Cannabinoids and Their Role in Chronic Pain Treatment: Current Concepts and a Comprehensive Review by Islam Shehata, Ahmed Hashim, Ahmed Saad Elsaeidy, Anagha Nair, Ivan Urits, Omar Viswanath, Alan D. Kaye, Marian Habib

“…These different approaches carry many pharmacological hazards together with the lack of efficacy and safety of many interventional and surgical management techniques for chronic pain have mandated searching for other effective therapies including alternative treatments. …”
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Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages by E. E. Mannick, J. Mishra, J. Marque, M. Clavell, M. J. S. Miller, P. D. Oliver

“…The aim of this study was to determine if three pharmacologic inhibitors of NF-κB, pyrrolidine dithiocarbamate, N-tosyl-L-lysl chloromethyl ketone and calpain I inhibitor, induce apoptosis in a murine macrophage cell line (RAW 264.7) at doses similar to those required for NF-κB inhibition. …”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…Therapeutic strategies are limited for RVF, as basic and clinical research has historically focused mainly on the left ventricle. Novel pharmacological interventions targeting metabolism, calcium homeostasis, oxidative stress, extracellular matrix remodeling, endothelial function, and inflammation are needed to address RVF effectively. …”
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Membrane Currents in Airway Smooth Muscle: Mechanisms and Therapeutic Implications by Luke J Janssen

“…Electrophysiological and pharmacological techniques were used to characterize the membrane conductance changes underlying spasmogen-evoked depolarization in airway smooth muscle (ASM). …”
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Neuro-inflammation, depression and fatigue in ESRD: Emerging role of microglia and acupuncture as a new treatment addressing neuro-inflammation in ESRD by Suandika Made, Handayani Rahmaya Nova, Muti Refa Teja

“…Acupuncture, as a non-pharmacological option, has been shown to reduce chronic inflammation and enhance clinical results for ERSD patients’ quality of life. …”
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Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report by Angelo Giovanni Icro Maremmani, Luca Rovai, Fabio Rugani, Silvia Bacciardi, Matteo Pacini, Liliana Dell'Osso, Icro Maremmani

“…Nowadays, the misuse of benzodiazepines (BZDs) is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction. …”
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Crocetin Alleviates Inflammation in MPTP-Induced Parkinson’s Disease Models through Improving Mitochondrial Functions by Na Dong, Zhong Dong, Ying Chen, Xiaosu Gu

“…Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects. …”
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Prediction of drug-drug plasma protein binding interactions of resveratrol in combination with celecoxib and leflunomide by molecular docking combined with an ultrafiltration techn... by Zhou Peng, Hua Fang

“…Celecoxib or leflunomide, even at high tested doses, did not affect the plasma protein binding of resveratrol, thus suggesting pharmacological suitability of the investigated combinations.…”
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Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity by Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Laura Hurtado-Navarro, Laura Hurtado-Navarro

“…Additionally, we discuss emerging pharmacological strategies aimed at targeting fusogenic molecules as a means to prevent metastatic dissemination.…”
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Clinical Implications of the Transversus Abdominis Plane Block in Adults by Mark J. Young, Andrew W. Gorlin, Vicki E. Modest, Sadeq A. Quraishi

“…As such, we provide a brief historical perspective on the TAP block, describe relevant anatomy, review current techniques, discuss pharmacologic considerations, and summarize the existing literature regarding its clinical utility with an emphasis on recently published studies that have not been included in other systematic reviews or meta-analyses.…”
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Transcription factor specificity protein (SP) family in renal physiology and diseases by Wei Zhou, Jiaxi Fang, Qingqing Jia, Hanyan Meng, Fei Liu, Jianhua Mao

“…The review further discusses pharmacological modulation of SPs and its implications for treatment. …”
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New Therapeutic Targets for Mood Disorders by Rodrigo Machado-Vieira, Giacomo Salvadore, Nancy DiazGranados, Lobna Ibrahim, David Latov, Cristina Wheeler-Castillo, Jacqueline Baumann, Ioline D. Henter, Carlos A. Zarate

“…Existing pharmacological treatments for bipolar disorder (BPD) and major depressive disorder (MDD) are often insufficient for many patients. …”
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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury by Xiaoling Zhong, Wenjiao Tai, Meng-Lu Liu, Shuaipeng Ma, Tianjin Shen, Yuhua Zou, Chun-Li Zhang

“…In this study, we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis, tauopathy, lesion size, and behavioral deficits. Pharmacological inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology domain. …”
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RING finger protein 5 is a key anti-FMDV host factor through inhibition of virion assembly. by Wei Zhang, Weiwei Li, Yang Yang, Weijun Cao, Wenhua Shao, Mengyao Huang, Jiali Wang, Zhitong Chen, Jiantao Cai, Hongyi Liu, Xiaoyi Zhao, Xingyan Dong, Tingting Zhou, Hong Tian, Zixiang Zhu, Fan Yang, Haixue Zheng

“…Importantly, the RNF5 pharmacological activator Analog-1 alleviates disease development in a mouse infection model. …”
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Pengaruh Terapi Individu Generalis dengan Pendekatan Strategi Pelaksanaan Komunikasi Terhadap Frekuensi Halusinasi pada Pasien Halusinasi by Wan Muharyati, Esi Afriyanti, Adelse Prima Mulya

“… One of the non-pharmacological therapies that can be used to reduce the frequency of hallucinations is general individual therapy by the implementation of communication strategies. …”
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Quantitative Analysis and Fingerprint Profiles for Quality Control of Fructus Schisandrae by Gas Chromatography: Mass Spectrometry by Yong-Gang Xia, Bing-You Yang, Jun Liang, Qi Yang, Di Wang, Hai-Xue Kuang

“…Meanwhile, relative peak areas may be a feasible approach to discriminate the S. chinensis and S. sphenanthera. Finally, these pharmacologically active constituents in the titled plant, schisandrins A–C and schizandrols A and B, were quantitatively determined using a validated GC-MS method.…”
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The Use of Benzodiazepines in the Management of Hypertensive Crisis: A Literature Review by Łukasz Stojak, Mateusz Grego, Mateusz Baczewski, Dariusz Popiela, Karina Urbańska, Katarzyna Grego, Filip Kwiatkowski, Witold Czyż

“… Hypertensive crisis is a medical emergency that requires urgent pharmacological intervention to prevent organ damage. …”
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Pharmacodynamics of interspecies interactions in polymicrobial infections by C. Herzberg, J. G. C. van Hasselt

“…Our analyses suggest that both interspecies interactions, modifying either drug sensitivity or bacterial growth rate, and drug-specific pharmacological properties drive the bacterial pharmacodynamic response. …”
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Critical Review on Hamsa Pottali Rasa-A Herbo-mineral Formulation by Pooja B, Seema M B, Surekha S Medikeri

“…The action of a formulation depends on various factors such as ingredients and their pharmacological actions time of collection method of preparation dose route of administration and adjuvants. …”
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Up-to-date overview of imaging techniques in the diagnosis and management of inflammatory bowel diseases by Katarzyna B. Biernacka, Dobromiła Barańska, Piotr Grzelak, Elżbieta Czkwianianc, Katarzyna Szabelska-Zakrzewska

“…Both ulcerative colitis and Crohn’s disease, due to multiple remissions and relapses, require repetitive examinations to evaluate the disease extent, severity, and response to pharmacological treatment. Whereas the use of barium contrast studies is progressively reduced, plain radiography confirms its utility as a first-line imaging tool for acute abdomen. …”
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