Recent Advances in Potential Clinical Application of Ghrelin in Obesity by Christine Delporte

“…Several classes of ghrelin-related pharmacological tools for the treatment of obesity have been or could be developed to modulate the identified molecular targets.…”
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Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study by P. Pronzato, G. Mustacchi, A. De Matteis, F. Di Costanzo, E. Rulli, I. Floriani, M. E. Cazzaniga

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The Development of Publications on Catheter-Related Bladder Discomfort: A Bibliometric Analysis by Jiang W, Chen X, Peng Y, Zhai W, Zhang X, Zhou Y, Zhou R

“…Previous studies mainly focused on the pharmacological and pharmacological methods to CRBD. However, CRBD is not fully settled. …”
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Transcutaneous vagus nerve stimulation as a pain modulator in knee osteoarthritis: a randomized controlled clinical trial by Gehad Gamal Elsehrawy, Maha Emad Ibrahim, Nermeen Hassan A.moneim, Mohamed Ahmed Hefny, Nashwa Kamel El Shaarawy

“…Conclusion There is preliminary evidence to support the benefits of tVNS in OA, suggesting that neuromodulation can be used as an adjunct to existing pharmacological and non-pharmacological treatments. Trial registration The study was registered on ClinicalTrials.gov (NCT05387135) on 24/05/2022.…”
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Oral Opportunistic Infection Induced by Stress and Silent Type 2 Diabetes Mellitus in Young Adult Patient: A Case Report by Karina D, Heldayani I, Hidayat W

“…Non-pharmacologic therapy dental included oral hygiene instruction and education on oral therapy and referral to the internal medicine clinic for DM management. …”
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Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity by Velid Unsal, Erkan Oner, Reşit Yıldız, Başak Doğru Mert

“…It will also enable researchers to focus on the most promising compounds, providing an effective design strategy. Their pharmacological activity was carried out using computer-based computational techniques including DFT, molecular docking, ADMET analysis, biological targeting, and activity methods. …”
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Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial. by Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John E Walker, Tim Matheson, Matthew McLaughlin, Jennifer Jain, Eric Vittinghoff, Steven L Batki

“…<h4>Conclusion</h4>We found that it is feasible, acceptable, and tolerable to conduct a placebo-controlled pharmacologic trial for MSM with CUD who are actively using cocaine. …”
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Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment by Zeng Qingfang, Luo Cairong, Cho Junlae, Lai Donna, Shen Xiangchun, Zhang Xiaoyan, Zhou Wei

“…Typically, this natural compound shows a variety of pharmacological activities such as antitumor, antibacterial, anti-inflammatory and antioxidant effects. …”
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Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease by Zhihao Qi, Quan Li, Shuhua Yang, Chun Fu, Burong Hu

“…Moreover, we found potential regulatory mechanisms of risk variants on IBD and potential pharmacological targets.…”
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Orofacial Pains by Vahid Rakhshan, Francesca A. Bianchi, Lucindo J. Quintans-Júnior, Aurelio A. Alonso

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Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining by Beibei Ma, Jiameng Li, Tianyu Lou, Yaoyue Liang, Chenxiao Wang, Ruiji Li, Tingting Wang, Jinhui Liu, Yudong Guo, Zhibin Wang, Jing Wang

“…Phillyrin, a well-known bisepoxylignan, has been shown to have many critical pharmacological activities. In this study, a novel strategy for the extensive acquisition and use of data was established based on UHPLC-Q-Exactive mass spectrometry to analyze and identify the in vivo metabolites of phillyrin and to elucidate the in vivo metabolic pathways of phillyrin. …”
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Activity-Dependent NPAS4 Expression and the Regulation of Gene Programs Underlying Plasticity in the Central Nervous System by José Fernando Maya-Vetencourt

“…This view has been recently challenged by experimental strategies based on the enhancement of environmental stimulation levels, genetic manipulations, and pharmacological treatments, which all have demonstrated that the adult brain retains a degree of plasticity that allows for a rewiring of neuronal circuitries over the entire life course. …”
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Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome by Han Y. Yin, Nicholas Hadjokas, Kanish Mirchia, Robert Swan, Samuel Alpert

“…The use of a commercial CBD product should be cautioned due to potential for series of drug reactions to the cannabis product and the risk for reaction to other unregulated other pharmacological components.…”
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

“…Furthermore, we show that, in both yeast cells and mammalian cells, SY1 IBs are associated with mitochondria. Pharmacological inhibition of the sphingolipid metabolism pathway or knockout of its key genes results in a delayed IB maturation and increased SY1 cytotoxicity. …”
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Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma by Deanna Tiek, Xiao Song, Xiaozhou Yu, Runxin Wu, Rebeca Iglesia, Alicia Catezone, Katy McCortney, Jordain Walshon, Craig Horbinski, Pouya Jamshidi, Rudolph Castellani, Robert Vassar, Jason Miska, Bo Hu, Shi-Yuan Cheng

“…We further observe that the byproduct of GGCT—pyroglutamic acid—can bind aggregating proteins and that genetic and pharmacological inhibition of GGCT prevents protein aggregation. …”
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In Silico Study of Ceftaroline’s Molecular Properties by Elso Manuel Cruz Cruz, Eslhey Sánchez Domínguez

“…Its molecular modeling can help deepening the structural bases underpinning its pharmacological characteristics. <br /><strong>Objective:</strong> to model structural and electronic properties of the ceftaroline.…”
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Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review by Laith Jumaah Al-Gburi, Taghreed H. Al-Noor, Eid Ahmed Abdalrazaq

“…Some organic drugs, including sulfamethoxazole, exhibit toxicological and pharmacological properties that can be administered in the form of metal complexes. …”
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The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review by Chunhao Gao, Nengyun Gong, Fangtian Chen, Shiran Hu, Qingxin Zhou, Xiang Gao

“…Diet and functional ingredients play a pivotal role in seeking non-pharmacological strategies to prevent and ameliorate MS. …”
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Utility Potential of Parthenium hysterophorus for Its Strategic Management by Anita Saini, Neeraj K. Aggarwal, Anuja Sharma, Manpreet Kaur, Anita Yadav

“…Chemical constituents of Parthenium show extensive range of pharmacological activities suggesting its role as a chemotherapeutic agent. …”
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Therapeutic Potential of Retinoid X Receptor Modulators for the Treatment of the Metabolic Syndrome by Jane A. Pinaire, Anne Reifel-Miller

“…These recent findings suggest that, with continued research efforts, RXR-specific ligands with improved pharmacological profiles may eventually be available as additional treatment options for the current epidemic of obesity, insulin resistance, type 2 diabetes, and all of the associated metabolic sequelae.…”
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