Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus by Randah Dahlan, Ameen Patel, Shariq Haider

“…A case of soft tissue infection of the toe caused by Fusarium chlamydosporum and Candida guilliermondii in a liver transplant patient on sirolimus, who was successfully treated with the new antifungal agent posaconazole, is described. The pharmacokinetic interactions of sirolimus and the new triazoles, and their impact on treatment choices are briefly discussed.…”
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Targeting ASK1 by CS17919 alleviates kidney‐ and liver‐related diseases in murine models by Guoqiang Liao, Qianjiao Yang, Xuhua Mao, Yiru Zhao, Beizhong Chen, Kun Zhang, Yu Zhang, Ping Zhang, Zhengli Chen, Shengjian Huang

“…CS17919 also showed pronounced pharmacokinetic properties such as a high plasma concentration. …”
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Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice by Pabitra K. Sardar, Steven Yeung, Ruby Tow, Jacqueline Luga, Matthew Huang, Ayaz Shahid, Bradley T. Andresen, Ying Huang

“…Methods Efficacy of orally delivered R-carvedilol was examined in SKH-1 mice exposed to repeated UV radiations for 25 weeks. Pharmacokinetic studies were conduced in mice to evaluate the drug levels in plasma and skin tissues. …”
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Ritonavir loaded solid lipid nanoparticles for oral drug delivery and bioavailability enhancement by Ananda Kumar Chettupalli, Sarad Pawar Naik Bukke, Shaik Abdul Rahaman, Aziz Unnisa, Madhumitha Adepu, Marati Kavitha, Molakpogu Ravindra Babu, Bayapa Reddy Narapureddy, Hope Onohuean

“…In addition, in-vitro drug release studies confirmed a biphasic release pattern, and followed Higuchi’s model. The in vivo pharmacokinetic studies showed an increase in bioavailability by 4.3 folds as compared to marketed formulation. …”
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The inhibition of acne protease by some flavones: DFT, SWISSADMET and molecular docking by Latona Dayo, Taiwo Abiodun, Asibor Yemisi, Olarinoye Funke, Semire Banjo

“…SWISSADMET was employed to ascertain the pharmacokinetic properties of the ligands, and molecular docking was achieved by using PyRx and discovery studiosoft wares. …”
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Gompertz model with delays and treatment: Mathematical analysis by Marek Bodnar, Monika Joanna Piotrowska, Urszula Foryś

“…The analytical results are extended by numerical simulations for a pharmacokinetic treatment function.…”
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Role of Dolutegravir/Lamivudine in the Management of Pregnant People Living with HIV-1: A Narrative Review by William R. Short, Parul Patel, Gustavo Verdier, Ana Puga, Vani Vannappagari, Annemiek de Ruiter, Bryn Jones

“…Updated data from the Tsepamo and Eswatini surveillance studies (> 14,000 DTG exposures from conception) indicate no increased risk of neural tube defects with DTG. Pharmacokinetic data for DTG and 3TC indicate that exposures in pregnancy are within the therapeutically effective range seen in non-pregnant adults. …”
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Stapled peptides: targeting protein-protein interactions in drug development by Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang

“…This review outlined the continuous progress of stapled peptides mainly concerning the design principle, structural stability, bioactivity, cell permeability, and potential applications in therapeutics, which is aimed at providing a broad reference for the design and exploration of stapled peptides with enhanced biological and pharmacokinetic properties as the next-generation therapeutic peptide drugs targeting various diseases.…”
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A Need for Further Education on Buprenorphine in Pain Medicine by Jamal Hasoon, Anvinh Nguyen, Ivan Urits, Christopher Robinson, Omar Viswanath, Alan D Kaye

“…Buprenorphine also has a unique set of side effects as well pharmacodynamic and pharmacokinetic properties that require special attention, especially if these patients require future surgical interventions. …”
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Antidiabetic Potential of Phytochemicals Found in Vernonia amygdalina by Archna Talwar, Neha Chakraborty, Manaal Zahera, Shruti Anand, Irshad Ahmad, Samra Siddiqui, Avni Nayyar, Ashanul Haque, Mohd Saeed

“…This review examined the antidiabetic and pharmacokinetic characteristics of phytoconstituents found in V. amygdalina.…”
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Anti-Inflammatory and Anticoagulant Activities of Synthesized NSAID Prodrug Esters by Murad N. Abualhasan, Motasem Y. Al- Masri, Rufaida Manasara, Lana Yadak, Nael S. Abu-Hasan

“…The synthesized drugs are expected to improve patient’s compliance in terms of administration frequency and will have better pharmacokinetic properties with fewer side effects.…”
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Phytocompounds from Indonesia Medicinal Herbs as Potential Apelin Receptor Agonist for Heart Failure Therapy: An In-silico Approach by Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Muhammad Habiburrahman, Somasundaram Arumugam, Heri Wibowo, Suci Widya Primadhani, Aryo Tedjo, Surya Dwira, Nurul Gusti Khatimah

“…Gambogic acid demonstrated favorable pharmacokinetic properties: good bioavailability, minimal blood-brain barrier penetration, no cytochrome P450 (CYP) enzyme interactions, and low toxicity. …”
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DigiLoCS: A leap forward in predictive organ-on-chip simulations. by Manoja Rajalakshmi Aravindakshan, Chittaranjan Mandal, Alex Pothen, Stephan Schaller, Christian Maass

“…Physiologically based pharmacokinetic (PBPK) model estimation of liver clearance is explored. …”
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Cloud-Point Extraction Combined with Liquid Chromatography for the Determination of Ergosterol, a Natural Product with Diuretic Activity, in Rat Plasma, Urine, and Faeces by Dan-Qian Chen, Jun-Min An, Ya-Long Feng, Ting Tian, Xiang-Yang Qin, Ying-Yong Zhao

“…The method was successfully applied to the pharmacokinetic studies of ergosterol in rats. The results indicate that the ergosterol levels in feces are much higher than those in plasma and urine of the rat.…”
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A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection by Adesh Kumar Agrawal, Soumitra Das, Lorenzo Abednego B. Adre, Nakka Raghuma, Sharanya Kaushik, Adarsha Adhikari

“…We reviewed clozapine’s pharmacokinetic properties to understand why serum levels rose during infection. …”
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Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications by Mario Sznol, Naiyer Rizvi

“…The disappointing data raise important questions about the potential efficacy of other interleukin-2 variants, however, several of the other variants appear to be sufficiently differentiated in anticipated pharmacokinetic properties and immune modulatory effects to warrant continued clinical development.…”
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Hybrid Quantum Cycle Generative Adversarial Network for Small Molecule Generation by Matvei Anoshin, Asel Sagingalieva, Christopher Mansell, Dmitry Zhiganov, Vishal Shete, Markus Pflitsch, Alexey Melnikov

“…The new hybrid quantum machine learning algorithms, as well as the achieved scores of pharmacokinetic properties, contribute to the development of fast and accurate drug discovery processes.…”
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Pharmacological and Pharmacodynamic Implications of Nonsteroidal Anti-Inflammatory Drug Therapy in Elderly Arthritic Patients by W Watson Buchanan

“…Physiological changes, which include reduced muscle mass, total body water and albumin levels, as well as effects on renal and hepatic function, affect pharmacokinetic factors, including absorption, distribution, biotransformation and renal clearance. …”
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Interleukin 2-Based Fusion Proteins for the Treatment of Cancer by Alana MacDonald, T.-C. Wu, Chien-Fu Hung

“…Over the past three decades, efforts have focused on circumventing IL-2-related toxicities by engineering methods to localize IL-2 to the tumor or secondary lymphoid tissue, preferentially activate CD8+ T cells and NK cells, and alter pharmacokinetic properties to increase bioavailability. …”
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Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies by Amani M. El Sisi, Essam M. Eissa, Ahmed H. E. Hassan, Marina A. Bekhet, Fatma I. Abo El-Ela, Eun Joo Roh, Rasha M. Kharshoum, Adel A. Ali

“…The current inquiry intended to fabricate nose-to-brain chitosan-grafted cationic leciplexes of MRZ (CS-MRZ-LPX) to improve its pharmacokinetic weaknesses and boost the pharmacodynamics aspects. …”
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