PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…By incorporating such radionuclides into molecules of interest, we can directly assess their pharmacokinetic and pharmacodynamic (PK/PD) characteristics in vivo without changing their physicochemical characteristics or eliciting a pharmacological response. As such, PET imaging has long been used as a tool to aid drug discovery programs from preclinical biomarker validation all the way through to clinical trials. …”
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Effects of NSAIDs on the Release of Calcitonin Gene-Related Peptide and Prostaglandin E2 from Rat Trigeminal Ganglia by Vittorio Vellani, Giorgia Moschetti, Silvia Franchi, Chiara Giacomoni, Paola Sacerdote, Giada Amodeo

“…The release of CGRP and prostaglandin E2 (PGE2) from freshly isolated rat trigeminal ganglia was evaluated after oral administration of nimesulide, etoricoxib, and ketoprofen, NSAIDs with different pharmacological features. Thirty minutes after oral administration, nimesulide, 10 mg/Kg, decreased the GCRP release induced by an inflammatory soup, while the other NSAIDs were ineffective at this point in time. …”
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Molecular modelling of four penicillins: bencylpenicillin, phenoxymethylpenicillin, ampicillin and amoxicillin by Elso Manuel Cruz Cruz, Eslhey María Sánchez Domínguez

“…At the same time, they have differences in their pharmacological action that can be associated to modifications included in the betalactamic ring and/or effects localized in the same chains. …”
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Early intervention in eating disorders: introducing the chronopathogram by Antonio Preti, Francesco Bevione, Maria Carla Lacidogna, Andrea Raballo, Michele Poletti, Giovanni Abbate-Daga

“…Despite advancements in psychosocial and pharmacological treatments, improvements remain limited. …”
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Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits by Shoucui Gao, Xiaojing Wang, Daxing Cheng, Jiayan Li, Lu Li, Linwu Ran, Sihai Zhao, Jianglin Fan, Enqi Liu

“…High levels of plasma high-density lipoprotein-cholesterol (HDL-C) are inversely associated with the risk of atherosclerosis and other cardiovascular diseases; thus, pharmacological inhibition of cholesteryl ester transfer protein (CETP) is considered to be a therapeutic method of raising HDL-C levels. …”
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Extraction, Purification, Structural Characteristics, Biological Activities, and Applications of Polysaccharides from <i>Gastrodia elata</i>: A Review by Yan Yang, Yonglin Hai, Yongcheng Yang, Rouyuan Wen, Le Wang, Yan Qian, Jiaxian Zhang, Yongguo Li, Zhilong Shi, Haizhu Zhang

“…Additionally, it delves into structure-activity relationships and pharmacological mechanisms of these polysaccharides, giving support for future research to enhance their application in medicine, food, health products, and cosmetics.…”
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The Elevation of LC-ESI-Q-TOF-MS Response in the Analysis of Isoquinoline Alkaloids from Some Papaveraceae and Berberidaceae Representatives by Wirginia Kukula-Koch

“…Twenty-five methanol extracts obtained from various representatives of Papaveraceae and Berberidaceae botanical families (genera: Papaver, Argemone, Eschscholzia, Chelidonium, Glaucium, and Berberis) were screened for their alkaloid content in an optimized method suitable for the LC-ESI-Q-TOF-MS analysis. Twelve pharmacologically important isoquinoline alkaloids from four groups, aporphines, benzylisoquinolines, protoberberines, and benzophenanthridines, present in these traditionally used plant species were quantitatively determined in each studied sample, providing their alkaloid profile. …”
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Gambaran Drug Related Problems (DRPs) Terapi Farmakologi Pasien ISPA Pediatrik di Rumah Sakit PKU Muhammadiyah Gamping Yogyakarta by Nadia Husna, Siwi Padmasari

“…Keywords:  acute respiratory infection, hospital, pediatrics, pharmacologic therapy…”
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Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome by Alicia A. Thorp, Markus P. Schlaich

“…This review will discuss the regulatory role of the sympathetic nervous system in metabolic control and the proposed pathophysiology linking sympathetic overactivity to metabolic abnormalities. Pharmacological and device-based approaches that target central sympathetic drive will also be discussed as possible therapeutic options to improve metabolic control in at-risk patient cohorts.…”
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Black Pepper’s Anti-Aging and Chemoprevention Properties: A Review by Endah

“…Piperine, chavicine, caryophyllene, and sabinene are a few examples of black pepper components that exhibit pharmacological characteristics. This article reviews black pepper's main ingredients and discusses how effective it is at preventing aging and cancer. …”
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Hemoglobin Variants as Targets for Stabilizing Drugs by Miroslava Žoldáková, Michal Novotný, Krishna P. Khakurel, Gabriel Žoldák

“…Here, we review the progress in research, including the use of allosteric modulators, pharmacological chaperones, and antioxidant treatments, which has begun to improve hemoglobin stability and oxygen affinity. …”
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Isolation of Intact Mitochondria From Drosophila melanogaster and Assessment of Mitochondrial Respiratory Capacity Using Seahorse Analyzer by Christopher Groen, Anthony Windebank

“…The rapid biochemical assessment of mitochondria, in combination with the utility of Drosophila as an in vivo genetic model system, offers great potential for researchers to probe the impact of genetics and pharmacologic interventions on mitochondrial respiratory capacity.…”
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Intracranial artery dolichoectasia: What should the neurologist know? by Lorena Dellagnesi Depieri, Renan Rodrigues Neves Ribeiro do Nascimento, Lorena Souza Viana

“…Finally, we highlight the unmet clinical needs related to IADE management, which may involve pharmacological and surgical therapies tailored to individual cases, with careful consideration of safety and efficacy.…”
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Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats by Olivia A. Ortelli, Jeffrey L. Weiner

“…Furthermore, we assessed the sensitivity of the response requirement choice paradigm by administering the pharmacological stressor yohimbine and by altering the taste of the ethanol solution. …”
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T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives by Alessia Alunno, Francesco Carubbi, Onelia Bistoni, Sara Caterbi, Elena Bartoloni, Giulia Mirabelli, Francesca Cannarile, Paola Cipriani, Roberto Giacomelli, Roberto Gerli

“…In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue. …”
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The Protective Effects of 18β-Glycyrrhetinic Acid on Imiquimod-Induced Psoriasis in Mice via Suppression of mTOR/STAT3 Signaling by Haiming Chen, Huazhen Liu, Bin Tang, Yuchao Chen, Ling Han, Jingjie Yu, Yuhong Yan, Chuanjian Lu

“….), has been shown to have numerous pharmacological effects such as antioxidative, antitumor, and anti-inflammatory activities. …”
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Therapeutic Potential of 5-HT2C Receptor Ligands by Nanna H. Jensen, Thomas I. Cremers, Florence Sotty

“…Modulation of these receptors has therefore been proposed to be of interest in the search for novel pharmacological strategies for the treatment of various pathological conditions, including schizophrenia and mood disorders, as well as obesity. …”
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Digestive cancers: mechanisms, therapeutics and management by Tianzuo Zhan, Johannes Betge, Nadine Schulte, Lena Dreikhausen, Michael Hirth, Moying Li, Philip Weidner, Antonia Leipertz, Andreas Teufel, Matthias P. Ebert

“…We comprehensively describe the current stage-dependent pharmacological management of these malignancies, including chemo-, targeted, and immunotherapy. …”
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Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer by Xiaoxia Jin, Yingze Wei, Yushan Liu, Xiaoyun Lu, Fei Ding, Jiatai Wang, Shuyun Yang

“…Resveratrol (RES) is a phytoalexin with pharmacological antitumor properties, but its underlying mechanisms are not clearly understood in the treatment of DOX‐resistant breast cancer. …”
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Stable coding of aversive associations in medial prefrontal populations by Herry, Cyril, Jercog, Daniel

“…To address this question, we performed electrophysiological single-unit population recordings in the dorsal mPFC while mice faced threat-predicting cues eliciting defensive behaviours, and performed pharmacological and optogenetic inactivations of this area and the amygdala. …”
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