The Effect of Hand Reflexology Massage on Pain and Fatigue in Patients after Coronary Angiography: A Randomized Controlled Clinical Trial by Nahid Rejeh, Seyed Davood Tadrisi, Shahrooz Yazdani, Kiarash Saatchi, Mojtaba Vaismoradi

“…Hand reflexology as a nonpharmacological and safe technique can be used by nurses along with other pharmacologic interventions in order to reduce patients’ suffering related to invasive procedures. …”
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Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels by Jenifer d’El-Rei, Ana Rosa Cunha, Michelle Trindade, Mario Fritsch Neves

“…Thus, nutritional interventions are recognized as important strategies for primary prevention of hypertension and as adjuvants to pharmacological therapies to reduce cardiovascular risk. …”
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Autologous Minimally Invasive Cell-Based Therapy for Meniscal and Anterior Cruciate Ligament Regeneration by Pradeep V. Mahajan, Swetha Subramanian, Siddhesh C. Parab, Sanskruti Mahajan

“…Sudden twisting movements during weight bearing or trauma can cause injury to the menisci, which leads to symptoms such as pain, swelling, and difficulty in performing movements, among others. Conventional pharmacological and surgical treatments are effective in treating the condition; however, do not result in regeneration of healthy tissues. …”
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Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins by Sharon Inberg, Yael Iosilevskii, Alba Calatayud-Sanchez, Hagar Setty, Meital Oren-Suissa, Michael Krieg, Benjamin Podbilewicz

“…Our genetic results, supported by optogenetic, behavioral, and pharmacological evidence, suggest an activity-dependent homeostatic mechanism for dendritic structural plasticity, that in parallel controls escape response to noxious mechanosensory stimuli.…”
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Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells by Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-Oliveira, Miguel A. Prieto, Ka-Wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao

“…Dietary flavonoids are abundant in natural plants and possess multiple pharmacological and nutritional activities. In this study, apigenin, luteolin, and baicalein were chosen to evaluate their anti-diabetic effect in high-glucose and dexamethasone induced insulin-resistant (IR) HepG2 cells. …”
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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

“…These findings suggest two complementary mechanisms by which aspirin regulates the degradation of soluble and insoluble proteins, providing insights into its diverse pharmacological effects that can aid in future drug development efforts.…”
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Importance and Relevance of Phytochemicals Present in Galenia africana by Dario Heredia, Ivan Green, Jeremy Klaasen, Farzana Rahiman

“…This is a report on the phytochemical composition of G. africana and a review on the pharmacological importance and relevance of these phytochemicals. …”
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Physical activity and depression by Monika Wojtasik, Katarzyna Żak, Adam Załóg, Maria Nowak, Edyta Pietryszak, Wojciech Kulej, Paulina Szołtek, Rafał Pardela, Marcel Paruzel, Martyna Łęcka

“…In a therapeutic context, the article examines how physical activity can be an effective complement to traditional methods of treating depression, both pharmacological and psychotherapeutic. The importance of adapting training programs to individual needs and preferences of patients is also emphasized. …”
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Telomere-to-telomere Phragmites australis reference genome assembly with a B chromosome provides insights into its evolution and polysaccharide biosynthesis by Jipeng Cui, Rui Wang, Ruoqing Gu, Minghui Chen, Ziyao Wang, Li Li, Jianming Hong, Suxia Cui

“…Based on multi-tissue transcriptomic data, we identified structural genes in the biosynthetic pathway of pharmacologically active Phragmitis rhizoma polysaccharides with essential roles in rhizome development. …”
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Pancreatic lipase inhibitory activity of selected pharmaceutical agents by Hamdan Imad I., Kasabri Violet N., Al-Hiari Yusuf M., El-Sabawi Dina, Zalloum Hiba

“…In conclusion, synergistic lipase inhibitory activity between OsT and some other pharmaceutical compounds was demonstrated for the first time, which might help improve the pharmacological effect of OsT.…”
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Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells by Geng Yin, Ying Wang, Xiao-min Cen, Min Yang, Yan Liang, Qi-bing Xie

“…Our results indicated that products of lipid peroxidations, 4-HNE, may induce synovial intrinsic inflammations by activating NF-κB pathways and it may lead to cell apoptosis. Pharmacological inhibition of NF-κB activation may reduce the 4-HNE mediated inflammation responses and subsequent cell apoptosis. …”
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Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…Systematic reviews and meta-analyses indicate that only a minority of patients with neuropathic pain have an adequate response to pharmacological treatment and that most drugs have dose-limiting side effects. …”
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Aerobic Exercise Improves Signs of Restless Leg Syndrome in End Stage Renal Disease Patients Suffering Chronic Hemodialysis by Mojgan Mortazavi, Babak Vahdatpour, Aida Ghasempour, Diana Taheri, Shahrzad Shahidi, Firouzeh Moeinzadeh, Bahareh Dolatkhah, Shahaboddin Dolatkhah

“…Although there are some known pharmacological managements for this syndrome, the adverse effect of drugs causes a limitation for using them. …”
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Pengaruh Terapi Murotal Terhadap Tingkat Kecemasan Menghadapi Persalinan Pada Ibu Hamil di Wilayah Kerja Puskesmas Andalas by Riza Wahyuni, Deswita

“…Anxiety can have an impact on physically and psychologically in both the mother, the fetus and the labour procces. Non pharmacological management such as murotal therapy. The purpose of this research was to determine the effect of the murotal therapy on anxiety level to face the labour. …”
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Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue by Ye Seul Park, Md Jamal Uddin, Lingjuan Piao, Inah Hwang, Jung Hwa Lee, Hunjoo Ha

“…Interestingly, catalase deficiency also enhanced classical macrophage activation (M1) and inflammation but suppressed alternative activation (M2) regardless of diet. Similarly, pharmacological inhibition of catalase activity using 3-aminotriazole induced the same phenotypic switch and inflammatory response in RAW264.7 macrophages. …”
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The effect of rehabilitation on remission following detoxification treatment in alcohol and substance use disorders: A pilot study by Mustafa Danisman, Gamze Zengin Ispir, Kubra Sezer Katar, Zehra Ucar Hasanli, Ziya Bilgin

“…In the treatment of ASUD, in addition to pharmacological treatment and the treatment of comorbid psychiatric disorders, the inclusion of rehabilitation in the treatment processes is also essential because of the high relapse rates after detoxification treatment. …”
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Real and Pseudoaccommodation in Accommodative Lenses by Ioannis G. Pallikaris, Georgios A. Kontadakis, Dimitra M. Portaliou

“…Objective measurement of the accommodative capability offered by the accommodative IOLs is extremely difficult to obtain, and different methods such as autorefractometers, retinoscopy, and ultrasound imaging during accommodative effort, ray tracing, or pharmacological stimulation have been developed but the results are sometimes inconsistent. …”
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The role of diet and physical activity in PCOS - A Quick Review by Natalia Pawelec, Weronika Mazur, Artur Hawajski, Natalia Jankowska, Adrianna Świerzyńska, Alicja Kapciak, Julia Górny, Katarzyna Naja

“…These recommendations are often overlooked or undervalued, with patients frequently expecting immediate pharmacological treatment and not believing in the potential effects of lifestyle changes. …”
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The Hippo pathway promotes platinum-based chemotherapy by inhibiting MTF1-dependent heavy metal response by Hui Chen, Yue Xu, Dingshan Chen, Di Xiao, Bing Yang, Wenqi Wang, Han Han

“…This resistance is mitigated by Hippo pathway-mediated phosphorylation of MTF1. Moreover, pharmacological activation of the Hippo pathway sensitizes cancer cells to platinum-based compounds. …”
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The Angiotensin II Type 2 Receptor in Brain Functions: An Update by Marie-Odile Guimond, Nicole Gallo-Payet

“…If confirmed, these new pharmacological tools should help to improve impaired cognitive performance, not only through its action on brain microcirculation and inflammation, but also through more specific effects on neurons. …”
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