito Miyake, Tomo Suzuki, Shigeru Kinoshita, Yuki Hamada, Hikari Uehara, Mamiko Machida, Takeshi Nakajima, Emi Hasegawa, Masao Doi

“…Here, we performed radioactive tracer studies in combination with pharmacological enzyme inhibition, followed by targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, and found three androgen metabolites—androstanedione, androsterone, and epiandrosterone—in mouse and human meibomian glands. …”
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Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats by Manal A. Hamed, Sanaa A. Ali, Nagy Saba El-Rigal

“…Further studies are required in order to identify the molecules responsible of the pharmacological activity.…”
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(Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity and Tumorigenicity by Ž. Večerić-Haler, A. Cerar, M. Perše

“…Despite intensive investigations there is still no pharmacological agent that could provide complete protection against cisplatin nephrotoxicity. …”
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Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable by Elisabetta Bianchini, Lynn Roth, Pierre Boutouyrie, Smriti Badhwar, Achim Schwarz, Vincenzo Gemignani, Rosa Maria Bruno, Bernhard Hametner, Chloe Park, Giacomo Pucci, Ioana Mozos, Dimitrios Terentes-Printzios, Rachel E. Climie, Andrea Guala, Jordi Alastruey, Christopher C. Mayer

“…Despite significant progress, the development of pharmacological interventions to mitigate vascular aging remains a critical need. …”
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Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress by Na Wang, Han Yang, Yelei Chen, Hekun Wang, Chaorui Wang, Jianglin Fan, Yajie Chen, Yinghua Li, Maobi Zhu

“…Formononetin (FMN) is a flavonoid that has been shown to have various pharmacological effects, including antioxidants. In this study, we delved into the impact of FMN, acting as an antioxidant, on the in vitro development of oocytes and blastocysts within the culture system. …”
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New Oxygenated Methoxy-<i>p</i>-Cymene Derivatives from Leopard’s Bane (<i>Doronicum columnae</i> Ten., Asteraceae) Essential Oil: Synthesis Facilitating the Identification of Isom... by Milan Ž. Dimitrijević, Marko Z. Mladenović, Milica D. Nešić, Milan S. Dekić, Vidak N. Raičević, Niko S. Radulović

“…Species of the genus <i>Doronicum</i> are known for their pharmacological properties and essential oils, the chemical composition of which remains inadequately studied. …”
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Evaluating the Thymoquinone Content and Antioxidant Properties of Black Cumin (<i>Nigella sativa</i> L.) Seed Oil During Storage at Different Thermal Treatments by Grażyna Neunert, Wiktoria Kamińska, Joanna Nowak-Karnowska

“…Black cumin seeds (<i>Nigella sativa</i>) and black cumin seed oil (BCSO) exhibit various pharmacological activities, most of which are attributed to the presence of thymoquinone (TQ). …”
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The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments by Bruna Bombassaro, Eliana P. Araujo, Licio A. Velloso

“…This review presents an overview of the mechanisms involved in the hypothalamic regulation of energy balance and discusses how advancements in this field are contributing to the development of new pharmacological strategies to treat obesity.…”
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Allergen-Induced Asthma by Donald W Cockcroft

“…A standardized allergen inhalation challenge model has been developed and is proving to be a valuable research tool in the investigation of asthma pathophysiology and of potential new pharmacological agents for the treatment of asthma.…”
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Emotional stress increases GluA2 expression and potentiates fear memory via adenylyl cyclase 5 by Qian Yang, Ahmad Abdulla, Muhammad Farooq, Yoshihiro Ishikawa, Siqiong June Liu

“…Therefore, AC5 is a promising pharmacological target for preventing stress-enhanced fear memory.…”
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Kinetic study on the extraction of ethanimidic acid from hibiscus flowers using microwave assisted hydrodistillation by Hesham Hussein Rassem, Mohd Hairul Bin Khamidun, Ahmer Ali Siyal, Radin Maya Saphira Radin Mohamed

“…The second-order kinetic model ensures precise control of ethanimidic acid extraction, enabling efficient scalability for industrial production and consistent quality for pharmacological applications, emphasizing sustainable and cost-effective manufacturing practices. …”
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Effectiveness of Yoga as a Complementary Therapy for Anorexia Nervosa: A Systematic Review by Massimiliano Buoli, Francesca Legnani, Monic Mastroianni, Letizia Maria Affaticati, Enrico Capuzzi, Massimo Clerici, Alice Caldiroli

“…It would be also interesting to verify in comparative trials the effectiveness of yoga with respect to other treatments such as psychotherapy or the administration of pharmacological compounds. Finally, the practice should be modified adapting to the specific needs of this type of patient.…”
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Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels by Itsuro Kazama

“…Based on the recent in vitro evidence that revealed the pharmacological properties of the channels, the most recent studies have revealed novel therapeutic implications of targeting the lymphocyte Kv1.3-channels for the treatment of renal diseases.…”
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ACUTE PAIN NURSING CARE WITH CONGESTIVE HEART FAILURE by Fatkhiyatul Fitria, Ilkafah Ilkafah, Cucuk Rachmadi Prasetyo

“…Conclusion: from the research conducted, found that deep breath relaxation technique is one of the effective non-pharmacological pain management methods to reduce pain.…”
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Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone by Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li, Xiaomeng Li

“…Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, have been found to have various pharmacological actions including anti-inflammatory, antimicrobial, and anticancer properties, with no significant toxicity. …”
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Attention deficit/hyperactivity disorder (ADHD) dimensions mediate the relationship between adverse childhood experiences and adult aggression depending on cognitive reappraisal by Steffen Barra, Paulina Klaudia Machalica, Petra Retz-Junginger, Johannes Merscher, Anselm Crombach, Wolfgang Retz

“…Respective gender-sensitive prevention and treatment for aggressive behavior should include adequate pharmacological and psychological approaches that address ADHD core symptoms, whilst also aiming to improve emotion regulation techniques.…”
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Short- and long-term complications of bariatric surgery by Miguel Licea Videaux, Roberto Santana Caballero, Jesús Javier Sánchez Mata, Isabel García Morales, Dania Piñeiro Pérez, Daryl Rodríguez Denis

“…<p>Obesity affects mostly young men and women, both in developed and developing countries. Pharmacological treatments have proven to be ineffective, leaving surgery as the only therapeutic option. …”
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CCR9 Antagonists in the Treatment of Ulcerative Colitis by Pirow Bekker, Karen Ebsworth, Matthew J. Walters, Robert D. Berahovich, Linda S. Ertl, Trevor T. Charvat, Sreenivas Punna, Jay P. Powers, James J. Campbell, Timothy J. Sullivan, Juan C. Jaen, Thomas J. Schall

“…In addition, we determined the effect of CCR9 pharmacological inhibition in the mdr1a−/− mouse model of ulcerative colitis. …”
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Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment by Bassel Alsaed, Linh Lin, Jieun Son, Jiaqi Li, Johannes Smolander, Timothy Lopez, Pinar Ö. Eser, Atsuko Ogino, Chiara Ambrogio, Yoonji Eum, Tran Thai, Haiyun Wang, Eva Sutinen, Hilma Mutanen, Hanna Duàn, Nina Bobik, Kristian Borenius, William W. Feng, Behnam Nabet, Satu Mustjoki, Sanna Laaksonen, Benjamin K. Eschle, Michael J. Poitras, David Barbie, Ilkka Ilonen, Prafulla Gokhale, Pasi A. Jänne, Heidi M. Haikala

“…The EGFR-low cells secrete Transforming growth factor beta (TGFβ) family cytokines, leading to increased recruitment of cancer-associated fibroblasts and immune suppression, thus contributing to the drug-tolerant tumor microenvironment. Notably, pharmacological induction of EGFR using epigenetic inhibitors sensitizes the resistant cells to EGFR inhibition. …”
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Antiproliferative Effect of Grammatophyllum speciosum Ethanolic Extract and Its Bioactive Compound on Human Breast Cancer Cells by Verisa Chowjarean, Kamala Sadabpod

“…Grammatophyllum speciosum Blume exhibits various promising pharmacological activities. However, its effect on breast cancer has not been determined. …”
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