4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain by Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang

“…Finally, we utilized network pharmacology analysis to predict the mechanism of 4-OI in treating PTOA synovitis and conducted preliminary validation. …”
Get full text

Pharmacogenomic profiling of variants affecting efficacy and toxicity of anti-infective medicines in a south Asian population from Sri Lanka by Priyanga Ranasinghe, Hajanthy Jeyapragasam, Nirmala Sirisena, D. P. Bhagya Hendalage, Vajira H. W. Dissanayake

Get full text

Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP-Elevating Agents by Bianca de Luca, Pedro Xavier-Elsas, Mônica Barradas, Ricardo A. Luz, Túlio Queto, Carla Jones, Maria Augusta Arruda, Thiago Mattar Cunha, Fernando Queiroz Cunha, Maria Ignez Gaspar-Elsas

Get full text

Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis by Phuong T.T. Nguyen, Mia Shiue, Nina Kuprasertkul, Pedro Costa-Pinheiro, Luke T. Izzo, Laura V. Pinheiro, Hayley A. Affronti, Gabriel Gugiu, Shivani Ghaisas, Joyce Y. Liu, Jordan C. Harris, Charles W. Bradley, John T. Seykora, Xiaolu Yang, Taku Kambayashi, Clementina Mesaros, Brian C. Capell, Kathryn E. Wellen

Get full text

ChromaFold predicts the 3D contact map from single-cell chromatin accessibility by Vianne R. Gao, Rui Yang, Arnav Das, Renhe Luo, Hanzhi Luo, Dylan R. McNally, Ioannis Karagiannidis, Martin A. Rivas, Zhong-Min Wang, Darko Barisic, Alireza Karbalayghareh, Wilfred Wong, Yingqian A. Zhan, Christopher R. Chin, William S. Noble, Jeff A. Bilmes, Effie Apostolou, Michael G. Kharas, Wendy Béguelin, Aaron D. Viny, Danwei Huangfu, Alexander Y. Rudensky, Ari M. Melnick, Christina S. Leslie

Get full text

Supplementation of Arjun (Terminalia arjuna) bark powder prevented oxidative stress and enhanced antioxidants in kidneys on isoproterenol-treated Swiss albino mice model by Rashedul Haque, Sajib Paul, Md. Tipu Sultan, Faizul Islam Chowdhury, Md. Kawser, Shariful Islam Nayan, S.M. Hafiz Hassan, Afsana Kabir Chowdhury, Raiyana Huda, Sauda Sumaya Dina, Sheikh Zahir Raihan

Get full text

Spatiotemporal range dynamics and conservation optimization for endangered medicinal plants in the Himalaya by Fu-Lv Liu, Winnie Wanjiku Mambo, Jie Liu, Guang-Fu Zhu, Raees Khan, Abdullah, Shujaul Mulk Khan, Lu Lu

Get full text

Sex Differences in the Prognostic Value of Circulating Biomarkers in Patients Presenting With Acute Chest Pain by Gard Mikael Sæle Myrmel, MD, Nasir Saeed, Ole Thomas Steiro, MD, Hilde Lunde Tjora, MD, PhD, Jørund Langørgen, MD, PhD, Rune Oskar Bjørneklett, MD, PhD, Øyvind Skadberg, MD, Vernon Vijay Singha Bonarjee, MD, PhD, Øistein Rønneberg Mjelva, MD, Eva Ringdal Pedersen, MD, PhD, Kjell Vikenes, MD, PhD, Torbjørn Omland, MD, PhD, Kristin Moberg Aakre, MD, PhD

Get full text

Imidazole: Having Versatile Biological Activities by Amita Verma, Sunil Joshi, Deepika Singh

“…Imidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. …”
Get full text

Aluminum Poisoning with Emphasis on Its Mechanism and Treatment of Intoxication by Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Roghayeh Jafarian Amiri, Marzieh Pirzadeh, Ali Akbar Moghadamnia

Get full text

HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions by Sungkyoung Choi, Sungyoung Lee, Taesung Park

Get full text

Opioid Therapy for Chronic Nonmalignant Pain by Russell K Portenoy

“…A critical review of the medical literature pertaining to chronic pain, opioid pharmacology and addiction medicine can clarify misconceptions about opioid therapy and provide a foundation for patient selection and drug administration. …”
Get full text

Public health care system, a quasi-experimental study: Acceptance and attitude to implicate clinical services by Gillani Syed Wasif, Abdul Mohi Iqbal Mohammad

Get full text

Antibacterial and Oxacillin Resistance Reversing Effect of Harmaline in Different Strains of Staphylococcus Aureus by Zaid Ibraheem

Get full text

A Quantitative Study on the Trachea of the Red Sokoto (Maradi) Goat (Capra hircus) by O. Byanet, J. A. Bosha, B. O. Onoja

Get full text

Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications by Han Han, Erika M. Wolff, Gangning Liang

“…In addition, their dynamic nature and reversibility with pharmacological interventions open new and exciting avenues for therapies. …”
Get full text

Medical Ethics in Perspective of Islamic Teachings by Syed Muhammad Tahir Shah, Mohammad Akram Randhawa

Get full text

Activation of CD147 with Cyclophilin A Induces the Expression of IFITM1 through ERK and PI3K in THP-1 Cells by Ju-Young Kim, Ho Kim, Kyoungho Suk, Won-Ha Lee

Get full text

The Role of Glial Cells in the Pathophysiology of Epilepsy by Filiz Onat, My Andersson, Nihan Çarçak

Get full text

Role of dietary and nutritional interventions in ceramide-associated diseases by Shengnan Wang, Zihui Jin, Biyu Wu, Andrew J. Morris, Pan Deng

“…Elevated cellular and circulating ceramide levels are consistently associated with pathological conditions including cardiometabolic diseases, neurological diseases, autoimmune diseases, and cancers. Although pharmacological inhibition of ceramide formation often protects against these diseases in animal models, pharmacological modulation of ceramides in humans remains impractical. …”
Get full text