Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients by Lara Marques, Nuno Vale

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External validation of population pharmacokinetic models of gentamicin in paediatric population from preterm newborns to adolescents by Črček Mateja, Grabnar Iztok, Zdovc Jurij Aguiar, Grosek Štefan, Kos Mojca Kerec

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A Multi-Method Comparison of Machine Learning in predicting pharmacokinetic parameters: A simulation study by marziyeh Doostfatemeh, kamal Amini, Elham Haem

Subjects: “…Population pharmacokinetics…”
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Physiology‐based pharmacokinetic model with relative transcriptomics to evaluate tissue distribution and receptor occupancy of anifrolumab by Pradeep Sharma, David W. Boulton, Lynn N. Bertagnolli, Weifeng Tang

“…The IFNAR1 expression and PBPK model were validated by testing their ability to predict clinical pharmacokinetics over a large dose range from different clinical scenarios after subcutaneous and intravenous anifrolumab dosing. …”
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Dissolution and Pharmacokinetic Studies of Paracetamol-4,4′-Bipyridine Cocrystals Obtained Using Four Methods by Xiaoming Zhang, Yejia Huang, Jinliang Li, Yiying Chen, Jialing Lian

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Pharmacokinetics of tebipenem pivoxil used in children suffering from shigellosis: a pilot study in Bangladesh by Sharika Nuzhat, Md Ridwan Islam, Syed Jayedul Bashar, Subhasish Das, Rukaeya Amin, Firdausi Qadri, Farhana Khanam, Dilruba Ahmed, Patricia B. Pavlinac, Cindy X. Zhang, Samuel L. M. Arnold, Amy Newlands, Mohammod Jobayer Chisti, Tahmeed Ahmed

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HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats by Dahu Liang, Zijing Wu, Yanhao Liu, Chao Li, Xianghong Li, Bin Yang, Haitang Xie, Hua Sun

“…This study sought to design a sensitive and efficient HPLC-MS/MS approach to measuring Schisandrol B levels in rat plasma and tissues in order to assess the pharmacokinetics, oral bioavailability, and tissue distributions of this compound in vivo. …”
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Pharmacokinetics, biological effects, and distribution of (1→3)-β-D-glucan in blood and organs in rabbits by Minoru Yoshida, Robert I. Roth, Carl Grunfeld, Kenneth R. Feingold, Jack Levin

“…The pharmacokinetics, biological effects and distribution in blood and organs of 125I-labeled (1→3)-β-D-glucan purified from Candida albicans were analyzed in rabbits during the 24-h period following an intravenous administration.The intravascular half-life of (1→3)-β- D-glucan was 1.8 min in the low-dose group (9.3 μg/kg) and 1.4 min in the high-dose group (222 μg/kg), and the mean (±SD) total body clearance was 1.12 ± 0.30 and 1.17 ± 0.16 ml/min, respectively. …”
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A prospective study to evaluate high dose daptomycin pharmacokinetics and pharmacodynamics in spp. infective endocarditis by Simona De Gregori, Annalisa De Silvestri, Mara Capone, Vincenzina Monzillo, Paola Giordani, Raffaele Bruno, Elena Seminari

“…Background: Daptomycin pharmacokinetics and pharmacodynamics data relative to higher doses in patients are necessary for clinical practice. …”
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Population pharmacokinetics of ramipril in patients with chronic heart failure: A real-world longitudinal study by Trobec Katja Čvan, Grabnar Iztok, Trontelj Jurij, Lainščak Mitja, Kos Mojca Kerec

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Pharmacokinetics of Transdermal Flunixin Meglumine Following a Single Dose in Marine Toads (Rhinella marina) by Gregory Scott, Meghan M. Louis, Julie A. Balko, Claire M. Bublitz, Brigid V. Troan, Ronald E. Baynes, Dustin Smith, Larry J. Minter

“…Despite this, there are relatively few studies that investigate transdermal pharmacokinetics in amphibians. The objective of this study was to investigate the pharmacokinetics of transdermal flunixin meglumine applied topically to marine toads (Rhinella marina). …”
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Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…Here, we used carbon-11-labeled CEP-32496 ([ 11 C]CEP-32496) as a positron emission tomography (PET) radiotracer to evaluate its pharmacokinetic properties and explore its potential for in vivo imaging. …”
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Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase‐CYP substrates by Nihan Izat, Jayaprakasam Bolleddula, Pasquale Carione, Leticia Huertas Valentin, Robert S. Jones, Priyanka Kulkarni, Darren Moss, Vincent C. Peterkin, Dan‐Dan Tian, Andrea Treyer, Karthik Venkatakrishnan, Michael A. Zientek, Jill Barber, J. Brian Houston, Aleksandra Galetin, Daniel Scotcher

“…This study aimed to evaluate the utility of physiologically based pharmacokinetic (PBPK) modeling in the development of AO and dual AO‐CYP substrates. …”
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Development and Application of Physiologically-Based Pharmacokinetic Model to Predict Systemic and Organ Exposure of Colorectal Cancer Drugs by Sara Peribañez-Dominguez, Zinnia Parra-Guillen, Iñaki F. Troconiz

Subjects: “…physiologically-based pharmacokinetic model…”
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Determination of Tenacissoside G, Tenacissoside H, and Tenacissoside I in Rat Plasma by UPLC-MS/MS and Their Pharmacokinetics by Fan Chen, Yizhe Ma, Ying Cui, Wanhang Wang, Chenchen Mei, Jingjing Nie, Congcong Wen, Xiuwei Shen, Xuzhao Zhou

“…The established UPLC-MS/MS method was successfully applied to pharmacokinetic studies of tenacissoside G, tenacissoside H, and tenacissoside I, and the bioavailability was 22.9%, 89.8%, and 9.4%, respectively.…”
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Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract by Ji Shi, Xiaohang Ren, Jia Wang, Xiaofeng Wei, Bonan Liu, Tianzhu Jia

“…The compounds monotropein, rubiadin, and rubiadin 1-methyl ether are the major effective components of Morinda officinalis How. To clarify the pharmacokinetics and tissue distribution of these three compounds, we employed liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to determine the contents of the three components in rat plasma and tissues. …”
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Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…It has been successfully applied to the pharmacokinetic studies of PPIs and P-CABs, offering a valuable tool for clinical research and therapeutic drug monitoring.Keywords: acid-suppressing drugs, PPIs, P-CAB, UPLC-MS/MS…”
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Probabilistic nested model selection in pharmacokinetic analysis of DCE-MRI data in animal model of cerebral tumor by Hassan Bagher-Ebadian, Stephen L. Brown, Mohammad M. Ghassemi, Prabhu C. Acharya, Indrin J. Chetty, Benjamin Movsas, James R. Ewing, Kundan Thind

“…The time-trace of change in the longitudinal-relaxivity (ΔR1) for all animals’ brain voxels was calculated. DCE-MRI pharmacokinetic (PK) analysis was performed using NMS to estimate three model regions: Model-1: normal vasculature without leakage, Model-2: tumor tissues with leakage without back-flux to the vasculature, Model-3: tumor vessels with leakage and back-flux. …”
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Erratum to “Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration” by Mohamed Aboubakr, Ahmed Soliman

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Virtual Screening, Toxicity Evaluation and Pharmacokinetics of Erythrina Alkaloids as Acetylcholinesterase Inhibitor Candidates from Natural Products by Permana A, Akili AWR, Hardianto A, Latip JB, Sulaeman AP, Herlina T

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