Molecular Mechanism of Macrophage Activation by Red Ginseng Acidic Polysaccharide from Korean Red Ginseng by Se Eun Byeon, Jaehwi Lee, Ji Hye Kim, Woo Seok Yang, Yi-Seong Kwak, Sun Young Kim, Eui Su Choung, Man Hee Rhee, Jae Youl Cho

“…RGAP-induced NO production was accompanied with enhanced mRNA levels of iNOS and increases in nuclear transcription factors such as NF-κB, AP-1, STAT-1, ATF-2, and CREB. According to pharmacological evaluation with specific enzyme inhibitors, Western blot analysis of intracellular signaling proteins and inhibitory pattern using blocking antibodies, ERK, and JNK were found to be the most important signaling enzymes compared to LPS signaling cascade. …”
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Optimization of Liquid Culture Condition of a Novel Fungus Hygrophoropsis sp. and Antioxidant Activity of Extracts by Liang Huang, Chunxia Li, Ning Sun, Yu Wang, Hongpeng Yang, Yiting Li, Litong Ban

“…To evaluate pharmacological activities of a novel fungus Hygrophoropsis sp., the influence of aeration rate on the production of mycelial biomass, exopolysaccharides (EPS), and intrapolysaccharides (IPS) in the fungus Hygrophoropsis sp. was investigated. …”
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Integration of Therapeutic Components in the Rehabilitation of Patients with Parkinson’s Disease by Sonia Viviané Jiménez Carpi, Jorge Luis Abreus Mora, Vivian Bárbara González Curbelo, Ernesto Julio Bernal Valladares, Fernando Jesús Del Sol Santiago

“…Currently, there is a trend towards the inclusion of rehabilitation therapies as a complement to the pharmacological treatment of patients with Parkinson's disease, which leads to a transition to interdisciplinary management. …”
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Development and Evaluation of Photoprotective O/W Emulsions Containing Hydroalcoholic Extract of Neoglaziovia variegata (Bromeliaceae) by Raimundo Gonçalves de Oliveira-Júnior, Grasielly Rocha Souza, Christiane Adrielly Alves Ferraz, Ana Paula de Oliveira, Camila de Souza Araújo, Sarah Raquel Gomes de Lima-Saraiva, Silvio Alan Gonçalves Bomfim Reis, Talita Mota Gonçalves, Larissa Araújo Rolim, Pedro José Rolim-Neto, Francine Celise Siqueira César, Jackson Roberto Guedes da Silva Almeida

“…Neoglaziovia variegata is a Bromeliaceae plant species widely found in Brazil with several pharmacological properties, including photoprotective activity. …”
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Natural product virtual-interact-phenotypic target characterization: A novel approach demonstrated with Salvia miltiorrhiza extract by Rui Xu, Hengyuan Yu, Yichen Wang, Boyu Li, Yong Chen, Xuesong Liu, Tengfei Xu

“…The study not only underscores the importance of SM in treating IS but also sets a precedent for NP research, proposing a comprehensive approach that could be adapted for broader pharmacological explorations.…”
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Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review by Aref Yarahmadi, Hamed Afkhami, Ali Javadi, Mojtaba Kashfi

“…Furthermore, the review underscores the integration of microbial metabolites with pharmacological agents such as orlistat and semaglutide in restoring microbial homeostasis. …”
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Prediction of the Binding to the Nuclear Factor NF-Kappa-B by Constituents from <i>Teucrium polium</i> L. Essential Oil by Renilson Castro de Barros, Renato Araújo da Costa, Nesrine Guenane, Boulanouar Bakchiche, Farouk Benaceur, Omer Elkiran, Suelem Daniella Pinho Farias, Vanessa Regina Silva Mota, Maria Fani Dolabela

“…Chemical studies have already isolated different types of terpenes from the species, and studies have established its pharmacological potential. The present study evaluates the components of <i>T. polium</i> essential oil cultivated in the Algerian Saharan Atlas. …”
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Designing hydrogel for application in spinal surgery by Rongpeng Dong, Shuang Zheng, Xueliang Cheng

“…Hydrogels can be designed for the localized and controlled delivery of pharmacological agents to enhance therapeutic effects and reduce adverse reactions. …”
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Gaps in the Management of Type 2 Diabetic Patients in a Metropolitan Area of Havana by Armando Rodríguez Salvá, Linet Céspedes Hernández, Addys Díaz Piñera, René García Roche, Susana Balcindes Acosta

“…The main gap was follow-up, with only 69.7 % of the patients consulted in the last year. 68.3 % have indicated pharmacological treatment, and of these 77.5 % is adhered to according to the Morinsky test 83.4 % had their blood glucose levels checked. …”
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Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases by Reem Y. Mahran, Ehab A Fouad, Sozan S Tous, Nermin E. Eleraky

“…Abstract Metformin hydrochloride (MTF) has pharmacological properties for managing inflammatory skin conditions. …”
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Acute toxicity test combination of binahong leaves extract (Anredera cordifolia) and catfish oil (Pangasius micronema Blkr.) in mice by Rahma Shabrina Auliya, Meitasari Annisa Diyan, Sasongko Heru

“…Binahong (Anredera cordifolia) and catfish (Pangasius micronema Blkr.) plants have been proven to have pharmacological effects through various studies. However, there has been no research on the toxicity level of the combination of two ingredients. …”
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Efficacy of a complex plant-based preparation for poultry mycotoxicosis by E. V. Kuzminova, E. P. Dolgov, M. P. Semenenko, P. V. Miroshnichenko

“…Use of fibralin in the feed (3 kg per one ton) for 10 days reduced clinical signs of intoxication, increased flock survival by 13.5% and stimulated body weight gain by 15.8%. Pharmacological effect of fibralin was demonstrated by improvement of blood morphobiochemical parameters in poultry, i.e. reduction of leukocytes by 19.3% and cholesterol by 13.6%; and an increase in the number of erythrocytes by 19.4%, hemoglobin by 8.1% and calcium by 9.5%. …”
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Slow Metabolism–Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone‐Induced Obesity‐Specific Liver Injury by Guanting Li, Yourong Hu, Han Zhao, Ziyu Peng, Xin Shang, Jia Zhang, Kunxin Xie, Meiwei Li, Xiaohang Zhou, Qinyao Zhou, Kai Li, Fang Zhou, Heyao Wang, Zhijian Xu, Jiali Liu, Peng Sun

“…In this study, through a combined multi‐omics, pharmacological, and pharmacokinetic approaches, it is found that BBR‐induced obesity‐specific DILI is primarily through the potentiation of peroxisome proliferator‐activated receptor gamma (PPARγ) signaling pathways. …”
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Physical Exercise as a Diagnostic, Rehabilitation, and Preventive Tool: Influence on Neuroplasticity and Motor Recovery after Stroke by Caroline Pin-Barre, Jérôme Laurin

“…For the last few years, physical training has been combined with pharmacological treatments to accentuate and/or accelerate beneficial neural and motor effects. …”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Maraviroc-mediated pharmacological blockade of the CCL5/CCR5 axis effectively mitigates muscle dystrophy and improves muscle performance. …”
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L-theanine modulates tissue cortisol levels in zebrafish after single stress by Vinícius Luís da Silva, Mariana Spanamberg Mayer, Andriele dos Reis Severo, Andressa Leal Zambra, Joanna Moraes De Almeida, Laura Moura Sestari, Mariana Migliorini Parisi, Ana Cristina Vendrametto Varrone Giacomini, Murilo Sander De Abreu, Josiane Woutheres Bortolotto, Gabriela Bonfanti-Azzolin

“…Stress is a situation characterized by the stimulus to cortisol secretion and without specific pharmacological therapies. Thus, this study investigates the effect of L-theanine on the response to acute stress, evaluated by tissue cortisol level, oxidative status markers, and behavioral parameters, in zebrafish. …”
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A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model by Liqun Chi, Wenyuan Gao, Xiangrong Shu, Xin Lu

“…Icariin, a natural flavonoid glucoside isolated from plants in the Epimedium family, has been proven to have various pharmacological activities. A recent study showed that icariin suppressed cartilage and bone degradation in mice of collagen-induced arthritis. …”
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Insights into the formulation properties, biocompatibility, and permeability of poorly water-soluble methoxyflavones with PEG400 and propylene glycol by Eze Fredrick Nwude, Jansakul Chaweewan, Srichana Teerapol

“…Furthermore, PEG400 and propylene glycol solutions of the methoxyflavones were shown to be compatible with Caco-2 cells at pharmacologically effective concentrations. In vitro transport studies across the Caco-2 cell monolayer revealed high Papp values of 24.07 × 10–6 to 19.63 × 10–6 cm s–1 for PEG400 solutions of the methoxyflavones. …”
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A Spiritual Care Program for Patients With Cancer and Psychosomatic Disorders in Iran: A Protocol Study by Rahmatollah Marzband, Seyed Hamzeh Hosseini, Zeinab Hamzehgardeshi, Mahmood Moosazadeh, Mohammad Eslamijouybari, Tahereh Yaghoubi, Marzieh Azizi, Fereshteh Araghian Mojarad, Ehsan Abedini

“…Conclusion: The developed cost-effective, non-pharmacological program for spiritual care can be used for patients with psychosomatic disorders and cancers in Iran.…”
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Polyphenolic Compounds in Fabaceous Plants with Antidiabetic Potential by Lucia Guerrero-Becerra, Sumiko Morimoto, Estefania Arrellano-Ordoñez, Angélica Morales-Miranda, Ramón G. Guevara-Gonzalez, Ana Angélica Feregrino-Pérez, Consuelo Lomas-Soria

“…Natural products with antidiabetic and pharmacological treatment potential improve diabetes management by offering more effective and complementary alternatives. …”
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