Ultrasound-assisted extraction of peanut shell by-product: Chemical properties, antioxidant, and anti-inflammatory effects by Kang Jung Wook, Lee In Chul

“…Peanut shell by-products have been explored for their pharmacological potential, particularly through applications developed from their utilization. …”
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Current Perspectives in Detection of Bioactive Compounds From Costus spicatus Through GC–MS and LC-MS/MS: Antioxidant Properties and In Silico Analysis for Industrial Applications... by Dharmar Manimaran, Ararsa Tessema, M. Govindarajulu Yadav, S. Parthasarathi, Vasan Palanisamy

“…Members of the Costus genus are the conventional medicinal plants used in the therapeutic management of numerous ailments, especially for their antioxidant and pharmacological activities. The crude extract of Costus spicatus was profiled using high-resolution GC–MS and LC-MS/MS techniques to determine possible bioactive compounds that are vital to the antioxidant activity. …”
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Diffusion Smart-seq3 of breast cancer spheroids to explore spatial tumor biology and test evolutionary principles of tumor heterogeneity by Antony Cougnoux, Loay Mahmoud, Per A. Johnsson, Alper Eroglu, Louise Gsell, Jakob Rosenbauer, Rickard Sandberg, Jean Hausser

“…Spatial gene and pathway expression patterns suggest biologies specific to spheroid regions, which we validate by immunostainings and pharmacological interventions. We use the Smart-seq3D data to test evolutionary principles of spatial tumor heterogeneity. …”
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Optimum Conditions and LC-ESI-MS Analysis of Phenolic Rich Extract from Eucalyptus marginata L. under Maceration and Ultrasound-Assisted Extraction Methods Using Response Surface M... by Soumaya Hasni, Ghayth Rigane, Hanene Ghazghazi, Hajer Riguene, Amir Bouallegue, Olfa Khedher, Moufida A. Oueslati, Ridha Ben Salem

“…Eucalyptus marginata L. has a significant value in traditional medicine and recently has been shown to possess many pharmacological properties in vitro. The main goal of the present study was to optimize the extraction parameters of phenolic compounds from Eucalyptus marginata L. leaves using the extraction technique assisted by ultrasound in comparison with maceration using response surface methodology as a predicted tool. …”
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Corticolimbic circuitry as a druggable target in schizophrenia spectrum disorders: a narrative review by Abigail Gee, Paola Dazzan, Anthony A. Grace, Gemma Modinos

“…We then integrate how these findings may inform the identification of novel therapeutic and preventive targets for SSD symptomatology. A range of pharmacological interventions have shown initial promise in correcting corticolimbic dysfunction and improving negative, cognitive and treatment-resistant symptoms. …”
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Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis by Ning Jin, Yi-yu Qian, Xiao-fei Jiao, Zhen Wang, Xin Li, Wen Pan, Jin-kai Jiang, Pu Huang, Si-yuan Wang, Ping Jin, Qing-lei Gao, Dan Liu, Yu Xia

“…Notably, under niraparib exposure, a critical fatty acid transporter CD36 was dramatically upregulated in tumors, facilitating excessive uptake of fatty acids. Pharmacological inhibition of either ferroptosis or CD36 impaired the anti-tumor activity of niraparib both in vitro and in murine intraperitoneal ID8 tumor models. …”
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Personalized prediction of anticancer potential of non-oncology drugs through learning from genome derived molecular pathways by Xiaobao Dong, Huanhuan Liu, Ting Tong, Liuxing Wu, Jianhua Wang, Tianyi You, Yongjian Wei, Xianfu Yi, Hongxi Yang, Jie Hu, Haitao Wang, Xiaoyan Wang, Mulin Jun Li

“…Utilizing protein–protein interaction networks, CHANCE harmonizes multilevel mutation annotations and integrates pharmacological information across different drugs into a single model. …”
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Role of intestinal mucin-2 in the effectiveness of the treatment of Helicobacter spp. infection in laboratory mice by E. A. Litvinova, M. D. Belyaev, A. V. Prokhortchouk, V. S. Korostina, E. B. Prokhortchouk, E. N. Kozhevnikova

“…The high susceptibility to antibiotics allows Muc2 knockout mice to be used as a test model to evaluate the pharmacological safety of new antibiotics.…”
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Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics by George S. Biggs, Emma E. Cawood, Aini Vuorinen, William J. McCarthy, Harry Wilders, Ioannis G. Riziotis, Antonie J. van der Zouwen, Jonathan Pettinger, Luke Nightingale, Peiling Chen, Andrew J. Powell, David House, Simon J. Boulton, J. Mark Skehel, Katrin Rittinger, Jacob T. Bush

“…Abstract Identifying pharmacological probes for human proteins represents a key opportunity to accelerate the discovery of new therapeutics. …”
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Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy by Tarek Kamal Abouzed, Seiichi Munesue, Ai Harashima, Yusuke Masuo, Yukio Kato, Khaled Khailo, Hiroshi Yamamoto, Yasuhiko Yamamoto

“…In this study, we evaluated whether pharmacological interventions with salicylate, compared to pyridoxamine, could prevent diabetic nephropathy in mice. …”
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Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression by Soo Jung Park, Kyung Won Kim, Eun Jeong Lee

“…Given the accessibility of the gut to both dietary and pharmacological interventions, targeting gut-localized α-synuclein represents a promising avenue for developing effective Parkinson’s disease therapies.…”
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Establishment of a Virus-Induced Gene Silencing System in <i>Abelmoschus manihot</i> L. by Ting Zhang, Jiaqi Hou, Hongtao Chu, Pengyu Guo, Qianzi Sang, Zhongxu Liu, Li Cao

“…(Jinhuakui, JHK) is widely cultivated for its pharmacological properties owing to its high flavonoid content and is commonly used as a garden landscape plant. …”
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Postural Stability in Parkinson’s Disease Patients Is Improved after Stochastic Resonance Therapy by Oliver Kaut, Daniel Brenig, Milena Marek, Niels Allert, Ullrich Wüllner

“…Postural instability in Parkinson’s disease (PD) increases the risk of falls and is not improved by pharmacological therapy. Objective. We performed a double-blind, randomized sham-controlled study to test the effects of stochastic resonance (whole body vibration) therapy on postural stability in PD. …”
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Association of Leukocytosis with Amphetamine and Cocaine Use by John R. Richards, Valeria F. Farias, Chris S. Clingan

“…This may be explained by unique pharmacologic, neuroendocrine, and immunomodulatory differences.…”
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Flavonoid Compounds from Ethanol Extract of Sungkai Leaves (Peronema canescens. Jack) and Antibacterial Activity Test Against Staphylococcus epidermidis and Escherchia coli by Nindita Clourisa Amaris Susanto, Jammes Ardhica, Nelson, Madyawati Latief

“…Traditional medicinal plants have been widely recognized for their therapeutic potential, and Peronema canescens Jack is well-known to contain bioactive compounds. Among its pharmacological properties, its antibacterial potential has drawn scientific interest. …”
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Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice by Ayana N. Martin, Martha Alexander-Miller, Barbara K. Yoza, Vidula Vachharajani, Charles E. McCall

“…NAD+-sensing nuclear sirtuin1 (SIRT1) epigenetically guards immune and metabolic homeostasis during sepsis. Pharmacologically inhibiting SIRT1 deacetylase activity in septic mice reverses monocyte immune tolerance, clears infection, rebalances glycolysis and glucose oxidation, resolves organ dysfunction, and prevents most septic deaths. …”
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Electroconvulsive Therapy in a Renal Transplantation Patient: A Rare Combination of Disease and Treatment by Giovanni Malaty, Kerilyn Godbe, Mehdi Elmouchtari, Gurjot Malhi, Justin White, Azziza Bankole, Tracey Criss

“…The patient’s depressive and delusional history was well-documented and had been refractory to several courses of psychotherapeutic and pharmacologic management. Electroconvulsive therapy was subsequently initiated and was well-tolerated. …”
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The Lollipop with Lemon Aroma May Be Promising in Nausea and Vomiting in Pregnancy by Ismail Biyik, Fatih Keskin

“…Lemon-flavored lollipops are cheap and easily accessible and therefore promising as a non-pharmacological complementary treatment for nausea and vomiting of pregnancy. …”
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Near-Infrared Spectroscopy as a Process Analytical Technology Tool for Monitoring the Steaming Process of Gastrodiae rhizoma with Multiparameters and Chemometrics by Yamin Zuo, Jing Yang, Chen Li, Xuehua Deng, Shengsheng Zhang, Qing Wu

“…Steaming is a vital unit operation in traditional Chinese medicine (TCM), which greatly affects the active ingredients and the pharmacological efficacy of the products. Near-infrared (NIR) spectroscopy has already been widely used as a strong process analytical technology (PAT) tool. …”
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Effects of long-term adapted physical training on functional capacity and quality of life in older adults with Parkinson's disease by Oussama Gaied Chortane, Elmoetez Magtouf, Wael Maktouf, Sabri Gaied Chortane

“…Although physical activity is considered a therapeutic treatment to slow the progression of the disease, it is considered to be an effective non-pharmacological adjuvant to medication to improve the symptom management.MethodsThe training program was offered for all the participants (N = 50) in three non-consecutive sessions per week for 60 minutes and a total duration of 12 to 16 months. …”
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