Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy by Baoyi Feng, Chenxi Jin, Zhenzhe Cheng, Xingle Zhao, Zhuoer Sun, Xiaofei Zheng, Xiang Li, Tingting Dong, Yong Tao, Hao Wu

“…Mitochondrial dysfunction and pharmacological therapy were studied in neurodegeneration, providing new insights in mitochondrion-targeted treatment of AN. …”
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Research progress of artificial intelligence in evaluating the efficacy of neoadjuvant chemotherapy for breast cancer by Wei Wei, Menghang Ma, Zhenyu Liu

“…In clinical diagnostics, medical imaging has emerged as a critical tool for delineating the structural transformations within breast cancer tumors resulting from pharmacological interventions. The evolution of artificial intelligence (AI) technologies has precipitated the delineation and quantification of imaging-based phenotypic features, thereby translating these structural modifications into quantifiable data alterations. …”
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The Successful Use of Inhaled Nitric Oxide in the Management of Severe Hepatopulmonary Syndrome after Orthotopic Liver Transplantation by Joshua Santos, Philip Young, Igor Barjaktarevic, Catherine Lazar, Irawan Susanto, Tisha Wang

“…There is currently no pharmacologic intervention that has been shown to significantly affect outcomes and liver transplantation remains the mainstay of therapy. …”
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KINETOPROPHYLAXIS OF OSTEOPOROSIS IN ELDERLY PEOPLE IN THE POST COVID PERIOD by Zavalişca Aurica, Zavalişca Aurica

“…Kinesiotherapy is an essential non-pharmacological tool for maintaining and improving the physical functionality of individuals affected by this condition.Kinetic prophylaxis refers to the prevention and reduction of the risk of musculoskeletal deterioration through adapted and corrective physical exercises, which is particularly important in the post-pandemic context of COVID-19.…”
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In search of Alzheimer’s disease treatment methods: trends of clinical trials by G. Pakulaitė, V. Regelskytė, E. Audronytė, J. Kuzmickienė, G. Kaubrys

“… There is a strong necessity to develop new treatments for Alzheimer’s disease (AD) as its frequency is rapidly growing with the ageing population. There were 25 pharmacological agents involved in phase I trials, 52 in phase II, and 28 agents in phase III clinical trials in 2017. …”
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Mathematical analysis and simulations involving chemotherapy and surgeryon large human tumours under a suitable cell-kill functional response by Diego Samuel Rodrigues, Paulo Fernando de Arruda Mancera

“…Weuse some biological and pharmacological data in a numerical approach,where drug administration occurs in cycles (periodic infusion)and surgery is performed instantaneously. …”
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Chemical Composition and Mechanism of Vibriocidal Action of Essential Oil from Resin of Protium heptaphyllum by Josiane Lima Mendes, Thiago Ferreira de Araújo, Mário Geraldo de Carvalho, Francisco Eduardo Aragão Catunda Júnior, Renata Albuquerque Costa

“…Protium heptaphyllum is a plant widely distributed in Brazilian ecosystems that produce a resin which has pharmacological activities. In this study, the chemical composition, antimicrobial and antibiofilm activity, and the possible mechanism of action against the bacterium V. parahaemolyticus of essential oil from P. heptaphyllum (EOPH) were investigated. …”
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Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug by S. A. Bulgakov

“…Dalargin is the first synthetic opioid peptide agent created on the basis of endogenous leucineenkephaline. Pharmacological effects of dalargin are caused by opioid receptors. …”
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In silico (Eco)toxicology and molecular docking of halogenated and oxygenated rotenoid derivatives by Damião Sampaio de Sousa, Anthony Barbosa Belarmino, Victor Moreira de Oliveira, Francisco Rogênio da Silva Mendes, Emmanuel Silva Marinho, Gabrielle Silva Marinho

“… The rotenoids are compounds widely disseminated in the agro-industrial and chemical-pharmacological sectors due to their structural constitution and versatility in biological activities, however, these present toxic activity for fish. …”
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Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy by Moisés Blanco Calvo, Angélica Figueroa, Enrique Grande Pulido, Rosario García Campelo, Luís Antón Aparicio

“…Moreover, we describe the possible pharmacological interactions between drugs currently used in anticancer therapy and the expression or function of facilitative sugar transporters. …”
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Controversies in the Anesthetic Management of Intraoperative Rupture of Intracranial Aneurysm by Tumul Chowdhury, Andrea Petropolis, Marshall Wilkinson, Bernhard Schaller, Nora Sandu, Ronald B. Cappellani

“…The neuroprotective effects of various factors, including hypothermia, various anesthetic/pharmacologic agents, and burst suppression, remain poorly understood and have yet to be further elucidated. …”
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Hyponatremia and Congestive Heart Failure: A Marker of Increased Mortality and a Target for Therapy by Adam Romanovsky, Sean Bagshaw, Mitchell H. Rosner

“…The recent introduction of specific vasopressin-receptor antagonists offers a targeted pharmacological approach to these pathophysiological derangements. …”
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Adie pupil. Literature review by A. Judickaitė, A. Zizas, A. Varoniukaitė, L. Šemeklis, B. Glebauskienė

“… Anisocoria (unequal pupil size) is a condition described as various lacerations in iris sphincter or dilator muscles, innervation abnormalities, or conditions caused by external pharmacological agents. Adie pupil is one of the causes of anisocoria. …”
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Posterior Reversible Encephalopathy Syndrome Associated with Tacrolimus in Cardiac Transplantation by Julián Alejandro Rivillas, Stephania Galindo-Coral, Francisco Arias-Mora, Juan David Lopez-Ponce de Leon, Noel Alberto Florez-Alarcón, Pastor Olaya-Rojas, Juan Esteban Gomez-Mesa

“…Neurological complications occur between 50 and 70% of patients with heart transplantation, including cerebrovascular events, infections, seizures, encephalopathy, and neurotoxicity due to pharmacological immunosuppression. Mortality associated with cerebrovascular complications is 7.5% in the first 30 days and up to 5.3% after the first month and up to the first year after transplantation. …”
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A Case of Phenibut Withdrawal Management and Detoxification Using Baclofen in the Outpatient Setting by Emma DiFiore, Julie Pittman

“…The study underscores the need for further research on the pharmacological management of phenibut withdrawal, emphasizing the importance of raising awareness about phenibut’s dangers and associated clinical presentations.…”
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The Management of Hysteroscopy Complications by Ayla Eser, İlknur İnegöl Gümüş, Ebru Yüce, Nilüfer Akgün, Müberra Namlı Kalem

“…These include use of newer types of surgical instruments such as smaller-diameter hysteroscopes, pharmacological adjuvants and materials including hyaluronan gels such as Hyalobarrier®. …”
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Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review by Jie Ji, Chen Gong, Gengxi Lu, Junhang Zhang, Baoqiang Liu, Xunan Liu, Junhao Lin, Patrick Wang, Biju B. Thomas, Mark S. Humayun, Qifa Zhou

“…Furthermore, the review underscores the potential of sonogenetics in vision restoration, which involves leveraging pharmacological and genetic manipulations to inhibit or enhance the expression of related mechanosensitive channels, thereby modulating the strength of the ultrasound response. …”
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PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways by Jordi Camps, Anabel García-Heredia, Anna Rull, Carlos Alonso-Villaverde, Gerard Aragonès, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Jorge Joven

“…PON1 synthesis is upregulated by PPAR. Several pharmacological compounds (acting as antioxidants and, hence, atheroprotective) stimulate both PPAR activity and PON1 expression. …”
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Advantages of using biofilms to obtain high-value molecules by microbial biotransformations by Nicoly Subtil de Oliveira, Romeu Cassiano Pucci da Silva Ramos, Rafaela Caldas de Paula, Matheus Gonçalves da Costa Pereira, Rosimeire Takaki Rosa, Luiz Fernando Bianchini, Edvaldo Antonio Ribeiro Rosa

“…Microbial biotransformations are valuable tools from “green chemistry” and involve converting parental molecules into new daughter ones with unique physical, chemical, or pharmacological properties. These reactions are often carried out by cells grown under a planktonic phenotype. …”
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Role of Leukotrienes on Protozoan and Helminth Infections by Alexandre P. Rogerio, Fernanda F. Anibal

“…Leukotrienes (LTs), formed by the 5-lipoxygenase-(5-LO-) catalyzed oxidation of arachidonic acid, are lipid mediators that have potent proinflammatory activities. Pharmacologic or genetic inhibition of 5-LO biosynthesis in animals is associated with increased mortality and impaired clearance of bacteria, fungi, and parasites. …”
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