Principles of diuretic therapy at liver cirrhosis by A. I. Dyadyk, T. Ye. Kugler, I. S. Malovichko, N. F. Yarovaya, I. V. Rakitskaya

“…Therapeutic approach for edema syndrome at LC should be based on series of fundamental steps: edema pathophysiology understanding; comprehensive investigation of patients; assessment of edema severity and presence of complications; awareness of pharmacological features of diuretic drugs, their interaction and side effects; albumin or plasma substitutes administration, use of vasoconstrictors, transjugular intrahepatic portosystemic shunting and liver transplantation when required.…”
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Intratumor heterogeneity in KRAS signaling shapes treatment resistance by Oleksi Petrenko, Varvara Kirillov, Stephen D'Amico, Nancy C. Reich

“…Summary: KRAS mutations are linked to some of the deadliest forms of cancer. Pharmacological studies suggest that co-targeting KRAS with feedback/bypass pathways could lead to enhanced anti-tumor activity. …”
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Recent Nanotechnological Trends in the Management of Microbial Keratitis by Shraddha Jaiswal, Prabhavati Shinde, Vidya Tale

“…The broad-spectrum topical antimicrobial treatment is currently the main pharmacological approach for MK management, yet its efficacy is increasingly challenged by evolving antimicrobial resistance, including multidrug resistance. …”
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Regulators of Actin Dynamics in Gastrointestinal Tract Tumors by Konrad Steinestel, Eva Wardelmann, Wolfgang Hartmann, Inga Grünewald

“…In this review, we will summarize what is known about expression patterns and the functional role of actin regulators in gastrointestinal tumors and evaluate first pharmacological approaches to prevent invasion and metastatic dissemination of malignant cells.…”
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Management of Pain in Children with Burns by M. Gandhi, C. Thomson, D. Lord, S. Enoch

“…This clinical review article discusses the essential aspects of the pathophysiology of burns in children provides an overview of pain assessment, the salient principles in managing pain, and the essential pharmacodynamics of commonly used drugs in children with burn injuries. Both pharmacological and nonpharmacological treatment options are discussed, although a detailed review of the latter is beyond the scope and remit of this article.…”
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Molecular Imaging of Autoimmune Diseases and Inflammation by S. Anna Sargsyan, Joshua M. Thurman

“…Although tissue biopsy is still the gold standard for detecting these signatures, several molecular imaging markers have been developed. Pharmacologic agents that block specific immune molecules have recently entered the clinic, and these drugs have already transformed the way we care for patients with immune-mediated diseases. …”
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Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels by Zhirui Liu, Jie Tao, Pin Ye, Yonghua Ji

“…This paper will cover the state-of-the-art advances of researches on glycosylation-mediated VGSCs function and the possible underlying mechanisms of interactions between toxin and glycosylated VGSCs, which may therefore, fulfill the knowledge in identifying the pharmacological targets and therapeutic values of VGSCs.…”
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Phytochemical profile, therapeutic potentials, nutritional composition, and food applications of ginger: a comprehensive review by Great Iruoghene Edo, Ufuoma Augustina Igbuku, Raghda S. Makia, Endurance Fegor Isoje, Tayser Sumer Gaaz, Emad Yousif, Agatha Ngukuran Jikah, Khalid Zainulabdeen, Patrick Othuke Akpoghelie, Rapheal Ajiri Opiti, Arthur Efeoghene Athan Essaghah, Dina S. Ahmed, Huzaifa Umar

“…The compounds are responsible for the distinct aroma, flavor, and pharmacological activities such as anti-inflammatory, anti-oxidation, antimicrobial, anti-cancer, gastroprotective effects associated with ginger. …”
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Methotrexate and Valproic Acid Affect Early Neurogenesis of Human Amniotic Fluid Stem Cells from Myelomeningocele by Vardine Sahakyan, Enrico Pozzo, Robin Duelen, Jan Deprest, Maurilio Sampaolesi

“…Folic acid significantly reduces, and conversely, folate antagonist methotrexate (MTX) and valproic acid (VPA) increase the occurrence of NTDs, including MMC. How these pharmacological agents exactly influence the early neurulation process is still largely unclear. …”
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A Case of Spondyloarthritis in Patient Affected by Unicentric Castleman’s Disease Effectively Managed with Surgery Resection and Tocilizumab Treatment by M. Filippini, S. Cartella, O. Bonzanini, E. Morello, A. Tincani

“…She had a history of hyaline-vascular unicentric Castleman’s disease (HBV, HIV, and HHV-8 negative) treated with surgery resection. After a first pharmacological attempt with sulfasalazine (suspended for urticarial rash), we managed the patient with monotherapy tocilizumab 8 mg/kg, with full response of rheumatologic manifestations. …”
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Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy by Olga Simó-Servat, Cristina Hernández, Rafael Simó

“…Current treatments for DR (laser photocoagulation, intravitreal corticosteroids, intravitreal antivascular endothelial growth factor (VEGF) agents, and vitreo-retinal surgery) are applicable only at advanced stages of the disease and are associated with significant adverse effects. Therefore, new pharmacological treatments for the early stages of the disease are needed. …”
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Postpartum HELLP syndrome associated with posterior reversible encephalopathy syndrome by Rita Pinto Medeiros, Maria Ruão, Pedro Vita, Raquel Monte, Aníbal Marinho

“…The patient experienced seizures along with the maintenance of an arterial hypertensive profile resistant to pharmacological therapy. Brain magnetic resonance imaging allowed the diagnosis of PRES and pituitary adenoma/apoplexy. …”
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Anti-CTLA4 treatment reduces lymphedema risk potentially through a systemic expansion of the FOXP3+ Treg population by Stefan Wolf, Matiar Madanchi, Patrick Turko, Maija Hollmén, Sonia Tugues, Julia von Atzigen, Pietro Giovanoli, Reinhard Dummer, Nicole Lindenblatt, Cornelia Halin, Michael Detmar, Mitchell Levesque, Epameinondas Gousopoulos

“…Abstract Secondary lymphedema is a common sequel of oncologic surgery and presents a global health burden still lacking pharmacological treatment. The infiltration of the lymphedematous extremities with CD4+T cells influences lymphedema onset and emerges as a promising therapy target. …”
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Diagnostic, Treatment, and System Challenges in the Management of Recurrent Neuroleptic Malignant Syndrome on a General Medical Service by Karan Verma, Vivek Jayadeva, Raymond Serrano, Karthik Sivashanker

“…We advocated for timely electroconvulsive therapy in the setting of limited access and utilized creative pharmacologic strategies such as N-methyl-D-aspartate (NMDA) receptor antagonists and longer acting benzodiazepines while managing medical complications.…”
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Le désir sexuel des femmes, du DSM à la nouvelle médecine sexuelle by Marilène Vuille

“…It serves as an anchor for the co-production of categories as well as of diagnostic criteria and it underlies new trends in neurological and pharmacological research. It is also one of the specific tools used in the construction of a new « sexual medicine » that seeks recognition as a fully-fledged medical specialty.…”
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A Beautician’s Dystonia: Long-Lasting Effect of Botulinum Toxin by Siria Di Martino, Stefania Dalise, Giuseppe Lamola, Martina Venturi, Bruno Rossi, Carmelo Chisari

“…Here, we present the case of a 46-year-old beautician with focal dystonia in her left hand that affected her ability to work. Pharmacological treatment with clonazepam and gabapentin failed to resolve her symptoms and was discontinued due to side effects (sleepiness, gastrointestinal disorders). …”
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Gastroesophageal reflux disease, resistant to proton pump inhibitors by V. O. Kaybysheva, A. S. Trukhmanov, V. T. Ivashkin

“…To discuss the factors, promoting development of resistance at treatment of gastroesophageal reflux disease (GERD), and possible means to overcome it.Original positions. Pharmacological therapy of GERD is focused on change of refluxate properties besides decreasing of its volume and aggressive properties by such classes of drugs, as antacids, alginates and hydrochloric acid secretion inhibitors. …”
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Mitochondrial Dynamics: Biogenesis, Fission, Fusion, and Mitophagy in the Regulation of Stem Cell Behaviors by Wenyan Fu, Yang Liu, Hang Yin

“…Here, we summarize the recent research progress on (1) how mitochondrial dynamics controls stem cell behaviors, (2) intrinsic and extrinsic factors that regulate mitochondrial dynamics, and (3) pharmacological regulators of mitochondrial dynamics and their therapeutic potential. …”
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Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase by Yinhua Dong, Hongxin Wang, Zefeng Chen

“…Alpha-lipoic acid (ALA) has various pharmacological effects such as antioxidative, anti-inflammatory, and antiapoptotic properties. …”
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Cognitive Training in Parkinson’s Disease: A Review of Studies from 2000 to 2014 by Daniel Glizer, Penny A. MacDonald

“…To date, there is no effective pharmacological treatment for the range of cognitive impairments presented in PD. …”
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