Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice by Xianlei Wang, Shulin Wu, Junsheng Zuo, Keying Li, Yutong Chen, Zhijie Fan, Zhou Wu, Jun-Xia Yang, Weiyi Song, Jun-Li Cao, Mengqiao Cui

“…Moreover, we utilized translating ribosome affinity purification (TRAP) in combination with c-Fos-tTA strategy and pharmacological approaches and identified SIGMAR1 as a potential therapeutic molecular target. …”
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Successful Treatment of Actinic Keratosis with Kanuka Honey by Saras Mane, Joseph Singer, Andrew Corin, Alex Semprini

“…Actinic keratoses form as rough, scaly plaques on sun-exposed areas; they can be an important step in premalignant progression to squamous cell cancer of the skin. Currently, pharmacological treatments consist of topical immunomodulatory agents with poor side effect profiles. …”
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Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis by GONG Jin, ZHANG Jinjin, CHEN Lili, WANG Hui, XING Yanchao

“…Traditional treatment methods such as pharmacological injections and surgical interventions primarily aim to alleviate symptoms but have limited effects on cartilage repair. …”
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Pain management for the neurosurgical patient in spinal procedures: overview of historic and new modalities by Ashley M. Carter, Samantha Yost, Jessica Tobin, Simran Phuyal, Brandon Lucke-Wold

“…Additionally showcasing individualized multimodal strategies for postoperative pain management beyond pharmacological approaches such as cognitive behavioral therapy (CBT), physical therapy, and transcutaneous electrical nerve stimulation (TENS). …”
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Experimental methods of portal hypertension studying by D. V. Garbuzenko

“…To present methods of studying of portal hypertension and means of its pharmacological treatment in experiment settings.Original positions. …”
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Maternal Bradycardia Associated with Betamethasone Administration During Pregnancy by Mojirayo A. Sarumi, James W. Hole, Robert B. Gherman

“…Due to the asymptomatic nature of the maternal bradycardia, pharmacologic interventions were not recommended. With observation alone, a normal maternal heart rate returned by forty-nine hours after the original betamethasone injection. …”
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Beware of failure of early pregnancy induction – An incidental discovery of an undiagnosed bicornuate uterus at laparotomy by Rajasri G Yaliwal, Aruna M. Biradar, Laxmi Sangolli, Rakshitha Raghavendra

“…Medical termination of pregnancy (MTP) was attempted with pharmacological and mechanical methods, which all proved unsuccessful. …”
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Cytokine Reduction in the Treatment of Joint Conditions by J. D. Sipe, J. Martel-Pelletier, I. G. Otterness, J.-P. Pelletier

“…Potential agents for cytokine reduction include selective anti-cytokine antibodies, anticytokine receptor antibodies, cytokine receptor antagonist proteins, and soluble and chimeric cytokine receptor molecules. Pharmacologic regulation of IL-1 and TNFα remain primary targets for treatment of arthritis, and results of early clinical trials are promising. …”
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Toll-Like Receptor-Based Strategies for Cancer Immunotherapy by Saghar Pahlavanneshan, Ali Sayadmanesh, Hamidreza Ebrahimiyan, Mohsen Basiri

“…There are plenty of data on the pharmacological targeting of TLR signaling using agonist molecules that boost the antitumor immune response. …”
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Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection by Maša Ždralević, Nicoletta Guaragnella, Lucia Antonacci, Ersilia Marra, Sergio Giannattasio

“…Strong interest exists in pharmacological manipulation of mitochondrial metabolism and signaling. …”
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Pharmacotherapy of Posttraumatic Cognitive Impairments by David B. Arciniegas, Jonathan M. Silver

“…Based on the evidence provided by that review, augmentation of posttraumatic cerebral catecholaminergic and cholinergic function are suggested as potentially useful neurochemical targets for pharmacologic intervention in this population. More specifically, it is suggested that persons with posttraumatic impairments in arousal, speed of processing, and possibly attention may benefit most from treatment with an agent that augments cerebral catecholaminergic function, and that persons whose predominant posttraumatic impairment is in the domain of memory may benefit most from treatment with cholinesterase inhibitors. …”
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Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines by Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

“…In TGM2-expressing PDOs, pharmacological TGM2 inhibition or treatment with nocodazole increased T cell-mediated apoptosis. …”
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Discrepancies in safety reporting for chronic back pain clinical trials: an observational study from ClinicalTrials.gov and publications by Nick Boyne, Alison Duke, Jack Rea, Adam Khan, Alec Young, Jared Van Vleet, Matt Vassar

“…Abstract Introduction Chronic back pain (CBP) is a leading cause of disability worldwide and is commonly managed with pharmacological, non-pharmacological, and procedural interventions. …”
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Phytochemical and toxicological evaluation of aqueous leaf extract of Premna integrifolia L. in male balb/c mice by Suman, Pratibha Gaurav, Rajesh Saini, Kavindra Nath Tiwari, Gautam Geeta Jiwatram

“…Identification of pharmacologically active compounds in ALEPI was performed using UHPLC-HRMS analysis. …”
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Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review by Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Shin-Da Lee, Bor-Tsang Wu

“…The included studies utilized pharmacologically induced PD models in mice or rats with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine (6-OHDA). …”
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Deep Brain Stimulation in Parkinson’s Disease: New and Emerging Targets for Refractory Motor and Nonmotor Symptoms by Dustin Anderson, Grayson Beecher, Fang Ba

“…Parkinson’s disease (PD) is a progressive neurodegenerative condition characterized by bradykinesia, tremor, rigidity, and postural instability (PI), in addition to numerous nonmotor manifestations. Many pharmacological therapies now exist to successfully treat PD motor symptoms; however, as the disease progresses, it often becomes challenging to treat with medications alone. …”
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The drugs, interacting with opiate receptors, and their application in gastroenterological practice by S. A. Bulgakov

“…Article presents features of its synthesis, pharmacological effects, main directions of application: peptic ulcer of the stomach and duodenum, pancreatitis. …”
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Detection freezing of gait (FOG) in Parkinson's patients using wearable sensors and deep learning by Maryam Talebvand, Amir Lakizadeh, Faranak Fotouhi

“…The use of computational methods can provide non-pharmacological support and complementary information about the disease to neurologists by carefully examining patients’ FOG status and increasing the likelihood of a more effective treatment. …”
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Sarcopenia, a Neurogenic Syndrome? by Ping Kwan

“…The etiology of sarcopenia is currently found to be multifactorial, and most of the pharmacological researches are focused on the muscular factors in aging. …”
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Biological treatment options for eosinophilic asthma, with consideration of markers of eosinophilic inflammation as predictors of treatment efficacy by Aleksandra Niemiec, Olga Branicka, Barbara Rymarczyk, Radosław Gawlik

“…Asthma, particularly uncontrolled asthma, not only reduces the quality of life but is also a major cause of disability for employment. The current pharmacologic strategy to therapy consists mostly of inhaled glucocorticoids and β-agonists, as well as leukotriene antagonists, long-acting muscarinic antagonists, and oral corticosteroids. …”
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