Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner by Quan Vo, Zachary D. Simon, Gwoncheol Park, Dina C Nacionales, Carmelina Gorski, Evan L Barrios, Gemma Casadesus, Philip A Efron, Lyle L Moldawer, Ravinder Nagpal, Paramita Chakrabarty, Marcelo Febo

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The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency by Sara Posadas-Cantera, Sara Posadas-Cantera, Noriko Mitsuiki, Florian Emmerich, Virginia Patiño, Hanns-Martin Lorenz, Olaf Neth, Ingunn Dybedal, Kjetil Taskén, Alejandro A. Schäffer, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Laura Gámez-Díaz, Laura Gámez-Díaz

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Ellagic Acid from <i>Geranium thunbergii</i> and Antimalarial Activity of Korean Medicinal Plants by Hojong Jun, Joon-Hee Han, Min Hong, Fadhila Fitriana, Jadidan Hada Syahada, Wang-Jong Lee, Ernest Mazigo, Johnsy Mary Louis, Van-Truong Nguyen, Seok Ho Cha, Wanjoo Chun, Won Sun Park, Se Jin Lee, Sunghun Na, Soo-Ung Lee, Eun-Taek Han, Tae-Hyung Kwon, Jin-Hee Han

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Herbal HuoXueTongFu Formula with anti-inflammatory and fibrinolytic activity regulation for the prevention of postoperative peritoneal adhesions by Lili Yang, Lili Yang, Yali Wang, Yali Wang, Zhengjun Li, Zhengjun Li, Wen Li, Yanqi Chen, Ziyang Kong, Huixiang Zhang, Jiafei Wu, Mingqi Shang, Ming Li, Yaoyao Bian, Yaoyao Bian, Yaoyao Bian, Li Zeng, Li Zeng

“…The potential anti-fibrinolytic activity in the next stage of PPA formation was subsequently explored in PPA mice on Day 7 postsurgery.ResultsNetwork pharmacology revealed 160 common targets between HXTF and PPA. …”
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Green biosynthetic silver nanoparticles from Ageratum conyzoides as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for eff... by Yang Li, Yinfeng Tan, Huange Zhao, Shiting Chen, Azadeh Nilghaz, Rong Cao, Songlin Zhou

“…Subsequent experiments including scanning electron microscopy, flow cytometry, western blotting, and network pharmacology analysis have revealed that AC-AgNPs can cause platelet activation and aggregation, stimulated kallikrein-kinin system, shorten activated partial thromboplastin and prothrombin time, and increase fibrinogen content. …”
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Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot stu... by Sumaiah J. Alarfaj, Sahar M. El-Haggar, Sahar K. Hegazy, Sahar K. Hegazy, Maha M. Maher, Maha M. Maher, Monir M. Bahgat, Thanaa A. Elmasry, Sarah Alrubia, Amsha S. Alsegiani, Mostafa M. Bahaa

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The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia by Morgane M. Thibaut, Martin Roumain, Edwige Piron, Justine Gillard, Axelle Loriot, Audrey M. Neyrinck, Julie Rodriguez, Isabelle Massart, Jean-Paul Thissen, Joshua R. Huot, Fabrizio Pin, Andrea Bonetto, Nathalie M. Delzenne, Giulio G. Muccioli, Laure B. Bindels

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Patterns of beta-blocker use and dose optimization among ambulatory heart failure patients with reduced ejection fraction (HFrEF) attending public hospitals in Northeast Ethiopia:... by Minimize Hassen, Tsehaynesh Kebede Ebsa, Oumer Sada Muhammed, Tewodros Solomon, Mulat Belete Demessie, Teklehaimanot Fentie Wendie, Nuhamin Alemayehu Tesfaye, Mengistie Yirsaw Gobezie

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Identification of Lauric Acid as a Potent Sodium Channel NaV1.5 Blocker from Compound Chinese Medicine Wenxin Keli by Xie W, Gao J, Liang Y, Huang C, Zhang B, Chen X, Yao X, Nan G, Wu H, Wang Y, Wu L, Wang T, Zhu Y

“…Weiwei Xie,1,&ast; Jiaming Gao,2,&ast; Yingran Liang,1,&ast; Chenxing Huang,3 Boyong Zhang,1 Xiaonan Chen,1 Xi Yao,1 Guo Nan,1 Honghua Wu,1 Yuefei Wang,1 Lin Wu,4 Taiyi Wang,3,5 Yan Zhu1 1State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China; 2Institute of Basic Medical Sciences of Xiyuan Hospital, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing, 100091, People’s Republic of China; 3Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China; 4Department of Cardiology, Peking University First Hospital, Beijing, 100034 People’s Republic of China; 5Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Zhu, State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin, 301617, People’s Republic of China, Tel +86 22 59596168, Email yanzhu.harvard@icloud.com Taiyi Wang, Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China, Email wangtaiyi@sdutcm.edu.cnPurpose: The major cardiac voltage-gated sodium channel NaV 1.5 (INa) is essential for cardiac action potential initiation and subsequent propagation. …”
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Methylome analysis in long-lived men deciphers DNA methylation modifications associated with male longevity in humans by Fu-Hui Xiao, Hao-Tian Wang, Long Zhao, Tian-Rui Xia, Li-Qin Yang, Si-Yu Ma, Qing-Peng Kong

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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…Sachin Madhusudan More1 &ast;, Md Abdur Rashid,2 Rohini S Kharwade3 &ast;, Murtada Taha,4 Yahya Alhamhoom,2 Gamal Osman Elhassan,5 Purushottam Gangane,3 Turky Omar Asar,6 Ajay Pise,7 Mohammed Kaleem,1 Md Ali Mujtaba8,9 1Department of Pharmacology, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 2Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia; 3Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 4Department of Clinical Laboratory Science, Prince Sultan Military College of Health Sciences, Dhahran, Saudi Arabia; 5Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia; 6Department of Biology, College of Science and Arts at Alkamil, University of Jeddah, Jeddah, Saudi Arabia; 7Department of Regulatory Affairs Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, MH, 440037, India; 8Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia; 9Center for Health Research, Northern Border University, Arar, Saudi Arabia&ast; These authors contributed equally to this workCorrespondence: Md Ali Mujtaba; Mohammed Kaleem, Email m.mujtaba@nbu.edu.sa; kaleemmubin88@gmail.comIntroduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. …”
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gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism by Xiaochun Ma, Furong Wang, Xiaowen Zhen, Lifang Zhao, Li Fang, Zhenfang Dong, Wenbin Chen, Xiaoming Zhou

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Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial by Thanawala S, Shah R, Alluri KV, Bhupathiraju K, Prasad N, Agarwal Y

“…Shefali Thanawala,1 Rajat Shah,2 Krishnaraju Venkata Alluri,3 Kiran Bhupathiraju,4 Nandlal Prasad,5 Yash Agarwal6 1Medical Science and Research Department, Nutriventia Limited, Mumbai, Maharashtra, 400069, India; 2Executive Management, Nutriventia Limited, Mumbai, Maharashtra, 400069, India; 3Pharmacology and Clinical Research, Laila Nutraceuticals, Vijayawada, Andhra Pradesh, 520010, India; 4Research & Development, Laila Nutraceuticals, Vijayawada, Andhra Pradesh, 520010, India; 5Department of Orthopedics, Bajarang Memorial Fracture Accidental and Surgical Center, Varanasi, Uttar Pradesh, 221003, India; 6Department of Orthopedics, Sri Ram Ortho and Physio Rehab Centre, Varanasi, Uttar Pradesh, 221007, IndiaCorrespondence: Shefali Thanawala, Medical Science and Research Department, Unit 703 & 704, 7 th Floor Solaris One Premises Co-Operative Society Limited, N.S. …”
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Coupling Bio-Resonance Neurotechnology (BRNT) and Dual Hemispheric Repetitive Transcranial Magnetic Stimulation (rTMS) Reduces Comorbid Major Depressive Disorder (MDD) and Generali... by Sunder K, Makale MT, Makale M, Bodhanapati J, Murphy KT, Dennen CA, Baron D, Thanos PK, Hanna C, Ashford Jnr JW, Lewandrowski KU, Blum K

“…., Del Mar, CA, USA; 7Department of Family Medicine, Jefferson Health Northeast, Philadelphia, PA, USA; 8Division of Addiction Research & Education, Center for Sports, Exercise and Mental Health, Western University Health Sciences, Pomona, CA, USA; 9Behavioral Neuropharmacology and Neuroimaging Laboratory On Addictions (BNNLA), Research Institute On Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; 10Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel; 11Stanford University, Psychiatric /Public Mental Health & Population Sciences Palo Alto, Stanford, CA, USA; 12Department of Orthopaedics, Fundación Universitaria Sanitas, Bogotá D.C., Colombia&ast;These authors contributed equally to this workCorrespondence: Kenneth Blum, Email drd2gene@gmail.comAbstract: Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) are prevalent comorbidities related to a greater likelihood of poor treatment outcomes and prolonged treatment for Reward Deficiency Syndrome (RDS) behaviors. …”
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Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles by Hanjing Li, Yining Liu, Yuqing Lin, Sijia Li, Chenlu Liu, Ao Cai, Wei Li, Wanyu Zhang, Xinlu Gao, Zhongyu Ren, Haoyu Ji, Yang Yu, Xiuxiu Wang, Wenya Ma, Ning Wang, Dan Zhao, Tianlong Li, Yu Liu, Benzhi Cai

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Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study by Gideon Kofi Helegbe, Paul Armah Aryee, Baba Sulemana Mohammed, Anthony Wemakor, David Kolbila, Abdul-Wahid Abubakari, Salam Askanda, Rashid Alhassan, Collins Barnie, Afua Aboagyewaa Donkoh, Ernest Ofosu

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The role of artificial intelligence and machine learning in predicting and combating antimicrobial resistance by Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Muhammad Shafiq, Wenjie Fang, Rahat Ullah Khan, Mujeeb Ur Rahman, Xiaohui Li, Qiao-Li Lv, Bin Xu

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Development of a novel encystment medium: Enhancing diagnostic potential of Acanthamoeba spp. by Julalak Chuprom, Suthinee Sangkanu, Watcharapong Mitsuwan, Rachasak Boonhok, Alok K. Paul, Sonia M. Rodrigues Oliveira, Maria L. Pereira, Tajudeen O. Jimoh, Mohammed Rahmatullah, Polrat Wilairatana, Christophe Wiart, Ajoy K. Verma, Veeranoot Nissapatorn

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Influence of spine biomechanics and sagittal balance on the outcome of lumbar discectomy by José Poblete Carrizo, José Poblete Carrizo, Jesús Martínez, Julio González, Alejandra Mosteiro, Ramon Torné, Ramon Torné, Alberto Di Somma, Alberto Di Somma, José Ríos, Joaquim Enseñat, Joaquim Enseñat, Salvador Fuster, Salvador Fuster

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Impact of Mandatory Preoperative Dental Screening on Infective Endocarditis in Patients Undergoing Surgical Valve Replacement by Lytfi Krasniqi, MD, Poul Erik Mortensen, MD, Emil Johannes Ravn, MD, Marlene Tofterup, MD, Henrik Nissen, MD, PhD, Christian Juhl Terkelsen, MD, PhD, DMSCi, Niels Holmark Andersen, MD, PhD, DMSCi, Ivy Modrau, MD, DMSCi, Kasper Stokbro, DDS, PhD, Jonas A. Povlsen, MD, PhD, Oke Gerke, MSc, PhD, DMSCi, Jesper Hallas, MD, DMSCi, Marie-Annick Clavel, DVM, PhD, Lars Peter Schødt Riber, MD, PhD, DMSCi, Jordi Sanchez Dahl, MD, PhD, DMSCi

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