Gastroesophageal reflux disease, resistant to proton pump inhibitors by V. O. Kaybysheva, A. S. Trukhmanov, V. T. Ivashkin

“…To discuss the factors, promoting development of resistance at treatment of gastroesophageal reflux disease (GERD), and possible means to overcome it.Original positions. Pharmacological therapy of GERD is focused on change of refluxate properties besides decreasing of its volume and aggressive properties by such classes of drugs, as antacids, alginates and hydrochloric acid secretion inhibitors. …”
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Mitochondrial Dynamics: Biogenesis, Fission, Fusion, and Mitophagy in the Regulation of Stem Cell Behaviors by Wenyan Fu, Yang Liu, Hang Yin

“…Here, we summarize the recent research progress on (1) how mitochondrial dynamics controls stem cell behaviors, (2) intrinsic and extrinsic factors that regulate mitochondrial dynamics, and (3) pharmacological regulators of mitochondrial dynamics and their therapeutic potential. …”
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Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase by Yinhua Dong, Hongxin Wang, Zefeng Chen

“…Alpha-lipoic acid (ALA) has various pharmacological effects such as antioxidative, anti-inflammatory, and antiapoptotic properties. …”
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Cognitive Training in Parkinson’s Disease: A Review of Studies from 2000 to 2014 by Daniel Glizer, Penny A. MacDonald

“…To date, there is no effective pharmacological treatment for the range of cognitive impairments presented in PD. …”
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Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity by Khanh Tien Nguyen Pham, Takahito Miyake, Tomo Suzuki, Shigeru Kinoshita, Yuki Hamada, Hikari Uehara, Mamiko Machida, Takeshi Nakajima, Emi Hasegawa, Masao Doi

“…Here, we performed radioactive tracer studies in combination with pharmacological enzyme inhibition, followed by targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, and found three androgen metabolites—androstanedione, androsterone, and epiandrosterone—in mouse and human meibomian glands. …”
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Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats by Manal A. Hamed, Sanaa A. Ali, Nagy Saba El-Rigal

“…Further studies are required in order to identify the molecules responsible of the pharmacological activity.…”
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(Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity and Tumorigenicity by Ž. Večerić-Haler, A. Cerar, M. Perše

“…Despite intensive investigations there is still no pharmacological agent that could provide complete protection against cisplatin nephrotoxicity. …”
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Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable by Elisabetta Bianchini, Lynn Roth, Pierre Boutouyrie, Smriti Badhwar, Achim Schwarz, Vincenzo Gemignani, Rosa Maria Bruno, Bernhard Hametner, Chloe Park, Giacomo Pucci, Ioana Mozos, Dimitrios Terentes-Printzios, Rachel E. Climie, Andrea Guala, Jordi Alastruey, Christopher C. Mayer

“…Despite significant progress, the development of pharmacological interventions to mitigate vascular aging remains a critical need. …”
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New Oxygenated Methoxy-<i>p</i>-Cymene Derivatives from Leopard’s Bane (<i>Doronicum columnae</i> Ten., Asteraceae) Essential Oil: Synthesis Facilitating the Identification of Isom... by Milan Ž. Dimitrijević, Marko Z. Mladenović, Milica D. Nešić, Milan S. Dekić, Vidak N. Raičević, Niko S. Radulović

“…Species of the genus <i>Doronicum</i> are known for their pharmacological properties and essential oils, the chemical composition of which remains inadequately studied. …”
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The hypothalamus as the central regulator of energy balance and its impact on current and future obesity treatments by Bruna Bombassaro, Eliana P. Araujo, Licio A. Velloso

“…This review presents an overview of the mechanisms involved in the hypothalamic regulation of energy balance and discusses how advancements in this field are contributing to the development of new pharmacological strategies to treat obesity.…”
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Allergen-Induced Asthma by Donald W Cockcroft

“…A standardized allergen inhalation challenge model has been developed and is proving to be a valuable research tool in the investigation of asthma pathophysiology and of potential new pharmacological agents for the treatment of asthma.…”
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Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels by Itsuro Kazama

“…Based on the recent in vitro evidence that revealed the pharmacological properties of the channels, the most recent studies have revealed novel therapeutic implications of targeting the lymphocyte Kv1.3-channels for the treatment of renal diseases.…”
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Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone by Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li, Xiaomeng Li

“…Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, have been found to have various pharmacological actions including anti-inflammatory, antimicrobial, and anticancer properties, with no significant toxicity. …”
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Attention deficit/hyperactivity disorder (ADHD) dimensions mediate the relationship between adverse childhood experiences and adult aggression depending on cognitive reappraisal by Steffen Barra, Paulina Klaudia Machalica, Petra Retz-Junginger, Johannes Merscher, Anselm Crombach, Wolfgang Retz

“…Respective gender-sensitive prevention and treatment for aggressive behavior should include adequate pharmacological and psychological approaches that address ADHD core symptoms, whilst also aiming to improve emotion regulation techniques.…”
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Short- and long-term complications of bariatric surgery by Miguel Licea Videaux, Roberto Santana Caballero, Jesús Javier Sánchez Mata, Isabel García Morales, Dania Piñeiro Pérez, Daryl Rodríguez Denis

“…<p>Obesity affects mostly young men and women, both in developed and developing countries. Pharmacological treatments have proven to be ineffective, leaving surgery as the only therapeutic option. …”
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CCR9 Antagonists in the Treatment of Ulcerative Colitis by Pirow Bekker, Karen Ebsworth, Matthew J. Walters, Robert D. Berahovich, Linda S. Ertl, Trevor T. Charvat, Sreenivas Punna, Jay P. Powers, James J. Campbell, Timothy J. Sullivan, Juan C. Jaen, Thomas J. Schall

“…In addition, we determined the effect of CCR9 pharmacological inhibition in the mdr1a−/− mouse model of ulcerative colitis. …”
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Antiproliferative Effect of Grammatophyllum speciosum Ethanolic Extract and Its Bioactive Compound on Human Breast Cancer Cells by Verisa Chowjarean, Kamala Sadabpod

“…Grammatophyllum speciosum Blume exhibits various promising pharmacological activities. However, its effect on breast cancer has not been determined. …”
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Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential by Alexander Fuerlinger, Alina Stockner, Simon Sedej, Mahmoud Abdellatif

“…Furthermore, we discuss the potential for pharmacologically mimicking the beneficial effects of caloric restriction in HFpEF using clinically approved and emerging caloric restriction mimetics. …”
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Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice by Fabiola Silva Angulo, Claudine Vanessa Joseph, Lou Delval, Lucie Deruyter, Séverine Heumel, Marie Bicharel, Patricia Brito Rodrigues, Valentin Sencio, Tom Bourguignon, Marina Gomes Machado, Marie Fourcot, Stéphane Delhaye, Sophie Salomé-Desnoulez, Philippe Valet, Serge Adnot, Isabelle Wolowczuk, Jean-Claude Sirard, Muriel Pichavant, Bart Staels, Joel T. Haas, Ruxandra Gref, Jimmy Vandel, Arnaud Machelart, Hélène Duez, Benoit Pourcet, François Trottein

“…In young-adult mice, we discovered an interaction between Rev-erb-α and the apelinergic axis that controls host defenses against S. pneumoniae via alveolar macrophages. Pharmacological repression of Rev-erb-α in elderly mice resulted in greater resistance to pneumococcal infection. …”
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Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential by Lyca R. da Fonseca, Rafaele de A. Rodrigues, Aline de S. Ramos, Jefferson D. da Cruz, José Luiz P. Ferreira, Jefferson Rocha de A. Silva, Ana Claudia F. Amaral

“…Thus, this article was based on a search into the uses of the main species of the genus Passiflora with anxiolytic activity and its main secondary metabolites and some pharmacological studies, patents, and registered products containing Passiflora. …”
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