Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model by Yoshiaki Katsuda, Yusuke Kemmochi, Mimi Maki, Ryuhei Sano, Yasufumi Toriniwa, Yukihito Ishii, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta

Get full text

Nicotine Replacement Combined with a Novel Compound (ProBAN) for Smoking Cessation: A Pilot Study by Richard Leigh, Norman M Viner, Gerard Cox, Jeffrey W Balon, Douglas MC Wilson, Denise O’Shaughnessy, Corinne Walker, Gerry Brosky, Malcolm R Sears

“…BACKGROUND: Smoking cessation rates with available pharmacological therapies remain suboptimal. Anecdotal observations with a combination of sublingual pralidoxime and ipratropium (ProBAN) suggested that these agents in combination with nicotine gum improved quit rates.…”
Get full text

Evidence-Based Guideline for Neuropathic Pain Interventional Treatments: Spinal Cord Stimulation, Intravenous Infusions, Epidural Injections and Nerve Blocks by Angela Mailis, Paul Taenzer

“…BACKGROUND: The Special Interest Group of the Canadian Pain Society has produced consensus-based guidelines for the pharmacological management of neuropathic pain. The society aimed to generate an additional guideline for other forms of neuropathic pain treatments.…”
Get full text

Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in... by Monica Marzagalli, Stefania Battaglia, Michela Raimondi, Fabrizio Fontana, Marco Cozzi, Francesca R. Ranieri, Roberto Sacchi, Valeria Curti, Patrizia Limonta

“…Patients suffering from this pathology frequently experience pain, swelling, stiffness, and muscle weakness. Current pharmacological interventions are based on nonsteroidal anti-inflammatory drugs; however, the effectiveness of these strategies remains ambiguous. …”
Get full text

Research Progress in Natural Sources, Biosynthesis and Metabolism Regulation of Rutin in Plant-Derived Food Materials by ZHOU Ting, WANG Haige, ZHANG Jixing, BAO Yingcai, YU Yongli, CHANG Jie

“…It possesses various pharmacological and physiological activities, including antioxidant, anti-aging, anti-inflammatory, anti-diabetic, and anti-cancer properties. …”
Get full text

Terpenoids and Their Biological Activities from Cinnamomum: A Review by Meiting Wu, Lin Ni, Haixiao Lu, Huiyou Xu, Shuangquan Zou, Xiaoxing Zou

“…Hence, further studies on the potential pharmacological effects need to be conducted in the future.…”
Get full text

Switching to Aripiprazole as a Strategy for Weight Reduction: A Meta-Analysis in Patients Suffering from Schizophrenia by Yoram Barak, Dov Aizenberg

“…Weight gain is one of the major drawbacks associated with the pharmacological treatment of schizophrenia. Existing strategies for the prevention and treatment of obesity amongst these patients are disappointing. …”
Get full text

Ethnopharmacology of Psychotria: Potential Use of P. malayana Jack Leaves as Antidiabetic Agent by Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Siti Zaiton Mat Soád, Qamar Uddin Ahmed, Zalikha Ibrahim

“…The focus is on the species’ ethnomedicinal applications, their potential as an antidiabetic agent, the pharmacologically active antidiabetic compounds possessed, and their toxicological profiles. …”
Get full text

To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents by Isaac Arbeláez-Quintero, Mauricio Palacios

“…AMPK activation has been described as one of the pharmacological mechanisms that explain the action of metformin and that lead to neuroprotective effects. …”
Get full text

Potential Neuroprotective Effect of the Endocannabinoid System on Parkinson’s Disease by María Fernanda Urmeneta-Ortíz, Aldo Rafael Tejeda-Martínez, Orfil González-Reynoso, Mario Eduardo Flores-Soto

“…Unfortunately, conventional pharmacological treatments fail to halt disease progression; therefore, new therapeutic strategies are needed, and currently, some are being investigated. …”
Get full text

Chronic pain in a family doctor practice – meaning, assessment, and therapeutic options by Dominika Prokop, Mikołaj Borek, Jan Baran, Dawid Rowiński, Oliwia Sikora, Katarzyna Chamera-Cyrek, Aneta Podczerwińska, Clara Kuzminski

“…According to the recommendations of the International Association for the Study of Pain, patients with chronic pain should be treated interdisciplinarily, incorporating not only pharmacological treatments but also psychological, rehabilitative, and other non-pharmacological methods. …”
Get full text

Isoliquiritigenin Inhibits Atherosclerosis by Blocking TRPC5 Channel Expression by Jie Qi, Jianguo Cui, Baobin Mi, Xiaohong Yan, Wenwen Xu, Hui Ma, Qingtan Zhang, Fang Xu

“…In conclusion, our findings provide novel insight into the pharmacological effects of ISL on atherosclerosis and suggest that ISL is beneficial for cardiovascular protection.…”
Get full text

Anti-Inflammatory Activity of Compounds Isolated from Plants by R.M. Perez G.

“…They have been classified in appropriate chemical groups and data are reported on their pharmacological effects, mechanisms of action, and other properties.…”
Get full text

Patient preferences for drug therapy in inflammatory arthritis: protocol for a living systematic review and evidence map to inform clinical practice guidelines by Rachelle Buchbinder, Peter Tugwell, Pablo Alonso-Coello, Mickael Hiligsmann, Nick Bansback, Laurie Proulx, Dawn P Richards, Wojtek Wiercioch, Glen Hazlewood, Samuel Whittle, Jordi Pardo Pardo, Marie Falahee, Holger Schünemann, Robby Nieuwlaat, Pakeezah Saadat, Simon Kuper

“…Introduction The pharmacological management of inflammatory arthritis often requires choices that involve trade-offs between benefits, risks and other attributes such as administration route, frequency and cost. …”
Get full text

Protective Role of the ACE2/Ang-(1–9) Axis in Cardiovascular Remodeling by María Paz Ocaranza, Jorge E. Jalil

“…Despite reduction in cardiovascular (CV) events and end-organ damage with the current pharmacologic strategies, CV disease remains the primary cause of death in the world. …”
Get full text

Heat therapy in rheumatic and musculoskeletal diseases – an overview of clinical and molecular effects by Philipp Klemm, Nils Schulz, Priyanka Boettger, Uwe Lange

“…Nonetheless, disease progression is often only slowed down. Moreover, pharmacological treatment does not improve functionality per se. …”
Get full text

FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology by Yusuke Murata, Morichika Konishi, Nobuyuki Itoh

“…These findings suggest the pharmacological effects to be distinct from the physiological roles. …”
Get full text

The Critical Management of Spinal Cord Injury: A Narrative Review by Emilio Moreno-González, Antonio Ibarra

“…This review includes 50 publications selected based on specific criteria to gather evidence on the current management of SCI in acute settings. Pharmacological agents have been studied for their neuroprotective properties, offering hope for improved neurological outcomes. …”
Get full text

Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy by Yuan-qiao Xu, Yanjiao Chen, Jia-xin Xing, Jun Yao

“…Abstract Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to ameliorate neurodegenerative diseases (NDs). …”
Get full text

Quantitative Determination of Flavonoids and Chlorogenic Acid in the Leaves of Arbutus unedo L. Using Thin Layer Chromatography by Željan Maleš, Darija Šarić, Mirza Bojić

“…The plant species Arbutus unedo shows numerous beneficial pharmacological effects (antiseptic, antidiabetic, antidiarrheal, astringent, depurative, antioxidant, antihypertensive, antithrombotic, and anti-inflammatory). …”
Get full text