Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang by Hyejin Shin, Jihyun Kim, Musun Park, Heeseon Jo, Myunggyo Lee, Seongwon Cha, Haeseung Lee, Sooseong You

“…Despite its known therapeutic benefits, the complexity of its action mechanisms owing to the combination of multiple compounds has limited its research and integration into modern pharmacological science. To address this challenge, we identified 38 herbal compounds as the major ingredients in SM and generated their transcriptome data from aged-mice ovaries by administering these individual compounds. …”
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Progress on neuromodulation for treatment of rare movement disorders by DONG Wen⁃wen, QIU Chang, XU Yi⁃chen, YANG An⁃chao, ZHANG Wen⁃bin

“…Traditional pharmacological treatments for rare movement disorders have limited efficacy. …”
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Cerebral Wegener’s Granuloma: Surgery Mandatory for Diagnosis and Treatment by Federico Nicolosi, Giovanni Nodari, Giannantonio Spena, Elena Roca, Karol Migliorati, Giacomo Esposito, Roberto Stefini, Marco Fontanella, Pier Paolo Panciani

“…The radiological findings were not useful for the diagnosis, and the pharmacological treatment was ineffective. The importance of a surgery in case of localized WG has been emphasized, in order to confirm the diagnosis and to avoid additional medicaments, like antiepileptic drugs, potentially harmful in immunosuppressed patients.…”
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<i>Eugenia uniflora</i> Effects on the Depressive-like Behavior of MPTP-Exposed Female Rats: Apoptosis and α-Synuclein Modulation by Anne Suély Pinto Savall, Jhuly Dorneles De Mello, Eduarda Monteiro Fidelis, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Gustavo Petri Guerra, Marina Prigol, Robson Puntel, Jean Ramos Boldori, Cristiane Casagrande Denardin, Tuane Bazanella Sampaio, Simone Pinton

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Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection by Shen Jie, Yang Kai, Sun Caihua, Zheng Minxia

“…Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. …”
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Ensuring Pain Relief for Children at the End of Life by Marie-Claude Grégoire, Gerri Frager

“…The present article reviews, through a case-based presentation, the nonpharmacological and pharmacological methods used to ensure adequate pain control in children facing end of life. …”
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Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq by Dmitry A. Smagin, Irina L. Kovalenko, Anna G. Galyamina, Anatoly O. Bragin, Yuriy L. Orlov, Natalia N. Kudryavtseva

“…This approach may be used to identify a pharmacological treatment of ribosome biogenesis abnormalities in the brain of patients with “ribosomopathies.”…”
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Surgical Management of Pediatric Gastroesophageal Reflux Disease by Hope T. Jackson, Timothy D. Kane

“…Treatment options to achieve these goals include dietary or behavioral modifications, pharmacologic intervention, and surgical therapy. This paper will review the clinical presentation of GERD and discuss options for surgical management and outcomes in these patients.…”
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Tardive Dyskinesia, Oral Parafunction, and Implant-Supported Rehabilitation by S. Lumetti, G. Ghiacci, G. M. Macaluso, M. Amore, C. Galli, E. Calciolari, E. Manfredi

“…The frequency and intensity of the movements were high, and no pharmacological intervention was possible. Moreover, the patient refused night-time splint therapy. …”
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Recent Advances in Epidural Analgesia by Maria Bauer, John E. George, John Seif, Ehab Farag

“…This paper will provide an overview of the pertinent anatomical, pharmacological, immunological, and technical aspects of epidural anesthesia in both adult and pediatric populations and will discuss the recent advances, the related rare but potentially devastating complications, and the current recommendations for the use of anticoagulants in the setting of neuraxial block placement.…”
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From Basic Visual Science to Neurodevelopmental Disorders: The Voyage of Environmental Enrichment-Like Stimulation by Alan Consorti, Gabriele Sansevero, Claudia Torelli, Nicoletta Berardi, Alessandro Sale

“…The aim of this review is to depict, mainly through the much explicative examples of amblyopia, Down syndrome, and Rett syndrome, the increasing interest in the potentialities and applications of enriched environment-like protocols in the field of neurodevelopmental disorders and the understanding of the molecular mechanisms underlying the beneficial effects of these protocols, which might lead to development of pharmacological interventions.…”
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Relationship Between Left Atrial Strain and Atrial Fibrillation: The Role of Stress Echocardiography by Alfredo Mauriello, Adriana Correra, Antonia Ascrizzi, Gerardo Elia Del Vecchio, Giovanni Benfari, Federica Ilardi, Matteo Lisi, Alessandro Malagoli, Giulia Elena Mandoli, Maria Concetta Pastore, Simona Sperlongano, Matteo Cameli, Vincenzo Russo, Antonello D’Andrea

“…The development of altered LAS during physical or pharmacological stress is a predictor of early LA disease. …”
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Clozapine-induced hypertension: A paradox by Hamza Hussain, P. C. B. Gupta, Rajeevi Keeta

“…We present a case where clozapine initiation led to hypertension requiring pharmacological intervention. A 42-year-old female with no prior hypertension and normal baseline blood pressure developed high blood pressure (150/90 mmHg) on clozapine 50 mg/day. …”
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Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? by Elizabeth A. Ellins, Julian P. J. Halcox

“…The first investigations in humans involved invasive pharmacological vascular function testing, which have been used to gain a detailed understanding of the mechanisms involved in the pathogenesis of endothelial dysfunction and atherosclerosis as well as novel targets for intervention. …”
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Impact of Incretin-Based Therapies on Adipokines and Adiponectin by Habib Yaribeygi, Mina Maleki, Stephen L. Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…In this review, we propose that incretin-based therapy may function through adipokine modulation that may result in pharmacologic properties beyond their direct antidiabetic effects, resulting in better management of diabetes and diabetes-related complications.…”
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PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease by Sharon Cresci

“…The peroxisome proliferator-activated receptors (PPARs) consist of three related transcription factors that serve to regulate a number of cellular processes that are central to cardiovascular health and disease. Numerous pharmacologic studies have assessed the effects of specific PPAR agonists in clinical trials and have provided insight into the clinical effects of these genes while genetic studies have demonstrated clinical associations between PPAR polymorphisms and abnormal cardiovascular phenotypes. …”
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Effectiveness of Electronic Quality Improvement Activities to Reduce Cardiovascular Disease Risk in People With Chronic Kidney Disease in General Practice: Cluster Randomized Trial... by Jo-Anne Manski-Nankervis, Barbara Hunter, Natalie Lumsden, Adrian Laughlin, Rita McMorrow, Douglas Boyle, Patty Chondros, Shilpanjali Jesudason, Jan Radford, Megan Prictor, Jon Emery, Paul Amores, An Tran-Duy, Craig Nelson

“…One module within FHT aims to facilitate cardiovascular disease (CVD) risk reduction in people with chronic kidney disease (CKD) through the recommendation of angiotensin-converting enzyme inhibitor inhibitors (ACEI), angiotensin receptor blockers (ARB), or statins according to Australian guidelines (defined as appropriate pharmacological therapy). ObjectiveThis study aimed to determine if the FHT program increases the proportion of general practice patients with CKD receiving appropriate pharmacological therapy (statins alone, ACEI or ARB alone, or both) to reduce CVD risk at 12 months postrandomization compared with active control (primary outcome). …”
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Effects of isometric contraction training on hypertensive patients: A Systematic Review by Yuan Hao Dong

“…The use of equal length contraction training or ischemic preconditioning as a non pharmacological blood pressure improvement strategy has been proven to be safe and effective, with high process controllability, and may be a more feasible strategy in the future. …”
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Oleanolic Acid Cubic Liquid Crystal Nanoparticle-Based Thermosensitive Gel Attenuates Depression Symptoms in Chronic Unpredictable Mild Stress Rats by Shi Z, Wang Q, Li Q, Jia F, Xu W

“…In this study, building upon a previous formulation of OA cubic liquid crystal nanoparticles (OA-LCNP), we combined nanoparticles with a thermosensitive gel for nasal administration and investigated the pharmacological effects of OA-LCNP thermosensitive gel (OANG) on depression. …”
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The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years by Miranda Olff, Irma Hein, Ananda B. Amstadter, Cherie Armour, Marianne Skogbrott Birkeland, Eric Bui, Marylene Cloitre, Anke Ehlers, Julian D. Ford, Talya Greene, Maj Hansen, Nathaniel G. Harnett, Debra Kaminer, Catrin Lewis, Alessandra Minelli, Barbara Niles, Nicole R. Nugent, Neil Roberts, Matthew Price, Anthony N. Reffi, Soraya Seedat, Antonia V. Seligowski, Anka A. Vujanovic

“…However, research on prevention is still scarce compared to treatment research where several evidence-based psychological, pharmacological and complementary/ integrative interventions exist, and novel forms of delivery have become available. …”
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