Safety and Phosphate‐Binding Capacity of Oxylanthanum Carbonate in Healthy Volunteers by Pablo E. Pergola, Melanie S. Joy, Armando Garsd, Steve J. Hasal, Atul Khare, Guru Reddy, Pramod Gupta, William F. Finn

“…In a double‐blind dose‐escalation phase 1 study, healthy volunteers (n = 32) were randomly divided into four treatment arms and randomly assigned to receive oxylanthanum carbonate tablets or a placebo over a period of 4 days to evaluate safety, urinary and fecal excretion of phosphorus, and pharmacokinetics. Each treatment arm evaluated a different dose of oxylanthanum carbonate: 500, 1000, 1500, or 2000 mg three times a day (TID). …”
Get full text

Development of Novel Fluticasone/Salmeterol/Tiotropium-Loaded Dry Powder Inhaler and Bioequivalence Assessment to Commercial Products in Rats by Hyukjun Cho, Hyunji Lee, Duhyeong Hwang

“…To investigate the bioequivalence of micronized FP/SX/TB-loaded DPI to commercial products, the dissolution profile of FP/SX/TB particles and pharmacokinetics in rats were evaluated and compared to commercial products. …”
Get full text

Phytomedicine nanoformulations for Parkinson's disease by Chinthu V. Saji, K P Mohanakumar, Rajesh A Shenoi

“…In vitro studies demonstrated enhanced cellular uptake and neuroprotective effects, while in vivo models showed improved pharmacokinetics, BBB permeability and neuroprotective outcomes. …”
Get full text

Enhancing gene transfer to renal tubules and podocytes by context-dependent selection of AAV capsids by Taisuke Furusho, Ranjan Das, Hideyuki Hakui, Anusha Sairavi, Kei Adachi, Mia S. Galbraith-Liss, Pratheppa Rajagopal, Masahiro Horikawa, Shuhua Luo, Lena Li, Kentaro Yamada, Nicole Andeen, Gregory A. Dissen, Hiroyuki Nakai

“…We demonstrate that these contrasting observations are partly due to differences in their pharmacokinetics. Importantly, we show that renal pelvis injection overcomes pre-existing immunity, leading to robust and exclusive proximal tubule transduction, in non-human primates (NHPs). …”
Get full text

Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements by Sanshita, Taneja Ayushi, Sangnim Tanikan, Huanbutta Kampanart, Sindhu Rakesh K., Singh Inderbir

“…In this review, liquorice's historical background, pharmacokinetics, therapeutic applications, different mechanism of actions is discussed with major emphasis on liquorice encapsulated novel formulations (nanoparticles, nanomicelles, liposomes, niosomes, microparticles, microspheres, self-nanoemulsifying system, self-micro-emulsifying system). …”
Get full text

Sorafenib-Loaded Silica-Containing Redox Nanoparticle Decreases Tumorigenic Potential of Lewis Lung Carcinoma by Babita Shashni, Hao Thi Tran, Long Binh Vong, Ren-Jei Chung, Yukio Nagasaki

“…<b>Background:</b> Orally administered sorafenib has shown limited improvement in overall survival for non-small-cell lung cancer patients, likely due to poor pharmacokinetics and adverse effects, including gastrointestinal toxicity. …”
Get full text

Phenolic Compounds from Ocimum basilicum Revealed as Antibacterial by Experimental and Computational Screening-Based Studies against Oral Infections by Salsabila Aqila Putri, Euis Julaeha, Natsuko Kagawa, Dikdik Kurnia

“…In addition, the strongest binding affinity of hydroxycinnamic acid derivatives is chlorogenic acid (−9.16 kcal·mol−1). The pharmacokinetics were predicted by ADMET analysis, and methyl caffeate (4) showed the best potential as a drug compound. …”
Get full text

Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host by Muhammad Naveed, Muzamal Hussain, Tariq Aziz, Nimra Hanif, Nazia Kanwal, Arooj Arshad, Ayaz Ali Khan, Abdulrahman Alshammari, Metab Alharbi

“…Imperatorin’s compliance with Lipinski’s Rule of 5 and favorable pharmacokinetics make it an ideal therapeutic agent against EBV. …”
Get full text

Essential oils used in the poultry industry: Would it be an effective green alternative against Salmonella spp. dissemination and antimicrobial resistance? by Heitor Leocádio de Souza Rodrigues, Isis Mari Miyashiro Kolososki, Valdinete Pereira Benevides, Mauro M.S. Saraiva, Angelo Berchieri Junior

“…Thus, investigations related to the pharmacokinetics, mechanisms of action, and adverse effects of EOs in the poultry's body are important to elucidate the treatment with these alternative antimicrobials, as well as to understand their interactions with both pathogenic bacteria and the bacteria that naturally compose the poultry's microbiota.…”
Get full text

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody by Eva Schlein, Ken G. Andersson, Tiffany Dallas, Stina Syvänen, Dag Sehlin

“…Blood and brain pharmacokinetics of radiolabeled antibodies were studied in wildtype (WT) and AD mice (AppNL-G-F). …”
Get full text

An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats by Archana K. Thikekar, Asha B. Thomas, Sohan S. Chitlange

“…The focus of this study is to investigate the effects of the herbal formulation IME-9 on the pharmacokinetics (PK) and pharmacodynamics (PD) of Glimepiride (GP) and whether it is advantageous, detrimental or has no consequences. …”
Get full text

Two chromatographic methods for analyzing paracetamol in spiked human plasma with its toxic metabolite, N-acetyl parabenzoquinone imine and its antidote, N-acetyl-l-cysteine by Omar M El-Abassy, Michael Gamal Fawzy, Ebraam B. Kamel

“…When it comes to pharmacokinetics or medication levels in children’s plasma, for example, this may be also very helpful. …”
Get full text

First-in-Man Evaluation of I-PGN650: A PET Tracer for Detecting Phosphatidylserine as a Biomarker of the Solid Tumor Microenvironment by Richard Laforest PhD, Farrokh Dehdashti MD, Yongjian Liu PhD, Jennifer Frye CMMT, Sarah Frye CMMT, Hannah Luehmann, Deborah Sultan, Joseph S. Shan PhD, Bruce D. Freimark PhD, Barry A. Siegel MD

“…In this phase 0 study, we evaluated the pharmacokinetics, safety, radiation dosimetry, and tumor targeting of this tracer in a cohort of patients with cancer. …”
Get full text

The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy by Huihui Guo, Hongsheng Xie, Yuanyuan Huang, Junxiang Jia, Xiangfei Kong, Qingliang Yang, Shun Gai, Wenjun Li, Lu Bai, Lingli Zhang, Xiaoxiao Chen, Zhicang Ye, Hangbo Ye, Linyao Zhao, Yifang Xu, Yong Du, Xiuzhen Zhang, Miaomiao Chen, Xiaomai Zhou, Robert Y. Zhao

“…This study examines the efficacy, pharmacokinetics, and safety profile of DX126-262, with a focus on Tubulysin-associated liver toxicity. …”
Get full text

Analysis of drug release models from biodegradable nanomodified chitosan based materials by М. О. Кумеда, Л. Б. Суходуб, Л. Ф. Суходуб

“…Results: HA is a good adsorbent, but a poorly soluble substance, so the pharmacokinetics of ANA release was mainly determined by the degree of adsorption of the drug on the surface of the material and its diffusion potential. …”
Get full text

Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 by Yanqing Liu, Jie Chen, Xiang Li, Yu Fan, Cheng Peng, Xiaochun Ye, Yingshuang Wang, Xin Xie

“…Additionally, we discuss the challenges faced by these natural products during clinical translation, including issues related to pharmacokinetics. Strategies such as combination therapy, structural optimization, and drug delivery systems are anticipated to enhance efficacy and overcome these challenges.…”
Get full text

Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease by Wang H, Zhou F, Shen M, Ma R, Yu Q

“…These formulations can enhance a drug’s pharmacokinetics by modifying its properties, improve its ability to cross barriers, and boost bioavailability. …”
Get full text

Damoctocog Alfa Pegol, a PEGylated B-domain Deleted Recombinant Extended Half-life Factor VIII for the Treatment of Hemophilia A: A Product Review by Mark T. Reding, Shadan Lalezari, Gili Kenet, Giovanni Di Minno, Jonathan Ducore, Alexander Solms, Anita Shah, Pål André Holme, Lone H. Poulsen, Karina Meijer, Mindy Simpson, Maria Elisa Mancuso

“…The efficacy, safety and pharmacokinetics (PK) of damoctocog alfa pegol have been studied extensively in the PROTECT VIII clinical trials, and its long-term safety and effectiveness profile is continuing to build through observational and interventional real-world studies. …”
Get full text

Evaluating the antagonist effect of naltrexone implant via opioid challenge tests with escalating doses of hydromorphone injection in former heroin dependent patients by Wei Qu, Xuyi Wang, Chongyang Dong, Tao Zhang, Shugui Yin, Zhijun Sun, Shiqiang Wang, Anni Guo, Wei Hao

“…This study (trial registration number: CTR20181954) aimed to evaluate the effect, safety, and pharmacokinetics of NTX-IMP in agonist effects via hydromorphone challenge test, and to determine optimal dosages for future research. …”
Get full text

Evaluation of [Cu]Cu-DOTA and [Cu]Cu-CB-TE2A Chelates for Targeted Positron Emission Tomography with an αβ-Specific Peptide by Sven H. Hausner, David L. Kukis, M. Karen J. Gagnon, Catherine E. Stanecki, Riccardo Ferdani, John F. Marshall, Carolyn J. Anderson, Julie L. Sutcliffe

“…Despite identical targeting peptide moiety and largely equal in vitro behavior, both 64 Cu-labeled tracers displayed inferior pharmacokinetics, making them in their present form less suitable candidates than the 18 F-labeled tracer for in vivo imaging of α v β 6…”
Get full text