Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance? by Monika Makar, Daria Michałka, Zuzanna Gałuszka, Natalie Papachristoforou, Justyna Głowacka, Aleksandra Kocjan, Emilia Bąk, Natalia Tekiela, Radosław Chmiel, Tomasz Bartuś

“… The objective of this article is to assess the efficacy and safety of diverse therapeutic strategies for treatment-resistant depression (TRD), encompassing both pharmacological and non-pharmacological interventions. …”
Get full text

The Dynamics of the Relationship between Attention Deficit Hyperactivity Disorder and Alcohol Use Disorder by Sevda Acar, Yeliz Aktaş

“…In this context, a multimodal strategy that inte- grates addiction treatment with mental health support is essential. Combining pharmacological and non- pharmacological interventions is crucial for enhancing patients’ quality of life and alleviating the impact of comorbid conditions. …”
Get full text

Mast Cell Deficiency Protects Mice from Surgery-Induced Neuroinflammation by Xiang Zhang, Hongquan Dong, Fei Wang, Jun Zhang

“…Surgery-induced BBB breakdown, microglial activation, and neuroinflammatory levels were significantly, pharmacologically reduced using a mast cell stabilizer, cromolyn sodium in WT mice (P<0.05). …”
Get full text

Costus afer: A Systematic Review of Evidence-Based Data in support of Its Medicinal Relevance by Daniel Boison, Cynthia Ayefoumi Adinortey, Godwin Kweku Babanyinah, Olga Quasie, Rosemary Agbeko, Gilbert Kofi Wiabo-Asabil, Michael Buenor Adinortey

“…However, these research reports are scattered, and thus, this systematic review seeks to provide a comprehensive update on it covering its traditional uses, phytochemical and nutritional constituents, pharmacological activities, and toxicological effects. …”
Get full text

Therapeutic Adherence of Patients with Type 2 Diabetes Mellitus in Four Health Areas of the Country by Addys María Díaz Piñera, Armando Rodríguez Salvá, Fernando Jesús Achiong Estupiñán, Dania Lidia Cardona Garbey, Geominia Maldonado Cantillo, Esteban Augusto Londoño Agudelo, Patrick Van der Stuyft

“…Variables were studied: sociodemographic (age, sex, skin color, occupation, level of education, cohabitation), risk factors and comorbidities, pharmacological and non-pharmacological treatment and their relationship with adherence. …”
Get full text

Phenolic Profile and Antioxidant Capacity of Invasive <i>Solidago canadensis</i> L.: Potential Applications in Phytopharmacy by Mirela Uzelac Božac, Danijela Poljuha, Slavica Dudaš, Josipa Bilić, Ivana Šola, Maja Mikulič-Petkovšek, Barbara Sladonja

“….), an invasive plant in Europe, is known for its allelopathic activity and is rich in bioactive compounds like flavonoids and phenolic acids, with significant pharmacological potential. This study presents the LC-MS phenolic profiles of leaf and flower extracts from <i>S. canadensis</i>, an invasive alien plant in the Istria region (Croatia). …”
Get full text

Intercostal Nerve Block in Patient with Chronic Obstructive Pulmonary Disease: Lessons Learned by Rhythm Mathur, Bharat Paliwal, Manoj Kamal, Pradeep Kumar Bhatia

“…An elderly male with chronic obstructive pulmonary disease and undergoing chemotherapy for mediastinal metastasis of small-cell liver carcinoma developed severe postherpetic neuralgia resistant to pharmacological therapy. An ultrasound-guided intercostal nerve block was performed which resulted in a pneumothorax, subsequently managed with an intercostal drain.…”
Get full text

Peroxisome Proliferator-Activated Receptors and Hepatitis C Virus-Induced Insulin Resistance by Francesco Negro

“…Whether and how this interaction may be manipulated pharmacologically, in order to improve the responsiveness to antivirals of insulin resistant chronic hepatitis C, patients remain to be fully explored.…”
Get full text

Combined Papillectomy and Autologous Conjunctival Membrane Graft as Management of Giant Papillae for Severe, Refractory Palpebral Vernal Keratoconjunctivitis—A Case Report by Devina Nur Annisa, Hernawita Suharko, Hasiana Lumban Gaol, Viona Viona

“…Conclusion: The management of VKC necessitates a comprehensive approach involving preventive measures, pharmacological treatment, and surgical interventions for refractory cases. …”
Get full text

Liquorice Health Check, Oro-Dental Implications, and a Case Report by Louis Z. G. Touyz

“…This article appraises physiological and pharmacological effects on health of liquorice, critiques products containing liquorice, describes a typical case report of liquorice-induced hypertension, and appraises oral effects from consumption of liquorice products.…”
Get full text

Initial bystander response to a simulated out-of-hospital cardiac arrest by Fran Wyffels, Geert Brône, Nathalie Charlier, Peter Iserbyt, Stijn De Beugher, Tessy Boedt, Toon Goedemé

Get full text

Real-practice thromboprophylaxis in atrial fibrillation by Deambrosis Paola, Bettiol Alessandra, Bolcato Jenny, Pirolo Roberta, Franchin Giulia, Themistoclakis Sakis, Pellizzari Michele, Chinellato Alessandro, Giusti Pietro

Get full text

Effectiveness of a Virtual Reality Serious Video Game (The Secret Trail of Moon) for Emotional Regulation in Children With Attention-Deficit/Hyperactivity Disorder: Randomized Clin... by Marina Martin-Moratinos, Marcos Bella-Fernández, María Rodrigo-Yanguas, Carlos González-Tardón, Chao Li, Ping Wang, Ana Royuela, Pilar Lopez-Garcia, Hilario Blasco-Fontecilla

“…Participants included individuals aged between 7 and 18 years who had a clinical diagnosis of ADHD and were receiving pharmacological treatment. They were randomized into 2 groups using an electronic case report form: the MOON group, receiving standard pharmacological treatment plus personalized cognitive training via a serious video game, and the control group, receiving standard pharmacological treatment. …”
Get full text

A Case Report of Accidental Intoxication following Ingestion of Foxglove Confused with Borage: High Digoxinemia without Major Complications by Maria Silvia Negroni, Arianna Marengo, Donatella Caruso, Alessandro Tayar, Patrizia Rubiolo, Flavio Giavarini, Simone Persampieri, Enrico Sangiovanni, Franca Davanzo, Stefano Carugo, Maria Laura Colombo, Mario Dell’Agli

Get full text

A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs by Valeria Bettinsoli, Gloria Melzi, Angelica Crea, Lorenzo Degli Esposti, Michele Iafisco, Daniele Catalucci, Paolo Ciana, Emanuela Corsini

Get full text

Coordination Behavior of 3-Ethoxycarbonyltetronic Acid towards Cu(II) and Co(II) Metal Ions by Giorgos Athanasellis, Georgia Zahariou, Stefanos Kikionis, Olga Igglessi-Markopoulou, John Markopoulos

“…Tetronic acids, 4-hydroxy-5H-furan-2-ones, constitute a class of heterocyclic compounds with potent biological and pharmacological activity. The β,β′-tricarbonyl moiety plays an integral role in biological systems and forms a variety of metal complexes. …”
Get full text

Refractory Immunological Thrombocytopenia Purpura and Splenectomy in Pregnancy by Santiago Bernal-Macías, Laura-Marcela Fino-Velásquez, Felipe E. Vargas-Barato, Lucio Guerra-Galue, Benjamín Reyes-Beltrán, Adriana Rojas-Villarraga

“…The disease was refractory to pharmacological treatments but had a favourable response to splenectomy. …”
Get full text

Methods for prevention of acute post-endoscopic retrograde cholangiopancreatography pancreatitis by Kamil Jaszczuk, Michał Lipiński, Grażyna Rydzewska

“…This review provides a broader summary of pharmacological methods and techniques aimed at reducing the risk of PEP.…”
Get full text

Treatment of arrhythmogenic right ventricular cardiomyopathy (dysplasia) by M.Т. Vatutin, G.S. Smyrnova, Y.V. Yeshchenko, G.E. Degtiarova, V.S. Kolesnikov, Y.P. Gritsenko

“…The information about risk stratification, follow-up, lifestyle changes, pharmacological therapy, catheter ablation, implantable defibrillator therapy and heart transplantation is given in detail.…”
Get full text

Nervous System of Periplaneta americana Cockroach as a Model in Toxinological Studies: A Short Historical and Actual View by Maria Stankiewicz, Marcin Dąbrowski, Maria Elena de Lima

“…Nervous system of Periplaneta americana cockroach is used in a wide range of pharmacological studies, including electrophysiological techniques. …”
Get full text