Trifolirhizin: A Phytochemical with Multiple Pharmacological Properties by Varun Jaiswal, Hae-Jeung Lee

“…These pathways are also implicated in various other diseases, suggesting the potential of trifolirhizin in therapeutic applications. Initial pharmacokinetic studies support the therapeutic candidature of trifolirhizin and provide the initial track that may be pursued for its development. …”
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Antibacterial and Oxacillin Resistance Reversing Effect of Harmaline in Different Strains of Staphylococcus Aureus by Zaid Ibraheem

“…Besides, an additive effect or mild synergy was noticed in the other combinations.Conclusion: Overall, harmaline can be suggested as a chemo-sensitizer or a pharmacophore to develop better synergistic drugs for oxacillin against MRSA but further safety and pharmacokinetic studies are indicated to optimize this effect.…”
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Complexation by γ-cyclodextrin as a way of improving anticancer potential of sumanene by Artur Kasprzak, Agnieszka Żuchowska, Hidehiro Sakurai

“…Based on our preliminary biological studies, we discovered that the formation of such complexes resulted in the improvement of anticancer properties of sumanene, expressed by high cell viabilities in vitro of healthy human mammary fibroblasts (HMF) together with low viabilities of human breast adenocarcinoma cells (MDA-MB-231). Improved pharmacokinetic (ADME-Tox) properties for sumanene@γCD and sumanene@HP-γCD complexes in comparison to native sumanene were also supported by in sillico modeling studies. …”
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Long-Term Stability of Hydromorphone in Human Plasma Frozen at −20°C for Three Years Quantified by LC-MS/MS by Andreas Wehrfritz, Stefanie Schmidt, Harald Ihmsen, Jürgen Schüttler, Christian Jeleazcov

“…This finding is of value for re-evaluations or delayed analyses for research purposes and in pharmacokinetic studies, such as in forensic medicine.…”
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Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer's disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors... by Fatima Zahra Guerguer, Bouchra Rossafi, Oussama Abchir, Yasir S Raouf, Dhabya Bakhit Albalushi, Abdelouahid Samadi, Samir Chtita

“…Out of the 63 Azo-8HQ derivatives analysed, two molecules, 14c and 17c, demonstrated strong affinities for AChE, BuChE, and MAO-B, along with favourable pharmacokinetic profiles and electronic properties. Molecular dynamics simulations confirmed the stability of these molecules within the active sites of the targets, and MM-GBSA calculations revealed low binding energies, indicating robust interactions. …”
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Passive Immunoprophylaxis for the Protection of the Mother and Her Baby: Insights from In Vivo Models of Antibody Transport by Yanqun Xu, Iftekhar Mahmood, Lilin Zhong, Pei Zhang, Evi B. Struble

“…The use of appropriate animal models of placental transfer and infectious disease during pregnancy would facilitate pharmacokinetic modeling to derive a starting dose in clinical trials.…”
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Ecofriendly spectrophotometric methods for simultaneous determination of remdesivir and moxifloxacin hydrochloride as co administered drugs in corona virus treatment by Eman A. Madbouly, Abdalla A. El-Shanawani, Sobhy M. El-adl, Ahmed S. Abdelkhalek

“…So, also, the ratio spectra were successfully manipulated for quantification of the two drugs. Regarding the pharmacokinetic profile of remdesivir (Cmax 4420 ng/mL) and moxifloxacin hydrochloride (Cmax 3.56 µg/mL), the proposed methods were effectively used to spectrophotometrically determine remdesivir and moxifloxacin hydrochloride in plasma matrix. …”
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PET in neurotherapeutic discovery and development by Melissa Chassé, Neil Vasdev

“…By incorporating such radionuclides into molecules of interest, we can directly assess their pharmacokinetic and pharmacodynamic (PK/PD) characteristics in vivo without changing their physicochemical characteristics or eliciting a pharmacological response. …”
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Promising inhibitors against main protease of SARS CoV-2 from medicinal plants: In silico identification by EBENEZER OLUWAKEMI, SHAPI MICHAEL

“…To pinpoint the drug-like compound among the top-ranked compounds, the Lipinski’s rule of five and pharmacokinetic properties of all the selected compounds were evaluated. …”
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Potential of cumin essential oil as inhibitor of deamination during ensiling process: A meta-analysis and in-silico approach by Susanto Irwan, Mahendra Fachrur R., Rahmadani Mardiah, Ridwan Roni, Jayanegara Anuraga

“…The observed metrics included energy values derived from the Vina program, pharmacokinetic analysis, and free ammonia concentration in silage. …”
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Comprehensive review of preclinical evaluation strategies for COVID-19 vaccine candidates: assessing immunogenicity, toxicology, and safety profiles by Delaram Doroud, Mojtaba Daneshi, Fatemeh Kazemi-Lomedash, Zohre Eftekhari

“…In toxicology studies, several factors must be considered, such as the appropriate animal species and strains, dosing timetable, mode of administration, time of sampling for biochemistry and antibody evaluation, and necropsy. Pharmacokinetic/ biodistribution studies are not usually required for infectious disease prophylaxis vaccines unless the vaccine contains a novel substance. …”
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The Effect of the Thioether-Bridged, Stabilized Angiotensin-(1–7) Analogue Cyclic Ang-(1–7) on Cardiac Remodeling and Endothelial Function in Rats with Myocardial Infarction by Matej Durik, Richard van Veghel, Anneke Kuipers, Rick Rink, Marijke Haas Jimoh Akanbi, Gert Moll, A. H. Jan Danser, Anton J. M. Roks

“…However Ang-(1–7) has limited clinical potential due to its unfavorable pharmacokinetic profile. We investigated effects of a stabilized, thioether-bridged analogue of Ang-(1–7) called cyclic Ang-(1–7) in rat model of myocardial infarction. …”
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Adaptation of an in vitro one-compartment pharmacodynamic chemostat for testing efficacy of ceftazidime against Burkholderia pseudomallei outside a BSL3 facility by Hana Farizah Zamri, Mohammad Ridhuan Mohd Ali, Ahmad Izzan Irfan Sha'ari, Nurul Husna Mohd Mazalan, Norazah Ahmad, Nur Asyura Nor Amdan, Nusaibah Abdul Rahim, Zakuan Zainy Deris

“…Non-clinical pharmacokinetic-pharmacodynamic (PKPD) models are crucial in the initial design of drug-dosage regimens and in drug development but has rarely been employed for testing high-risk organisms due to stringent handling procedures. …”
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Application of a Plug-and-Play Immunogenicity Assay in Cynomolgus Monkey Serum for ADCs at Early Stages of Drug Development by Montserrat Carrasco-Triguero, Helen Davis, Yuda Zhu, Daniel Coleman, Denise Nazzal, Paul Vu, Surinder Kaur

“…It is rarely predictive for clinical studies and evidence for the presence of anti-drug antibodies (ADAs) may be inferred from the pharmacokinetic (PK) profile. However, collecting and banking samples during the course of the study are prudent for confirmation and a deeper understanding of the impact on PK and safety. …”
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Arsenic accumulation and reproductive toxicity in freshwater snail (Pomacea canaliculata) by Xiaoyang Bi, Zhifei Shi, Dongqin Li, Wenhui Zhan, Zhixiong Wang, Huashou Li, Benliang Zhao, Guikui Chen

“…An eight-compartment physiologically based pharmacokinetic (PBPK) model was utilized to simulate the distribution and depuration kinetics of arsenite and arsenate in the snails. …”
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Adjuvant Bidirectional Chemotherapy with Intraperitoneal Pemetrexed Combined with Intravenous Cisplatin for Diffuse Malignant Peritoneal Mesothelioma by Lana Bijelic, O. Anthony Stuart, Paul Sugarbaker

“…The median survival for all 10 patients was 33.5 months. Pharmacokinetic analysis of intraperitoneal pemetrexed showed a peritoneal to plasma area under the curve ratio of 70. …”
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Validation of Colchicine Assay Method for Therapeutic Drug Monitoring in Human Plasma by Fadime Canbolat

“…It has been thought that pharmacokinetic studies of COL in plasma can be performed easily using this validated method…”
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Exploration of Potent Human α-Glucosidase Inhibitors Using In Silico Approaches: Molecular Docking, DFT, Molecular Dynamics Simulations, and MMPBSA by Jyoti Bashyal, Bimal Kumar Raut, Siddha Raj Upadhyaya, Kabita Sharma, Niranjan Parajuli

“…We studied a library of 80 secondary metabolites ascribed to their antidiabetic properties and screened the most potent inhibitors using a comprehensive in silico approach, including molecular docking, DFT study, MD simulation, PCA, MMPBSA calculation, and pharmacokinetic analysis. Scolopianate A and ponasterone A emerged as potent α-glucosidase inhibitors, forming hydrogen bonds with the catalytic diad and exhibiting prominent binding affinities of −8 kcal/mol. …”
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Validation of a Model for Predicting Magnesium Concentration in Women with Preeclampsia: A Retrospective Cohort Study by Erik Holmström Thalme, Magnus Frödin-Bolling

“…Success rate is lower in heavy women, which is of particular importance considering their predisposition to develop preeclampsia. The validated pharmacokinetic model performs well and may be used to individually tailor treatment from the outset.…”
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Tacrolimus Concentration Is Effectively Predicted Using Combined Clinical and Genetic Factors in the Perioperative Period of Kidney Transplantation and Associated with Acute Reject... by Fang Cheng, Qiang Li, Zheng Cui, Zhendi Wang, Fang Zeng, Yu Zhang

“…Tacrolimus has unpredictable pharmacokinetic (PK) characteristics, which are partially attributed to CYP3A5 polymorphism. …”
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