The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent by Sebastiaan ter Horst, Aleksandra Siekierska, Ann-Sofie De Meulemeester, Arno Cuvry, Laura Cools, Johan Neyts, Peter de Witte, Joana Rocha-Pereira

Get full text

Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products by Irina-Iuliana Costache, Anca Miron, Monica Hăncianu, Viviana Aursulesei, Alexandru Dan Costache, Ana Clara Aprotosoaie

“…Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of these interactions may lead to unexpected clinical outcomes. …”
Get full text

INTEGRATING HYPERTONIA REHABILITATION, INTRAORAL REHABILITATION, AND ANXIETY MANAGEMENT FOR COMPREHENSIVE PATIENT CARE- PART1 by Lucian Stefan Burlea, Doriana Agop Forna, Mihaela Salceanu, Violina Budu, Vlad Proca, Bogdan Petru Bulancea, Tudor Hamburda, Maria Antonela Beldiman

“…As premedication, miorelaxants, adjuvants for inflammatory processes (which result in antalgic hypertonic phenomena), and during local anesthesia through neuromuscular transmission blockage, miorelaxants are a class of pharmacological agents with various structures and mechanisms of action that are highly helpful in treating stomatognatic dysfunctions. …”
Get full text

Cytokine-Leukotriene Receptor Interactions by Marek Rola-Pleszczynski, Jana Stankova

“…Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. …”
Get full text

Progress on neuromodulation for treatment of central pain by GAN Yu, WAN Jun⁃ge, LI Zhong⁃hua, LI Shuai, HAN Shuai

“…Central pain often arises as a sequela of lesions in the central somatosensory nervous system, and the intensity of pain is generally severe, significantly impacting patients' quality of life. Conventional pharmacological therapies usually have limited efficacy. …”
Get full text

Resveratrol as a potential broad-spectrum compound for cancer treatment by Li Kar Stella Tan, Chee Wun How, Jhi Biau Foo, Kooi Yeong Khaw, Bey Hing Goh, Yong Sze Ong

“…Resveratrol (RSV), the stilbenes found in red wine, is one of the phytochemicals that exhibits various pharmacological therapeutic effects including cancer. …”
Get full text

Anesthetic Related Advances with Cyclodextrins by Mark Welliver, John P. McDonough

“…This unique ability to encapsulate lipophilic molecules and maintain water solubility confers numerous pharmacologic advantages for both drug delivery and removal. …”
Get full text

Buprenorphine for Chronic Pain: A Safer Alternative to Traditional Opioids by Suhani Dalal, Ahish Chitneni, Amnon A. Berger, Vwaire Orhurhu, Bilal Dar, Bennett Kramer, Anvinh Nguyen, John Pruit, Charles Halsted, Alan D. Kaye, Jamal Hasoon

“…Buprenorphine offers a safer alternative for patients who require opioids to manage chronic pain, given the unique pharmacological properties that allow it to provide adequate analgesia with less abuse potential.…”
Get full text

Risperidone-Induced Neutropenia in a Schizophrenic Patient: A Case Report and Literature Review by Ayodele Atolagbe, Stanley Nkemjika, Olusegun Popoola, Oluwatoyin Oladeji, Irina Kogan, Haroon Saeed, Tolulope Olupona

“…Neutropenia is an adverse effect of various pharmacological therapies, including antipsychotics. Among the second-generation antipsychotic (SGA) medications, clozapine is most notable for neutropenic adverse effect. …”
Get full text

Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications by Marta Szekalska, Agata Puciłowska, Emilia Szymańska, Patrycja Ciosek, Katarzyna Winnicka

“…The focus of the paper is to describe biological and pharmacological activity of alginates and to discuss the present use and future possibilities of alginates as a tool in drug formulation. …”
Get full text

PHARMACEUTICAL TECHNIQUES FOR THE FABRICATION OF POOR WATERSOLUBLE DRUGS A REVIEW by Rabia Noor

“…Majority of the drugs possesses low solubility leading to poor absorption and erratic bioavailability and thus failed to achieve a desired pharmacological response. Therefore formulation scientists have adopted various techniques to overcome solubility and bioavailability issues following oral administration. …”
Get full text

Synthesis of 1H-pyrazolo[3,4-b]pyridine analogues by Yen Nguyen, Greg Petruncio, Schroeder M. Noble, Mikell Paige

“…Many compounds containing the pyrazolo[3,4-b]pyridine scaffold have been found to have various pharmacological activities such as anticancer, anti-inflammatory, anti-bacterial, antihyperglycemic, and anxiolytic properties. …”
Get full text

Resistant Hypertension and Obstructive Sleep Apnea: The Sparring Partners by Costas Thomopoulos, Helena Michalopoulou, Alexandros Kasiakogias, Anna Kefala, Thomas Makris

“…Effective CPAP therapy qualifies as an effective “add-on” to the underlying antihypertensive pharmacological therapy, and emerging evidence underlines the favorable effect of mineralocorticoid antagonists on both resistant hypertension and obstructive sleep apnea treatment.…”
Get full text

Resolution of Osseous Sarcoidosis with Methotrexate by Christopher Kanner, Bonita Libman, Morgan Merchand, Diego Lemos

“…We present a case of widespread skeletal involvement of sarcoidosis without evidence of concurrent pulmonary disease demonstrating marked clinical improvement and near-complete resolution of imaging abnormalities on magnetic resonance imaging (MRI) following the use of methotrexate as the primary pharmacologic agent.…”
Get full text

Dynamic renoscintigraphy in cardiology and cardiac surgery by V.Yu. Kundin, I.V. Noverko, A.G. Mazur

“…The article presents the pharmacological test with captopril used for evaluation of renal function in hypertension, features of such test in cardiology practice and its evaluation in different clinical situations. …”
Get full text

Traditional Uses, Chemical Constituents, and Biological Activities of Bixa orellana L.: A Review by Daniela de Araújo Vilar, Marina Suênia de Araujo Vilar, Túlio Flávio Accioly de Lima e Moura, Fernanda Nervo Raffin, Márcia Rosa de Oliveira, Camilo Flamarion de Oliveira Franco, Petrônio Filgueiras de Athayde-Filho, Margareth de Fátima Formiga Melo Diniz, José Maria Barbosa-Filho

“…This study shows the well-characterized pharmacological actions that may be considered relevant for the future development of an innovative therapeutic agent.…”
Get full text

A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology by Ge Wang, Xiaoyan Peng

“…On the other hand, although MTX has an excellent pharmacological efficacy, MTX associated side effects in clinical use, which vary from patient to patient, are nonnegligible. …”
Get full text

Spinal Cord Injury Research in Mice: 2008 Review by Inge Steuer, Pierre A. Guertin

“…A variety of approaches, including advanced genetics and molecular techniques, have allowed a number of key findings in the field of secondary degeneration, repair, regeneration (including insights from peripheral nerve lesion models), metabolic dysfunctions, and pharmacological neuromodulation.…”
Get full text

A Review of Current Management of Vitreomacular Traction and Macular Hole by Alfredo García-Layana, José García-Arumí, José M. Ruiz-Moreno, Lluís Arias-Barquet, Francisco Cabrera-López, Marta S. Figueroa

“…A treatment algorithm to be used in clinical practice in patients with VMA, VMT, and MH based on the presence of symptoms, visual acuity, associated epiretinal membrane, and width of the vitreous attachment is presented. Observation, pharmacologic vitreolysis with ocriplasmin, and surgical treatment are positioned as treatment options in the different steps of the therapeutic algorithm, with clear indications of the paths to be followed according to the initial presenting manifestations and the patient’s clinical course.…”
Get full text

Benefits that Asthmatic Patients Receive after the Application of a Physiotherapeutic and Rehabilitative Treatment by Ismaray Sacerio González, Vivian Isabel Chávez Pérez, Belkis González Aguiar

“…Its prevalence continues to increase despite the fact that effective therapeutic manuals are currently available for the correct management of the main symptoms of the disease. The non-pharmacological treatment of this condition is based on three pillars: education about the disease, guides for professionals and patients, and respiratory physiotherapy. …”
Get full text