Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair by Yinan Xiao, Yu Wu, Qilong Wang, Mo Li, Chaolin Deng, Xiaoyang Gu

“…Inhibition of PFKFB3, both genetically and pharmacologically, sensitized OC cells to PARPis, impaired HR repair and increased DNA damage. …”
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Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: a systematic review and meta-analysis of 381 studies (the meta-TENS... by Gareth Jones, Mark I. Johnson, Carole A. Paley, Matthew R. Mulvey, Priscilla G. Wittkopf

“…Pain intensity was lower during or immediately after TENS compared with pharmacological and non-pharmacological treatments used as part of standard of care (61 RCTs, 61 samples, n=3155, SMD = −0·72 (95% CI −0·95 to –0·50], low-certainty evidence). …”
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A minimally invasive animal model of atherosclerosis and neointimal hyperplasia for translational research by Max L. A. Ebert, Vanessa F. Schmidt, Osman Öcal, Anne von Thaden, Olaf Dietrich, Bastian Popper, Sandra Elges, Max Seidensticker, Jens Ricke, Melanie A. Kimm, Astrid Jeibmann, Moritz Wildgruber

“…This minimal invasive model allows for clinical translation, including pharmacological investigations and vessel wall imaging. …”
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The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…However, recent studies highlight gaps in healthcare providers’ competencies in managing pediatric chronic pain, and the need to update professional training and explore further non-pharmacological approaches to improve its management. …”
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Emotion regulation-based internet-delivered cognitive behavioural therapy for premenstrual dysphoric disorder: study protocol for a randomised controlled trial in Sweden by Filipa Sampaio, Alkistis Skalkidou, Gerhard Andersson, Cornelia Weise, Johanna M. Hoppe, Maria Kleinstaeuber, Johan Vegelius, Erika Comasco, Maria Gröndal, Elisavet Kaltsouni, Felicia Sundström, Monica Buhrman

“…Thus, non-pharmacological treatments are needed as an alternative or additive treatment strategy. …”
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Hypnotic Effect of A. absinthium Hydroalcoholic Extract in Pentobarbital-Treated Mice by Hassan Rakhshandeh, Amirhossein Heidari, Ali Mohammad Pourbagher-Shahri, Roghayeh Rashidi, Fatemeh Forouzanfar

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An interpretable machine learning tool for in-home monitoring of agitation episodes in people living with dementia: a proof-of-concept studyResearch in context by Marirena Bafaloukou, Ann-Kathrin Schalkamp, Nan Fletcher-Lloyd, Alex Capstick, Chloe Walsh, Cynthia Sandor, Samaneh Kouchaki, Ramin Nilforooshan, Payam Barnaghi

“…We designed an interactive tool that enables the exploration of personalised non-pharmacological interventions, such as modifying ambient light and temperature. …”
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Strategies in the Surgical Management of Atrial Fibrillation by Leanne Harling, Thanos Athanasiou, Hutan Ashrafian, Justin Nowell, Antonios Kourliouros

“…An increased understanding of AF pathophysiology has led to enhanced pharmacological and medical therapies; however this is often limited by toxicity, variable symptom control, and inability to modulate the atrial substrate. …”
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Statins as Modulators of Regulatory T-Cell Biology by David A. Forero-Peña, Fredy R. S. Gutierrez

“…Statins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol. …”
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Cannabinoids and Their Role in Chronic Pain Treatment: Current Concepts and a Comprehensive Review by Islam Shehata, Ahmed Hashim, Ahmed Saad Elsaeidy, Anagha Nair, Ivan Urits, Omar Viswanath, Alan D. Kaye, Marian Habib

“…These different approaches carry many pharmacological hazards together with the lack of efficacy and safety of many interventional and surgical management techniques for chronic pain have mandated searching for other effective therapies including alternative treatments. …”
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Inhibitors of nuclear factor kappa B cause apoptosis in cultured macrophages by E. E. Mannick, J. Mishra, J. Marque, M. Clavell, M. J. S. Miller, P. D. Oliver

“…The aim of this study was to determine if three pharmacologic inhibitors of NF-κB, pyrrolidine dithiocarbamate, N-tosyl-L-lysl chloromethyl ketone and calpain I inhibitor, induce apoptosis in a murine macrophage cell line (RAW 264.7) at doses similar to those required for NF-κB inhibition. …”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…Therapeutic strategies are limited for RVF, as basic and clinical research has historically focused mainly on the left ventricle. Novel pharmacological interventions targeting metabolism, calcium homeostasis, oxidative stress, extracellular matrix remodeling, endothelial function, and inflammation are needed to address RVF effectively. …”
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Membrane Currents in Airway Smooth Muscle: Mechanisms and Therapeutic Implications by Luke J Janssen

“…Electrophysiological and pharmacological techniques were used to characterize the membrane conductance changes underlying spasmogen-evoked depolarization in airway smooth muscle (ASM). …”
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Neuro-inflammation, depression and fatigue in ESRD: Emerging role of microglia and acupuncture as a new treatment addressing neuro-inflammation in ESRD by Suandika Made, Handayani Rahmaya Nova, Muti Refa Teja

“…Acupuncture, as a non-pharmacological option, has been shown to reduce chronic inflammation and enhance clinical results for ERSD patients’ quality of life. …”
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Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report by Angelo Giovanni Icro Maremmani, Luca Rovai, Fabio Rugani, Silvia Bacciardi, Matteo Pacini, Liliana Dell'Osso, Icro Maremmani

“…Nowadays, the misuse of benzodiazepines (BZDs) is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction. …”
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Crocetin Alleviates Inflammation in MPTP-Induced Parkinson’s Disease Models through Improving Mitochondrial Functions by Na Dong, Zhong Dong, Ying Chen, Xiaosu Gu

“…Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects. …”
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Prediction of drug-drug plasma protein binding interactions of resveratrol in combination with celecoxib and leflunomide by molecular docking combined with an ultrafiltration techn... by Zhou Peng, Hua Fang

“…Celecoxib or leflunomide, even at high tested doses, did not affect the plasma protein binding of resveratrol, thus suggesting pharmacological suitability of the investigated combinations.…”
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Cell fusion as a driver of metastasis: re-evaluating an old hypothesis in the age of cancer heterogeneity by Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Eduardo López-Collazo, Laura Hurtado-Navarro, Laura Hurtado-Navarro

“…Additionally, we discuss emerging pharmacological strategies aimed at targeting fusogenic molecules as a means to prevent metastatic dissemination.…”
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Clinical Implications of the Transversus Abdominis Plane Block in Adults by Mark J. Young, Andrew W. Gorlin, Vicki E. Modest, Sadeq A. Quraishi

“…As such, we provide a brief historical perspective on the TAP block, describe relevant anatomy, review current techniques, discuss pharmacologic considerations, and summarize the existing literature regarding its clinical utility with an emphasis on recently published studies that have not been included in other systematic reviews or meta-analyses.…”
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Transcription factor specificity protein (SP) family in renal physiology and diseases by Wei Zhou, Jiaxi Fang, Qingqing Jia, Hanyan Meng, Fei Liu, Jianhua Mao

“…The review further discusses pharmacological modulation of SPs and its implications for treatment. …”
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