Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin by Céline Hivelin, Sophie Béraud-Dufour, Christelle Devader, Amar Abderrahmani, Sébastien Moreno, Hamid Moha ou Maati, Alaeddine Djillani, Catherine Heurteaux, Marc Borsotto, Jean Mazella, Thierry Coppola

“…Taken together, this work identifies SPA as a novel potential pharmacological agent able to control insulin secretion and glucose homeostasis.…”
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Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects by Massimo Mammucari, Enrica Maggiori, Domenico Russo, Chiara Giorgio, Gianpaolo Ronconi, Paola E Ferrara, Flora Canzona, Luciano Antonaci, Bartolomeo Violo, Renato Vellucci, Domenico Rocco Mediati, Alberto Migliore, Umberto Massafra, Barbara Bifarini, Fabio Gori, Massimo di Carlo, Stefano Brauneis, Teresa Paolucci, Piergiovanni Rocchi, Anna Cuguttu, Raffaele Di Marzo, Alessandro Bomprezzi, Stefania Santini, Manuela Giardini, Anna Rosa Catizzone, Fiammetta Troili, Dario Dorato, Alessandra Gallo, Costanza Guglielmo, Silvia Natoli

“…It could be suggested when a systemic drug-sparing effect is useful, when other therapies have failed (or cannot be used), and when it can synergize with other pharmacological or nonpharmacological therapies. Despite the lack of randomized clinical trials in some fields of application, a general consensus is also reached in nonpharmacological mechanism of action, the technique execution modalities, the scientific rationale to apply it in some indications, and the usefulness of the informed consent. …”
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Curing cryptoglandular anal fistulas—Is it possible without surgery? by Chuang Wu, Zubing Mei, Zhenyi Wang

“…Conclusions: Ongoing developments in pharmacological research offer opportunities for alternative treatment options, shedding light on the prospects of noninvasive anal fistula management.…”
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Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges by Kamran Sheikhi, Salah Ghaderi, Hassan Firouzi, Sarvenaz Rahimibarghani, Ehsan Shabani, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Aref Yarahmadi

“…Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, and cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail to arrest disease progression or entirely reverse CNS damage. …”
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Moringa oleifera: A review on nutritive importance and its medicinal application by Lakshmipriya Gopalakrishnan, Kruthi Doriya, Devarai Santhosh Kumar

“…This review explores the use of moringa across disciplines for its medicinal value and deals with cultivation, nutrition, commercial and prominent pharmacological properties of this “Miracle Tree”.…”
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Bicuspid Aortic Valve and Thoracic Aortic Aneurysm: Three Patient Populations, Two Disease Phenotypes, and One Shared Genotype by Robert B. Hinton

“…A better understanding of the BAV-TAA association will provide an opportunity to leverage molecular information to modify clinical care through more sophisticated diagnostic testing, improved counseling, and ultimately new pharmacologic therapies.…”
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Granulomatous Osteonecrosis in Crohn’s Disease by Hugh J Freeman, David Owen, Mario Millan

“…She had a complex clinical course that required treatment with multiple pharmacological agents, including intravenous, oral and rectal corticosteroids. …”
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mTOR Inhibition: From Aging to Autism and Beyond by Matt Kaeberlein

“…Although overly simplistic, this framework can be useful when considering the myriad functions ascribed to mTOR and the pleiotropic phenotypes associated with genetic or pharmacological modulation of mTOR signaling. In this review, I will consider mTOR function in this context and attempt to summarize and interpret the growing body of literature demonstrating interesting and varied effects of mTOR inhibitors. …”
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Medical Devices Made of Substances: The Need for a Change in Approach in Paediatrics by Stefano Stagi

“…This is true for pharmacological therapies and also natural remedies used as add-on therapy. …”
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Therapeutic Approaches for Peripheral and Central Neuropathic Pain by Délia Szok, János Tajti, Aliz Nyári, László Vécsei

“…Central chronic neuropathic pain can develop as a result of spinal cord or brain injury, stroke, or multiple sclerosis. As first-line pharmacological treatment options, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and gabapentinoids are recommended. …”
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Synthesis of Kojic Ester Derivatives as Potential Antibacterial Agent by Carolynne Zie Wei Sie, Zainab Ngaini, Nurashikin Suhaili, Eswaran Madiahlagan

“…The search for lead product with beneficial pharmacological properties has become a great challenge and costly. …”
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Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application. by I.A. Khabarov, S.D. Sergazy, A.S. Maikenova, A.N. Zhabayeva, O.V. Maslova, S.M. Adekenov

“… Herbal ingredients are widely used in practice due to their broad pharmacological effects and absence of side effects. However, despite their remarkable pharmacodynamic activity, most of the herbal ingredients have shown lower bioavailability in vivo conditions. …”
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Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy by Eugenia Hovsepian, Federico Penas, Gerardo A. Mirkin, Nora B. Goren

“…This review summarizes our knowledge about T. cruzi infection as well as about the activation of PPARs and the potential role of their ligands in the resolution of inflammation, with the aim to address a new pharmacological approach to improve the host health.…”
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Updating Experimental Models of Diabetic Cardiomyopathy by J. Fuentes-Antrás, B. Picatoste, A. Gómez-Hernández, J. Egido, J. Tuñón, Ó. Lorenzo

“…The study of specific pathways or factors responsible for cardiac failures may be useful to design new pharmacological strategies for diabetic patients.…”
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Update on Edoxaban for the Prevention and Treatment of Thromboembolism: Clinical Applications Based on Current Evidence by Ali Zalpour, Thein Hlaing Oo

“…These targeted anticoagulants are known as direct oral anticoagulants (DOACs). Two pharmacologically distinct classes of targeted agents are dabigatran etexilate (Direct Thrombin Inhibitor (DTI)) and rivaroxaban, apixaban, and edoxaban (direct oral factor Xa inhibitors (OFXaIs)). …”
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Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems by Casanova Yaquelyn, Negro Sofia, Barcia Emilia

“…In the past decades, animal models of PD have been proven to be valuable tools in elucidating the nature of the pathogenic processes involved in the disease, and in designing new pharmacological approaches. Here, we review the use of neurotoxin-induced and pesticide-induced animal models of PD, specifically those induced by rotenone, paraquat, maneb, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and 6-OHDA (6-hydroxydopamine), and their application in the development of new drug delivery systems for PD.…”
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Anti-inflammatory actions of acupuncture by Freek J. Zijlstra, Ineke van den Berg-de Lange, Frank J. P. M. Huygen, Jan Klein

“…Acupuncture has a beneficial effect when treating many diseases and painful conditions, and therefore is thought to be useful as a complementary therapy or to replace generally accepted pharmacological intervention. The attributive effect of acupuncture has been investigated in inflammatory diseases, including asthma, rhinitis, inflammatory bowel disease, rheumatoid arthritis, epicondylitis, complex regional pain syndrome type 1 and vasculitis. …”
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Molecular Implications of the PPARs in the Diabetic Eye by Andreea Ciudin, Cristina Hernández, Rafael Simó

“…Current treatments for DR (laser photocoagulation, intravitreal corticosteroids, intravitreal anti-VEGF agents, and vitreoretinal surgery) are applicable only at advanced stages of the disease and are associated with significant adverse effects. Therefore, new pharmacological treatments for the early stages of the disease are needed. …”
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Antibiotic Treatment of Dogs and Cats during Pregnancy by Marcela Rebuelto, María Elena Loza

“…The use of pharmacological agents in pregnant females poses a major clinical challenge due to the marked physiological changes that may modify the pharmacokinetics of drugs and to the potential effects on the fetus. …”
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Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice by Xianlei Wang, Shulin Wu, Junsheng Zuo, Keying Li, Yutong Chen, Zhijie Fan, Zhou Wu, Jun-Xia Yang, Weiyi Song, Jun-Li Cao, Mengqiao Cui

“…Moreover, we utilized translating ribosome affinity purification (TRAP) in combination with c-Fos-tTA strategy and pharmacological approaches and identified SIGMAR1 as a potential therapeutic molecular target. …”
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