Anticancer potential of coumarins from the Ferulago genus by Mansour Mofasseri, Elham Eini, Saber Mofasseri, Bahram Hanifehpour, Fatemeh Zanbili, Ahmad Poursattar Marjani

“…Accordingly, continued investigations into their pharmacological properties and therapeutic applications will be crucial in developing novel anticancer therapies, ultimately contributing to improved patient quality of life.…”
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Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum by Katharine L. Dobson, Tomas C. Bellamy

“…Stimulation of parallel fibre inputs at 16 Hz evoked LTP of synaptic transmission, but LTD of ectopic transmission. Pharmacological activation of adenylyl cyclase by forskolin caused LTP at Purkinje neurons, but only transient potentiation at Bergmann glia, reinforcing the concept that ectopic sites lack the capacity to express sustained cAMP-dependent potentiation. …”
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Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer's disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors... by Fatima Zahra Guerguer, Bouchra Rossafi, Oussama Abchir, Yasir S Raouf, Dhabya Bakhit Albalushi, Abdelouahid Samadi, Samir Chtita

“…An exhaustive in silico analysis was conducted, encompassing docking studies, ADMET analysis, density functional theory (DFT) studies, molecular dynamics simulations, and subsequent MM-GBSA calculations to examine the pharmacological potential of these molecules with the specific targets of interest. …”
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Isolated Subclinical Hyperthyrotropinemia in Obese Children: Does Levothyroxine (LT4) Improve Weight Reduction during Combined Behavioral Therapy? by Pawel Matusik, Aneta Gawlik, Aleksandra Januszek-Trzciakowska, Ewa Malecka-Tendera

“…This finding suggests that moderately elevated levels of TSH are a consequence rather than cause of overweight and pharmacological treatment should be avoided.…”
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Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer by Kouji Banno, Miho Iida, Megumi Yanokura, Haruko Irie, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki

“…The goals of drug repositioning are to find a new pharmacological effect of a drug for which human safety and pharmacokinetics are established and to expand the therapeutic range of the drug to another disease. …”
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Spinal Involvement of TRPV1 and PI3K/AKT/mTOR Pathway During Chronic Postoperative Pain in Mice by Gabriela Xavier Santos, Tayllon dos Anjos-Garcia, Ana Carolina de Jesus Vieira, Giovane Galdino

“…The nociceptive threshold was measured by the von Frey filament test. For pharmacological evaluation, TRPV1 and PI3K/AKT/mTOR inhibitors were administered intrathecally. …”
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Idiopathic intracranial hypertension. Case report and literature review by L. Lauruvėnaitė, R. Raugalas, J. Grikinienė

“…She was administered dehydrating medical therapy of acetazolamide and mannitol. With pharmacological treatment not being effective enough, ventriculoperitoneal shunting operation was performed, after which symptoms of intracranial hypertension disappeared. …”
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Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors by Jinpu Yang, Keerat Kaur, Li Lin Ong, Carol A. Eisenberg, Leonard M. Eisenberg

“…Collectively, these data indicate that BIX01294 has utility as a pharmacological agent that could enhance the ability of an abundant and accessible stem cell population to regenerate new myocytes for cardiac repair.…”
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Post-Graduate Course in Selection and Management with Antimicrobial in Respiratory and Urinary Infections by Diana Rosa Fernández Ruiz, Maira Quiros Enríquez, Olga Lidia Cuevas Pérez, Eidys Rodríguez Herrera, Myriam Damaris Padilla Labrado

“…<strong>Background</strong>: one of the pharmacologic groups of bigger prescription and use in Primary Health Attention, for his efficacy in the treatment of multiple infections constitute the antimicrobial. …”
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Lignans from Patrinia scabiosaefolia improve insulin resistance by activating PI-3K/AKT pathway and promoting GLUT4 expression by Zhenhua Liu, Mengke Wang, Lijun Meng, Yixiao Chen, Qiuyi Wang, Yan Zhang, Xuefeng Xi, Wenyi Kang

“…Patrinia scabiosaefolia, is used as wild vegetable in China for more than 2 000 years, with a variety of pharmacological activities, including anti-inflammatory, anti-tumor and hypoglycemic. …”
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Discovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from <i>Taenia solium</i> Using Computational and Bioinformatics Tools by César Sánchez-Juárez, Roberto Flores-López, Lluvia de Carolina Sánchez-Pérez, Ponciano García-Gutiérrez, Lucía Jiménez, Abraham Landa, Rafael A. Zubillaga

“…Glutathione S-transferases (GSTs) are promising pharmacological targets for developing antiparasitic agents against helminths, as they play a key role in detoxifying cytotoxic xenobiotics and managing oxidative stress. …”
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Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais by Luiz Alberto Bomjardim Pôrto, Maria Aparecida de Faria Grossi, Edilamar Silva de Alecrim, Marcus Henrique de Souza Brito Xavier, Frederico Paiva e Silva, Amalia Sathler Pires, Fabianny Sanglard da Silva, Sandra Lyon

“…All patients were multibacillary; four people had pulmonary embolism (PE); there were 11 unilateral and five bilateral DVT cases; 12 cases were proximal, two distal, and two unspecified. Pharmacological thromboprophylaxis was used on two individuals. …”
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Sex-Related Effects of Adrenergic Drugs on Conditioned Pain Modulation: A Randomized Controlled Cross-Over Double-Blind Trial by Marie-Philippe Harvey, Marie-Chantal Dubois, Philippe Chalaye, Yanick Sansoucy, Serge Marchand

“…The aim of this study is to describe the effect of pharmacological manipulations of autonomic activity on CPM efficacy. …”
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Using RAD-seq to identify and differentiate the medicinal herb Scrophularia ningpoensis and its adulterants by Lei Guo, Xia Wang, Hong Li, Mengli Zhou, Liqin Liu, Ruihong Wang, Pan Li

“…., belongs to the Scrophulariaceae family and is known for its diverse pharmacological effects, such as antihypertensive, anti-inflammatory, and antitumor properties. …”
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Righting response and electrocardiographic evaluation of juvenile tambaqui (Colossoma macropomum) (Cuvier, 1818) exposed to immersion baths with different concentrations of bushy l... by Thaysa de Sousa Reis, Clarissa Araújo da Paz, Daniella Bastos de Araújo, Luciana Eiró Quirino, Yris da Silva Deiga, Tays Mata Câmara, Moisés Hamoy

“…Among the essential oils studied, Lippia alba has attracted attention due to its diverse pharmacological properties, including sedative and anesthetic effects. …”
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Classification of Epileptic Seizures by Simple Machine Learning Techniques: Application to Animals&#x2019; Electroencephalography Signals by Illia Pidvalnyi, Anna Kostenko, Oleksandr Sudakov, Dmytro Isaev, Oleksandr Maximyuk, Oleg Krishtal, Olena Iegorova, Ievgen Kabin, Zoya Dyka, Steffen Ortmann, Peter Langendorfer

“…Small electronic devices capable of doing that will improve the quality of life for epilepsy patients while also open new opportunities for pharmacological intervention. This paper presents a novel approach using machine learning techniques to detect seizures onset using intracranial electroencephalography (EEG) signals. …”
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Analysis of Polygala tenuifolia Transcriptome and Description of Secondary Metabolite Biosynthetic Pathways by Illumina Sequencing by Hongling Tian, Xiaoshuang Xu, Fusheng Zhang, Yaoqin Wang, Shuhong Guo, Xuemei Qin, Guanhua Du

“…Radix polygalae contains various saponins, xanthones, and oligosaccharide esters and these compounds are responsible for several pharmacological properties. To provide basic breeding information, enhance molecular biological analysis, and determine secondary metabolite biosynthetic pathways of P. tenuifolia, we applied Illumina sequencing technology and de novo assembly. …”
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Ultrasound-assisted extraction of phenolic compounds from ear mushrooms (Auricularia auricula-judae): Assessing composition and antioxidant activity during fruiting body developmen... by Albert Nugraha, Asadin Briliantama, M Umar Harun, Li Sing-Chung, Chin Xuan Tan, Vuanghao Lim, Amir Husni, Widiastuti Setyaningsih

“…Auricularia auricula-judae (ear mushroom) exhibits significant biological and pharmacological properties, particularly as an antioxidant due to its phenolic compounds. …”
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Focusing on the recent progress of tea polyphenol chemistry and perspectives by Shiming Li, Liang Zhang, Xiaochun Wan, Jianfeng Zhan, Chi-Tang Ho

“…More intensive research is warranted to elucidate the mechanisms of action underlying the biological activity of flavoalkaloids and the pharmacological application of tea polyphenols in scavenging RCS and impeding detrimental AGEs.…”
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Sustained Regression of Hydroxycarbamide Induced Actinic Keratoses after Switching to Anagrelide by Georgios Gaitanis, Dora Gougopoulou, Eleni Kapsali, Ioannis D. Bassukas

“…In conclusion, the impressive and sustainable AK remission under anagrelide draws attention to a possible role of the phosphodiesterase 3 pathway, the major pharmacological target of anagrelide, as a potential therapeutic target for keratinocytic cancers.…”
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