Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids by Tatsuya Inui, Yusei Uraya, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi

“…Thus, there is room for some adjustment in the ALI culture model to optimize its applicability to pharmacokinetic studies using ELC-org-mono.…”
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Silybin Cocrystals with Improved Solubility and Bioavailability by Bingqing Zhu, Zhenfeng Ding, Xiaoyi Rong, Shengqiang Li, Xuefeng Mei

“…Dissolution tests were conducted in various pH solutions, and the impact of precipitation inhibitors was evaluated. Furthermore, pharmacokinetic study in rats were performed to assess the bioavailability. …”
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Virtual screening and molecular docking of Indonesian phytoconstituents as potential inhibitors of peroxisome proliferator-activated receptor gamma in polycystic ovary syndrome by Tunjungseto Arif, Iffatunnisa Fakhriyah, Pratiwi Intan Winta, Alif Azzam Muhyiddin Afrizal, Ahsan Fadhil, Santoso Budi

“…This study aimed to identify potential Indonesian phytoconstituents that inhibit PPARG both from a pharmacokinetic and pharmacodynamic perspective based on the in silico approach. …”
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Determination of Platycodin D and Platycodin D3 in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry by Tae-Hyun Kim, Byung Eui Lee, Eun Joo Kim, Yong Seok Choi, Keun-Sung Lee, Hak Rim Kim, Hyung-Gun Kim

“…The present method can be applied to pharmacokinetic analysis of platycodins and platycosides of the PG.…”
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Magnetic precision: Unleashing the therapeutic potential of paclitaxel-loaded nanoparticles in breast cancer treatment by N. Shobhana, N Raghavendra Naveen, Prakash Goudanavar

“…This study employs a comprehensive methodology encompassing various in vitro characterizations, cytotoxicity assessments, cellular uptake studies, in vivo experiments, and pharmacokinetic analyses to systematically evaluate the efficacy of paclitaxel-loaded MNPs. …”
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Discrepancies Between Bayesian Vancomycin Models Can Affect Clinical Decisions in the Critically Ill by Asad E. Patanwala, Danijela Spremo, Minji Jeon, Yann Thoma, Jan-Willem C. Alffenaar, Sophie Stocker

“…To assess the agreement in 24-hour area under the curve (AUC24) value estimates between commonly used vancomycin population pharmacokinetic models in the critically ill. Materials and Methods. …”
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Effects of Oral Ginger Supplementation on the INR by Daniel Rubin, Vishal Patel, Eric Dietrich

“…This brief case report discusses the potential scope of the problem as well as the proposed pharmacokinetic and pharmacodynamic interactions between these two commonly used agents.…”
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Bioequivalence study of fluticasone propionate nebuliser suspensions in healthy Chinese subjects by Feng Cheng, Tao Shen, Fucheng Zhang, Chenghao Lei, Ye Zhu, GuoJun Luo, Dawei Xiao

“…No severe, suspicious or unexpected serious adverse reactions were reported.ConclusionThe test and reference formulations of fluticasone propionate nebuliser suspension were pharmacokinetic bioequivalent and were well tolerated and safe in all subjects.…”
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Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity by Aditya R. Kumar, Lyndsey S. Benson, Erica M. Wymore, Jocelyn E. Phipers, Jennifer C. Dempsey, Lucinda A. Cort, Jashvant D. Unadkat

“…Our maternal-fetal physiologically based pharmacokinetic model can guide future studies to inform risks associated with prenatal cannabis use.…”
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Risk Factors and Prevention of Upper Gastrointestinal Complications Associated with Nonsteroidal Anti-Inflammatory Drugs by N. V. Bakulina, S. V. Tikhonov, K. A. Nagornova

“…Esomeprazole has a number of pharmacokinetic advantages — a large area under the pharmacokinetic curve, the ability to inhibit CYP4502C19, which determines the high efficiency of therapy in fast and ultrafast metabolizers. …”
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Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications by Devan Buchanan, Shogo Mori, Ahmed Chadli, Siva S. Panda

“…Their unique ability to combine high specificity with desirable pharmacokinetic properties makes them valuable tools in addressing unmet medical needs, such as combating drug-resistant pathogens and targeting challenging biological pathways. …”
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Exploring the antifungal potential of Cannabis sativa-derived stilbenoids and cannabinoids against novel targets through in silico protein interaction profiling by Kevser Kübra Kırboğa, Aman Karim, Ecir Uğur Küçüksille, Mithun Rudrapal, Johra Khan, Raghu Ram Achar, Ekaterina Silina, Natalia Manturova, Victor Stupin

“…The ligands with the highest binding affinities were identified, and their pharmacokinetic profiles were analyzed using ADMET analysis. …”
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Computational analysis of Allium sativum compounds to identify thermolabile hemolysin inhibitors against Vibrio alginolyticus in shrimp by Sayed Mashequl Bari, Nafees Bin Reza, Meamaching Marma, Sk. Foisal Ahmed, Md Arif Hussain, Md Naimuddin Jabed, Md Alomgir Hossain, Maria Manzoor, Md Saiful Alam

“…Various computational approaches, including molecular docking, pharmacokinetic analysis, and molecular dynamics simulation, were conducted to predict the compounds that can inhibit the phospholipase and hemolysis activities of the thermolabile hemolysin protein. …”
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Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review by Mardiana L, Milanda T, Hadisaputri YE, Chaerunisaa AY

“…This review aims to investigate how phytosome encapsulation improves the pharmacokinetic profiles and anticancer effectiveness of these bioactive compounds.Patients and Methods: This comprehensive review is based on an analysis of recent literature retrieved from PubMed, Scopus, and ScienceDirect databases. …”
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Liposome-like encapsulation of fish oil-based self-nano emulsifying formulation for improved bioavailability by Iqbal Ahmad, Aparana Dogra, Tanya Nagpal, Chandvi Sharma, Sudhakar Singh, Nikhil Shaiva, Gaurav Saini, Kanishk Luhach

“…The enhanced pharmacokinetic profile suggests that this novel formulation could offer superior clinical benefits, including but not limited to managing lipid profile and hypertension, improving cognition, glycaemic control, and reducing inflammation. …”
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Investigations of Long-Acting Formulations in Children, Adolescents, and Pregnant Women: A Systematic Review by Lynn Bertagnolli, Zhengyi Deng, Melissa Davy-Rothwell, Elaine J. Abrams, Charles Flexner, Ethel D. Weld

“…Only 9.3% of the studies in children and 16.7% of the studies in pregnant people collected any pharmacokinetic (PK) data. <b>Conclusions:</b> Long-acting formulations may behave differently (both pharmacokinetically and pharmacodynamically) in childhood, adolescence, and pregnancy as compared to non-pregnant adulthood. …”
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On the MTD paradigm and optimal control for multi-drug cancer chemotherapy by Urszula Ledzewicz, Heinz Schättler, Mostafa Reisi Gahrooi, Siamak Mahmoudian Dehkordi

“…In this paper, we briefly discuss therationale behind this therapy approach and, using as examplemulti-drug cancer chemotherapy with a cytotoxic and cytostatic agent, show thatthese types of protocols are optimal in the sense of minimizing a weightedaverage of the number of tumor cells (taken both at the end of therapy and atintermediate times) and the total dose given if it is assumed that the tumorconsists of a homogeneous population of chemotherapeutically sensitive cells.A $2$-compartment linear model is used to model the pharmacokinetic equations for the drugs.…”
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Critically Ill Patients with Renal Hyperfiltration: Optimizing Antibiotic Dose by Jorge Rico-Fontalvo, José Correa-Guerrero, María Cristina Martínez-Ávila, Rodrigo Daza-Arnedo, Tomás Rodriguez-Yanez, Amilkar Almanza-Hurtado, José Cabrales, Carmen Julia Mendoza-Paternina, Alvaro Frías-Salazar, Julio Morales-Fernández

“…The current review discusses the available evidence related to the RHF phenomenon, including definition, epidemiology, risk factors, pathophysiology, pharmacokinetic variability, and considerations for optimizing the dosage of antibiotics in critically ill patients.…”
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Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient by Serena Patel, Michel H. Mendler, Mark A. Valasek, Shirley M. Tsunoda

“…This report includes a brief review of the pharmacokinetic properties of everolimus, a review of the relevant literature, and an analysis using the RUCAM and Naranjo algorithms.…”
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A case report of exacerbation of extrapyramidal symptoms following the switch from risperidone to paliperidone during valproate therapy by Emi Hata, Masatoshi Miyauchi, Nobuhiko Noguchi, Takeshi Asami

“…Discussion This case highlights the pharmacokinetic interaction between valproate and paliperidone, which can elevate plasma levels of paliperidone and exacerbate EPS. …”
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