Chronic Disease Management in Patients with Non-infectious Arthritis: Challenges and Solutions by WENG Xisheng, ZHANG Fengchun

“…To address these challenges, a systematic strategy for chronic disease management of NIS needs to be developed at the national level, which encompasses increasing popularization of science, improving the referral system, using artificial intelligence (AI) technology to assist in early diagnosis, and implementing interventions including optimized pharmacological/surgical treatments and multidisciplinary collaboration. …”
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NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway by Alexander J. Gill, Matthew D. Smith, Danny Galleguillos, Thomas Garton, Jackson W. Mace, Sachin P. Gadani, Swati Kumar, Aayush Pokharel, Krista Solem, Saahith Potluri, Omar Hussein, Giuliana Sardi Rogines, Arihant Singh, Annatje Clark, Peter A. Calabresi, Marjan Gharagozloo

“…These data suggest that pharmacologic NLRX1 activators have the potential to limit inflammatory neurodegeneration. …”
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GluN2D-containing NMDA receptors in parvalbumin neurons in the nucleus accumbens regulate nocifensive responses in neuropathic pain by Sukanya G. Gakare, Gajanan P. Shelkar, Dinesh Y. Gawande, Ratnamala Pavuluri, Pauravi J. Gandhi, Shashank M. Dravid

“…Specifically, both GluN2D knockout (KO) mice and pharmacological blockade of GluN2D-containing receptors produced robust reduction in mechanical nocifensive response in CINP. …”
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Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study by Sonia López-Monzoni, Gloria Hernando Benito, Sofía Romero-Peralta, Laura Silgado-Martínez, Maria Esther Viejo-Ayuso, Leticia Álvarez-Balado, Enrique Rodríguez Matarranz, Carles Forné Izquierdo, Manuel Sánchez-de-la-Torre, Juan Fernando Masa, Ferrán Barbé, Francisco García-Río, Antonio Martínez-Nicolás, Belén García-Mediano, Esther Solano-Pérez, Olga Mediano

“…The limitations of pharmacological treatments for chronic pain have become increasingly evident: dependency, side effects, resistance, and diminishing efficacy. …”
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Secondary prevention of preeclampsia by Muhammad Ilham Aldika Akbar, Muhammad Ilham Aldika Akbar, Roudhona Rosaudyn, Khanisyah Erza Gumilar, Khanisyah Erza Gumilar, Renuka Shanmugalingam, Gustaaf Dekker, Gustaaf Dekker

“…Secondary prevention involves pharmacological therapies aimed at stopping the disease’s progression before clinical signs. …”
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Cirrhotic cardiomyopathy by S. N. Mammayev, A. M. Karimova, T. E. Il’yasova, A. Sh. Khasayev

“…In studies, that were carried out, main clinical manifestations of CCM, effect on its course and the prognosis of various pharmacological drugs, application of TIPS and OTL were demonstrated. …”
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Patients' perceived needs of osteoarthritis health information: A systematic scoping review. by Louisa Chou, Lisa Ellis, Michelle Papandony, K L Maheeka D Seneviwickrama, Flavia M Cicuttini, Kaye Sullivan, Andrew J Teichtahl, Yuanyuan Wang, Andrew M Briggs, Anita E Wluka

“…They want more information not only about pharmacological management options, but also non-pharmacological options to help them manage their symptoms. …”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype by Nadia Cobo‐Vuilleumier, Silvia Rodríguez‐Fernandez, Livia López‐Noriega, Petra I. Lorenzo, Jaime M. Franco, Christian C. Lachaud, Eugenia Martin Vazquez, Raquel Araujo Legido, Akaitz Dorronsoro, Raul López‐Férnandez‐Sobrino, Beatriz Fernández‐Santos, Carmen Espejo Serrano, Daniel Salas‐Lloret, Nila vanOverbeek, Mireia Ramos‐Rodriguez, Carmen Mateo‐Rodríguez, Lucia Hidalgo, Sandra Marin‐Canas, Rita Nano, Ana I. Arroba, Antonio Campos Caro, Alfred CO Vertegaal, Alejandro Martín‐Montalvo, Franz Martín, Manuel Aguilar‐Diosdado, Lorenzo Piemonti, Lorenzo Pasquali, Roman González Prieto, Maria Isabel García Sánchez, Decio L. Eizirik, Maria Asuncion Martínez‐Brocca, Marta Vives‐Pi, Benoit R. Gauthier

“…LRH‐1/NR5A2 agonistic activation expands a CD4+/CD25+/FoxP3+ T‐cell subpopulation. Pharmacological activation of LRH‐1/NR5A2 improves the survival iPSC‐islets‐like organoids co‐cultured with PBMCs from individuals with T1D.…”
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Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development by Katharina Weinhäupl, Louis Meuret, Sandy Desrat, Fanny Roussy, Nelly Morellet, Sandra Beaupierre, Catherine Guillou, Carine van Heijenoort, Olga Abian, Sonia Vega, Ian Wolf, Tatos Akopian, Olga Krandor, Eric Rubin, Adrian Velazquez-Campoy, Diego Gauto, Hugo Fraga

“…Recent studies have shown that several natural product antibiotics targeting the unfoldase N-terminal domain can impair MtbClpC1 function resulting in cell death. While the pharmacological properties of these natural product antibiotics prevent their use in the clinic, similar molecules binding to the same binding pockets can result in new drugs against Mtb. …”
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Exploring Marine Cyanobacteria for Lead Compounds of Pharmaceutical Importance by Bushra Uzair, Sobia Tabassum, Madiha Rasheed, Saima Firdous Rehman

“…Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immunodeficiency syndrome (AIDS), arthritis, and so forth, while other compounds have been developed as analgesics or to treat inflammation, and so forth. …”
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Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine by Yanfei Ma, Yifan Zhong, Wenjie Tang, Teresa G. Valencak, Jingliang Liu, Zhaoxi Deng, Jiangdi Mao, Daren Liu, Shanshan Wang, Yuhao Wang, Haifeng Wang

“…Spermidine treatment mimics the metabolic effects of L. reuteri ZJ617, whereas pharmacological inhibition of spermidine biosynthesis in mice abolishes these benefits. …”
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Primary Hyperparathyroidism in Patients with Multiple Endocrine Neoplasia Type 1 by Grzegorz Piecha, Jerzy Chudek, Andrzej Więcek

“…It also summarises the recent advances in the pharmacological therapy with a new group of drugs—calcimimetics.…”
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Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives by Selvaraj Jubie, Rajamanickam Gayathri, Rajagopal Kalirajan

“…Their structures were confirmed by using 1H NMR, IR, and mass analysis. In pharmacological evaluation, the synthesized compounds showed its curative effect against ethidium-bromide-induced demyelination in rats. …”
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Topical Tacrolimus and Periodontal Therapy in the Management of a Case of Oral Chronic GVHD Characterized by Specific Gingival Localization by Davide Conrotto, Roberto Broccoletti, Paola Carcieri, Luisa Giaccone, Paolo G. Arduino

“…The oral lesions are difficult to control with a systemic pharmacological therapy. Case Description. A 63-year-old female patient, who underwent an allogeniec transplantation for acute myeloid leukemia, developed a chronic oral and cutaneous GVHD. …”
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Sex and gender differences in pain perception and management in clinical settings by Jakara Morgan, Krystal Magwood, Joslyn Smith, Marjorie R. Jenkins, Alyson J. McGregor, Kelly M. Quesnelle

“…Despite the current pharmacologic recommendations for pain treatment, there are differences in how medications are prescribed to patients. …”
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Cloud-Point Extraction Combined with Liquid Chromatography for the Determination of Ergosterol, a Natural Product with Diuretic Activity, in Rat Plasma, Urine, and Faeces by Dan-Qian Chen, Jun-Min An, Ya-Long Feng, Ting Tian, Xiang-Yang Qin, Ying-Yong Zhao

“…Ergosterol from many medicinal fungi has been demonstrated to possess a variety of pharmacological activities in vivo and in vitro. A new method based on cloud-point extraction has been developed, optimized and validated for the determination of ergosterol in rat plasma, urine and faeces by liquid chromatography. …”
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Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy by Baoyi Feng, Chenxi Jin, Zhenzhe Cheng, Xingle Zhao, Zhuoer Sun, Xiaofei Zheng, Xiang Li, Tingting Dong, Yong Tao, Hao Wu

“…Mitochondrial dysfunction and pharmacological therapy were studied in neurodegeneration, providing new insights in mitochondrion-targeted treatment of AN. …”
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The Successful Use of Inhaled Nitric Oxide in the Management of Severe Hepatopulmonary Syndrome after Orthotopic Liver Transplantation by Joshua Santos, Philip Young, Igor Barjaktarevic, Catherine Lazar, Irawan Susanto, Tisha Wang

“…There is currently no pharmacologic intervention that has been shown to significantly affect outcomes and liver transplantation remains the mainstay of therapy. …”
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In search of Alzheimer’s disease treatment methods: trends of clinical trials by G. Pakulaitė, V. Regelskytė, E. Audronytė, J. Kuzmickienė, G. Kaubrys

“… There is a strong necessity to develop new treatments for Alzheimer’s disease (AD) as its frequency is rapidly growing with the ageing population. There were 25 pharmacological agents involved in phase I trials, 52 in phase II, and 28 agents in phase III clinical trials in 2017. …”
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Mathematical analysis and simulations involving chemotherapy and surgeryon large human tumours under a suitable cell-kill functional response by Diego Samuel Rodrigues, Paulo Fernando de Arruda Mancera

“…Weuse some biological and pharmacological data in a numerical approach,where drug administration occurs in cycles (periodic infusion)and surgery is performed instantaneously. …”
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