Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey by Nataša Milošević, Maja Milanović, Milica Medić Stojanoska, Varomyalin Tipmanee, Ilias Smyrnioudis, George V. Dedoussis, Nataša Milić

“…Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease without an approved pharmacological approach for its prevention/treatment. …”
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Evidence and Potential Mechanisms of Traditional Chinese Medicine for the Adjuvant Treatment of Coronary Heart Disease in Patients with Diabetes Mellitus: A Systematic Review and M... by Yu Wei, Qi-You Ding, Chak Yeung, Yi-shan Huang, Bo-xun Zhang, Li-li Zhang, Run-Yu Miao, Sha Di, Lin-Hua Zhao, Xiao-Lin Tong

“…We systematically assessed the efficacy and safety of TCM for the adjuvant treatment of patients with CHD and diabetes mellitus and examined the pharmacological effects and potential mechanisms of TCM medication/herbs on diabetes mellitus with CHD. …”
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Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury by Limei Wan, Weibin Wu, Shunjun Jiang, Shanhe Wan, Dongmei Meng, Zhipeng Wang, Jiajie Zhang, Li Wei, Pengjiu Yu

“…In this study, the pharmacological activity of mibefradil (a classical T-type calcium channel inhibitor) was assessed in a mouse model of lipopolysaccharide- (LPS-) induced ALI. …”
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Screening of potential GCMS derived antimigraine compound from the leaves of Abrus precatorius Linn to target “calcitonin gene related peptide” receptor using in silico analysis... by Parthasarathy V., Ajay Kumar T.V

“…Many strategies were employed to design antimigraine drug using various CGRP antagonist/ligands but most of them have failed due to their inability to reach the target “CGRP receptor” as they get metabolized before conferring their pharmacological action and exhibit toxic effect to the liver. …”
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Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-κB Pathway by Ling-yun Wu, Zhen-nan Ye, Zong Zhuang, Yongyue Gao, Chao Tang, Chen-hui Zhou, Chun-xi Wang, Xiang-sheng Zhang, Guang-bin Xie, Jing-peng Liu, Meng-liang Zhou, Chun-hua Hang, Ji-xin Shi

“…Biochanin A (BCA), a natural bioactive isoflavonoid, has been confirmed to emerge the anti-inflammatory pharmacological function. This original study was aimed at evaluating and identifying the neuroprotective role of BCA and the underlying molecular mechanism in an experimental Sprague-Dawley rat SAH model. …”
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Advanced application of metal nanoparticles in the diagnosis and treatment of rheumatoid arthritis by Wenjing Zhang, Tingting Xu, Yu Chen, Guiyang Zhang, Yongbo Song

“…Although current pharmacological treatments for RA have proven effective, considerable challenges remain, such as the need for high dosages, frequent administration, and a high incidence of severe side effects. …”
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Neural Compensations After Lesion of the Cerebral Cortex by Bryan Kolb, Russell Brown, Alane Witt-Lajeunesse, Robbin Gibb

“…Thus, combining behavioral therapies with pharmacological administration of compounds to increase the availability of trophic factors enhances functional outcome. …”
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Nonpharmacologic Interventions for the Self-Management of Anxiety in Parkinson’s Disease: A Comprehensive Review by Susan K. Chandler, Jo Lynne Robins, Patricia A. Kinser

“…Current treatment is largely pharmacologic, which can result in a myriad of undesirable and unsafe side effects. …”
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Animal Models of Diabetic Retinopathy: Summary and Comparison by Angela Ka Wai Lai, Amy C. Y. Lo

“…In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed. They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). …”
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Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity by Suzhen Chen, Yanping Wang, Qian Zhou, Qiqi Qian, Quanxin Jiang, Chuchu Liu, Yan Liu, Peihui Zhou, Jie Xiong, Yao Zhang, Ning Wang, Yang Emma Li, Limin Yin, Hongyuan Yang, Junli Liu

“…Moreover, individuals with obesity exhibit reduced Eepd1 expression. Pharmacological restoration of Eepd1 with Retigabine dihydrochloride effectively mitigates obesity. …”
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Case Report of Presumed (In)voluntary Capsaicin Intoxication Mimicking an Acute Abdomen by Simona Koprdova, Christine Schürmann, Dirk Peetz, Thomas Dürbye, Frank Kolligs, Herbert Koop

“…The clinical picture in the view of pharmacological investigations on intestinal capsaicin infusions suggests that excessive doses of capsaicin can induce severe abdominal pain; the prolonged symptoms were probably due to the failure to vomit. …”
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Diuretic Activity of the Aqueous Extract Leaves of Ficus glumosa Del. (Moraceae) in Rats by Fidèle Ntchapda, Djedouboum Abakar, Blaise Kom, Paulin Nana, Christian Bonabe, Maguirgue Kakesse, Emmanuel Talla, Théophile Dimo

“…The experiments were performed under the same conditions with two synthetic pharmacological diuretics considered as check (Furosemide and Amiloride hydrochlorothiazide). …”
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Inflammation in Diabetic Nephropathy by Andy K. H. Lim, Gregory H. Tesch

“…Lastly, we present the latest data on the pathogenic role of the stress-activated protein kinases in diabetic nephropathy, from studies on the p38 mitogen activated protein kinase and the c-Jun amino terminal kinase cell signalling pathways. The genetic and pharmacological approaches which reduce inflammation in diabetic nephropathy have not only enhanced our understanding of the pathophysiology of the disease but shown promise as potential therapeutic strategies.…”
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Functioning of Women with Migraine Headaches by Dorota Talarska, Małgorzata Zgorzalewicz-Stachowiak, Michał Michalak, Agrypina Czajkowska, Karolina Hudaś

“…This approach would greatly aid the individual in choosing the appropriate treatment, either pharmacological or others.…”
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Spectrum-Effect Relationships of Flavonoids in Glycyrrhiza uralensis Fisch. by Tingting Li, Shiyao Hua, Jiahua Ma, Lin Dong, Fang Xu, Xueyan Fu

“…The spectrum-effect relationships between the HPLC fingerprints and pharmacological activities of flavonoids in G. uralensis Fisch., including the heat clearing, detoxifying effects, cough relief, and phlegm elimination effects, were assessed by gray relational analysis and partial least squares regression. …”
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Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG by Alfredo Durand-Rivera, Efren Alatorre-Miguel, Elizabeth Zambrano-Sánchez, Celia Reyes-Legorreta

“…Attention deficit hyperactivity disorder (ADHD) affects 5-6% of school aged children worldwide. Pharmacological therapy is considered the first-line treatment and methylphenidate (MPH) is considered the first-choice medication. …”
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Research progress of auricular point therapy to relieve preoperative period anxiety before elective surgery in adults (耳穴压豆缓解成年人择期手术术前焦虑的研究进展)... by GAO Yuan (高原), XU Lingzhi (徐凌志), LI Suxia (李素霞)

“…To alleviate this issue, non-pharmacological interventions such as prayer, massage, music, imagery, and acupuncture have been widely employed. …”
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The Croton genera (Euphorbiaceae) and its richness in chemical constituents with potential range of applications by Carlos Andrés Coy-Barrera, Laura Galvis, Maria Juliana Rueda, Sergio Alejandro Torres-Cortés

“…It aims to summarize information gathered worldwide from studies of Croton species concerning ethnobotanical, pharmacological, and other uses over the past ten years and the respective discussion. …”
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Estradiol-dependent and independent effects of FGF21 in obese female mice by T. V. Jakovleva, A. Yu. Kazantseva, A. D. Dubinina, N. Yu. Balybina, K. O. Baranov, E. N. Makarova, N. M. Bazhan

“…However, estradiol affects the transcriptional effects of FGF21 in the liver, white adipose tissue, and hypothalamus, which may underlie sex differences in the FGF21 effect on the expression of metabolic genes and, possibly, in pharmacological FGF21 effects.…”
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Animal Models of Diabetes and Metabolic Disease by Tomohiko Sasase, Marcus G. Pezzolesi, Norihide Yokoi, Takahisa Yamada, Kozo Matsumoto

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