Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application by Shuang-long Li, Yong-liang Zhu, Yi Zhang, Shu-han Liu, Xiang-die Wang, Xiang-jun Qiu

“…We had established a new method that had been applied to the pharmacokinetic study of enasidenib in rats.…”
Get full text

Simultaneous Determination of Multiple Active Components from Bushen Pills and Application in a Pharmacokinetic Study in Rats by Houli Li, Benjie Wang, Guiyan Yuan, Xiaoyan Liu, Jing Huang, Lilong Xiong, Di Zhang, Weiyi Feng, Ruichen Guo

“…The proposed method has been successfully applied to the pharmacokinetic study of BSPs in rats after a single dose.…”
Get full text

A pharmacological view on accounting for pharmacokinetic factors in the estimation of pharmaceutical emissions based on drug usage data by Frank Klont, J. Stein Bellinga, Valentina Giunchi, Spyros Balafas, Eelko Hak

Get full text

QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite by Namrata Gautam, Debopriya Dutta, Saurabh Mittal, Perwez Alam, Nasr A. Emad, Mohamed H. Al-Sabri, Suraj Pal Verma, Sushama Talegaonkar

Subjects: Get full text

Pharmacokinetic Comparison of Isoalantolactone and Alantolactone in Rats after Administration Separately by Optimization of an UPLC-MS2 Method by Renjie Xu, Mengyue Wang, Ying Peng, Xiaobo Li

“…This method was used to compare the pharmacokinetic characteristics of isoalantolactone and alantolactone at a single dose of 5 mg/kg into male Sprague-Dawley rats by intravenous administration separately. …”
Get full text

The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region by Toru Chikui, Makoto Obara, Arjan W. Simonetti, Masahiro Ohga, Shoichi Koga, Shintaro Kawano, Yoshio Matsuo, Takeshi Kamintani, Tomoko Shiraishi, Erina Kitamoto, Katsumasa Nakamura, Kazunori Yoshiura

“…This paper will introduce the method of pharmacokinetic analysis and also describe the clinical application of this technique in the head and neck region.…”
Get full text

Telomerase inhibiting phytochemicals derived from Blumea eriantha for cancer treatment: A comprehensive computational analysis by Rahil Ummar Faruk Abbu, Shaik Mohammad Abdul Fayaz, Divyashree M S, Raghu Chandrashekhar H, Prasanna Kumar Reddy Gayam, Archana Mahadev Rao

Subjects: Get full text

Comparative study on the bioavailability and bioequivalence of rifapentine capsules in humans by Ying Qi, Pengfei Zhao

Subjects: Get full text

Pharmacokinetics and Bioequivalence of Two Fixed-Dose Combination Tablets of Valsartan/Amlodipine (80/5 Mg) in Healthy Chinese Subjects by Tian M, Huang J, Chen Y, Jin Q, Jiang H, Shi C, Mei J, Xu M, Yu X, Yang S

Subjects: Get full text

Evaluating the pharmacokinetics and safety of blonanserin tablets and Lonasen®: a randomized, open-label, two-period, two-sequence, self-crossover phase I clinical trial by Bo Qiu, Bo Qiu, Haojing Song, Haojing Song, Xue Sun, Xue Sun, Congyang Ding, Congyang Ding, Runxuan Du, Wanjun Bai, Wanjun Bai, Zhanjun Dong, Zhanjun Dong

Subjects: Get full text

Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins Using Two-Compartment Mathematical Model by Sergey Shityakov, Carola Förster

Get full text

Personalized metronomic radiopharmaceutical therapy through injection profile optimization via physiologically based pharmacokinetic (PBPK) modeling by Aryan Golzaryan, M. Soltani, Farshad Moradi Kashkooli, Babak Saboury, Arman Rahmim

“…We developed a physiologically-based pharmacokinetic (PBPK) model applied to metastatic castration-resistant prostate cancer patients to analyze the impact of metronomic framework and various infusion durations (1–4 h) on absorbed doses (ADs) in tumors and organ-at-risk (OAR). …”
Get full text

The population pharmacokinetics of dolutegravir co‐administered with rifampicin in Thai people living with HIV: Assessment of alternative dosing regimens by Baralee Punyawudho, Anan Chanruang, Thornthun Ueaphongsukkit, Sivaporn Gatechompol, Sasiwimol Ubolyam, Yong Soon Cho, Jae Gook Shin, Anchalee Avihingsanon

“…This study aimed to develop the population pharmacokinetic model of DTG when co‐administered with rifampicin. …”
Get full text

Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics by Jonathan B. Ford, Mac T. Wayment, Timothy E. Albertson, Kelly P. Owen, Joshua B. Radke, Mark E. Sutter

Get full text

Pharmacokinetics of Eight Flavonoids in Rats Assayed by UPLC-MS/MS after Oral Administration of Drynariae rhizoma Extract by Zhan-Ling Xu, Ming-Yue Xu, Hai-Tao Wang, Qing-Xuan Xu, Ming-Yang Liu, Chun-Peng Jia, Fang Geng, Ning Zhang

“…Extraction recovery, matrix effect, and stability were satisfactory. The pharmacokinetic characteristics of the eight flavonoids of interest were clearly elucidated.…”
Get full text

Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats by Chunling Zhou, Xiaoxin Li, Aiping He, Tianzhu Liu, Jinmiao Tian, Meihua Jiang, Lina Fang

“…The established method allows for the quantification of VS-5584 in rat plasma in detail and can be utilized to successfully describe the pharmacokinetic profile of VS-5584.…”
Get full text

Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics by Xiuwei Shen, Xiangyi Dai, Yifan He, Congcong Wen, Qingwei Zhang

“…The established UPLC-MS/MS method is suitable for pharmacokinetic studies of senegenin and tenuifolin in mice.…”
Get full text

The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin—A Randomized, Controlled, Crossover Study by Liva K. Stuhr, Joshua B. Feinberg, Thea Christoffersen, Konstantinos Dimopoulos, Mikkel B. Christensen, David P. Sonne, Troels Riis, Peter S. Plomgaard, Jens P. Goetze, Emil L. Larsen, Kristian Karstoft

Subjects: Get full text

Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice by Joy L. Kovar, Lael L. Cheung, Melanie A. Simpson, D. Michael Olive

Get full text

Simultaneous Determination of 13 Constituents of Radix Polygoni Multiflori in Rat Plasma and Its Application in a Pharmacokinetic Study by Wenhao Cheng, Yinghui Li, Wei Yang, Siyang Wu, Mengmeng Wei, Yang Gao, Chen Kang, Shuofeng Zhang, Yingfei Li

“…However, information on the pharmacokinetics of stilbenes and anthraquinones at a subtoxic dose of RPM is limited. …”
Get full text