Potential epidemiological impact of the 2017 American College of Cardiology/American Heart Association high blood pressure guideline on the Chinese population: a cross-sectional st... by Zhao Li, Guozhe Sun, Yingxian Sun, Zhaoqing Sun, Yue Dai, Jia Zheng, Yuanyuan Dong, Xiaofan Guo, Yanxia Xie, Yali Wang, Rongrong Guo, Liqiang Zheng

“…Objectives The present study estimated the percentage of rural Chinese adults with hypertension and recommended pharmacological antihypertensive treatment according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline compared with the 2010 Chinese Guideline for the Management of Hypertension.Design Cross-sectional study.Setting Three counties in rural areas of northeastern China.Participants A total of 11 747 eligible individuals aged ≥35 years from rural areas of northeastern China were selected for the present analysis.Main outcome measures The percentage of rural Chinese adults with hypertension and recommended pharmacological antihypertensive treatment according to the 2017 ACC/AHA guideline and the 2010 Chinese Guideline for the Management of Hypertension, and the proportion of rural Chinese adults taking antihypertensive medication with blood pressure (BP) above the 2017 ACC/AHA guideline and the 2010 Chinese guideline treatment goal.Results The mean age of the study population was 53.9±10.8 years and 53.7% of the participants were women. …”
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Combined effects of reflexology massage and respiratory relaxation on pain following chest tube removal in heart surgery patients by Zainab Bahramian, Majid Kazemi, Reza Vazirinejad, Hadi Hasani

“…Abstract Background and aim Removing the chest tube in cardiac patients after surgery is one of the worst experiences of hospitalization in the intensive care units. Various pharmacological and non-pharmacological methods are available to control pain in these patients. …”
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Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids by Akimi Yonezawa, Kana Shimomura, Koji Okamoto, Haruna Takeda

“…The results were validated by pharmacological inhibition experiments with JQ1 in human CRC organoids. …”
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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…Moreover, our results indicated that sorafenib induced the accumulation of MDSCs mediated by CCR2, and pharmacological blockade of CCR2 markedly reduced MDSCs migration and tumor growth. …”
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4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets by Angel H. Romero, Francisco Delgado

“…Moreover, beyond the pharmacological exigencies, there are other challenges concerning its parasitic nature, such as its great genetic plasticity and adaptability, enabling it to activate a battery of genes to develop resistance quickly. …”
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Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis by Yu Dai, Ling Liu, Guiyuan Yu, Yan Peng, Na Chen, Jiahong Gao, Qiuling Shi, Ping Jin

“…Objectives To observe the therapeutic efficacy of high-intensity focused ultrasound (HIFU) combined with different pharmacological treatments for adenomyosis.Materials and methods A total of 126 patients with adenomyosis who underwent HIFU combined with pharmacological treatment were retrospectively reviewed. …”
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Crude Drugs for Clearing Heat Contain Compounds Exhibiting Anti-Inflammatory Effects in Interleukin-1β-Treated Rat Hepatocytes by Airi Fujii, Saki Onishi, Nodoka Watanabe, Mizuki Kajimura, Kentaro Ito, Keita Minamisaka, Yuto Nishidono, Saki Shirako, Yukinobu Ikeya, Mikio Nishizawa

“…., Kampo medicines, consist of crude drugs (mostly plants) that have empirical pharmacological functions (‘<i>Yakuno</i>’ in Japanese), such as clearing heat. …”
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Students Perceptions, Satisfactions and Challenges on Problem-Based Learning (PBL): A Survey Study Among Final Year Pharmacy Students by Engku Nuraishah Huda E. Zainudin, Fakhira Damia Khaidir, May Khin Soe, Nurul Asyiqin Yusof, Khairool Azizul Mohammad

“…Findings revealed that the majority agreed with statements on benefits that PBL significantly contributed to their knowledge acquisition (100.0%), stimulated the exploration of basic scientific concepts (98.8%), and enhanced their understanding in selecting both pharmacological and non-pharmacological approaches in disease management (97.6%, 95.2% respectively). …”
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Non-alcoholic fatty liver disease: comparative assessment of diagnostic and treatment approaches in the Russian Federation and People’s Republic of China by M. Ch. Semenistaya, Fan Jian-Gao, O. B. Velichenko, Ye. A. Kuznetsova, Ch. S. Pavlov

“…Etiological and pathogenetic features of NAFLD require diverse therapeutic actions from dietic recommendations and physical activity correction of the prescription of various pharmacological agents. Results of clinical efficacy estimation of the new drug Bicyclol in the Russian market, that it was developed in the People’s Republic of China demonstrate reduction of severity of inflammation, steatosis, fibrosis and decrease of NAFLD activity scores.…”
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Phenolic compounds of Iris adriatica and their antimycobacterial effects by Ochensberger Sandra, Alperth Fabian, Mitić Božena, Kunert Olaf, Mayer Stefanie, Mourão Maria Ferreira, Turek Ivana, Luca Simon Vlad, Skalicka-Woźniak Krystyna, Maleš Željan, Hruševar Dario, Duka Ivan, Bucar Franz

“…Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). …”
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The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis by Samuel García, Carmen Conde

“…In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes. …”
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Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence by Yasuhito Nagai, Yuko Tajima, Koichi Miyakawa

“…Abstract Background Dextromethorphan (DXM) is an over‐the‐counter drug that is commonly abused by teenagers. Its main pharmacological property is a low‐affinity N‐methyl‐d‐aspartate (NMDA) receptor antagonist. …”
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Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents by Ammad Ahmad Farooqi, Iqra Mobeen, Rukset Attar, Khalida I. Noel, Baojun Xu, William C. Cho

“…Interdisciplinary researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic (Allium sativum). …”
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Exercise and Physical Activity in the Therapy of Substance Use Disorders by Elisabeth Zschucke, Andreas Heinz, Andreas Ströhle

“…Exercise and physical activity are constantly gaining attention as adjuvant treatment for substance use disorders, supplementing classical pharmacological and psychotherapeutic approaches. The present work reviews studies addressing the therapeutic effects of exercise in alcohol abuse/dependence, nicotine abuse/dependence, and illicit drug abuse/dependence. …”
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Molecular pathogenesis of Cryptosporidium and advancements in therapeutic interventions by Lu Yilong, Zhang Xiaoning, Guan Zhiyu, Ji Rui, Peng Fujun, Zhao Chunzhen, Gao Wei, Gao Feng

“…Ongoing research is focused on understanding the molecular pathogenesis of Cryptosporidium and developing pharmacological treatments. In this review, we examine the signaling pathways activated by Cryptosporidium infection within the host and their role in protecting host epithelial cells. …”
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Asymmetric Dimethyl Arginine as a Biomarker of Atherosclerosis in Rheumatoid Arthritis by Manuela Di Franco, Bruno Lucchino, Fabrizio Conti, Guido Valesini, Francesca Romana Spinelli

“…The purpose of this review is to describe the main causes of increased methylarginine levels in RA, their implication in accelerated atherosclerosis, the possible role as biomarkers of cardiovascular risk, and finally the available data on current pharmacological treatment.…”
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CATHINONES AND VIAGRA IN CHEMSEX: AN AUTOETHNOGRAPHY OF TOUCH, MASCULINITIES AND AESTHETICS by Jorge Humberto Lucero Díaz

“…The results reveal that chemsex practices are deeply relational, influenced by both pharmacological effects and aesthetic norms. The study concludes that chemsex constitutes a space of complex cultural transformation, where new forms of relationship, pleasure, and gender expression are challenged and redefined.…”
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Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources by Xiaolong Ji, Jianhang Guo, Tengzheng Cao, Tingting Zhang, Yanqi Liu, Yizhe Yan

“…We have summarized recent research of natural polysaccharides with hypoglycemic activities, focusing on different pharmacological mechanisms in various cell and animal models. …”
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Pharmacomechanical Thrombolysis in the Management of Paget-Schroetter Syndrome by Elli Papantoniou, Luke Morgan-Rowe, Edward Johnston, Duncan Brennand, Jowad Raja, Julian Hague

“…As CDT is associated with major haemorrhage and high overall treatment cost, pharmacomechanical thrombectomy (PMT) seems to be an attractive alternative which combines pharmacological thrombolysis with mechanical clot disruption. …”
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Macular Hole of the Left Eye in a 41-year-old Patient with Retinitis pigmentosa. A Case Report by Bożena Kmak, Tomasz Siewierski, Anna Szot, Sebastian Sirek

“…Retinitis pigmentosa is a genetic disorder, therefore genetic counseling and screening of family members for retinitis pigmentosa is important. The specific pharmacological treatment is still unknown. In severe cases posterior vitrectomy is performed as a basic method of curing macular holes.…”
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