Effects of photobiomodulation therapy in patients with chronic non-specific low back pain: protocol for a randomised placebo-controlled trial by Lucíola da Cunha Menezes Costa, Shaiane Silva Tomazoni, Leonardo Oliveira Pena Costa, Layana de Souza Guimarães, Amanda Costa Araujo, Dafne Port Nascimento, Flávia Cordeiro de Medeiros, Marina Athayde Avanzi

“…Photobiomodulation therapy (PBMT) is a frequently used non-pharmacological therapy for the treatment of musculoskeletal disorders. …”
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Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents by Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu

“…The structure–activity relationship (SAR) studies suggested that the presences of amide group, four-carbon linker, and para hydroxyl benzene ring were advantageous pharmacophores for above two pharmacological actions. This research would open new avenues for developing amide-guanidine-based cardioprotective agents. …”
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Methods of forensic examination of Nalbuphine by I. О. Besedina

“…It is emphasised that nalbuphine hydrochloride is a synthetic opioid analgesic, which is chemically similar to morphine and phenanthrene. In terms of pharmacological action, it belongs to the group of opioid receptor agonists-antagonists (pentazocine, buprenorphine, butorphanol). …”
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Chemical Composition, Total Phenolic Content, and Antioxidant Activities of the Essential Oils of the Leaves and Fruit Pulp of Annona muricata L. (Soursop) from Ghana by Joseph Nana Gyesi, Rita Opoku, Lawrence Sheringham Borquaye

“…Annona muricata, also called soursop, is widespread in many tropical countries, and various parts of the plant have been shown to possess very good pharmacological properties. This work evaluated the chemical composition and antioxidant activities of essential oils obtained from the fruit pulp and leaves of soursop. …”
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Effect of hypnotherapy on paediatric cancer pain management in Indonesia: A quasi-experimental study by Sri Hartini M.A, Nafisatun Nisa, Satriya Pranata, Mudy Oktiningrum, Sri Puguh Kristiawati

“…Hypnotherapy, a non-pharmacological intervention, has shown promise in pain management. …”
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Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

“…Tirzepatide and semaglutide are two pharmacological agents which show best results in terms of weight loss.   …”
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Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII by Nishan Mandal, Apurba Das, Rupak Datta

“…Collectively, our study reveals a pharmacologically targetable mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in MPS VII.…”
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The Association between Hypertension and Dementia in the Elderly by Michiya Igase, Katsuhiko Kohara, Tetsuro Miki

“…We review five studies, all using subjects 60 years or older, which investigated different antihypertensive pharmacological treatments. Data from two trials (Syst-Eur, PROGRESS) open the way toward the prevention of dementia (AD or VaD) by antihypertensive treatments. …”
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The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Recept... by Richard N Redinger

“…Other nuclear hormone receptors such as pregnan X receptor, which share the obligate partner, retinoid X receptor, and vitamin D receptor also function as bile acid sensors to signal detoxification by hydroxylation of toxic bile acids. Pharmacologically targeted receptor agonists (or antagonists) may be developed that alter cholesterol and bile salt concentrations by modulating nuclear hormone receptors and/or their coactivators or corepressors to positively affect cholesterol homeostasis and bile salt metabolism. …”
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The Skin as a Window to Diabetes Mellitus: Manifestations, Complications and Clinical Insights by Aleksandra Kutaj, Zuzanna Adamowicz

“…Their presence underscores the need for timely interventions, including lifestyle modifications, pharmacological treatments, and patient education. Dermatological assessments, particularly in resource-limited settings, offer an accessible approach to monitoring therapy effectiveness and predicting complications. …”
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Therapeutic applications of artemisinin in ophthalmic diseases by Hao Sun, Ping Zhao, Lianghui Zhao, Zhizhong Zhao, Haoyu Chen, Cong Ren, Bin Guo

“…In recent years, with the development of plant secondary metabolite research, other potential pharmacological effects of artemisinin-based drugs have received increasing attention; in particular, reports of their application for the potential treatment of ophthalmology-related diseases have gradually increased. …”
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Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives by Cristina Martín-Escura, Maria Angeles Bonache, Alicia Medina-Peris, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz

“…Ca2+ microfluorometry assays were used for TRPM8 antagonist activity assessment, and then confirmed through electrophysiology (patch-clamp assay). The pharmacological activity in vivo was studied on a mice model of oxaliplatin-induced peripheral neuropathy. …”
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Broad-Purpose Solutions of N-Chlorotaurine: A Convenient Synthetic Approach and Comparative Evaluation of Stability and Antimicrobial Activity by Bohdan Murashevych, Dmitry Girenko, Iryna Koshova, Ganna Maslak, Konstantin Burmistrov, Dmytro Stepanskyi

“…Solutions of N-chlorotaurine (NCT) are effective microbiocidal agents with a broad spectrum of pharmacological activity and outstanding tolerability. …”
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Thymus ad astra, or spaceflight-induced thymic involution by Wataru Muramatsu, Wataru Muramatsu, Maria Maryanovich, Maria Maryanovich, Maria Maryanovich, Taishin Akiyama, Taishin Akiyama, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis

“…Advances in countermeasures, such as pharmacological interventions targeting thymic regeneration and bioengineering approaches to protect thymic architecture, are emerging as vital strategies to preserve immune resilience during prolonged space exploration. …”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…In the cytoplasm, SIRT5 interacted with the scaffold protein JNK-interacting protein 4 (JIP4) to finely regulate MAPK signaling, which was critical for osteoclast differentiation and activation. Pharmacological inhibition of the catalytic activity of SIRT5 effectively reversed bone loss in ovariectomized mice. …”
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GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway by Wenjing Xue, Ying Li, Yanna Ma, Feng Zhang

“…Mechanistically, GDF15 was found to promote the expression of key glycolytic genes, particularly the glucose transporter GLUT1, through the activation of the TGFβ signaling pathway. Pharmacological inhibition of the TGFβ signaling pathway effectively abrogated the oncogenic activities of GDF15 in MM cells, including cell proliferation, apoptosis, and fermentation. …”
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A scoping review of conventional and laser acupuncture as a modality of treatment for migraine by Chizoba ANYIMUKWU, Vinayak K. NAHAR, Sunita KAPUR, Manoj SHARMA

“…Despite the wide variety of pharmacological medications, patients still experience frequent attacks or are unable to get complete relief from the prescribed medications. …”

Bioactive Compounds in Herbal Bitter Drinks and Effects on selected Hepatic Biomarkers in Albino Wister Rats in Lagos, Nigeria by A.B. Ojekale, O. Lawal, M.O. Lasisi, C.A. Bamgbose, F.A. Dosu

“…Only 11 (about 35%) of the 31 compounds  identified have established and documented pharmacological use. Some of the bioactive components in each of the bitters support the advertised usage of the formulations. …”
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Insomnia: definition, pathophysiological models, diagnosis, and treatment by E. Sakalauskaitė-Juodeikienė, R. Masaitienė

“…Cognitive behavioural therapy is recommended as the first-line treatment for chronic insomnia in adults of any age. A pharmacological intervention can be offered if cognitive behavioural therapy is not effective or not available. …”
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Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens by Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa

“…Eight key genes associated with signal transduction (MAPK14, MAP3K8, PIK3CD, STAT1, STAT3, MAPK11, LRRK2, and GATA3) were validated via real-time PCR in chicken peripheral blood mononuclear cells (PBMCs) from six biological replicates. Pharmacological inhibitors or chloroquine were employed to elucidate the signalling pathways. …”
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