Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection by Shen Jie, Yang Kai, Sun Caihua, Zheng Minxia

“…Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. …”
Get full text

Ensuring Pain Relief for Children at the End of Life by Marie-Claude Grégoire, Gerri Frager

“…The present article reviews, through a case-based presentation, the nonpharmacological and pharmacological methods used to ensure adequate pain control in children facing end of life. …”
Get full text

Dysfunction in Ribosomal Gene Expression in the Hypothalamus and Hippocampus following Chronic Social Defeat Stress in Male Mice as Revealed by RNA-Seq by Dmitry A. Smagin, Irina L. Kovalenko, Anna G. Galyamina, Anatoly O. Bragin, Yuriy L. Orlov, Natalia N. Kudryavtseva

“…This approach may be used to identify a pharmacological treatment of ribosome biogenesis abnormalities in the brain of patients with “ribosomopathies.”…”
Get full text

Tardive Dyskinesia, Oral Parafunction, and Implant-Supported Rehabilitation by S. Lumetti, G. Ghiacci, G. M. Macaluso, M. Amore, C. Galli, E. Calciolari, E. Manfredi

“…The frequency and intensity of the movements were high, and no pharmacological intervention was possible. Moreover, the patient refused night-time splint therapy. …”
Get full text

Recent Advances in Epidural Analgesia by Maria Bauer, John E. George, John Seif, Ehab Farag

“…This paper will provide an overview of the pertinent anatomical, pharmacological, immunological, and technical aspects of epidural anesthesia in both adult and pediatric populations and will discuss the recent advances, the related rare but potentially devastating complications, and the current recommendations for the use of anticoagulants in the setting of neuraxial block placement.…”
Get full text

From Basic Visual Science to Neurodevelopmental Disorders: The Voyage of Environmental Enrichment-Like Stimulation by Alan Consorti, Gabriele Sansevero, Claudia Torelli, Nicoletta Berardi, Alessandro Sale

“…The aim of this review is to depict, mainly through the much explicative examples of amblyopia, Down syndrome, and Rett syndrome, the increasing interest in the potentialities and applications of enriched environment-like protocols in the field of neurodevelopmental disorders and the understanding of the molecular mechanisms underlying the beneficial effects of these protocols, which might lead to development of pharmacological interventions.…”
Get full text

Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function? by Elizabeth A. Ellins, Julian P. J. Halcox

“…The first investigations in humans involved invasive pharmacological vascular function testing, which have been used to gain a detailed understanding of the mechanisms involved in the pathogenesis of endothelial dysfunction and atherosclerosis as well as novel targets for intervention. …”
Get full text

Impact of Incretin-Based Therapies on Adipokines and Adiponectin by Habib Yaribeygi, Mina Maleki, Stephen L. Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar

“…In this review, we propose that incretin-based therapy may function through adipokine modulation that may result in pharmacologic properties beyond their direct antidiabetic effects, resulting in better management of diabetes and diabetes-related complications.…”
Get full text

PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease by Sharon Cresci

“…The peroxisome proliferator-activated receptors (PPARs) consist of three related transcription factors that serve to regulate a number of cellular processes that are central to cardiovascular health and disease. Numerous pharmacologic studies have assessed the effects of specific PPAR agonists in clinical trials and have provided insight into the clinical effects of these genes while genetic studies have demonstrated clinical associations between PPAR polymorphisms and abnormal cardiovascular phenotypes. …”
Get full text

Effectiveness of Electronic Quality Improvement Activities to Reduce Cardiovascular Disease Risk in People With Chronic Kidney Disease in General Practice: Cluster Randomized Trial... by Jo-Anne Manski-Nankervis, Barbara Hunter, Natalie Lumsden, Adrian Laughlin, Rita McMorrow, Douglas Boyle, Patty Chondros, Shilpanjali Jesudason, Jan Radford, Megan Prictor, Jon Emery, Paul Amores, An Tran-Duy, Craig Nelson

“…One module within FHT aims to facilitate cardiovascular disease (CVD) risk reduction in people with chronic kidney disease (CKD) through the recommendation of angiotensin-converting enzyme inhibitor inhibitors (ACEI), angiotensin receptor blockers (ARB), or statins according to Australian guidelines (defined as appropriate pharmacological therapy). ObjectiveThis study aimed to determine if the FHT program increases the proportion of general practice patients with CKD receiving appropriate pharmacological therapy (statins alone, ACEI or ARB alone, or both) to reduce CVD risk at 12 months postrandomization compared with active control (primary outcome). …”
Get full text

Oleanolic Acid Cubic Liquid Crystal Nanoparticle-Based Thermosensitive Gel Attenuates Depression Symptoms in Chronic Unpredictable Mild Stress Rats by Shi Z, Wang Q, Li Q, Jia F, Xu W

“…In this study, building upon a previous formulation of OA cubic liquid crystal nanoparticles (OA-LCNP), we combined nanoparticles with a thermosensitive gel for nasal administration and investigated the pharmacological effects of OA-LCNP thermosensitive gel (OANG) on depression. …”
Get full text

The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years by Miranda Olff, Irma Hein, Ananda B. Amstadter, Cherie Armour, Marianne Skogbrott Birkeland, Eric Bui, Marylene Cloitre, Anke Ehlers, Julian D. Ford, Talya Greene, Maj Hansen, Nathaniel G. Harnett, Debra Kaminer, Catrin Lewis, Alessandra Minelli, Barbara Niles, Nicole R. Nugent, Neil Roberts, Matthew Price, Anthony N. Reffi, Soraya Seedat, Antonia V. Seligowski, Anka A. Vujanovic

“…However, research on prevention is still scarce compared to treatment research where several evidence-based psychological, pharmacological and complementary/ integrative interventions exist, and novel forms of delivery have become available. …”
Get full text

Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids by Akimi Yonezawa, Kana Shimomura, Koji Okamoto, Haruna Takeda

“…The results were validated by pharmacological inhibition experiments with JQ1 in human CRC organoids. …”
Get full text

Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…Moreover, our results indicated that sorafenib induced the accumulation of MDSCs mediated by CCR2, and pharmacological blockade of CCR2 markedly reduced MDSCs migration and tumor growth. …”
Get full text

4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets by Angel H. Romero, Francisco Delgado

“…Moreover, beyond the pharmacological exigencies, there are other challenges concerning its parasitic nature, such as its great genetic plasticity and adaptability, enabling it to activate a battery of genes to develop resistance quickly. …”
Get full text

Crude Drugs for Clearing Heat Contain Compounds Exhibiting Anti-Inflammatory Effects in Interleukin-1β-Treated Rat Hepatocytes by Airi Fujii, Saki Onishi, Nodoka Watanabe, Mizuki Kajimura, Kentaro Ito, Keita Minamisaka, Yuto Nishidono, Saki Shirako, Yukinobu Ikeya, Mikio Nishizawa

“…., Kampo medicines, consist of crude drugs (mostly plants) that have empirical pharmacological functions (‘<i>Yakuno</i>’ in Japanese), such as clearing heat. …”
Get full text

Students Perceptions, Satisfactions and Challenges on Problem-Based Learning (PBL): A Survey Study Among Final Year Pharmacy Students by Engku Nuraishah Huda E. Zainudin, Fakhira Damia Khaidir, May Khin Soe, Nurul Asyiqin Yusof, Khairool Azizul Mohammad

“…Findings revealed that the majority agreed with statements on benefits that PBL significantly contributed to their knowledge acquisition (100.0%), stimulated the exploration of basic scientific concepts (98.8%), and enhanced their understanding in selecting both pharmacological and non-pharmacological approaches in disease management (97.6%, 95.2% respectively). …”
Get full text

Non-alcoholic fatty liver disease: comparative assessment of diagnostic and treatment approaches in the Russian Federation and People’s Republic of China by M. Ch. Semenistaya, Fan Jian-Gao, O. B. Velichenko, Ye. A. Kuznetsova, Ch. S. Pavlov

“…Etiological and pathogenetic features of NAFLD require diverse therapeutic actions from dietic recommendations and physical activity correction of the prescription of various pharmacological agents. Results of clinical efficacy estimation of the new drug Bicyclol in the Russian market, that it was developed in the People’s Republic of China demonstrate reduction of severity of inflammation, steatosis, fibrosis and decrease of NAFLD activity scores.…”
Get full text

Phenolic compounds of Iris adriatica and their antimycobacterial effects by Ochensberger Sandra, Alperth Fabian, Mitić Božena, Kunert Olaf, Mayer Stefanie, Mourão Maria Ferreira, Turek Ivana, Luca Simon Vlad, Skalicka-Woźniak Krystyna, Maleš Željan, Hruševar Dario, Duka Ivan, Bucar Franz

“…Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). …”
Get full text

The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis by Samuel García, Carmen Conde

“…In these diseases, the pharmacological inhibition of PARP-1 has shown a beneficial effect, suggesting that PARP-1 regulates their inflammatory processes. …”
Get full text