Imaging Dose-dependent Pharmacokinetics of an RGD-Fluorescent Dye Conjugate Targeted to αβ Receptor Expressed in Kaposi's Sarcoma by Sunkuk Kwon, Shi Ke, Jessica P. Houston, Wei Wang, Qingping Wu, Chun Li, Eva M. Sevick-Muraca

“…The fluorescence images were acquired using an intensified charge-coupled device system and were analyzed with a three-compartment pharmacokinetic (PK) model to determine uptake parameters in the tumor and normal tissue regions of interest as a function of administered dose. …”
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Idarubicin-loaded drug-eluting microspheres transarterial chemoembolization for intermediate stage hepatocellular carcinoma: safety, efficacy, and pharmacokinetics by Korsic Spela, Osredkar Josko, Smid Alojz, Steblovnik Klemen, Popovic Mark, Locatelli Igor, Trontelj Jurij, Popovic Peter

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Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods by Kashiwagura Yasuharu, Takusagawa Shota, Ikematsu Yasuyuki, Tanaka Shimako, Namiki Noriyuki, Uchida Shinya

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Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects by Kentaro Nishioka, Kentaro Nishioka, Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama

“…Previous studies indicated that achieving a maximum concentration (Cmax) of 3-HB in plasma at 0.28 mM could initiate ketone metabolism in the brain; we hypothesized that attaining this Cmax would improve brain health.MethodsWe aimed to demonstrate the efficacy of an optimized single oral dose of 3-HB on cognitive function and mood through two clinical studies: a pharmacokinetic study and an efficacy study. In the pharmacokinetic study, healthy subjects were ingested 2 and 4 g of 3-HB to construct a compartment model to predict the minimum oral dose of 3-HB needed to achieve the target Cmax. …”
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Integrated serum pharmacochemistry, pharmacokinetics, and network analysis to explore active components of BuShao Tiaozhi Capsule on hyperlipidemia by Ruiyin Tang, Guanlin Xiao, Yanchang Liu, Dezheng Jia, Zhihao Zeng, Canchao Jia, Dongmei Li, Yangxue Li, Jieyi Jiang, Sumei Li, Xiaoli Bi

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Snake Venom Pharmacokinetics and Acute Toxic Outcomes Following <i>Daboia siamensis</i> Envenoming: Experimental and Clinical Correlations by Sethapong Lertsakulbunlue, Wipapan Khimmaktong, Orawan Khow, Wittawat Chantkran, Jureeporn Noiphrom, Kanyanat Promruangreang, Lawan Chanhome, Janeyuth Chaisakul

“…An understanding of snake venom pharmacokinetics is essential for determining clinical outcomes of envenoming and developing therapeutic approaches to the treatment of envenoming, especially regarding the timing and optimal dosage of antivenom administration. …”
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Postpartum changes in maternal physiology and milk composition: a comprehensive database for developing lactation physiologically-based pharmacokinetic models by Neel Deferm, Neel Deferm, Jean Dinh, Jean Dinh, Amita Pansari, Masoud Jamei, Khaled Abduljalil

“…In silico tools, such as physiologically-based pharmacokinetic (PBPK) models, can help to bridge this knowledge gap. …”
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Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients by C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian

“…Objectives. To compare the pharmacokinetics of tacrolimus in paediatric liver transplant recipients with their donors’ CYP3A5 genotypes, considering both donor and recipient characteristics. …”
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Effects of Borneol on Pharmacokinetics and Tissue Distribution of Notoginsenoside R1 and Ginsenosides Rg1 and Re in Panax notoginseng in Rabbits by Shixiang Wang, Weijin Zang, Xinfeng Zhao, Weiyi Feng, Ming Zhao, Xi He, Qinshe Liu, Xiaohui Zheng

“…The purpose of this study is to investigate the effects of Borneol on the pharmacokinetics of notoginsenoside R1 (NGR1) and the ginsenosides Rg1 (GRg1) and Re (GRe) in Panax notoginseng. …”
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Development and Validation of a LC/MS/MS Method for the Determination of Duloxetine in Human Plasma and Its Application to Pharmacokinetic Study by D. Chandrapal Reddy, A. T. Bapuji, V. Surayanarayana Rao, V. Himabindu, D. Rama Raju, Syed Syedba, H. L. V. Ravikiran

“…Recovery of duloxetine in human plasma is 80.31% and ISTD recovery is 81.09%. The main pharmacokinetic parameters were Tmax (hr) = (7.25±1.581), Cmax (ng/mL) (44.594±18.599), AUC0→t, = (984.702±526.502) and AUC0→∞, (1027.147±572.790) respectively.…”
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Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes by Lixuan Qian, Tao Zhang, Jean Dinh, Mary F. Paine, Zhu Zhou

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Pharmacokinetics study of a supersaturatable self-microemulsifying drug delivery system for ellagic acid by UHPLC-Q-TOF-MS by Wang Jinglong, Fan Liqun, Zhang Lihua, Zheng Dandan, Wang Yingzi, Sun Xiao, Ji Yonghui

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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

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A Joint Technology Combining the Advantages of Capillary Microsampling with Mass Spectrometry Applied to the Trans-Resveratrol Pharmacokinetic Study in Mice by Ying Xu, Song-xia Zhang, Jing Guo, Li-jie Chen, Yu-ligh Liou, Tai Rao, Jing-bo Peng, Ying Guo, Wei-hua Huang, Zhi-rong Tan, Dong-sheng Ou-yang, Hong-hao Zhou, Wei Zhang, Yao Chen

“…Mice are the most frequently used animals in pharmacokinetic studies; however, collecting series of blood samples from mice is difficult because of their small sizes and tiny vessels. …”
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Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics by Jose Antonio Mancillas-Quiroz, Miriam del Carmen Carrasco-Portugal, Karina Mondragón-Vásquez, Juan Carlos Huerta-Cruz, Juan Rodríguez-Silverio, Leyanis Rodríguez-Vera, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Jorge Guillermo Domínguez-Chávez, Héctor Isaac Rocha-González

“…The mechanism of action was determined by cytokine quantification, and pharmacokinetic parameters were obtained through UPLC-MS/MS. …”
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Population pharmacokinetic modeling of zavegepant, a calcitonin gene‐related peptide receptor antagonist, in healthy adults and patients with migraine by Craig M. Comisar, Jose Francis, Jim H. Hughes, Rajinder Bhardwaj, Richard Bertz, Jing Liu

“…The zavegepant population pharmacokinetic model adequately characterized zavegepant concentration–time profiles, the bioavailability of intranasal and oral zavegepant, as well as the effect of intrinsic and extrinsic factors on zavegepant pharmacokinetics.…”
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Population Pharmacokinetic–Pharmacodynamic Modeling of Granulocyte Colony‐Stimulating Factor to Optimize Dosing and Timing for CD34+ Cell Harvesting by Xu Jiang, Jun Seok Cha, Byung Hak Jin, Choon Ok Kim, Dongwoo Chae

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A phase I, randomized, placebo‐controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults by Xiaomeng Mao, Xiaohan Hua, Chengyi Wu, Xiaoyun Ge, Jie Zhang, Xiaojie Wu, Robert J. Kubiak, Ulrika Wählby Hamrén, Tonya Villafana, Georgios Christou, Jannine Green, Therese Takas, Yuwen Jin

“…To inform the investigation of nirsevimab for the prevention of RSV LRTI in Chinese infants, this Phase I, randomized, placebo‐controlled trial evaluated the pharmacokinetics (PK) and safety of nirsevimab in healthy Chinese adults. …”
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LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study by Wenjuan Cui, Qin Liu, Shan Xiong, Lujun Qiao

“…The validated method was successfully applied in pharmacokinetic studies of dexmedetomidine, dezocine, and midazolam following intravenous injection.…”
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